CRIS Current Research Information System

CAPRANICO, GIOVANNI
 Distribuzione geografica
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Continente #
NA - Nord America 5.724
EU - Europa 5.638
AS - Asia 5.557
AF - Africa 363
SA - Sud America 251
OC - Oceania 12
Continente sconosciuto - Info sul continente non disponibili 9
Totale 17.554
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Nazione #
US - Stati Uniti d'America 5.640
IT - Italia 2.045
CN - Cina 1.696
SG - Singapore 1.641
GB - Regno Unito 981
VN - Vietnam 974
DE - Germania 541
SE - Svezia 422
FR - Francia 359
HK - Hong Kong 351
UA - Ucraina 295
IN - India 285
RU - Federazione Russa 209
IE - Irlanda 178
KR - Corea 161
BR - Brasile 158
CI - Costa d'Avorio 140
JP - Giappone 120
FI - Finlandia 105
NL - Olanda 105
CH - Svizzera 100
ZA - Sudafrica 95
EE - Estonia 60
JO - Giordania 53
TG - Togo 50
CA - Canada 49
SC - Seychelles 47
PK - Pakistan 43
AR - Argentina 39
BG - Bulgaria 37
AT - Austria 31
BD - Bangladesh 31
PL - Polonia 31
BE - Belgio 29
TR - Turchia 29
PH - Filippine 28
MX - Messico 24
ID - Indonesia 23
TH - Thailandia 23
DK - Danimarca 22
GR - Grecia 21
ES - Italia 19
HR - Croazia 19
TW - Taiwan 16
IQ - Iraq 14
EC - Ecuador 13
IR - Iran 10
AU - Australia 9
SY - Repubblica araba siriana 9
BO - Bolivia 8
EU - Europa 8
RO - Romania 8
UZ - Uzbekistan 8
CL - Cile 7
MY - Malesia 7
SA - Arabia Saudita 7
TN - Tunisia 7
VE - Venezuela 7
EG - Egitto 6
IL - Israele 6
PE - Perù 6
PY - Paraguay 6
CO - Colombia 5
CZ - Repubblica Ceca 5
LB - Libano 5
BY - Bielorussia 4
NG - Nigeria 4
KE - Kenya 3
KZ - Kazakistan 3
NP - Nepal 3
NZ - Nuova Zelanda 3
OM - Oman 3
PT - Portogallo 3
SK - Slovacchia (Repubblica Slovacca) 3
AE - Emirati Arabi Uniti 2
AZ - Azerbaigian 2
CR - Costa Rica 2
DZ - Algeria 2
ET - Etiopia 2
JM - Giamaica 2
LT - Lituania 2
MU - Mauritius 2
SN - Senegal 2
UY - Uruguay 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AG - Antigua e Barbuda 1
BZ - Belize 1
CV - Capo Verde 1
DO - Repubblica Dominicana 1
GA - Gabon 1
GE - Georgia 1
GP - Guadalupe 1
KW - Kuwait 1
LA - Repubblica Popolare Democratica del Laos 1
LU - Lussemburgo 1
LV - Lettonia 1
MD - Moldavia 1
ME - Montenegro 1
ML - Mali 1
PR - Porto Rico 1
Totale 17.551
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Città #
Singapore 1.195
Southend 807
Bologna 529
Ashburn 499
Chandler 456
Hefei 422
Santa Clara 416
Fairfield 386
San Jose 341
Hong Kong 281
Ann Arbor 247
Woodbridge 242
Cambridge 209
Ho Chi Minh City 198
Jacksonville 194
Wilmington 192
Seattle 191
Princeton 189
Milan 183
Hanoi 181
Houston 178
Dublin 177
Dong Ket 149
Seoul 147
Abidjan 140
Beijing 124
Boardman 122
Naples 116
Tokyo 114
Dallas 112
Helsinki 90
Lauterbourg 90
Nanjing 89
Rome 84
Westminster 83
Padova 75
Bern 71
Los Angeles 71
Berlin 59
Jinan 58
New York 55
Amman 52
Hyderabad 51
Lomé 50
Buffalo 49
Shenyang 46
Guangzhou 44
Medford 42
Munich 41
Da Nang 40
Mülheim 39
Shanghai 38
Frankfurt am Main 37
Sofia 37
Saint Petersburg 36
Changsha 35
Bengaluru 34
Florence 32
Hebei 30
Haiphong 29
Falkenstein 28
Nanchang 28
Redondo Beach 28
Verona 28
Brussels 27
Council Bluffs 25
Mahé 25
San Diego 25
Zhengzhou 23
Phoenix 22
Redmond 22
Vienna 21
Mardan 20
Tianjin 20
Wuhan 20
Des Moines 19
São Paulo 19
Fremont 18
Redwood City 18
Reggio Emilia 18
Hangzhou 17
Jakarta 17
Jiaxing 17
Montreal 17
Lanzhou 16
Chicago 15
Johannesburg 15
The Dalles 15
Turin 15
Warsaw 15
Dearborn 14
Fuzhou 14
Hải Dương 14
Ningbo 14
Biên Hòa 13
Falls Church 13
Ferrara 13
Parma 13
Shenzhen 13
Denver 12
Totale 11.070
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Nome #
Biotecnologie e modificazioni genetiche. Scienza, etica, diritto 575
