CRIS Current Research Information System

BARTOLINI, MANUELA
 Distribuzione geografica
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Continente #
NA - Nord America 9.809
EU - Europa 8.675
AS - Asia 3.368
AF - Africa 534
Continente sconosciuto - Info sul continente non disponibili 36
SA - Sud America 36
OC - Oceania 24
Totale 22.482
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Nazione #
US - Stati Uniti d'America 9.737
GB - Regno Unito 2.226
IT - Italia 2.057
CN - Cina 1.167
DE - Germania 1.089
SE - Svezia 848
VN - Vietnam 810
UA - Ucraina 660
SG - Singapore 568
IN - India 530
FR - Francia 371
IE - Irlanda 314
RU - Federazione Russa 289
EE - Estonia 174
ZA - Sudafrica 158
CI - Costa d'Avorio 156
TG - Togo 145
CH - Svizzera 99
BG - Bulgaria 89
FI - Finlandia 60
CA - Canada 58
ES - Italia 58
JO - Giordania 58
SC - Seychelles 57
HR - Croazia 56
KR - Corea 53
IR - Iran 48
BE - Belgio 46
EU - Europa 35
GR - Grecia 34
JP - Giappone 29
PT - Portogallo 29
AT - Austria 28
CZ - Repubblica Ceca 27
RO - Romania 26
PL - Polonia 25
TR - Turchia 21
BR - Brasile 20
NL - Olanda 19
AU - Australia 18
PK - Pakistan 18
LB - Libano 13
HK - Hong Kong 12
CL - Cile 10
MX - Messico 10
NG - Nigeria 10
DK - Danimarca 9
NO - Norvegia 9
HU - Ungheria 8
SI - Slovenia 7
BD - Bangladesh 6
NZ - Nuova Zelanda 6
IQ - Iraq 5
PH - Filippine 5
TW - Taiwan 5
CU - Cuba 4
EG - Egitto 3
LT - Lituania 3
LV - Lettonia 3
MD - Moldavia 3
SK - Slovacchia (Repubblica Slovacca) 3
UZ - Uzbekistan 3
AL - Albania 2
AR - Argentina 2
AZ - Azerbaigian 2
CO - Colombia 2
DZ - Algeria 2
ID - Indonesia 2
LK - Sri Lanka 2
MU - Mauritius 2
MY - Malesia 2
OM - Oman 2
RS - Serbia 2
SA - Arabia Saudita 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AE - Emirati Arabi Uniti 1
EC - Ecuador 1
FK - Isole Falkland (Malvinas) 1
IL - Israele 1
KW - Kuwait 1
LA - Repubblica Popolare Democratica del Laos 1
MK - Macedonia 1
SM - San Marino 1
SN - Senegal 1
TH - Thailandia 1
Totale 22.482
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Città #
Southend 2.008
Fairfield 1.045
Chandler 1.029
Ashburn 823
Houston 575
Wilmington 575
Bologna 545
Woodbridge 523
Princeton 494
Singapore 493
Dong Ket 461
Jacksonville 455
Seattle 448
Ann Arbor 390
Cambridge 378
Dublin 314
Nanjing 218
Westminster 209
Padova 178
Berlin 170
Abidjan 156
Lomé 145
Milan 132
Jinan 130
Santa Clara 130
Medford 104
Shenyang 102
Saint Petersburg 97
Sofia 85
Mülheim 78
Bern 75
Turin 72
Changsha 67
Nanchang 67
Falls Church 66
Hebei 65
Redmond 64
San Diego 62
New York 60
Beijing 59
Amman 58
Boardman 57
Helsinki 54
Mahé 54
Redwood City 54
Rome 51
Jiaxing 45
Tianjin 45
Des Moines 44
Dearborn 43
Haikou 43
Brussels 41
Los Angeles 39
Bremen 36
Norwalk 34
Zhengzhou 33
Olalla 31
Hangzhou 30
Taiyuan 30
Guangzhou 28
Verona 28
Fremont 24
Paris 22
Kunming 21
Vienna 21
Tokyo 20
Lanzhou 18
Ningbo 18
Pune 18
Taizhou 18
Catania 17
London 17
Madrid 17
Mountain View 17
Ottawa 17
Bühl 16
Hyderabad 16
Shanghai 16
Florence 15
Lisbon 15
Phoenix 15
Barcelona 14
Boydton 14
Chicago 14
Bengaluru 13
Brno 13
Ravenna 13
San Jose 13
Seoul 13
Fuzhou 12
Bari 11
Toronto 11
Varanasi 11
Ancona 10
Cesena 10
Frankfurt Am Main 10
Hefei 10
Istanbul 10
Melbourne 10
Mumbai 10
Totale 14.605
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Nome #
Preparazione del campione - metodi estrattivi 398
A small molecule targeting the multifactorial nature of Alzheimer's disease 240
null 222
Discovery of novel benzofuran-based compounds with neuroprotective and immunomodulatory properties for Alzheimer's disease treatment 214
Advanced analytical methodologies in Alzheimer's disease drug discovery 209
