CRIS Current Research Information System

CAPRANICO, GIOVANNI
 Distribuzione geografica
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Continente #
EU - Europa 5.085
NA - Nord America 5.045
AS - Asia 4.153
AF - Africa 336
SA - Sud America 210
Continente sconosciuto - Info sul continente non disponibili 9
OC - Oceania 9
Totale 14.847
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Nazione #
US - Stati Uniti d'America 4.992
IT - Italia 1.755
CN - Cina 1.500
SG - Singapore 1.253
GB - Regno Unito 949
DE - Germania 528
SE - Svezia 422
VN - Vietnam 388
HK - Hong Kong 327
UA - Ucraina 290
IN - India 264
FR - Francia 247
RU - Federazione Russa 209
IE - Irlanda 162
KR - Corea 151
CI - Costa d'Avorio 140
BR - Brasile 134
CH - Svizzera 99
NL - Olanda 96
ZA - Sudafrica 85
JP - Giappone 82
EE - Estonia 60
FI - Finlandia 56
JO - Giordania 51
TG - Togo 50
SC - Seychelles 47
BG - Bulgaria 37
PK - Pakistan 35
AR - Argentina 34
AT - Austria 30
CA - Canada 29
BE - Belgio 25
PL - Polonia 23
DK - Danimarca 22
ID - Indonesia 22
TR - Turchia 21
GR - Grecia 19
MX - Messico 19
HR - Croazia 18
ES - Italia 17
EC - Ecuador 12
BD - Bangladesh 10
IR - Iran 10
AU - Australia 8
EU - Europa 8
SY - Repubblica araba siriana 7
CL - Cile 6
PE - Perù 6
PY - Paraguay 6
UZ - Uzbekistan 6
BO - Bolivia 5
RO - Romania 5
TW - Taiwan 5
IL - Israele 4
NG - Nigeria 4
BY - Bielorussia 3
CO - Colombia 3
CZ - Repubblica Ceca 3
LB - Libano 3
MY - Malesia 3
SK - Slovacchia (Repubblica Slovacca) 3
VE - Venezuela 3
KE - Kenya 2
LT - Lituania 2
MU - Mauritius 2
PH - Filippine 2
PT - Portogallo 2
TH - Thailandia 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AE - Emirati Arabi Uniti 1
AZ - Azerbaigian 1
BZ - Belize 1
CR - Costa Rica 1
CV - Capo Verde 1
DO - Repubblica Dominicana 1
EG - Egitto 1
GA - Gabon 1
GE - Georgia 1
JM - Giamaica 1
KW - Kuwait 1
KZ - Kazakistan 1
LA - Repubblica Popolare Democratica del Laos 1
LU - Lussemburgo 1
LV - Lettonia 1
ME - Montenegro 1
ML - Mali 1
NZ - Nuova Zelanda 1
PR - Porto Rico 1
PS - Palestinian Territory 1
SN - Senegal 1
TN - Tunisia 1
UY - Uruguay 1
Totale 14.847
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Città #
Singapore 937
Southend 807
Bologna 469
Chandler 456
Ashburn 450
Hefei 420
Santa Clara 410
Fairfield 386
Hong Kong 263
Ann Arbor 247
Woodbridge 242
Cambridge 207
Jacksonville 194
Wilmington 192
Seattle 191
Princeton 189
Houston 177
Milan 165
Dublin 161
Dong Ket 149
Seoul 146
Abidjan 140
Boardman 121
Beijing 120
Dallas 106
Nanjing 87
Westminster 83
Naples 82
Tokyo 79
Padova 75
Rome 72
Bern 71
Los Angeles 60
Ho Chi Minh City 59
Berlin 58
Jinan 56
Amman 51
Hanoi 51
Lomé 50
Buffalo 49
Hyderabad 49
Shenyang 46
Medford 42
Helsinki 41
Munich 41
Mülheim 39
Sofia 37
Saint Petersburg 36
Bengaluru 34
Guangzhou 34
New York 34
Changsha 33
Frankfurt am Main 31
Hebei 30
Falkenstein 28
Nanchang 28
Redondo Beach 28
Shanghai 28
Verona 27
Mahé 25
Brussels 24
San Diego 24
Florence 23
Redmond 22
Zhengzhou 22
Mardan 20
Vienna 20
Des Moines 18
Fremont 18
Redwood City 18
Wuhan 17
Jakarta 16
Lanzhou 16
Phoenix 16
Reggio Emilia 16
São Paulo 16
Tianjin 16
Jiaxing 15
Dearborn 14
Falls Church 13
Ferrara 13
Ningbo 13
Parma 13
Fuzhou 12
Noicattaro 12
Southfield 12
Taizhou 12
Warsaw 12
Yubileyny 12
Haikou 11
Hangzhou 11
Kunming 11
Olalla 11
Turin 11
Bonn 10
Chicago 10
Da Nang 10
Islamabad 10
Modena 10
Montreal 10
Totale 9.609
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Nome #
Biologia molecolare. Con ebook. Con software di simulazione 421
Biotecnologie e modificazioni genetiche. Scienza, etica, diritto 409
