CRIS Current Research Information System

BARTOLINI, MANUELA
 Distribuzione geografica
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Continente #
NA - Nord America 13.494
AS - Asia 13.466
EU - Europa 10.720
AF - Africa 794
SA - Sud America 719
OC - Oceania 38
Continente sconosciuto - Info sul continente non disponibili 36
Totale 39.267
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Nazione #
US - Stati Uniti d'America 13.282
SG - Singapore 3.605
CN - Cina 3.568
VN - Vietnam 3.331
IT - Italia 2.570
GB - Regno Unito 2.383
DE - Germania 1.294
HK - Hong Kong 914
SE - Svezia 871
IN - India 734
UA - Ucraina 673
FR - Francia 668
RU - Federazione Russa 571
BR - Brasile 508
IE - Irlanda 334
KR - Corea 308
CI - Costa d'Avorio 282
JP - Giappone 259
NL - Olanda 226
ZA - Sudafrica 211
FI - Finlandia 176
EE - Estonia 174
TG - Togo 145
CA - Canada 127
CH - Svizzera 103
ES - Italia 94
BG - Bulgaria 91
PH - Filippine 84
AR - Argentina 83
SC - Seychelles 78
ID - Indonesia 74
PL - Polonia 72
TR - Turchia 70
BD - Bangladesh 69
IR - Iran 69
JO - Giordania 67
HR - Croazia 59
AT - Austria 55
MX - Messico 55
BE - Belgio 54
PK - Pakistan 51
IQ - Iraq 48
CZ - Repubblica Ceca 46
TW - Taiwan 46
TH - Thailandia 41
GR - Grecia 39
PT - Portogallo 36
EU - Europa 35
EC - Ecuador 30
AU - Australia 28
RO - Romania 28
CO - Colombia 24
CL - Cile 21
SA - Arabia Saudita 21
DK - Danimarca 18
UZ - Uzbekistan 17
PY - Paraguay 16
LB - Libano 15
MY - Malesia 15
SI - Slovenia 15
LT - Lituania 14
NG - Nigeria 14
VE - Venezuela 14
EG - Egitto 12
HU - Ungheria 12
NO - Norvegia 10
NP - Nepal 10
TN - Tunisia 10
DZ - Algeria 9
NZ - Nuova Zelanda 8
OM - Oman 8
PE - Perù 8
AE - Emirati Arabi Uniti 7
AL - Albania 7
AZ - Azerbaigian 7
BO - Bolivia 6
IL - Israele 6
KE - Kenya 6
MA - Marocco 6
MD - Moldavia 6
SK - Slovacchia (Repubblica Slovacca) 6
UY - Uruguay 6
DO - Repubblica Dominicana 5
GT - Guatemala 5
HN - Honduras 5
LK - Sri Lanka 5
CU - Cuba 4
LV - Lettonia 4
PS - Palestinian Territory 4
SN - Senegal 4
AO - Angola 3
BA - Bosnia-Erzegovina 3
BH - Bahrain 3
ET - Etiopia 3
JM - Giamaica 3
KG - Kirghizistan 3
KZ - Kazakistan 3
MK - Macedonia 3
RS - Serbia 3
CG - Congo 2
Totale 39.238
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Città #
Singapore 2.518
Southend 2.008
Ashburn 1.328
Fairfield 1.046
Chandler 1.029
Hong Kong 844
Ho Chi Minh City 737
Santa Clara 714
San Jose 644
Hanoi 637
Bologna 625
Houston 585
Wilmington 575
Hefei 544
Woodbridge 523
Princeton 494
Dong Ket 461
Jacksonville 455
Seattle 454
Ann Arbor 390
Cambridge 378
Beijing 366
Dublin 334
Boardman 313
Abidjan 282
Seoul 231
Nanjing 227
Lauterbourg 226
Tokyo 223
Westminster 209
Los Angeles 206
Milan 184
Padova 178
Berlin 171
Dallas 162
Council Bluffs 149
Helsinki 149
Jinan 147
Lomé 145
New York 121
Buffalo 115
Guangzhou 109
Shenyang 106
Medford 105
Saint Petersburg 97
Da Nang 95
Haiphong 94
Sofia 87
Shanghai 82
Rome 81
Changsha 80
Mülheim 78
Redondo Beach 78
Bern 75
Turin 75
Bengaluru 70
Tianjin 69
Nanchang 68
Amman 67
Falls Church 66
Munich 66
Hebei 65
Redmond 65
San Diego 64
Frankfurt am Main 61
Zhengzhou 58
Mahé 54
Redwood City 54
São Paulo 53
Jiaxing 50
Des Moines 48
Brussels 47
Hangzhou 46
Jakarta 44
Chicago 43
Dearborn 43
Haikou 43
London 43
Orem 41
Phoenix 40
Cardiff 39
Nuremberg 39
Hải Dương 38
Bremen 36
Taiyuan 36
Biên Hòa 35
Falkenstein 35
Johannesburg 35
Norwalk 34
Yubileyny 34
Warsaw 33
Olalla 31
Montreal 30
Amsterdam 29
Can Tho 29
Verona 29
Vienna 29
Brooklyn 27
Florence 27
Kunming 27
Totale 24.389
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Nome #
Preparazione del campione - metodi estrattivi 631
A small molecule targeting the multifactorial nature of Alzheimer's disease 511
Discovery of novel benzofuran-based compounds with neuroprotective and immunomodulatory properties for Alzheimer's disease treatment 325
Bis(7)-tacrine Derivatives as Multitarget-Directed Ligands: Focus on Anticholinesterase and Antiamyloid Activities 297