Multitarget Strategy to Address Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and Computational Studies of Coumarin-Based Derivatives 184
Cholinesterase inhibitors: xanthostigmine derivatives blocking the acetylcholinesterase-induced beta-amyloid aggregation. 172
Tau-Centric Multitarget Approach for Alzheimer's Disease: Development of First-in-Class Dual Glycogen Synthase Kinase 3β and Tau-Aggregation Inhibitors 165
2-Arylbenzofuran-based molecules as multipotent Alzheimer's disease modifying agents 160
Bis(7)-tacrine Derivatives as Multitarget-Directed Ligands: Focus on Anticholinesterase and Antiamyloid Activities 152
Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 3. Effect of replacing the inner polymethylene chain with cyclic moieties 151
Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease 151
Dual-Acting Cholinesterase-Human Cannabinoid Receptor 2 Ligands Show Pronounced Neuroprotection in Vitro and Overadditive and Disease-Modifying Neuroprotective Effects in Vivo 149
Analysis of amaryllidaceae alkaloids from Narcissus by GC-MS and capillary electrophoresis 145
Benzofuran-Based Hybrid Compounds for the Inhibition of Cholinesterase Activity, Abeta Amyloid Aggregation, and Abeta Neurotoxicity 144
Rational Approach to discover multipotent anti-Alzheimer drugs 143
Analogues of the dual acetylcholinesterase inhibitor AP2238: synthesis and SAR 143
Sustainable Drug Discovery of Multi-Target-Directed Ligands for Alzheimer's Disease 143
Nature-Inspired Multifunctional Ligands: Focusing on Amyloid-Based Molecular Mechanisms of Alzheimer’s Disease 142
Design, synthesis, and biological evaluation of conformationally restricted rivastigmine analogues 141
Fatty Acid Amide Hydrolase (FAAH), Acetylcholinesterase (AChE), and Butyrylcholinesterase (BuChE): Networked Targets for the Development of Carbamates as Potential Anti-Alzheimer's Disease Agents 141
Benzophenone-based derivatives: A novel series of potent and selective dual inhibitors of acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation 140
Exploiting the chalcone scaffold to develop multifunctional agents for Alzheimer’s disease 140
Extensive SAR and computational studies of 3-{4-[(benzylmethylamino)methyl]phenyl}-6,7-dimethoxy-2H-2-chromenone (AP2238) derivatives. 136
A Fluorescent Styrylquinoline with Combined Therapeutic and Diagnostic Activities against Alzheimer's and Prion Diseases 135
ON-LINE GLYCAN RELEASE AND ANALYSIS BY AN INTEGRATED PNGASE F-IMER LC-ESI-Q-TOF APPROACH 134
Multitarget Drug Design Strategy: Quinone–Tacrine Hybrids Designed To Block Amyloid-β Aggregation and To Exert Anticholinesterase and Antioxidant Effects 133
Choosing the right chromatographic support in making a new acetylcholinesterase-micro-immobilised enzyme reactor for drug discovery. 129
Cystamine-tacrine dimer: A new multi-target-directed ligand as potential therapeutic agent for Alzheimer's disease treatment. 129
Progettazione e sintesi di derivati poliamminici per il trattamento della malattia di Alzheimer 128
Structure-activity relationships of memoquin: Influence of the chain chirality in the multi-target mechanism of action 128
Multitargeted drugs discovery: Balancing anti-amyloid and anticholinesterase capacity in a single chemical entity 127
A MULTI-METHODOLOGICAL APPROACH FOR BETA-AMYLOID AGGREGATION AND INHIBITION STUDIES 127
Characterization of reversible and pseudo-irreversible Acetylcholinesterase inhibitors by means of immobilized enzyme reactor 125
Immobilized Enzyme Reactors: an Overview of Applications in Drug Discovery from 2008 to 2018 125
Multi-Target-Directed Drug Design Strategy: From a Dual Binding Site Acetylcholinesterase Inhibitor to a Trifunctional Compound against Alzheimer's Disease 124
