CRIS Current Research Information System

CAPRANICO, GIOVANNI
 Distribuzione geografica
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Continente #
NA - Nord America 5.997
EU - Europa 5.830
AS - Asia 5.621
AF - Africa 368
SA - Sud America 259
Continente sconosciuto - Info sul continente non disponibili 259
OC - Oceania 12
Totale 18.346
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Nazione #
US - Stati Uniti d'America 5.890
IT - Italia 2.237
CN - Cina 1.693
SG - Singapore 1.651
GB - Regno Unito 978
VN - Vietnam 970
DE - Germania 539
SE - Svezia 420
FR - Francia 363
HK - Hong Kong 355
UA - Ucraina 288
IN - India 284
RU - Federazione Russa 207
IE - Irlanda 175
BR - Brasile 163
KR - Corea 160
CI - Costa d'Avorio 139
JP - Giappone 120
NL - Olanda 108
FI - Finlandia 105
CH - Svizzera 100
ZA - Sudafrica 95
BD - Bangladesh 75
CA - Canada 59
EE - Estonia 58
JO - Giordania 52
PK - Pakistan 50
TG - Togo 50
SC - Seychelles 47
AR - Argentina 40
BG - Bulgaria 37
PL - Polonia 34
AT - Austria 32
BE - Belgio 29
MX - Messico 29
TR - Turchia 29
PH - Filippine 28
DK - Danimarca 24
ID - Indonesia 24
TH - Thailandia 22
GR - Grecia 21
ES - Italia 19
HR - Croazia 19
TW - Taiwan 19
IR - Iran 15
CZ - Repubblica Ceca 13
EC - Ecuador 13
IQ - Iraq 13
AU - Australia 9
BO - Bolivia 9
SY - Repubblica araba siriana 9
EU - Europa 8
RO - Romania 8
UZ - Uzbekistan 8
CL - Cile 7
MY - Malesia 7
SA - Arabia Saudita 7
TN - Tunisia 7
VE - Venezuela 7
ZW - Zimbabwe 7
CO - Colombia 6
EG - Egitto 6
IL - Israele 6
PE - Perù 6
PY - Paraguay 6
JM - Giamaica 5
LB - Libano 5
AE - Emirati Arabi Uniti 4
BY - Bielorussia 4
NG - Nigeria 4
KE - Kenya 3
KZ - Kazakistan 3
NP - Nepal 3
NZ - Nuova Zelanda 3
OM - Oman 3
PT - Portogallo 3
SK - Slovacchia (Repubblica Slovacca) 3
AZ - Azerbaigian 2
CR - Costa Rica 2
DZ - Algeria 2
LT - Lituania 2
MU - Mauritius 2
SN - Senegal 2
TT - Trinidad e Tobago 2
UY - Uruguay 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AG - Antigua e Barbuda 1
BS - Bahamas 1
BZ - Belize 1
CV - Capo Verde 1
DO - Repubblica Dominicana 1
ET - Etiopia 1
GA - Gabon 1
GE - Georgia 1
GP - Guadalupe 1
HN - Honduras 1
KW - Kuwait 1
LA - Repubblica Popolare Democratica del Laos 1
LU - Lussemburgo 1
LV - Lettonia 1
Totale 18.088
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Città #
Singapore 1.205
Southend 801
Bologna 571
Ashburn 515
Chandler 451
Hefei 422
Santa Clara 417
Fairfield 386
San Jose 340
Hong Kong 285
Ann Arbor 246
Woodbridge 242
Cambridge 208
Ho Chi Minh City 196
Jacksonville 193
Milan 191
Seattle 191
Wilmington 191
Princeton 187
Hanoi 180
Houston 178
Dublin 174
Council Bluffs 156
Dong Ket 149
Seoul 147
Abidjan 139
Boardman 128
Beijing 127
Naples 121
Dallas 113
Tokyo 113
Helsinki 90
Lauterbourg 90
Rome 89
Nanjing 88
Westminster 82
Los Angeles 76
Padova 74
Bern 71
New York 60
Berlin 58
Jinan 57
Buffalo 53
Amman 51
Hyderabad 51
Lomé 50
Shenyang 45
Guangzhou 43
Medford 41
Munich 41
Da Nang 40
Shanghai 39
Mülheim 38
Sofia 37
Florence 36
Frankfurt am Main 36
Saint Petersburg 36
Changsha 35
Bengaluru 34
Hebei 30
Haiphong 29
Verona 29
Nanchang 28
Brussels 27
Falkenstein 27
Redondo Beach 27
San Diego 25
Mahé 24
Phoenix 22
Redmond 22
São Paulo 22
Vienna 22
Zhengzhou 21
Mardan 20
Tianjin 20
Wuhan 20
Des Moines 19
Reggio Emilia 19
Rimini 19
Fremont 18
Modena 18
Montreal 18
Redwood City 18
The Dalles 18
Chicago 17
Hangzhou 17
Jakarta 17
Jiaxing 17
Warsaw 17
Johannesburg 15
Lanzhou 15
Turin 15
Fuzhou 14
Hải Dương 14
Paris 14
Atlanta 13
Biên Hòa 13
Dearborn 13
Falls Church 13
Ferrara 13
Totale 11.303
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Nome #
Biotecnologie e modificazioni genetiche. Scienza, etica, diritto 657