Advanced analytical methodologies in Alzheimer's disease drug discovery 290
Multitarget Strategy to Address Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and Computational Studies of Coumarin-Based Derivatives 287
Benzofuran-Based Hybrid Compounds for the Inhibition of Cholinesterase Activity, Abeta Amyloid Aggregation, and Abeta Neurotoxicity 281
Quinolinetrione-tacrine hybrids as multi-target-directed ligands against Alzheimer's disease 273
Discovery of Dual Aβ/Tau Inhibitors and Evaluation of Their Therapeutic Effect on a Drosophila Model of Alzheimer's Disease 271
Tau-Centric Multitarget Approach for Alzheimer's Disease: Development of First-in-Class Dual Glycogen Synthase Kinase 3β and Tau-Aggregation Inhibitors 257
Galantamine-memantine hybrids for Alzheimer's disease: The influence of linker rigidity in biological activity and pharmacokinetic properties 256
Sustainable Drug Discovery of Multi-Target-Directed Ligands for Alzheimer's Disease 254
Solid Lipid Microparticles for Oral Delivery of Catalase: Focus on the Protein Structural Integrity and Gastric Protection 251
Cholinesterase inhibitors: xanthostigmine derivatives blocking the acetylcholinesterase-induced beta-amyloid aggregation. 250
New insights into the altered binding capacity of pharmaceutical-grade human serum albumin: site-specific binding studies by induced circular dichroism spectroscopy 250
Dual-Acting Cholinesterase-Human Cannabinoid Receptor 2 Ligands Show Pronounced Neuroprotection in Vitro and Overadditive and Disease-Modifying Neuroprotective Effects in Vivo 247
Structure-Activity Relationships and Binding Mode in the Human Acetylcholinesterase Active Site of Pseudo-Irreversible Inhibitors Related to Xanthostigmine 244
Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease 227
N-1,2,3-triazole-isatin derivatives for cholinesterase and β-amyloid aggregation inhibition: A comprehensive bioassay study 227
null 222
No G-Quadruplex Structures in the DNA of Parvovirus B19: Experimental Evidence versus Bioinformatic Predictions 222
5-Methyl-N-(8-(5,6,7,8-tetrahydroacridin-9-ylamino)octyl)-5 H -indolo[2,3- b] quinolin-11-amine: a highly potent human cholinesterase inhibitor 220
Determination of Effective Albumin in Patients With Decompensated Cirrhosis: Clinical and Prognostic Implications 220
Analogues of the dual acetylcholinesterase inhibitor AP2238: synthesis and SAR 216
Analysis of amaryllidaceae alkaloids from Narcissus by GC-MS and capillary electrophoresis 215
Nature-Inspired Multifunctional Ligands: Focusing on Amyloid-Based Molecular Mechanisms of Alzheimer’s Disease 215
Targeting neuronal calcium channels and GSK3β for Alzheimer's disease with naturally-inspired Diels-Alder adducts 214
Rational Approach to discover multipotent anti-Alzheimer drugs 214
Centrally Active Multitarget Anti-Alzheimer Agents Derived from the Antioxidant Lead CR-6 213
Fatty Acid Amide Hydrolase (FAAH), Acetylcholinesterase (AChE), and Butyrylcholinesterase (BuChE): Networked Targets for the Development of Carbamates as Potential Anti-Alzheimer's Disease Agents 210
Exploiting the chalcone scaffold to develop multifunctional agents for Alzheimer’s disease 209
Association between Albumin Alterations and Renal Function in Patients with Type 2 Diabetes Mellitus 208
Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 3. Effect of replacing the inner polymethylene chain with cyclic moieties 208
Discovery of the 4-aminopiperidine-based compound EM127 for the site-specific covalent inhibition of SMYD3 206
Exopolysaccharides from vaginal lactobacilli modulate microbial biofilms 206
2-Arylbenzofuran-based molecules as multipotent Alzheimer's disease modifying agents 206
In vitro thrombogenicity of drug-eluting and bare metal stents 200
Design, synthesis, and biological evaluation of conformationally restricted rivastigmine analogues 199