CHOLINESTERASE INHIBITORS: SAR AND ENZYME INHIBITORY ACTIVITY OF 3-[omega-(BENZYLMETHYLAMINO)ALKOXY]XANTHEN-9-ONES 124
Discovery of sustainable drugs for Alzheimer's disease: cardanol-derived cholinesterase inhibitors with antioxidant and anti-amyloid properties 124
null 123
Acetylcholinesterase oriented immobilization on nanopatterned bilayered surfaces for biosensing devices 122
Monolytic micro-immobilized-enzyme reactor with human recombinant acetylcholinesterase for on-line inhibition studies 119
Toward a rational design of multitarget-directed antioxidants: merging memoquin and lipoic acid molecular frameworks 118
null 118
Determination of Effective Albumin in Patients With Decompensated Cirrhosis: Clinical and Prognostic Implications 118
Analytical approaches in Alzheimer’s disease Drug Discovery 116
ALZHEIMER'S DISEASE DRUG DISCOVERY: NEW ANALYTICAL APPROACHES FOR LEAD SELECTION AND OPTIMIZATION PBA 2009 (20h International Symposium on Pharmaceutical and Biomedical Analysis), Agra, India 01-04 Marzo 2009 115
New tacrine dimers with antioxidant linkers as dual drugs: Anti-Alzheimer's and antiproliferative agents 115
Fluorinated benzophenone derivatives: balanced multipotent agents for Alzheimer's disease 115
Bivalent tacrine-based acetylcholinesterase inhibitors: role of the spacer in the recognition process of the enzyme gorge 114
New insights into the altered binding capacity of pharmaceutical-grade human serum albumin: site-specific binding studies by induced circular dichroism spectroscopy 114
AMYLOID-b-PEPTIDE SELF ASSEMBLY KINETICS BY AFM AND MALDI-TOF MASS SPECTROMETRY 112
Solid Lipid Microparticles for Oral Delivery of Catalase: Focus on the Protein Structural Integrity and Gastric Protection 112
Characterization of Cholinesterase inhibitors by means of immobilized enzyme reactor 111
Tacrine-based dual binding site acetylcholinesterase inhibitors as potential disease-modifying anti-Alzheimer drug candidates 111
Novel bis(7)-tacrine derivatives as multitarget ligands: focus on anti-cholinesterase and anti-amyloid activities 111
From the dual function lead AP2238 to AP2469, a multi-target-directed ligand for the treatment of Alzheimer’s disease 111
CHOOSING THE RIGHT CHROMATOGRAPHIC SUPPORT FOR ENZYME-BASED MICRO-IMERS. 110
Novel Class of Quinone-Bearing Polyamines as Multi-Target-Directed Ligands To Combat Alzheimer's Disease 110
Unveiling the Biochemistry of the Epigenetic Regulator SMYD3 109
Design, Synthesis and Biological Evaluation of Dual Binding Site Acetylcholinesterase Inhibitors: New Disease Modifying Agents for Alzheimer's Disease 108
The role of Li(+), Na(+), and K(+) in the ligand binding inside the human acetylcholinesterase gorge 108
Targeting Alzheimer’s disease: Novel indanone hybrids bearing a pharmacophoric fragment of AP2238 108
null 108
Phenothiazine-Tacrine Heterodimers: Pursuing Multitarget Directed Approach in Alzheimer's Disease 108
Batch-wise covalent immobilisation of human acetylcholinesterase: kinetic and inhibition spectrophotometric studies 107
Design, synthesis, and evaluation of benzophenone derivatives as novel acetylcholinesterase inhibitors 107
Uleine disrupts key enzymatic and non-enzymatic biomarkers that leads to Alzheimer's disease 107
IMMOBILIZED ENZYMES AS TOOLS IN DRUG DISCOVERY 106
Polyamine Conjugation as a Promising Strategy To Target Amyloid Aggregation in the Framework of Alzheimer’s Disease 106
Turning Donepezil into a Multi-Target-Directed Ligand through a Merging Strategy 106
Quinones bearing non-steroidal anti-inflammatory fragments as multitarget ligands for Alzheimer’s disease 105