Biologia molecolare. Con ebook. Con software di simulazione 544
G-quadruplex–R-loop interactions and the mechanism of anticancer G-quadruplex binders 388
Mechanistic roles of R-loops and micronuclei in the innate immune response induced by anticancer G-quadruplex binders 387
Balancing Affinity, Selectivity, and Cytotoxicity of Hydrazone-Based G-Quadruplex Ligands for Activation of Interferon β Genes in Cancer Cells 293
G-quadruplex binders as cytostatic modulators of innate immune genes in cancer cells 290
R loop-driven genome instability by G-quadruplex binders in BRCA2-silenced human cancer cells. 288
DNA damage and genome instability by G-quadruplex ligands are mediated by R loops in human cancer cells 271
Human DNA topoisomerase I poisoning causes R loop-mediated genome instability attenuated by transcription factor IIS 265
G-quadruplex binders cause DNA damage by inducing R loops in human cancer cells. 256
Enhanced CPT sensitivity of yeast cells and selective relaxation of Gal4 motif-containing DNA by novel Gal4-Topoisomerase I fusion proteins. 250
Topoisomerase I poison-triggered immune gene activation is markedly reduced in human small-cell lung cancers by impairment of the cGAS/STING pathway 241
Novel DNA Topoisomerase IIα Inhibitors from Combined Ligand- and Structure-Based Virtual Screening 241
Toward the Development of Specific G‑Quadruplex Binders: Synthesis, Biophysical, and Biological Studies of New Hydrazone Derivatives 234
Anthracyclines as Topoisomerase II Poisons: From Early Studies to New Perspectives 231
Characterization of novel antisense HIF-1α transcripts in human cancers 229
DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF SUSTITUTED NAPHTHALENE IMIDES AND DIIMIDES AS ANTICANCER AGENT 227
DNA Topoisomerase I differentially modulates R-loops across the human genome 222
MYCN Amplification, along with Wild-Type RB1 Expression, Enhances CDK4/6 Inhibitors’ Efficacy in Neuroblastoma Cells 217
Monohydrazone Based G-Quadruplex Selective Ligands Induce DNA Damage and Genome Instability in Human Cancer Cells 217
A specific transcriptional response of yeast cells to camptothecin dependent on the Swi4 and Mbp1 factors. 216
Ligands stimulating antitumour immunity as the next G-quadruplex challenge 214
Interaction model for anthracycline activity against DNA topoisomerase II. 203
Dual Processing of R-Loops and Topoisomerase I Induces Transcription-Dependent DNA Double-Strand Breaks 198
Non-canonical activating roles of RCoR2 sustain transcription in adrenergic neuroblastoma 197
Early effects of topoisomerase I inhibition on RNA polymerase II along transcribed genes in human cells. 197
Antisense transcripts enhanced by camptothecin at divergent CpG-island promoters associated with bursts of topoisomerase I-DNA cleavage complex and R-loop formation 195
Genome instability by G-quadruplex ligands are mediated by R-loops in human cancer cells 194
Dissecting the transcriptional functions of human DNA topoisomerase I by selective inhibitors: Implications for physiological and therapeutic modulation of enzyme activity. 191
In hepatocellular carcinoma miR-519d is up-regulated by p53 and DNA hypomethylation and targets CDKN1A/p21, PTEN, AKT3 and TIMP2. 190
Non-B DNA structures as a booster of genome instability 183
Natural product triptolide mediates cancer cell death by triggering CDK7-dependent degradation of RNA polymerase II 181
RNA G-Quadruplexes in Kirsten Ras (KRAS) Oncogene as Targets for Small Molecules Inhibiting Translation 180
Specific histone patterns and acetylase/deacetylase activity at the breakpoint-cluster region of the human MLL gene. 179
