CRIS Current Research Information System

BARTOLINI, MANUELA
 Distribuzione geografica
Salva come PNG Salva come JPEG
Continente #
NA - Nord America 14.529
AS - Asia 13.624
EU - Europa 10.917
AF - Africa 795
SA - Sud America 737
OC - Oceania 38
Continente sconosciuto - Info sul continente non disponibili 36
Totale 40.676
Salva come PNG Salva come JPEG
Nazione #
US - Stati Uniti d'America 14.272
SG - Singapore 3.616
CN - Cina 3.579
VN - Vietnam 3.332
IT - Italia 2.776
GB - Regno Unito 2.372
DE - Germania 1.293
HK - Hong Kong 922
SE - Svezia 868
IN - India 737
UA - Ucraina 673
FR - Francia 665
RU - Federazione Russa 568
BR - Brasile 526
IE - Irlanda 333
KR - Corea 307
CI - Costa d'Avorio 281
JP - Giappone 259
NL - Olanda 230
ZA - Sudafrica 211
BD - Bangladesh 191
FI - Finlandia 175
EE - Estonia 173
CA - Canada 156
TG - Togo 145
CH - Svizzera 105
ES - Italia 96
BG - Bulgaria 91
AR - Argentina 84
PH - Filippine 84
SC - Seychelles 78
ID - Indonesia 74
PL - Polonia 74
TR - Turchia 70
IR - Iran 69
JO - Giordania 67
MX - Messico 61
HR - Croazia 60
PK - Pakistan 56
AT - Austria 55
BE - Belgio 54
IQ - Iraq 48
CZ - Repubblica Ceca 46
TW - Taiwan 46
TH - Thailandia 41
GR - Grecia 40
PT - Portogallo 36
EU - Europa 35
RO - Romania 30
EC - Ecuador 29
AU - Australia 28
CO - Colombia 24
CL - Cile 21
SA - Arabia Saudita 20
DK - Danimarca 18
PY - Paraguay 16
SI - Slovenia 16
UZ - Uzbekistan 16
LB - Libano 15
MY - Malesia 15
LT - Lituania 14
NG - Nigeria 14
VE - Venezuela 14
EG - Egitto 12
HU - Ungheria 12
NO - Norvegia 10
NP - Nepal 10
TN - Tunisia 10
DZ - Algeria 9
HN - Honduras 8
NZ - Nuova Zelanda 8
OM - Oman 8
PE - Perù 8
AE - Emirati Arabi Uniti 7
AL - Albania 7
AZ - Azerbaigian 7
MA - Marocco 7
BO - Bolivia 6
GT - Guatemala 6
IL - Israele 6
KE - Kenya 6
MD - Moldavia 6
SK - Slovacchia (Repubblica Slovacca) 6
UY - Uruguay 6
DO - Repubblica Dominicana 5
LK - Sri Lanka 5
CR - Costa Rica 4
CU - Cuba 4
ET - Etiopia 4
LV - Lettonia 4
PS - Palestinian Territory 4
SN - Senegal 4
AO - Angola 3
BA - Bosnia-Erzegovina 3
BH - Bahrain 3
JM - Giamaica 3
KG - Kirghizistan 3
KZ - Kazakistan 3
MK - Macedonia 3
RS - Serbia 3
Totale 40.643
Salva come PNG Salva come JPEG
Città #
Singapore 2.531
Southend 1.995
Ashburn 1.418
Fairfield 1.046
Chandler 1.027
San Jose 899
Hong Kong 851
Ho Chi Minh City 735
Santa Clara 735
Bologna 665
Hanoi 636
Houston 592
Wilmington 574
Hefei 544
Woodbridge 523
Princeton 492
Jacksonville 462
Dong Ket 461
Seattle 456
Ann Arbor 390
Cambridge 382
Beijing 374
Dublin 334
Boardman 319
Council Bluffs 284
Abidjan 281
Seoul 231
Los Angeles 230
Nanjing 226
Lauterbourg 225
Tokyo 223
Westminster 208
Milan 196
New York 179
Padova 177
Dallas 174
Berlin 170
Helsinki 148
Jinan 147
Lomé 145
Buffalo 122
Guangzhou 109
Shenyang 106
Medford 104
Rome 99
Saint Petersburg 96
Da Nang 95
Haiphong 93
Sofia 87
Shanghai 83
Changsha 80
Mülheim 78
Redondo Beach 78
Turin 76
Bern 75
Bengaluru 72
Tianjin 69
Amman 67
Nanchang 67
Falls Church 66
Munich 66
Redmond 66
San Diego 66
Hebei 65
Frankfurt am Main 61
São Paulo 57
Zhengzhou 57
Mahé 54
Redwood City 53
Chicago 50
Jiaxing 49
Des Moines 48
Brussels 47
Phoenix 47
Hangzhou 46
Dearborn 45
Jakarta 44
Orem 44
Haikou 43
London 43
Cardiff 39
Nuremberg 39
Hải Dương 38
Bremen 37
Taiyuan 36
Biên Hòa 35
Falkenstein 35
Johannesburg 35
Norwalk 34
Yubileyny 34
Brooklyn 33
Warsaw 33
Atlanta 32
Montreal 32
Florence 31
Olalla 31
San Francisco 31
Toronto 31
Verona 30
Vienna 30
Totale 25.134
Salva come PNG Salva come JPEG
Nome #
Preparazione del campione - metodi estrattivi 669
A small molecule targeting the multifactorial nature of Alzheimer's disease 533
Discovery of novel benzofuran-based compounds with neuroprotective and immunomodulatory properties for Alzheimer's disease treatment 338
Bis(7)-tacrine Derivatives as Multitarget-Directed Ligands: Focus on Anticholinesterase and Antiamyloid Activities 297
Multitarget Strategy to Address Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and Computational Studies of Coumarin-Based Derivatives 295