Increasing polarity in tacrine and huprine derivatives: Potent anticholinesterase agents for the treatment of myasthenia gravis 105
Preparation of (hetero)aromatic (hetero)cyclic carboxamides for the treatment of Alzheimer's disease 104
Benzophenone derivatives as Inhibitors of Acetylcholinesterase 104
Heterocyclic inhibitors of AChE acylation and peripheral sites. 104
Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimers Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography 104
Immobilized enzyme-based analytical tools in the -omics era: recent advances 104
Circular dichroism investigation on amyloid bata(1-42) peptide self-aggregation 102
Fluorescence biosensing micropatterned surfaces based on immobilized human acetylcholinesterase 102
Combination of human acetylcholinesterase and serum albumin sensing surfaces as highly informative analytical tool for inhibitor screening 102
In vitro thrombogenicity of drug-eluting and bare metal stents 102
Structure-Activity Relationships and Binding Mode in the Human Acetylcholinesterase Active Site of Pseudo-Irreversible Inhibitors Related to Xanthostigmine 101
Multi-target strategy to address Alzheimer’s disease: Design, synthesis and biological evaluation of new tacrine-based dimers 101
Synthesis and multitarget biological profiling of a novel family of rhein derivatives as disease-modifying anti-Alzheimer agents. 101
ANALYTICAL STRATEGIES FOR THE CHARACTERIZATION OF PROTEIN AGGREGATION AND INHIBITION IN HUMAN DISEASES 100
Tacripyrimidines, the first tacrine-dihydropyrimidine hybrids, as multi-target-directed ligands for Alzheimer's disease 100
Multi-target-directed coumarin derivatives: hAChE and BAC1 inhibitors as potential anti-Alzheimer compounds 99
Discovery of Dual Aβ/Tau Inhibitors and Evaluation of Their Therapeutic Effect on a Drosophila Model of Alzheimer's Disease 98
Derivati a struttura benzofenonica come inibitori dell'acetilcolinesterasi 98
null 98
Inhibition of Acetylcholinesterase, Beta-Amyloid Aggregation, and NMDA Receptors in Alzheimer's Disease: A Promising Direction for the Multi-target-Directed Ligands Gold Rush 97
Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease. 97
Immobilized butyrylcholinesterase in the characterization of new inhibitors that could ease Alzheimer's disease. 97
Preparation of 2,5-bis-diamine-[1,4]benzoquinone derivatives for the treatment of Alzheimer's disease and a process for their preparation and intermediates thereof. 97
Synthesis of Monomeric Derivatives To Probe Memoquin's Bivalent Interactions 97
Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer's disease. 97
A patent review of butyrylcholinesterase inhibitors and reactivators 2010–2017 96
The bivalent ligand approach as a tool for improving the in vitro anti-Alzheimer multitarget profile of dimebon 95
Imidazopyranotacrines as Non-Hepatotoxic, Selective Acetylcholinesterase Inhibitors, and Antioxidant Agents for Alzheimer's Disease Therapy 95
INTEGRATED ANALYTICAL APPROACHES FOR ALZHEIMER’S DISEASE NEW DRUG DISCOVERY 94
Totale 12.496
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Categoria #
all - tutte 58.799
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 58.799
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20204.312 0 0 122 309 445 484 568 736 655 425 258 310
2020/20213.561 708 186 120 186 79 220 135 304 284 199 181 959
2021/20224.376 434 157 215 262 468 272 88 374 194 332 843 737
2022/20234.771 489 610 263 594 316 309 147 318 789 205 399 332
2023/20241.754 115 248 109 122 149 308 128 123 76 139 140 97
2024/20251.136 284 849 3 0 0 0 0 0 0 0 0 0
Totale 23.180