CRIS Current Research Information System

BARTOLINI, MANUELA
 Distribuzione geografica
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Continente #
NA - Nord America 12.201
AS - Asia 10.223
EU - Europa 10.111
AF - Africa 731
SA - Sud America 587
Continente sconosciuto - Info sul continente non disponibili 36
OC - Oceania 33
Totale 33.922
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Nazione #
US - Stati Uniti d'America 12.044
CN - Cina 3.180
SG - Singapore 3.104
IT - Italia 2.435
GB - Regno Unito 2.341
VN - Vietnam 1.650
DE - Germania 1.264
SE - Svezia 870
HK - Hong Kong 785
UA - Ucraina 663
IN - India 645
RU - Federazione Russa 566
BR - Brasile 438
FR - Francia 429
IE - Irlanda 328
KR - Corea 283
CI - Costa d'Avorio 279
NL - Olanda 207
ZA - Sudafrica 186
EE - Estonia 174
JP - Giappone 171
TG - Togo 145
FI - Finlandia 118
CH - Svizzera 100
CA - Canada 96
BG - Bulgaria 91
ES - Italia 79
SC - Seychelles 78
IR - Iran 69
AR - Argentina 65
JO - Giordania 61
ID - Indonesia 60
HR - Croazia 59
PL - Polonia 59
AT - Austria 54
BE - Belgio 51
CZ - Repubblica Ceca 42
TR - Turchia 42
MX - Messico 41
GR - Grecia 37
EU - Europa 35
PT - Portogallo 33
PK - Pakistan 28
RO - Romania 28
AU - Australia 25
BD - Bangladesh 25
EC - Ecuador 25
DK - Danimarca 17
TW - Taiwan 17
CL - Cile 16
SI - Slovenia 15
CO - Colombia 14
IQ - Iraq 14
LB - Libano 13
PH - Filippine 12
NG - Nigeria 11
LT - Lituania 10
PY - Paraguay 10
NO - Norvegia 9
TH - Thailandia 9
HU - Ungheria 8
MY - Malesia 8
SA - Arabia Saudita 8
DZ - Algeria 6
NZ - Nuova Zelanda 6
AE - Emirati Arabi Uniti 5
EG - Egitto 5
IL - Israele 5
LK - Sri Lanka 5
PE - Perù 5
UY - Uruguay 5
UZ - Uzbekistan 5
VE - Venezuela 5
AL - Albania 4
CU - Cuba 4
LV - Lettonia 4
NP - Nepal 4
SK - Slovacchia (Repubblica Slovacca) 4
AZ - Azerbaigian 3
BA - Bosnia-Erzegovina 3
BH - Bahrain 3
BO - Bolivia 3
DO - Repubblica Dominicana 3
GT - Guatemala 3
HN - Honduras 3
MA - Marocco 3
MD - Moldavia 3
MK - Macedonia 3
OM - Oman 3
SN - Senegal 3
TN - Tunisia 3
AO - Angola 2
CG - Congo 2
KE - Kenya 2
KZ - Kazakistan 2
MU - Mauritius 2
RS - Serbia 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AF - Afghanistan, Repubblica islamica di 1
CM - Camerun 1
Totale 33.905
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Città #
Singapore 2.068
Southend 2.008
Ashburn 1.222
Fairfield 1.046
Chandler 1.029
Hong Kong 766
Santa Clara 693
Bologna 595
Houston 579
Wilmington 575
Hefei 541
Woodbridge 523
Princeton 494
Dong Ket 461
Jacksonville 455
Seattle 454
Ann Arbor 390
Cambridge 378
Beijing 350
Dublin 328
Boardman 312
Ho Chi Minh City 294
Abidjan 279
Seoul 229
Hanoi 224
Nanjing 224
Westminster 209
Los Angeles 187
Padova 178
Milan 177
Berlin 170
Dallas 158
Tokyo 154
Jinan 147
Lomé 145
Buffalo 114
Medford 105
Shenyang 105
New York 103
Saint Petersburg 97
Helsinki 92
Sofia 87
Guangzhou 83
Changsha 79
Mülheim 78
Redondo Beach 78
Bern 75
Turin 75
Bengaluru 68
Nanchang 67
Rome 67
Shanghai 67
Falls Church 66
Munich 66
Tianjin 66
Hebei 65
Redmond 65
San Diego 62
Amman 61
Zhengzhou 56
Mahé 54
Redwood City 54
Jiaxing 48
Brussels 45
São Paulo 45
Des Moines 44
Dearborn 43
Haikou 43
Hangzhou 42
Jakarta 42
Cardiff 38
Frankfurt am Main 38
Chicago 37
Nuremberg 37
Bremen 36
Falkenstein 35
Phoenix 35
Taiyuan 35
Norwalk 34
Yubileyny 34
Haiphong 33
London 32
Olalla 31
Council Bluffs 29
Verona 29
Vienna 29
Brooklyn 26
Kunming 26
Catania 24
Fremont 24
Ottawa 24
Taizhou 24
Warsaw 24
Lanzhou 23
Ningbo 23
Paris 23
Florence 22
San Jose 22
Toronto 22
Amsterdam 21
Totale 21.319
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Nome #
Preparazione del campione - metodi estrattivi 547
A small molecule targeting the multifactorial nature of Alzheimer's disease 473
Discovery of novel benzofuran-based compounds with neuroprotective and immunomodulatory properties for Alzheimer's disease treatment 288
