CRIS Current Research Information System

BARTOLINI, MANUELA
 Distribuzione geografica
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Continente #
NA - Nord America 8450
EU - Europa 7889
AS - Asia 2597
AF - Africa 458
Continente sconosciuto - Info sul continente non disponibili 36
SA - Sud America 28
OC - Oceania 12
Totale 19470
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Nazione #
US - Stati Uniti d'America 8393
GB - Regno Unito 2187
IT - Italia 1606
CN - Cina 1138
DE - Germania 1023
SE - Svezia 841
VN - Vietnam 809
UA - Ucraina 658
IN - India 435
IE - Irlanda 369
FR - Francia 347
RU - Federazione Russa 286
EE - Estonia 174
ZA - Sudafrica 158
TG - Togo 145
CI - Costa d'Avorio 84
BE - Belgio 75
JO - Giordania 58
SC - Seychelles 57
HR - Croazia 56
CA - Canada 47
IR - Iran 37
ES - Italia 36
EU - Europa 35
AT - Austria 31
KR - Corea 28
PT - Portogallo 28
FI - Finlandia 27
GR - Grecia 26
RO - Romania 25
JP - Giappone 24
CH - Svizzera 22
NL - Olanda 15
BR - Brasile 14
TR - Turchia 14
LB - Libano 13
PL - Polonia 12
CL - Cile 10
MX - Messico 10
AU - Australia 9
CZ - Repubblica Ceca 9
NG - Nigeria 9
HU - Ungheria 8
BG - Bulgaria 7
DK - Danimarca 6
PK - Pakistan 6
SG - Singapore 6
IQ - Iraq 5
BD - Bangladesh 3
MD - Moldavia 3
NZ - Nuova Zelanda 3
TW - Taiwan 3
UZ - Uzbekistan 3
AL - Albania 2
AR - Argentina 2
DZ - Algeria 2
ID - Indonesia 2
LK - Sri Lanka 2
LV - Lettonia 2
MU - Mauritius 2
MY - Malesia 2
PH - Filippine 2
RS - Serbia 2
SA - Arabia Saudita 2
SK - Slovacchia (Repubblica Slovacca) 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AZ - Azerbaigian 1
EC - Ecuador 1
FK - Isole Falkland (Malvinas) 1
HK - Hong Kong 1
IL - Israele 1
KW - Kuwait 1
LA - Repubblica Popolare Democratica del Laos 1
MK - Macedonia 1
NO - Norvegia 1
SI - Slovenia 1
SM - San Marino 1
SN - Senegal 1
Totale 19470
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Città #
Southend 2008
Fairfield 1045
Chandler 1029
Houston 575
Wilmington 575
Woodbridge 523
Ashburn 494
Princeton 494
Dong Ket 461
Jacksonville 455
Seattle 438
Bologna 410
Ann Arbor 390
Cambridge 378
Dublin 369
Nanjing 218
Westminster 209
Padova 175
Berlin 168
Lomé 145
Jinan 128
Medford 104
Shenyang 102
Saint Petersburg 97
Abidjan 84
Mülheim 78
Milan 71
Brussels 70
Changsha 67
Nanchang 67
Turin 67
Falls Church 66
Hebei 65
Redmond 64
San Diego 62
Amman 58
Beijing 57
Mahé 54
Redwood City 54
Boardman 53
Jiaxing 45
Tianjin 45
Des Moines 44
Dearborn 43
Haikou 43
Bremen 34
Norwalk 34
Rome 34
Zhengzhou 33
Olalla 31
Hangzhou 30
Taiyuan 30
Boydton 29
Guangzhou 28
Verona 28
Helsinki 27
Vienna 25
Fremont 22
Kunming 21
London 20
Paris 19
Lanzhou 18
Ningbo 18
Taizhou 18
Ottawa 17
Tokyo 17
Phoenix 15
Chicago 14
Lisbon 14
Mountain View 13
San Jose 13
Catania 12
Fuzhou 12
Madrid 11
Toronto 11
Frankfurt Am Main 10
Hefei 10
Shanghai 10
Abeokuta 9
Ancona 9
Bucharest 9
Costa Mesa 9
Lausanne 9
Napoli 9
Ravenna 9
Trieste 9
Buffalo 8
Dallas 8
Edmonton 8
Florence 8
Istanbul 8
San Venanzo 8
Siracusa 8
Acerra 7
Plauen 7
Ponta Delgada 7
São Paulo 7
Zanjan 7
Caserta 6
Cormano 6
Totale 13100
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Nome #
Preparazione del campione - metodi estrattivi 242
null 222
Advanced analytical methodologies in Alzheimer's disease drug discovery 197
Discovery of novel benzofuran-based compounds with neuroprotective and immunomodulatory properties for Alzheimer's disease treatment 193
Multitarget Strategy to Address Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and Computational Studies of Coumarin-Based Derivatives 163