Biologia molecolare. Con ebook. Con software di simulazione 517
Mechanistic roles of R-loops and micronuclei in the innate immune response induced by anticancer G-quadruplex binders 376
G-quadruplex–R-loop interactions and the mechanism of anticancer G-quadruplex binders 364
Balancing Affinity, Selectivity, and Cytotoxicity of Hydrazone-Based G-Quadruplex Ligands for Activation of Interferon β Genes in Cancer Cells 286
G-quadruplex binders as cytostatic modulators of innate immune genes in cancer cells 284
R loop-driven genome instability by G-quadruplex binders in BRCA2-silenced human cancer cells. 279
DNA damage and genome instability by G-quadruplex ligands are mediated by R loops in human cancer cells 265
G-quadruplex binders cause DNA damage by inducing R loops in human cancer cells. 252
Enhanced CPT sensitivity of yeast cells and selective relaxation of Gal4 motif-containing DNA by novel Gal4-Topoisomerase I fusion proteins. 244
Human DNA topoisomerase I poisoning causes R loop-mediated genome instability attenuated by transcription factor IIS 241
Novel DNA Topoisomerase IIα Inhibitors from Combined Ligand- and Structure-Based Virtual Screening 238
Topoisomerase I poison-triggered immune gene activation is markedly reduced in human small-cell lung cancers by impairment of the cGAS/STING pathway 235
Toward the Development of Specific G‑Quadruplex Binders: Synthesis, Biophysical, and Biological Studies of New Hydrazone Derivatives 229
Characterization of novel antisense HIF-1α transcripts in human cancers 227
DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF SUSTITUTED NAPHTHALENE IMIDES AND DIIMIDES AS ANTICANCER AGENT 224
Anthracyclines as Topoisomerase II Poisons: From Early Studies to New Perspectives 224
DNA Topoisomerase I differentially modulates R-loops across the human genome 215
A specific transcriptional response of yeast cells to camptothecin dependent on the Swi4 and Mbp1 factors. 214
MYCN Amplification, along with Wild-Type RB1 Expression, Enhances CDK4/6 Inhibitors’ Efficacy in Neuroblastoma Cells 211
Monohydrazone Based G-Quadruplex Selective Ligands Induce DNA Damage and Genome Instability in Human Cancer Cells 209
Ligands stimulating antitumour immunity as the next G-quadruplex challenge 207
Interaction model for anthracycline activity against DNA topoisomerase II. 198
Antisense transcripts enhanced by camptothecin at divergent CpG-island promoters associated with bursts of topoisomerase I-DNA cleavage complex and R-loop formation 194
Early effects of topoisomerase I inhibition on RNA polymerase II along transcribed genes in human cells. 192
Dual Processing of R-Loops and Topoisomerase I Induces Transcription-Dependent DNA Double-Strand Breaks 191
Genome instability by G-quadruplex ligands are mediated by R-loops in human cancer cells 189
In hepatocellular carcinoma miR-519d is up-regulated by p53 and DNA hypomethylation and targets CDKN1A/p21, PTEN, AKT3 and TIMP2. 186
Dissecting the transcriptional functions of human DNA topoisomerase I by selective inhibitors: Implications for physiological and therapeutic modulation of enzyme activity. 185
RNA G-Quadruplexes in Kirsten Ras (KRAS) Oncogene as Targets for Small Molecules Inhibiting Translation 177
Specific histone patterns and acetylase/deacetylase activity at the breakpoint-cluster region of the human MLL gene. 177
Natural product triptolide mediates cancer cell death by triggering CDK7-dependent degradation of RNA polymerase II 176
The effects of camptothecin on RNA polymerase II transcription: roles of DNA topoisomerase I. 174
G1 Cell-Cycle Arrest and Apoptosis by Histone Deacetylase Inhibition in MLL-AF9 Acute Myeloid Leukemia Cells Is MLL-AF9 Independent 174