G-quadruplex–R-loop interactions and the mechanism of anticancer G-quadruplex binders 338
Mechanistic roles of R-loops and micronuclei in the innate immune response induced by anticancer G-quadruplex binders 333
R loop-driven genome instability by G-quadruplex binders in BRCA2-silenced human cancer cells. 242
G-quadruplex binders as cytostatic modulators of innate immune genes in cancer cells 242
Balancing Affinity, Selectivity, and Cytotoxicity of Hydrazone-Based G-Quadruplex Ligands for Activation of Interferon β Genes in Cancer Cells 240
DNA damage and genome instability by G-quadruplex ligands are mediated by R loops in human cancer cells 231
Enhanced CPT sensitivity of yeast cells and selective relaxation of Gal4 motif-containing DNA by novel Gal4-Topoisomerase I fusion proteins. 225
G-quadruplex binders cause DNA damage by inducing R loops in human cancer cells. 224
Novel DNA Topoisomerase IIα Inhibitors from Combined Ligand- and Structure-Based Virtual Screening 219
Topoisomerase I poison-triggered immune gene activation is markedly reduced in human small-cell lung cancers by impairment of the cGAS/STING pathway 205
Characterization of novel antisense HIF-1α transcripts in human cancers 201
Human DNA topoisomerase I poisoning causes R loop-mediated genome instability attenuated by transcription factor IIS 196
DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF SUSTITUTED NAPHTHALENE IMIDES AND DIIMIDES AS ANTICANCER AGENT 193
Anthracyclines as Topoisomerase II Poisons: From Early Studies to New Perspectives 192
DNA Topoisomerase I differentially modulates R-loops across the human genome 187
A specific transcriptional response of yeast cells to camptothecin dependent on the Swi4 and Mbp1 factors. 186
Interaction model for anthracycline activity against DNA topoisomerase II. 183
Toward the Development of Specific G‑Quadruplex Binders: Synthesis, Biophysical, and Biological Studies of New Hydrazone Derivatives 181
Monohydrazone Based G-Quadruplex Selective Ligands Induce DNA Damage and Genome Instability in Human Cancer Cells 177
Ligands stimulating antitumour immunity as the next G-quadruplex challenge 176
Antisense transcripts enhanced by camptothecin at divergent CpG-island promoters associated with bursts of topoisomerase I-DNA cleavage complex and R-loop formation 175
Early effects of topoisomerase I inhibition on RNA polymerase II along transcribed genes in human cells. 174
Dissecting the transcriptional functions of human DNA topoisomerase I by selective inhibitors: Implications for physiological and therapeutic modulation of enzyme activity. 164
Novel symmetric and asymmetric DNA scission determinants for streptococcus pneumoniae topoisomerase IV and gyrase are clustered at the DNA breakage site. 158
Specific histone patterns and acetylase/deacetylase activity at the breakpoint-cluster region of the human MLL gene. 158
MYCN Amplification, along with Wild-Type RB1 Expression, Enhances CDK4/6 Inhibitors’ Efficacy in Neuroblastoma Cells 156
Development of DNA topoisomerase-related therapeutics. A short perspective of new challenges. 156
Dual Processing of R-Loops and Topoisomerase I Induces Transcription-Dependent DNA Double-Strand Breaks 156
The effects of camptothecin on RNA polymerase II transcription: roles of DNA topoisomerase I. 154
Intracellular beta-catenin relocalization after APC gene silencing by si-RNA in human madulloblastoma cell lines 152
Genome instability by G-quadruplex ligands are mediated by R-loops in human cancer cells 152
Effects of common buffer systems on drug activity: the case of clerocidin. 151
Correlation between neuronal differentiation and beta catenin distribution in medulloblastoma 150