Cholinesterase inhibitors: xanthostigmine derivatives blocking the acetylcholinesterase-induced beta-amyloid aggregation. 160
A small molecule targeting the multifactorial nature of Alzheimer's disease 159
Tau-Centric Multitarget Approach for Alzheimer's Disease: Development of First-in-Class Dual Glycogen Synthase Kinase 3β and Tau-Aggregation Inhibitors 146
Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 3. Effect of replacing the inner polymethylene chain with cyclic moieties 143
2-Arylbenzofuran-based molecules as multipotent Alzheimer's disease modifying agents 140
Bis(7)-tacrine Derivatives as Multitarget-Directed Ligands: Focus on Anticholinesterase and Antiamyloid Activities 139
Rational Approach to discover multipotent anti-Alzheimer drugs 133
Analysis of amaryllidaceae alkaloids from Narcissus by GC-MS and capillary electrophoresis 133
Nature-Inspired Multifunctional Ligands: Focusing on Amyloid-Based Molecular Mechanisms of Alzheimer’s Disease 131
Benzophenone-based derivatives: A novel series of potent and selective dual inhibitors of acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation 129
Fatty Acid Amide Hydrolase (FAAH), Acetylcholinesterase (AChE), and Butyrylcholinesterase (BuChE): Networked Targets for the Development of Carbamates as Potential Anti-Alzheimer's Disease Agents 129
Design, synthesis, and biological evaluation of conformationally restricted rivastigmine analogues 128
Sustainable Drug Discovery of Multi-Target-Directed Ligands for Alzheimer's Disease 128
Analogues of the dual acetylcholinesterase inhibitor AP2238: synthesis and SAR 127
Exploiting the chalcone scaffold to develop multifunctional agents for Alzheimer’s disease 127
Benzofuran-Based Hybrid Compounds for the Inhibition of Cholinesterase Activity, Abeta Amyloid Aggregation, and Abeta Neurotoxicity 127
Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease 126
null 123
Dual-Acting Cholinesterase-Human Cannabinoid Receptor 2 Ligands Show Pronounced Neuroprotection in Vitro and Overadditive and Disease-Modifying Neuroprotective Effects in Vivo 123
Structure-activity relationships of memoquin: Influence of the chain chirality in the multi-target mechanism of action 122
ON-LINE GLYCAN RELEASE AND ANALYSIS BY AN INTEGRATED PNGASE F-IMER LC-ESI-Q-TOF APPROACH 120
Choosing the right chromatographic support in making a new acetylcholinesterase-micro-immobilised enzyme reactor for drug discovery. 119
Characterization of reversible and pseudo-irreversible Acetylcholinesterase inhibitors by means of immobilized enzyme reactor 119
A Fluorescent Styrylquinoline with Combined Therapeutic and Diagnostic Activities against Alzheimer's and Prion Diseases 118
Cystamine-tacrine dimer: A new multi-target-directed ligand as potential therapeutic agent for Alzheimer's disease treatment. 118
null 118
Multitarget Drug Design Strategy: Quinone–Tacrine Hybrids Designed To Block Amyloid-β Aggregation and To Exert Anticholinesterase and Antioxidant Effects 117
Immobilized Enzyme Reactors: an Overview of Applications in Drug Discovery from 2008 to 2018 116
CHOLINESTERASE INHIBITORS: SAR AND ENZYME INHIBITORY ACTIVITY OF 3-[omega-(BENZYLMETHYLAMINO)ALKOXY]XANTHEN-9-ONES 115
Monolytic micro-immobilized-enzyme reactor with human recombinant acetylcholinesterase for on-line inhibition studies 114
Extensive SAR and computational studies of 3-{4-[(benzylmethylamino)methyl]phenyl}-6,7-dimethoxy-2H-2-chromenone (AP2238) derivatives. 114
Multitargeted drugs discovery: Balancing anti-amyloid and anticholinesterase capacity in a single chemical entity 113
Solid Lipid Microparticles for Oral Delivery of Catalase: Focus on the Protein Structural Integrity and Gastric Protection 113