Novel symmetric and asymmetric DNA scission determinants for streptococcus pneumoniae topoisomerase IV and gyrase are clustered at the DNA breakage site. 172
Chromatin binding sites of DNA topoisomerase I, RNA polymerase II and TBP in transcribed genes in human cancer cells 171
Development of DNA topoisomerase-related therapeutics. A short perspective of new challenges. 170
Non-B DNA structures as a booster of genome instability 169
Intracellular beta-catenin relocalization after APC gene silencing by si-RNA in human madulloblastoma cell lines 169
Stimulation of cGAS-STING pathway as a challenge in the treatment of small cell lung cancer: a feasible strategy? 168
Correlation between neuronal differentiation and beta catenin distribution in medulloblastoma 168
A long antisense RNA is transcribed at the 5’ end of the human HIF-1a gene upon drug inhibition of DNA Topoisomerase I. 167
DNA topoisomerase I as a transcription protein and a lethal cellular toxin. 166
Cyclohexa-2,5-diene-1,4-dione-based antiproliferative agents: design, synthesis, and cytotoxic evaluation. 165
Mapping and dynamics of DNA topoisomerase I recruitment at a transcribed human gene locus 163
Effects of common buffer systems on drug activity: the case of clerocidin. 162
Targeting human telomeric and promoter G-quardruplexes: synthesis, biophysical and biological studies of new guanylhydrazones as potential antitumor agents 161
Mapping DNA topoisomerase I, RNA polymerase II and other proteins at a human gene locus during transcription inhibition 160
Electron Paramagnetic Resonance (EPR) Study of Spin-Labeled Camptothecin Derivatives: A Different Look of the Ternary Complex. 160
Global transcription regulation by DNA topoisomerase I in exponentially growing Saccharomyces cerevisiae cells: Activation of telomere-proximal genes by TOP1 deletion 156
Sistema Wnt e differenziamento in linee cellulari di medulloblastoma 154
Transcriptional Stress by Camptothecin: Mechanisms and Implications for the Drug Antitumor Activity 152
DROPA: DRIP-seq optimized peak annotator 152
DNA topoisomerase I inhibition by camptothecin induces escape of RNA polymerase II from promoter-proximal pause site, antisense transcription and histone acetylation at the human HIF-1a gene locus. 151
Mapping and dynamics of DNA topoisomerase I recruitment at a transcribed human gene locus 148
G1 cell-cycle arrest and apoptosis by histone deacetylase inhibition in MLL-AF9 acute myeloid leukemia cells is p21 dependent and MLL-AF9 independent 148
Intracellular distribution of beta-catenin in human medulloblastoma cell lines with different degree of neuronal differentiation 146
Rapid and specific disassembly of RNA polymerase II from transcribed chromatin regions after topoisomerase I poison treatments of human cancer cells 145
Toward the development of specific G-quadruplex binders: biophysical studies of new hydrazone derivatives. 145
TDP1 mutation causing SCAN1 neurodegenerative syndrome hampers the repair of transcriptional DNA double-strand breaks 141
DNA topoisomerasi I e sviluppo di nuovi inibitori. 141
Gene expression signature of aneuploidy in acute myeloid leukemia 141
Wnt system and differentiation in medulloblastoma cell lines 139
Cellular response to camptothecin at transcribing chromatin 139
Synthesis and Evaluation of New Naphthalene and Naphthoquinone Derivatives as Anticancer Agents 139
Biologia molecolare 139
Antitumor AZA-anthrapyrazoles: biophysical and biochemical sudies on 8-aza and 9-aza regioisomers. 139
Immunofluorescence microscopy of G-quadruplexes and R-loops 138
Expression of down-regulated ERV LTR elements associates with immune activation in human small-cell lung cancers 138