Bis(7)-tacrine Derivatives as Multitarget-Directed Ligands: Focus on Anticholinesterase and Antiamyloid Activities 279
Advanced analytical methodologies in Alzheimer's disease drug discovery 271
Benzofuran-Based Hybrid Compounds for the Inhibition of Cholinesterase Activity, Abeta Amyloid Aggregation, and Abeta Neurotoxicity 265
Quinolinetrione-tacrine hybrids as multi-target-directed ligands against Alzheimer's disease 237
Cholinesterase inhibitors: xanthostigmine derivatives blocking the acetylcholinesterase-induced beta-amyloid aggregation. 236
Multitarget Strategy to Address Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and Computational Studies of Coumarin-Based Derivatives 234
Structure-Activity Relationships and Binding Mode in the Human Acetylcholinesterase Active Site of Pseudo-Irreversible Inhibitors Related to Xanthostigmine 225
Tau-Centric Multitarget Approach for Alzheimer's Disease: Development of First-in-Class Dual Glycogen Synthase Kinase 3β and Tau-Aggregation Inhibitors 225
null 222
Dual-Acting Cholinesterase-Human Cannabinoid Receptor 2 Ligands Show Pronounced Neuroprotection in Vitro and Overadditive and Disease-Modifying Neuroprotective Effects in Vivo 217
Discovery of Dual Aβ/Tau Inhibitors and Evaluation of Their Therapeutic Effect on a Drosophila Model of Alzheimer's Disease 213
Sustainable Drug Discovery of Multi-Target-Directed Ligands for Alzheimer's Disease 208
Rational Approach to discover multipotent anti-Alzheimer drugs 204
N-1,2,3-triazole-isatin derivatives for cholinesterase and β-amyloid aggregation inhibition: A comprehensive bioassay study 204
Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 3. Effect of replacing the inner polymethylene chain with cyclic moieties 201
Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease 198
Analogues of the dual acetylcholinesterase inhibitor AP2238: synthesis and SAR 196
Design, synthesis, and biological evaluation of conformationally restricted rivastigmine analogues 194
Analysis of amaryllidaceae alkaloids from Narcissus by GC-MS and capillary electrophoresis 192
Nature-Inspired Multifunctional Ligands: Focusing on Amyloid-Based Molecular Mechanisms of Alzheimer’s Disease 192
Centrally Active Multitarget Anti-Alzheimer Agents Derived from the Antioxidant Lead CR-6 190
2-Arylbenzofuran-based molecules as multipotent Alzheimer's disease modifying agents 188
Fatty Acid Amide Hydrolase (FAAH), Acetylcholinesterase (AChE), and Butyrylcholinesterase (BuChE): Networked Targets for the Development of Carbamates as Potential Anti-Alzheimer's Disease Agents 183
Benzophenone-based derivatives: A novel series of potent and selective dual inhibitors of acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation 182
Exploiting the chalcone scaffold to develop multifunctional agents for Alzheimer’s disease 182
Extensive SAR and computational studies of 3-{4-[(benzylmethylamino)methyl]phenyl}-6,7-dimethoxy-2H-2-chromenone (AP2238) derivatives. 181
SAR and binding mode at the h-AChE active site of pseudo-irreversible inhibitors related to Xanthostigmine 181
Exopolysaccharides from vaginal lactobacilli modulate microbial biofilms 178
Targeting neuronal calcium channels and GSK3β for Alzheimer's disease with naturally-inspired Diels-Alder adducts 178
Determination of Effective Albumin in Patients With Decompensated Cirrhosis: Clinical and Prognostic Implications 178
Choosing the right chromatographic support in making a new acetylcholinesterase-micro-immobilised enzyme reactor for drug discovery. 175
Progettazione e sintesi di derivati poliamminici per il trattamento della malattia di Alzheimer 175
Discovery of sustainable drugs for Alzheimer's disease: cardanol-derived cholinesterase inhibitors with antioxidant and anti-amyloid properties 175
Discovery of the 4-aminopiperidine-based compound EM127 for the site-specific covalent inhibition of SMYD3 174