Advanced analytical methodologies in Alzheimer's disease drug discovery 292
Benzofuran-Based Hybrid Compounds for the Inhibition of Cholinesterase Activity, Abeta Amyloid Aggregation, and Abeta Neurotoxicity 285
Quinolinetrione-tacrine hybrids as multi-target-directed ligands against Alzheimer's disease 277
Discovery of Dual Aβ/Tau Inhibitors and Evaluation of Their Therapeutic Effect on a Drosophila Model of Alzheimer's Disease 277
Galantamine-memantine hybrids for Alzheimer's disease: The influence of linker rigidity in biological activity and pharmacokinetic properties 270
Sustainable Drug Discovery of Multi-Target-Directed Ligands for Alzheimer's Disease 265
Tau-Centric Multitarget Approach for Alzheimer's Disease: Development of First-in-Class Dual Glycogen Synthase Kinase 3β and Tau-Aggregation Inhibitors 259
New insights into the altered binding capacity of pharmaceutical-grade human serum albumin: site-specific binding studies by induced circular dichroism spectroscopy 259
Solid Lipid Microparticles for Oral Delivery of Catalase: Focus on the Protein Structural Integrity and Gastric Protection 258
Cholinesterase inhibitors: xanthostigmine derivatives blocking the acetylcholinesterase-induced beta-amyloid aggregation. 252
Structure-Activity Relationships and Binding Mode in the Human Acetylcholinesterase Active Site of Pseudo-Irreversible Inhibitors Related to Xanthostigmine 252
Dual-Acting Cholinesterase-Human Cannabinoid Receptor 2 Ligands Show Pronounced Neuroprotection in Vitro and Overadditive and Disease-Modifying Neuroprotective Effects in Vivo 252
Determination of Effective Albumin in Patients With Decompensated Cirrhosis: Clinical and Prognostic Implications 240
Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease 236
N-1,2,3-triazole-isatin derivatives for cholinesterase and β-amyloid aggregation inhibition: A comprehensive bioassay study 233
5-Methyl-N-(8-(5,6,7,8-tetrahydroacridin-9-ylamino)octyl)-5 H -indolo[2,3- b] quinolin-11-amine: a highly potent human cholinesterase inhibitor 228
No G-Quadruplex Structures in the DNA of Parvovirus B19: Experimental Evidence versus Bioinformatic Predictions 226
Targeting neuronal calcium channels and GSK3β for Alzheimer's disease with naturally-inspired Diels-Alder adducts 224
Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 3. Effect of replacing the inner polymethylene chain with cyclic moieties 224
Association between Albumin Alterations and Renal Function in Patients with Type 2 Diabetes Mellitus 222
null 222
Analogues of the dual acetylcholinesterase inhibitor AP2238: synthesis and SAR 221
Analysis of amaryllidaceae alkaloids from Narcissus by GC-MS and capillary electrophoresis 221
Centrally Active Multitarget Anti-Alzheimer Agents Derived from the Antioxidant Lead CR-6 218
Exopolysaccharides from vaginal lactobacilli modulate microbial biofilms 217
Rational Approach to discover multipotent anti-Alzheimer drugs 217
Nature-Inspired Multifunctional Ligands: Focusing on Amyloid-Based Molecular Mechanisms of Alzheimer’s Disease 217
Turning Donepezil into a Multi-Target-Directed Ligand through a Merging Strategy 217
Discovery of the 4-aminopiperidine-based compound EM127 for the site-specific covalent inhibition of SMYD3 215
Exploiting the chalcone scaffold to develop multifunctional agents for Alzheimer’s disease 215
Fatty Acid Amide Hydrolase (FAAH), Acetylcholinesterase (AChE), and Butyrylcholinesterase (BuChE): Networked Targets for the Development of Carbamates as Potential Anti-Alzheimer's Disease Agents 214
2-Arylbenzofuran-based molecules as multipotent Alzheimer's disease modifying agents 208
Design, synthesis, and biological evaluation of conformationally restricted rivastigmine analogues 206
Cystamine-tacrine dimer: A new multi-target-directed ligand as potential therapeutic agent for Alzheimer's disease treatment. 206