Acetylcholinesterase oriented immobilization on nanopatterned bilayered surfaces for biosensing devices 110
A MULTI-METHODOLOGICAL APPROACH FOR BETA-AMYLOID AGGREGATION AND INHIBITION STUDIES 110
Fluorinated benzophenone derivatives: balanced multipotent agents for Alzheimer's disease 109
null 108
Multi-Target-Directed Drug Design Strategy: From a Dual Binding Site Acetylcholinesterase Inhibitor to a Trifunctional Compound against Alzheimer's Disease 107
Toward a rational design of multitarget-directed antioxidants: merging memoquin and lipoic acid molecular frameworks 107
Bivalent tacrine-based acetylcholinesterase inhibitors: role of the spacer in the recognition process of the enzyme gorge 106
Tacrine-based dual binding site acetylcholinesterase inhibitors as potential disease-modifying anti-Alzheimer drug candidates 104
Design, Synthesis and Biological Evaluation of Dual Binding Site Acetylcholinesterase Inhibitors: New Disease Modifying Agents for Alzheimer's Disease 103
From the dual function lead AP2238 to AP2469, a multi-target-directed ligand for the treatment of Alzheimer’s disease 103
New tacrine dimers with antioxidant linkers as dual drugs: Anti-Alzheimer's and antiproliferative agents 102
Unveiling the Biochemistry of the Epigenetic Regulator SMYD3 102
Heterocyclic inhibitors of AChE acylation and peripheral sites. 101
AMYLOID-b-PEPTIDE SELF ASSEMBLY KINETICS BY AFM AND MALDI-TOF MASS SPECTROMETRY 100
Targeting Alzheimer’s disease: Novel indanone hybrids bearing a pharmacophoric fragment of AP2238 100
IMMOBILIZED ENZYMES AS TOOLS IN DRUG DISCOVERY 99
Novel Class of Quinone-Bearing Polyamines as Multi-Target-Directed Ligands To Combat Alzheimer's Disease 99
Discovery of sustainable drugs for Alzheimer's disease: cardanol-derived cholinesterase inhibitors with antioxidant and anti-amyloid properties 99
Uleine disrupts key enzymatic and non-enzymatic biomarkers that leads to Alzheimer's disease 98
null 98
Batch-wise covalent immobilisation of human acetylcholinesterase: kinetic and inhibition spectrophotometric studies 97
Characterization of Cholinesterase inhibitors by means of immobilized enzyme reactor 97
The role of Li(+), Na(+), and K(+) in the ligand binding inside the human acetylcholinesterase gorge 97
Fluorescence biosensing micropatterned surfaces based on immobilized human acetylcholinesterase 97
Increasing polarity in tacrine and huprine derivatives: Potent anticholinesterase agents for the treatment of myasthenia gravis 97
New insights into the altered binding capacity of pharmaceutical-grade human serum albumin: site-specific binding studies by induced circular dichroism spectroscopy 97
Design, synthesis, and evaluation of benzophenone derivatives as novel acetylcholinesterase inhibitors 96
Quinones bearing non-steroidal anti-inflammatory fragments as multitarget ligands for Alzheimer’s disease 96
Analytical approaches in Alzheimer’s disease Drug Discovery 96
Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimers Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography 96
CHOOSING THE RIGHT CHROMATOGRAPHIC SUPPORT FOR ENZYME-BASED MICRO-IMERS. 95
Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease. 95
ALZHEIMER'S DISEASE DRUG DISCOVERY: NEW ANALYTICAL APPROACHES FOR LEAD SELECTION AND OPTIMIZATION PBA 2009 (20h International Symposium on Pharmaceutical and Biomedical Analysis), Agra, India 01-04 Marzo 2009 95
Synthesis and multitarget biological profiling of a novel family of rhein derivatives as disease-modifying anti-Alzheimer agents. 95