Stimulation of cGAS-STING pathway as a challenge in the treatment of small cell lung cancer: a feasible strategy? 178
The effects of camptothecin on RNA polymerase II transcription: roles of DNA topoisomerase I. 176
G1 Cell-Cycle Arrest and Apoptosis by Histone Deacetylase Inhibition in MLL-AF9 Acute Myeloid Leukemia Cells Is MLL-AF9 Independent 176
Chromatin binding sites of DNA topoisomerase I, RNA polymerase II and TBP in transcribed genes in human cancer cells 175
Intracellular beta-catenin relocalization after APC gene silencing by si-RNA in human madulloblastoma cell lines 174
Correlation between neuronal differentiation and beta catenin distribution in medulloblastoma 174
Novel symmetric and asymmetric DNA scission determinants for streptococcus pneumoniae topoisomerase IV and gyrase are clustered at the DNA breakage site. 173
Development of DNA topoisomerase-related therapeutics. A short perspective of new challenges. 171
DNA topoisomerase I as a transcription protein and a lethal cellular toxin. 171
A long antisense RNA is transcribed at the 5’ end of the human HIF-1a gene upon drug inhibition of DNA Topoisomerase I. 171
Cyclohexa-2,5-diene-1,4-dione-based antiproliferative agents: design, synthesis, and cytotoxic evaluation. 170
Targeting human telomeric and promoter G-quardruplexes: synthesis, biophysical and biological studies of new guanylhydrazones as potential antitumor agents 166
Mapping and dynamics of DNA topoisomerase I recruitment at a transcribed human gene locus 165
Effects of common buffer systems on drug activity: the case of clerocidin. 163
Mapping DNA topoisomerase I, RNA polymerase II and other proteins at a human gene locus during transcription inhibition 163
Electron Paramagnetic Resonance (EPR) Study of Spin-Labeled Camptothecin Derivatives: A Different Look of the Ternary Complex. 162
TDP1 mutation causing SCAN1 neurodegenerative syndrome hampers the repair of transcriptional DNA double-strand breaks 160
Sistema Wnt e differenziamento in linee cellulari di medulloblastoma 158
Global transcription regulation by DNA topoisomerase I in exponentially growing Saccharomyces cerevisiae cells: Activation of telomere-proximal genes by TOP1 deletion 158
Immunofluorescence microscopy of G-quadruplexes and R-loops 156
DROPA: DRIP-seq optimized peak annotator 156
Transcriptional Stress by Camptothecin: Mechanisms and Implications for the Drug Antitumor Activity 154
DNA topoisomerase I inhibition by camptothecin induces escape of RNA polymerase II from promoter-proximal pause site, antisense transcription and histone acetylation at the human HIF-1a gene locus. 153
Rapid and specific disassembly of RNA polymerase II from transcribed chromatin regions after topoisomerase I poison treatments of human cancer cells 152
Intracellular distribution of beta-catenin in human medulloblastoma cell lines with different degree of neuronal differentiation 151
Expression of down-regulated ERV LTR elements associates with immune activation in human small-cell lung cancers 150
Mapping and dynamics of DNA topoisomerase I recruitment at a transcribed human gene locus 150
DNA topoisomerasi I e sviluppo di nuovi inibitori. 149
G1 cell-cycle arrest and apoptosis by histone deacetylase inhibition in MLL-AF9 acute myeloid leukemia cells is p21 dependent and MLL-AF9 independent 148
Toward the development of specific G-quadruplex binders: biophysical studies of new hydrazone derivatives. 148
Gene expression signature of aneuploidy in acute myeloid leukemia 145
Wnt system and differentiation in medulloblastoma cell lines 144
Current Pharmaceutical Design 144
Biologia molecolare 144
Cellular response to camptothecin at transcribing chromatin 143