Novel multifunctional tacrine–donepezil hybrids against Alzheimer's disease: Design synthesis and bioactivity studies 206
Microsampling and enantioselective liquid chromatography coupled to mass spectrometry for chiral bioanalysis of novel psychoactive substances 205
Progettazione e sintesi di derivati poliamminici per il trattamento della malattia di Alzheimer 202
Multitarget Drug Design Strategy: Quinone–Tacrine Hybrids Designed To Block Amyloid-β Aggregation and To Exert Anticholinesterase and Antioxidant Effects 202
In vitro thrombogenicity of drug-eluting and bare metal stents 202
Immobilized Enzyme Reactors: an Overview of Applications in Drug Discovery from 2008 to 2018 201
Discovery of sustainable drugs for Alzheimer's disease: cardanol-derived cholinesterase inhibitors with antioxidant and anti-amyloid properties 201
Extensive SAR and computational studies of 3-{4-[(benzylmethylamino)methyl]phenyl}-6,7-dimethoxy-2H-2-chromenone (AP2238) derivatives. 200
SAR and binding mode at the h-AChE active site of pseudo-irreversible inhibitors related to Xanthostigmine 200
Benzophenone-based derivatives: A novel series of potent and selective dual inhibitors of acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation 197
New tacrine dimers with antioxidant linkers as dual drugs: Anti-Alzheimer's and antiproliferative agents 197
Multitargeted drugs discovery: Balancing anti-amyloid and anticholinesterase capacity in a single chemical entity 194
Phenothiazine-Tacrine Heterodimers: Pursuing Multitarget Directed Approach in Alzheimer's Disease 194
ON-LINE GLYCAN RELEASE AND ANALYSIS BY AN INTEGRATED PNGASE F-IMER LC-ESI-Q-TOF APPROACH 188
CHOLINESTERASE INHIBITORS: SAR AND ENZYME INHIBITORY ACTIVITY OF 3-[omega-(BENZYLMETHYLAMINO)ALKOXY]XANTHEN-9-ONES 186
The novel SMYD3 inhibitor EM127 impairs DNA repair response to chemotherapy-induced DNA damage and reverses cancer chemoresistance 184
Choosing the right chromatographic support in making a new acetylcholinesterase-micro-immobilised enzyme reactor for drug discovery. 184
Unveiling the Biochemistry of the Epigenetic Regulator SMYD3 184
Structure-activity relationships of memoquin: Influence of the chain chirality in the multi-target mechanism of action 183
Discovery of an Allosteric Ligand Binding Site in SMYD3 Lysine Methyltransferase 183
Inhibition of β-Amyloid Aggregation in Alzheimer's Disease: The Key Role of (Pro)electrophilic Warheads 181
(±)- BIGI-3h: Pentatarget-Directed Ligand combining Cholinesterase, Monoamine Oxidase, and Glycogen Synthase Kinase 3β Inhibition with Calcium Channel Antagonism and Antiaggregating Properties for Alzheimer's Disease 180
Monolytic micro-immobilized-enzyme reactor with human recombinant acetylcholinesterase for on-line inhibition studies 177
Toward a rational design of multitarget-directed antioxidants: merging memoquin and lipoic acid molecular frameworks 177
Bivalent tacrine-based acetylcholinesterase inhibitors: role of the spacer in the recognition process of the enzyme gorge 176
Multi-Target-Directed Drug Design Strategy: From a Dual Binding Site Acetylcholinesterase Inhibitor to a Trifunctional Compound against Alzheimer's Disease 176
Novel bis(7)-tacrine derivatives as multitarget ligands: focus on anti-cholinesterase and anti-amyloid activities 176
A Fluorescent Styrylquinoline with Combined Therapeutic and Diagnostic Activities against Alzheimer's and Prion Diseases 176
Polyamine Conjugation as a Promising Strategy To Target Amyloid Aggregation in the Framework of Alzheimer’s Disease 176
Stepwise Structural Simplification of the Dihydroxyanthraquinone Moiety of a Multitarget Rhein-Based Anti-Alzheimer Lead to Improve Drug Metabolism and Pharmacokinetic Properties 175
Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimers Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography 175
From combinations to single-molecule polypharmacology—cromolyn-ibuprofen conjugates for alzheimer’s disease 175