Chromatin binding sites of DNA topoisomerase I, RNA polymerase II and TBP in transcribed genes in human cancer cells 149
RNA G-Quadruplexes in Kirsten Ras (KRAS) Oncogene as Targets for Small Molecules Inhibiting Translation 149
Natural product triptolide mediates cancer cell death by triggering CDK7-dependent degradation of RNA polymerase II 147
Electron Paramagnetic Resonance (EPR) Study of Spin-Labeled Camptothecin Derivatives: A Different Look of the Ternary Complex. 146
Sistema Wnt e differenziamento in linee cellulari di medulloblastoma 145
A long antisense RNA is transcribed at the 5’ end of the human HIF-1a gene upon drug inhibition of DNA Topoisomerase I. 145
Cyclohexa-2,5-diene-1,4-dione-based antiproliferative agents: design, synthesis, and cytotoxic evaluation. 145
Mapping and dynamics of DNA topoisomerase I recruitment at a transcribed human gene locus 143
G1 Cell-Cycle Arrest and Apoptosis by Histone Deacetylase Inhibition in MLL-AF9 Acute Myeloid Leukemia Cells Is MLL-AF9 Independent 143
In hepatocellular carcinoma miR-519d is up-regulated by p53 and DNA hypomethylation and targets CDKN1A/p21, PTEN, AKT3 and TIMP2. 142
Mapping DNA topoisomerase I, RNA polymerase II and other proteins at a human gene locus during transcription inhibition 140
Transcriptional Stress by Camptothecin: Mechanisms and Implications for the Drug Antitumor Activity 135
Global transcription regulation by DNA topoisomerase I in exponentially growing Saccharomyces cerevisiae cells: Activation of telomere-proximal genes by TOP1 deletion 135
DROPA: DRIP-seq optimized peak annotator 133
DNA topoisomerase I as a transcription protein and a lethal cellular toxin. 131
Targeting human telomeric and promoter G-quardruplexes: synthesis, biophysical and biological studies of new guanylhydrazones as potential antitumor agents 131
Mapping and dynamics of DNA topoisomerase I recruitment at a transcribed human gene locus 129
Rapid and specific disassembly of RNA polymerase II from transcribed chromatin regions after topoisomerase I poison treatments of human cancer cells 129
Intracellular distribution of beta-catenin in human medulloblastoma cell lines with different degree of neuronal differentiation 128
Non-B DNA structures as a booster of genome instability 127
DNA topoisomerase I inhibition by camptothecin induces escape of RNA polymerase II from promoter-proximal pause site, antisense transcription and histone acetylation at the human HIF-1a gene locus. 127
G1 cell-cycle arrest and apoptosis by histone deacetylase inhibition in MLL-AF9 acute myeloid leukemia cells is p21 dependent and MLL-AF9 independent 127
Wnt system and differentiation in medulloblastoma cell lines 125
Stimulation of cGAS-STING pathway as a challenge in the treatment of small cell lung cancer: a feasible strategy? 123
Cellular response to camptothecin at transcribing chromatin 123
Current Pharmaceutical Design 123
Mapping DNA breaks by next-generation sequencing 123
Synthesis and Evaluation of New Naphthalene and Naphthoquinone Derivatives as Anticancer Agents 122
A rational selection of drug targets needs deeper insights into general regulation mechanisms. 121
Molecular modelling studies, synthesis and biological activity of a series of novel bisnaphthalimides and their development as new DNA topoisomerase II inhibitors. 118
Novel Ametantrone-Amsacrine Related Hybrids as Topoisomerase IIβ Poisons and Cytotoxic Agents 118
Expression of down-regulated ERV LTR elements associates with immune activation in human small-cell lung cancers 117