New insights into the altered binding capacity of pharmaceutical-grade human serum albumin: site-specific binding studies by induced circular dichroism spectroscopy 171
Multitarget Drug Design Strategy: Quinone–Tacrine Hybrids Designed To Block Amyloid-β Aggregation and To Exert Anticholinesterase and Antioxidant Effects 170
Cystamine-tacrine dimer: A new multi-target-directed ligand as potential therapeutic agent for Alzheimer's disease treatment. 168
ON-LINE GLYCAN RELEASE AND ANALYSIS BY AN INTEGRATED PNGASE F-IMER LC-ESI-Q-TOF APPROACH 168
Monolytic micro-immobilized-enzyme reactor with human recombinant acetylcholinesterase for on-line inhibition studies 166
Multitargeted drugs discovery: Balancing anti-amyloid and anticholinesterase capacity in a single chemical entity 164
A MULTI-METHODOLOGICAL APPROACH FOR BETA-AMYLOID AGGREGATION AND INHIBITION STUDIES 164
Immobilized Enzyme Reactors: an Overview of Applications in Drug Discovery from 2008 to 2018 164
Microsampling and enantioselective liquid chromatography coupled to mass spectrometry for chiral bioanalysis of novel psychoactive substances 163
Bivalent tacrine-based acetylcholinesterase inhibitors: role of the spacer in the recognition process of the enzyme gorge 163
A Fluorescent Styrylquinoline with Combined Therapeutic and Diagnostic Activities against Alzheimer's and Prion Diseases 163
CHOLINESTERASE INHIBITORS: SAR AND ENZYME INHIBITORY ACTIVITY OF 3-[omega-(BENZYLMETHYLAMINO)ALKOXY]XANTHEN-9-ONES 163
Solid Lipid Microparticles for Oral Delivery of Catalase: Focus on the Protein Structural Integrity and Gastric Protection 160
Structure-activity relationships of memoquin: Influence of the chain chirality in the multi-target mechanism of action 159
Turning Donepezil into a Multi-Target-Directed Ligand through a Merging Strategy 159
Phenothiazine-Tacrine Heterodimers: Pursuing Multitarget Directed Approach in Alzheimer's Disease 159
Galantamine-memantine hybrids for Alzheimer's disease: The influence of linker rigidity in biological activity and pharmacokinetic properties 158
Characterization of reversible and pseudo-irreversible Acetylcholinesterase inhibitors by means of immobilized enzyme reactor 157
Toward a rational design of multitarget-directed antioxidants: merging memoquin and lipoic acid molecular frameworks 157
In vitro thrombogenicity of drug-eluting and bare metal stents 157
ALZHEIMER'S DISEASE DRUG DISCOVERY: NEW ANALYTICAL APPROACHES FOR LEAD SELECTION AND OPTIMIZATION PBA 2009 (20h International Symposium on Pharmaceutical and Biomedical Analysis), Agra, India 01-04 Marzo 2009 156
Unveiling the Biochemistry of the Epigenetic Regulator SMYD3 155
5-Methyl-N-(8-(5,6,7,8-tetrahydroacridin-9-ylamino)octyl)-5 H -indolo[2,3- b] quinolin-11-amine: a highly potent human cholinesterase inhibitor 155
New tacrine dimers with antioxidant linkers as dual drugs: Anti-Alzheimer's and antiproliferative agents 154
Batch-wise covalent immobilisation of human acetylcholinesterase: kinetic and inhibition spectrophotometric studies 153
Multi-Target-Directed Drug Design Strategy: From a Dual Binding Site Acetylcholinesterase Inhibitor to a Trifunctional Compound against Alzheimer's Disease 153
Novel bis(7)-tacrine derivatives as multitarget ligands: focus on anti-cholinesterase and anti-amyloid activities 153
(±)- BIGI-3h: Pentatarget-Directed Ligand combining Cholinesterase, Monoamine Oxidase, and Glycogen Synthase Kinase 3β Inhibition with Calcium Channel Antagonism and Antiaggregating Properties for Alzheimer's Disease 153
Tacrine-based dual binding site acetylcholinesterase inhibitors as potential disease-modifying anti-Alzheimer drug candidates 151
CHOOSING THE RIGHT CHROMATOGRAPHIC SUPPORT FOR ENZYME-BASED MICRO-IMERS. 150
Tacripyrimidines, the first tacrine-dihydropyrimidine hybrids, as multi-target-directed ligands for Alzheimer's disease 149