From the dual function lead AP2238 to AP2469, a multi-target-directed ligand for the treatment of Alzheimer’s disease 174
New Coumarin derivatives as cholinergic and cannabinoid system modulators 174
ALZHEIMER'S DISEASE DRUG DISCOVERY: NEW ANALYTICAL APPROACHES FOR LEAD SELECTION AND OPTIMIZATION PBA 2009 (20h International Symposium on Pharmaceutical and Biomedical Analysis), Agra, India 01-04 Marzo 2009 173
Acetylcholinesterase oriented immobilization on nanopatterned bilayered surfaces for biosensing devices 171
Batch-wise covalent immobilisation of human acetylcholinesterase: kinetic and inhibition spectrophotometric studies 170
METODI ANALITICI INTEGRATI PER LA VALUTAZIONE DEL PROFILO D’AZIONE DI NUOVI FARMACI ANTI-ALZHEIMER. 170
Characterization of reversible and pseudo-irreversible Acetylcholinesterase inhibitors by means of immobilized enzyme reactor 170
A MULTI-METHODOLOGICAL APPROACH FOR BETA-AMYLOID AGGREGATION AND INHIBITION STUDIES 170
HSA-nanobinders crafted from bioresponsive prodrugs for combined cancer chemoimmunotherapy–an in vitro exploration 169
Derivati a struttura benzofenonica come inibitori dell'acetilcolinesterasi 169
Investigating in vitro amyloid peptide 1−42 aggregation: Impact of higher molecular weight stable adducts 169
Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice 169
Tacrine-based dual binding site acetylcholinesterase inhibitors as potential disease-modifying anti-Alzheimer drug candidates 168
Fluorinated benzophenone derivatives: balanced multipotent agents for Alzheimer's disease 168
Tacripyrimidines, the first tacrine-dihydropyrimidine hybrids, as multi-target-directed ligands for Alzheimer's disease 168
Immobilized enzyme-based analytical tools in the -omics era: recent advances 168
CHOOSING THE RIGHT CHROMATOGRAPHIC SUPPORT FOR ENZYME-BASED MICRO-IMERS. 167
Design, synthesis, and evaluation of benzophenone derivatives as novel acetylcholinesterase inhibitors 166
Combination of human acetylcholinesterase and serum albumin sensing surfaces as highly informative analytical tool for inhibitor screening 166
Targeting Alzheimer’s disease: Novel indanone hybrids bearing a pharmacophoric fragment of AP2238 165
Quinones bearing non-steroidal anti-inflammatory fragments as multitarget ligands for Alzheimer’s disease 164
Inhibition of Acetylcholinesterase, Beta-Amyloid Aggregation, and NMDA Receptors in Alzheimer's Disease: A Promising Direction for the Multi-target-Directed Ligands Gold Rush 163
Extraction of human serum albumin for functional studies using novel immunoaffinity-based CIMac-αHSA monolithic columns 163
Design, Synthesis and Biological Evaluation of Dual Binding Site Acetylcholinesterase Inhibitors: New Disease Modifying Agents for Alzheimer's Disease 162
DEVELOPMENT AND CHARACTERIZATION OF A PACKED AChE-micro-IMER FOR DRUG DISCOVERY IN ALZHEIMER’S DISEASE 161
Preparation of (hetero)aromatic (hetero)cyclic carboxamides for the treatment of Alzheimer's disease 161
Multi-target-directed coumarin derivatives: hAChE and BAC1 inhibitors as potential anti-Alzheimer compounds 161
Novel Class of Quinone-Bearing Polyamines as Multi-Target-Directed Ligands To Combat Alzheimer's Disease 161
1,2,3,4-Tetrahydrobenzo[h][1,6]naphthyridines as a new family of potent peripheral-to-midgorge-site inhibitors of acetylcholinesterase: synthesis, pharmacological evaluation and mechanistic studies 160
Totale 21.030
Salva come PNG Salva come JPEG
Categoria #
all - tutte 111.256
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 111.256
Salva come PNG Salva come JPEG


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021958 0 0 0 0 0 0 0 0 0 0 0 958
2021/20224.361 433 156 214 261 467 271 88 372 193 329 842 735
2022/20234.760 487 609 263 592 316 308 147 318 786 205 397 332
2023/20241.708 115 247 109 122 149 308 127 123 76 119 120 93
2024/20255.620 271 844 596 382 1.053 295 391 205 127 274 259 923
2025/202613.929 1.132 1.345 1.264 1.080 1.528 866 1.712 458 2.300 939 731 574
Totale 41.498