Camptothecin effects on transcription-related events. 142
Antitumor AZA-anthrapyrazoles: biophysical and biochemical sudies on 8-aza and 9-aza regioisomers. 142
Synthesis and Evaluation of New Naphthalene and Naphthoquinone Derivatives as Anticancer Agents 141
DNA Topoisomerase II Structures and Anthracycline Activity: Insights into Ternary Complex Formation. 138
The Natural Inhibitor of DNA Topoisomerase I, Camptothecin, Modulates HIF-1 alpha Activity by Changing miR Expression Patterns in Human Cancer Cells 138
Topoisomerase I specifically affects RNA polymerase II paused at promoter-proximal sites in human cells. 134
Discovery of new antisense transcripts induced by camptothecin at CpG island promoters of human cells. 134
Mapping DNA breaks by next-generation sequencing 134
Naphthoquinone Derivatives Exert Their Antitrypanosomal Activity via a Multi-Target Mechanism 133
A rational selection of drug targets needs deeper insights into general regulation mechanisms. 133
Dynamics of RNA polymerase II recruitment to active gene promoters following topoisomerase I (Top1)-mediated DNA damage in S. cerevisiae 133
Metallothionein cDNA cloning, metallothionein expression and haevy metals in Scapharca inaequivalvis along the Northern Adriatic coast of Italy 131
Discovery of the first dual G-triplex/G-quadruplex stabilizing compound: A new opportunity in the targeting of G-rich DNA structures? 131
Novel Ametantrone-Amsacrine Related Hybrids as Topoisomerase IIβ Poisons and Cytotoxic Agents 131
Molecular modelling studies, synthesis and biological activity of a series of novel bisnaphthalimides and their development as new DNA topoisomerase II inhibitors. 130
Induction of a novel long antisense RNA from the human HIF-1a locus may contribuite to HIF 1a regulation and inhibition by campotecin in cancer cells. 129
Significant effects of DNA topoisomerase I on global gene expression profiles in S. cerevisiae 129
Correlation between neuronal differentiation and beta catenin distribution in medulloblastoma 129
Anti-Cancer Agents in Medicinal Chemistry 127
Global gene expression analyses after camptothecin treatments of yeast cells 127
DNA-PK triggers histone ubiquitination and signaling in response to DNA double-strand breaks produced during the repair of transcription-blocking topoisomerase I lesions 127
Dynamic effects of topoisomerase i inhibition on R-loops and short transcripts at active promoters 126
Transcriptional Topoisomerase I functions: implications for tumor resistance to enzyme poisons. 122
Role of Flexibility in Protein-DNA-Drug Recognition: The Case of Asp677Gly-Val703Ile Topoisomerase Mutant Hypersensitive to Camptothecin 118
Metallothionein cDNA cloning and RT-PCR inhibitors in Scapharca inaequivalvis 116
Genomic context influences translesion synthesis DNA polymerase-dependent mechanisms of micronuclei induction by G-quadruplexes 110
null 108
Target specificity of effective anticancer therapeutics 99
Highly Purified Top1-Bound DNA Fragments 93
Type I DNA Topoisomerases 93
New functions of DNA topoisomerase I in the regulation of transcript elongation and maturation in tumor cells. 80
Totale 18.115
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Categoria #
all - tutte 47.473
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 47.473
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20221.632 0 52 138 176 170 130 42 152 86 79 317 290
2022/20232.208 201 286 106 258 131 155 91 240 398 45 132 165
2023/2024813 49 100 40 62 91 106 51 46 50 39 117 62
2024/20252.923 136 348 263 188 564 141 247 129 64 159 182 502
2025/20266.108 429 657 607 552 734 367 607 233 935 428 326 233
2026/2027291 153 138 0 0 0 0 0 0 0 0 0 0
Totale 18.346