Current Pharmaceutical Design 138
Camptothecin effects on transcription-related events. 136
Non-canonical activating roles of RCoR2 sustain transcription in adrenergic neuroblastoma 134
The Natural Inhibitor of DNA Topoisomerase I, Camptothecin, Modulates HIF-1 alpha Activity by Changing miR Expression Patterns in Human Cancer Cells 134
DNA Topoisomerase II Structures and Anthracycline Activity: Insights into Ternary Complex Formation. 133
Mapping DNA breaks by next-generation sequencing 133
A rational selection of drug targets needs deeper insights into general regulation mechanisms. 132
Discovery of new antisense transcripts induced by camptothecin at CpG island promoters of human cells. 131
Dynamics of RNA polymerase II recruitment to active gene promoters following topoisomerase I (Top1)-mediated DNA damage in S. cerevisiae 131
Topoisomerase I specifically affects RNA polymerase II paused at promoter-proximal sites in human cells. 130
Naphthoquinone Derivatives Exert Their Antitrypanosomal Activity via a Multi-Target Mechanism 130
DNA topoisomerase I (Top1) can regulate the coupling of RNA polymerase II (RNAP) pausing at promoter-proximal sites and transcript maturation in human cells. 129
Discovery of the first dual G-triplex/G-quadruplex stabilizing compound: A new opportunity in the targeting of G-rich DNA structures? 129
Correlation between neuronal differentiation and beta catenin distribution in medulloblastoma 128
Molecular modelling studies, synthesis and biological activity of a series of novel bisnaphthalimides and their development as new DNA topoisomerase II inhibitors. 127
Metallothionein cDNA cloning, metallothionein expression and haevy metals in Scapharca inaequivalvis along the Northern Adriatic coast of Italy 127
Novel Ametantrone-Amsacrine Related Hybrids as Topoisomerase IIβ Poisons and Cytotoxic Agents 127
Significant effects of DNA topoisomerase I on global gene expression profiles in S. cerevisiae 126
DNA-PK triggers histone ubiquitination and signaling in response to DNA double-strand breaks produced during the repair of transcription-blocking topoisomerase I lesions 126
Induction of a novel long antisense RNA from the human HIF-1a locus may contribuite to HIF 1a regulation and inhibition by campotecin in cancer cells. 125
Global gene expression analyses after camptothecin treatments of yeast cells 125
Anti-Cancer Agents in Medicinal Chemistry 124
Dynamic effects of topoisomerase i inhibition on R-loops and short transcripts at active promoters 123
Role of Flexibility in Protein-DNA-Drug Recognition: The Case of Asp677Gly-Val703Ile Topoisomerase Mutant Hypersensitive to Camptothecin 116
Transcriptional Topoisomerase I functions: implications for tumor resistance to enzyme poisons. 114
Metallothionein cDNA cloning and RT-PCR inhibitors in Scapharca inaequivalvis 114
null 108
Target specificity of effective anticancer therapeutics 97
Genomic context influences translesion synthesis DNA polymerase-dependent mechanisms of micronuclei induction by G-quadruplexes 94
Highly Purified Top1-Bound DNA Fragments 89
Type I DNA Topoisomerases 88
Totale 17.509
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Categoria #
all - tutte 44.321
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 44.321
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021390 0 0 0 0 0 0 0 0 0 0 115 275
2021/20221.792 149 53 138 177 171 131 42 153 86 79 319 294
2022/20232.227 202 288 106 260 131 158 92 241 403 46 134 166
2023/2024815 49 101 40 63 91 106 51 46 50 39 117 62
2024/20252.946 138 349 264 190 572 141 248 130 64 160 183 507
2025/20265.767 429 659 612 555 741 369 611 236 941 433 181 0
Totale 17.806