SAR and binding mode at the h-AChE active site of pseudo-irreversible inhibitors related to Xanthostigmine 199
Multitarget Drug Design Strategy: Quinone–Tacrine Hybrids Designed To Block Amyloid-β Aggregation and To Exert Anticholinesterase and Antioxidant Effects 198
Turning Donepezil into a Multi-Target-Directed Ligand through a Merging Strategy 198
Extensive SAR and computational studies of 3-{4-[(benzylmethylamino)methyl]phenyl}-6,7-dimethoxy-2H-2-chromenone (AP2238) derivatives. 197
Discovery of sustainable drugs for Alzheimer's disease: cardanol-derived cholinesterase inhibitors with antioxidant and anti-amyloid properties 197
Benzophenone-based derivatives: A novel series of potent and selective dual inhibitors of acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation 196
Progettazione e sintesi di derivati poliamminici per il trattamento della malattia di Alzheimer 193
Multitargeted drugs discovery: Balancing anti-amyloid and anticholinesterase capacity in a single chemical entity 192
Phenothiazine-Tacrine Heterodimers: Pursuing Multitarget Directed Approach in Alzheimer's Disease 192
Immobilized Enzyme Reactors: an Overview of Applications in Drug Discovery from 2008 to 2018 188
CHOLINESTERASE INHIBITORS: SAR AND ENZYME INHIBITORY ACTIVITY OF 3-[omega-(BENZYLMETHYLAMINO)ALKOXY]XANTHEN-9-ONES 186
ON-LINE GLYCAN RELEASE AND ANALYSIS BY AN INTEGRATED PNGASE F-IMER LC-ESI-Q-TOF APPROACH 185
Novel multifunctional tacrine–donepezil hybrids against Alzheimer's disease: Design synthesis and bioactivity studies 185
Unveiling the Biochemistry of the Epigenetic Regulator SMYD3 182
Microsampling and enantioselective liquid chromatography coupled to mass spectrometry for chiral bioanalysis of novel psychoactive substances 181
Choosing the right chromatographic support in making a new acetylcholinesterase-micro-immobilised enzyme reactor for drug discovery. 180
Structure-activity relationships of memoquin: Influence of the chain chirality in the multi-target mechanism of action 179
Cystamine-tacrine dimer: A new multi-target-directed ligand as potential therapeutic agent for Alzheimer's disease treatment. 178
New tacrine dimers with antioxidant linkers as dual drugs: Anti-Alzheimer's and antiproliferative agents 177
Discovery of an Allosteric Ligand Binding Site in SMYD3 Lysine Methyltransferase 175
The novel SMYD3 inhibitor EM127 impairs DNA repair response to chemotherapy-induced DNA damage and reverses cancer chemoresistance 174
A Fluorescent Styrylquinoline with Combined Therapeutic and Diagnostic Activities against Alzheimer's and Prion Diseases 174
(±)- BIGI-3h: Pentatarget-Directed Ligand combining Cholinesterase, Monoamine Oxidase, and Glycogen Synthase Kinase 3β Inhibition with Calcium Channel Antagonism and Antiaggregating Properties for Alzheimer's Disease 174
Inhibition of β-Amyloid Aggregation in Alzheimer's Disease: The Key Role of (Pro)electrophilic Warheads 173
Monolytic micro-immobilized-enzyme reactor with human recombinant acetylcholinesterase for on-line inhibition studies 173
Novel bis(7)-tacrine derivatives as multitarget ligands: focus on anti-cholinesterase and anti-amyloid activities 173
Stepwise Structural Simplification of the Dihydroxyanthraquinone Moiety of a Multitarget Rhein-Based Anti-Alzheimer Lead to Improve Drug Metabolism and Pharmacokinetic Properties 172
Bivalent tacrine-based acetylcholinesterase inhibitors: role of the spacer in the recognition process of the enzyme gorge 171
Toward a rational design of multitarget-directed antioxidants: merging memoquin and lipoic acid molecular frameworks 171
From the dual function lead AP2238 to AP2469, a multi-target-directed ligand for the treatment of Alzheimer’s disease 171
From combinations to single-molecule polypharmacology—cromolyn-ibuprofen conjugates for alzheimer’s disease 171
ALZHEIMER'S DISEASE DRUG DISCOVERY: NEW ANALYTICAL APPROACHES FOR LEAD SELECTION AND OPTIMIZATION PBA 2009 (20h International Symposium on Pharmaceutical and Biomedical Analysis), Agra, India 01-04 Marzo 2009 170