Association between Albumin Alterations and Renal Function in Patients with Type 2 Diabetes Mellitus 148
Derivati a struttura benzofenonica come inibitori dell'acetilcolinesterasi 148
Design, Synthesis and Biological Evaluation of Dual Binding Site Acetylcholinesterase Inhibitors: New Disease Modifying Agents for Alzheimer's Disease 148
Acetylcholinesterase oriented immobilization on nanopatterned bilayered surfaces for biosensing devices 148
Quinones bearing non-steroidal anti-inflammatory fragments as multitarget ligands for Alzheimer’s disease 147
Fluorinated benzophenone derivatives: balanced multipotent agents for Alzheimer's disease 147
Targeting Alzheimer’s disease: Novel indanone hybrids bearing a pharmacophoric fragment of AP2238 145
From the dual function lead AP2238 to AP2469, a multi-target-directed ligand for the treatment of Alzheimer’s disease 145
DEVELOPMENT AND CHARACTERIZATION OF A PACKED AChE-micro-IMER FOR DRUG DISCOVERY IN ALZHEIMER’S DISEASE 144
Design, synthesis, and evaluation of benzophenone derivatives as novel acetylcholinesterase inhibitors 144
Polyamine Conjugation as a Promising Strategy To Target Amyloid Aggregation in the Framework of Alzheimer’s Disease 144
Immobilized enzyme-based analytical tools in the -omics era: recent advances 144
Analytical approaches in Alzheimer’s disease Drug Discovery 142
Novel Class of Quinone-Bearing Polyamines as Multi-Target-Directed Ligands To Combat Alzheimer's Disease 141
Inhibition of Acetylcholinesterase, Beta-Amyloid Aggregation, and NMDA Receptors in Alzheimer's Disease: A Promising Direction for the Multi-target-Directed Ligands Gold Rush 140
Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimers Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography 140
No G-Quadruplex Structures in the DNA of Parvovirus B19: Experimental Evidence versus Bioinformatic Predictions 140
IMMOBILIZED ENZYMES AS TOOLS IN DRUG DISCOVERY 139
AMYLOID-b-PEPTIDE SELF ASSEMBLY KINETICS BY AFM AND MALDI-TOF MASS SPECTROMETRY 139
Uleine disrupts key enzymatic and non-enzymatic biomarkers that leads to Alzheimer's disease 139
Combination of human acetylcholinesterase and serum albumin sensing surfaces as highly informative analytical tool for inhibitor screening 139
The novel SMYD3 inhibitor EM127 impairs DNA repair response to chemotherapy-induced DNA damage and reverses cancer chemoresistance 138
Memoquin: a new compound to attack Alzheimer's disease drug discovery 138
Lipocrine, a multipotent drug for the investigation of Alzheimer's disease 138
New Coumarin derivatives as cholinergic and cannabinoid system modulators 138
Inhibition of β-Amyloid Aggregation in Alzheimer's Disease: The Key Role of (Pro)electrophilic Warheads 137
INTEGRATED ANALYTICAL APPROACHES FOR ALZHEIMER’S DISEASE NEW DRUG DISCOVERY 137
METODI ANALITICI INTEGRATI PER LA VALUTAZIONE DEL PROFILO D’AZIONE DI NUOVI FARMACI ANTI-ALZHEIMER. 137
Characterization of Cholinesterase inhibitors by means of immobilized enzyme reactor 137
Circular dichroism investigation on amyloid bata(1-42) peptide self-aggregation 136
Benzophenone derivatives as Inhibitors of Acetylcholinesterase 136
Preparation of (hetero)aromatic (hetero)cyclic carboxamides for the treatment of Alzheimer's disease 135
Totale 17.694
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Categoria #
all - tutte 96.296
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 96.296
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/20212.282 0 0 0 0 0 220 135 304 284 199 181 959
2021/20224.376 434 157 215 262 468 272 88 374 194 332 843 737
2022/20234.771 489 610 263 594 316 309 147 318 789 205 399 332
2023/20241.710 115 248 109 122 149 308 128 123 76 119 120 93
2024/20255.634 271 845 598 384 1.056 296 392 205 127 274 259 927
2025/20267.039 1.132 1.346 1.268 1.068 1.516 709 0 0 0 0 0 0
Totale 34.673