Circular dichroism investigation on amyloid bata(1-42) peptide self-aggregation 94
Structure-Activity Relationships and Binding Mode in the Human Acetylcholinesterase Active Site of Pseudo-Irreversible Inhibitors Related to Xanthostigmine 94
Novel bis(7)-tacrine derivatives as multitarget ligands: focus on anti-cholinesterase and anti-amyloid activities 93
Synthesis of Monomeric Derivatives To Probe Memoquin's Bivalent Interactions 93
Polyamine Conjugation as a Promising Strategy To Target Amyloid Aggregation in the Framework of Alzheimer’s Disease 93
Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer's disease. 93
Preparation of (hetero)aromatic (hetero)cyclic carboxamides for the treatment of Alzheimer's disease 92
ANALYTICAL STRATEGIES FOR THE CHARACTERIZATION OF PROTEIN AGGREGATION AND INHIBITION IN HUMAN DISEASES 92
Multi-target strategy to address Alzheimer’s disease: Design, synthesis and biological evaluation of new tacrine-based dimers 92
Chemical and Pharmacological Studies on Enantiomerically Pure p-Methoxytacripyrines, Promising Multi-Target-Directed Ligands for the Treatment of Alzheimer's Disease 92
The bivalent ligand approach as a tool for improving the in vitro anti-Alzheimer multitarget profile of dimebon 91
null 91
Inhibition of Acetylcholinesterase, Beta-Amyloid Aggregation, and NMDA Receptors in Alzheimer's Disease: A Promising Direction for the Multi-target-Directed Ligands Gold Rush 90
Immobilized butyrylcholinesterase in the characterization of new inhibitors that could ease Alzheimer's disease. 90
Combination of human acetylcholinesterase and serum albumin sensing surfaces as highly informative analytical tool for inhibitor screening 90
Immobilized enzyme-based analytical tools in the -omics era: recent advances 90
Development of immobilized enzyme reactors based on human recombinant cytochrome P450 enzymes for phase I drug metabolism studies. 89
Progettazione e sintesi di derivati poliamminici per il trattamento della malattia di Alzheimer 88
Benzophenone derivatives as Inhibitors of Acetylcholinesterase 88
Imidazopyranotacrines as Non-Hepatotoxic, Selective Acetylcholinesterase Inhibitors, and Antioxidant Agents for Alzheimer's Disease Therapy 88
Tacripyrimidines, the first tacrine-dihydropyrimidine hybrids, as multi-target-directed ligands for Alzheimer's disease 88
No G-Quadruplex Structures in the DNA of Parvovirus B19: Experimental Evidence versus Bioinformatic Predictions 88
INTEGRATED ANALYTICAL APPROACHES FOR ALZHEIMER’S DISEASE NEW DRUG DISCOVERY 87
Memoquin: a new compound to attack Alzheimer's disease drug discovery 87
Kinetic characterization of amyloid-beta 1-42 aggregation with a multimethodological approach. 87
Novel huprine derivatives with inhibitory activity toward β-amyloid aggregation and formation as disease-modifying anti-alzheimer drug candidates 86
Towards automation in protein digestion: Development of a monolithic trypsin immobilized reactor for highly efficient on-line digestion and analysis 86
Derivati a struttura benzofenonica come inibitori dell'acetilcolinesterasi 85
Totale 11132
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Categoria #
all - tutte 33927
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 33927
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2017/2018430 0000 00 00 0040129
2018/20191638 8420329224 40171 10185 128259105209
2019/20205321 868141122309 445484 568736 655425258310
2020/20213561 708186120186 79220 135304 284199181959
2021/20224376 434157215262 468272 88374 194332843737
2022/20234599 489610263594 316309 165340 8632304200
Totale 20118