The Natural Inhibitor of DNA Topoisomerase I, Camptothecin, Modulates HIF-1 alpha Activity by Changing miR Expression Patterns in Human Cancer Cells 117
Biologia molecolare 117
Correlation between neuronal differentiation and beta catenin distribution in medulloblastoma 116
Antitumor AZA-anthrapyrazoles: biophysical and biochemical sudies on 8-aza and 9-aza regioisomers. 116
Toward the development of specific G-quadruplex binders: biophysical studies of new hydrazone derivatives. 116
DNA Topoisomerase II Structures and Anthracycline Activity: Insights into Ternary Complex Formation. 114
Naphthoquinone Derivatives Exert Their Antitrypanosomal Activity via a Multi-Target Mechanism 112
DNA topoisomerasi I e sviluppo di nuovi inibitori. 111
Global gene expression analyses after camptothecin treatments of yeast cells 111
Gene expression signature of aneuploidy in acute myeloid leukemia 111
Topoisomerase I specifically affects RNA polymerase II paused at promoter-proximal sites in human cells. 110
Camptothecin effects on transcription-related events. 110
DNA topoisomerase I (Top1) can regulate the coupling of RNA polymerase II (RNAP) pausing at promoter-proximal sites and transcript maturation in human cells. 109
Anti-Cancer Agents in Medicinal Chemistry 109
Discovery of new antisense transcripts induced by camptothecin at CpG island promoters of human cells. 108
Significant effects of DNA topoisomerase I on global gene expression profiles in S. cerevisiae 108
null 108
Dynamics of RNA polymerase II recruitment to active gene promoters following topoisomerase I (Top1)-mediated DNA damage in S. cerevisiae 108
Role of Flexibility in Protein-DNA-Drug Recognition: The Case of Asp677Gly-Val703Ile Topoisomerase Mutant Hypersensitive to Camptothecin 107
TDP1 mutation causing SCAN1 neurodegenerative syndrome hampers the repair of transcriptional DNA double-strand breaks 106
Induction of a novel long antisense RNA from the human HIF-1a locus may contribuite to HIF 1a regulation and inhibition by campotecin in cancer cells. 106
DNA-PK triggers histone ubiquitination and signaling in response to DNA double-strand breaks produced during the repair of transcription-blocking topoisomerase I lesions 106
Metallothionein cDNA cloning, metallothionein expression and haevy metals in Scapharca inaequivalvis along the Northern Adriatic coast of Italy 102
Immunofluorescence microscopy of G-quadruplexes and R-loops 101
Dynamic effects of topoisomerase i inhibition on R-loops and short transcripts at active promoters 96
Transcriptional Topoisomerase I functions: implications for tumor resistance to enzyme poisons. 90
Discovery of the first dual G-triplex/G-quadruplex stabilizing compound: A new opportunity in the targeting of G-rich DNA structures? 86
Target specificity of effective anticancer therapeutics 85
Metallothionein cDNA cloning and RT-PCR inhibitors in Scapharca inaequivalvis 84
Highly Purified Top1-Bound DNA Fragments 73
null 68
Non-canonical activating roles of RCoR2 sustain transcription in adrenergic neuroblastoma 67
Type I DNA Topoisomerases 64
Totale 14.848
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Categoria #
all - tutte 39.070
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 39.070
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021828 0 0 0 0 0 159 27 64 96 92 115 275
2021/20221.792 149 53 138 177 171 131 42 153 86 79 319 294
2022/20232.227 202 288 106 260 131 158 92 241 403 46 134 166
2023/2024815 49 101 40 63 91 106 51 46 50 39 117 62
2024/20252.946 138 349 264 190 572 141 248 130 64 160 183 507
2025/20263.028 429 659 612 555 741 32 0 0 0 0 0 0
Totale 15.067