New Coumarin derivatives as cholinergic and cannabinoid system modulators 170
Multi-Target-Directed Drug Design Strategy: From a Dual Binding Site Acetylcholinesterase Inhibitor to a Trifunctional Compound against Alzheimer's Disease 169
A MULTI-METHODOLOGICAL APPROACH FOR BETA-AMYLOID AGGREGATION AND INHIBITION STUDIES 168
Polyamine Conjugation as a Promising Strategy To Target Amyloid Aggregation in the Framework of Alzheimer’s Disease 168
Tacripyrimidines, the first tacrine-dihydropyrimidine hybrids, as multi-target-directed ligands for Alzheimer's disease 167
Batch-wise covalent immobilisation of human acetylcholinesterase: kinetic and inhibition spectrophotometric studies 166
Characterization of reversible and pseudo-irreversible Acetylcholinesterase inhibitors by means of immobilized enzyme reactor 166
Immobilized enzyme-based analytical tools in the -omics era: recent advances 166
Tacrine-based dual binding site acetylcholinesterase inhibitors as potential disease-modifying anti-Alzheimer drug candidates 165
Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimers Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography 165
Derivati a struttura benzofenonica come inibitori dell'acetilcolinesterasi 164
CHOOSING THE RIGHT CHROMATOGRAPHIC SUPPORT FOR ENZYME-BASED MICRO-IMERS. 163
Quinones bearing non-steroidal anti-inflammatory fragments as multitarget ligands for Alzheimer’s disease 163
Acetylcholinesterase oriented immobilization on nanopatterned bilayered surfaces for biosensing devices 162
Fluorinated benzophenone derivatives: balanced multipotent agents for Alzheimer's disease 162
Combination of human acetylcholinesterase and serum albumin sensing surfaces as highly informative analytical tool for inhibitor screening 162
Investigating in vitro amyloid peptide 1−42 aggregation: Impact of higher molecular weight stable adducts 162
Design, synthesis, and evaluation of benzophenone derivatives as novel acetylcholinesterase inhibitors 161
Targeting Alzheimer’s disease: Novel indanone hybrids bearing a pharmacophoric fragment of AP2238 161
Inhibition of Acetylcholinesterase, Beta-Amyloid Aggregation, and NMDA Receptors in Alzheimer's Disease: A Promising Direction for the Multi-target-Directed Ligands Gold Rush 160
Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice 160
Design, Synthesis and Biological Evaluation of Dual Binding Site Acetylcholinesterase Inhibitors: New Disease Modifying Agents for Alzheimer's Disease 159
DEVELOPMENT AND CHARACTERIZATION OF A PACKED AChE-micro-IMER FOR DRUG DISCOVERY IN ALZHEIMER’S DISEASE 158
Novel Class of Quinone-Bearing Polyamines as Multi-Target-Directed Ligands To Combat Alzheimer's Disease 158
Preparation of (hetero)aromatic (hetero)cyclic carboxamides for the treatment of Alzheimer's disease 156
Multi-target-directed coumarin derivatives: hAChE and BAC1 inhibitors as potential anti-Alzheimer compounds 155
HSA-nanobinders crafted from bioresponsive prodrugs for combined cancer chemoimmunotherapy–an in vitro exploration 154
Synthesis of Monomeric Derivatives To Probe Memoquin's Bivalent Interactions 154
Analytical approaches in Alzheimer’s disease Drug Discovery 154
AChE inhibitors: affinity and kinetic studies using SPR technology 154
Totale 20.329
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Categoria #
all - tutte 104.842
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 104.842
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/20211.339 0 0 0 0 0 0 0 0 0 199 181 959
2021/20224.376 434 157 215 262 468 272 88 374 194 332 843 737
2022/20234.771 489 610 263 594 316 309 147 318 789 205 399 332
2023/20241.710 115 248 109 122 149 308 128 123 76 119 120 93
2024/20255.634 271 845 598 384 1.056 296 392 205 127 274 259 927
2025/202612.451 1.132 1.346 1.268 1.081 1.530 869 1.714 462 2.304 745 0 0
Totale 40.085