BARTOLINI, MANUELA
 Distribuzione geografica
Continente #
NA - Nord America 7163
EU - Europa 6230
AS - Asia 2512
AF - Africa 329
Continente sconosciuto - Info sul continente non disponibili 36
SA - Sud America 27
OC - Oceania 9
Totale 16306
Nazione #
US - Stati Uniti d'America 7120
GB - Regno Unito 2162
IT - Italia 1276
CN - Cina 1138
VN - Vietnam 808
UA - Ucraina 658
SE - Svezia 564
DE - Germania 524
IN - India 429
FR - Francia 325
RU - Federazione Russa 286
EE - Estonia 173
ZA - Sudafrica 158
TG - Togo 111
SC - Seychelles 57
HR - Croazia 56
CA - Canada 36
EU - Europa 35
IR - Iran 34
KR - Corea 28
ES - Italia 27
GR - Grecia 25
JP - Giappone 22
RO - Romania 22
BE - Belgio 20
CH - Svizzera 20
PT - Portogallo 20
BR - Brasile 14
LB - Libano 13
AT - Austria 12
PL - Polonia 11
TR - Turchia 11
CL - Cile 10
NL - Olanda 10
CZ - Repubblica Ceca 8
AU - Australia 7
MX - Messico 7
HU - Ungheria 6
BG - Bulgaria 5
DK - Danimarca 5
PK - Pakistan 5
FI - Finlandia 4
BD - Bangladesh 3
MD - Moldavia 3
SG - Singapore 3
TW - Taiwan 3
UZ - Uzbekistan 3
AR - Argentina 2
ID - Indonesia 2
MU - Mauritius 2
MY - Malesia 2
NZ - Nuova Zelanda 2
SA - Arabia Saudita 2
SK - Slovacchia (Repubblica Slovacca) 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AZ - Azerbaigian 1
FK - Isole Falkland (Malvinas) 1
HK - Hong Kong 1
KW - Kuwait 1
LA - Repubblica Popolare Democratica del Laos 1
LK - Sri Lanka 1
LV - Lettonia 1
MK - Macedonia 1
NO - Norvegia 1
PH - Filippine 1
RS - Serbia 1
SI - Slovenia 1
SM - San Marino 1
SN - Senegal 1
Totale 16306
Città #
Southend 2008
Fairfield 1045
Houston 575
Wilmington 575
Woodbridge 523
Princeton 494
Ashburn 476
Dong Ket 461
Jacksonville 455
Seattle 438
Ann Arbor 390
Cambridge 378
Bologna 353
Chandler 338
Nanjing 218
Westminster 209
Padova 174
Berlin 168
Jinan 128
Lomé 111
Medford 104
Shenyang 102
Saint Petersburg 97
Changsha 67
Nanchang 67
Falls Church 66
Hebei 65
Redmond 64
San Diego 62
Beijing 57
Milan 56
Mahé 54
Redwood City 54
Jiaxing 45
Tianjin 45
Des Moines 44
Dearborn 43
Haikou 43
Norwalk 34
Zhengzhou 33
Hangzhou 30
Taiyuan 30
Guangzhou 28
Verona 26
Fremont 22
Rome 22
Kunming 21
Lanzhou 18
Ningbo 18
Taizhou 18
Ottawa 17
Tokyo 17
Brussels 15
Phoenix 15
Lisbon 14
Fuzhou 12
Madrid 11
Toronto 11
Frankfurt Am Main 10
Hefei 10
San Jose 10
Shanghai 10
Costa Mesa 9
Lausanne 9
Napoli 9
Trieste 9
Bucharest 8
Buffalo 8
Dallas 8
San Venanzo 8
Siracusa 8
Plauen 7
São Paulo 7
Vienna 7
Zanjan 7
Genova 6
Philadelphia 6
Wayne 6
Andover 5
Chicago 5
Cislago 5
Ferrara 5
Istanbul 5
Kiev 5
Las Vegas 5
Leawood 5
Leeds 5
London 5
Muizenberg 5
Nagold 5
Paris 5
Pavia 5
Reggio Nell'emilia 5
Sofia 5
Wuhan 5
Ancona 4
Bruneck 4
Caserta 4
Casoria 4
Catania 4
Totale 11331
Nome #
null 222
Preparazione del campione - metodi estrattivi 186
Advanced analytical methodologies in Alzheimer's disease drug discovery 172
Discovery of novel benzofuran-based compounds with neuroprotective and immunomodulatory properties for Alzheimer's disease treatment 160
Multitarget Strategy to Address Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and Computational Studies of Coumarin-Based Derivatives 146
Cholinesterase inhibitors: xanthostigmine derivatives blocking the acetylcholinesterase-induced beta-amyloid aggregation. 138
A small molecule targeting the multifactorial nature of Alzheimer's disease 137
Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 3. Effect of replacing the inner polymethylene chain with cyclic moieties 128
Rational Approach to discover multipotent anti-Alzheimer drugs 126
Tau-Centric Multitarget Approach for Alzheimer's Disease: Development of First-in-Class Dual Glycogen Synthase Kinase 3β and Tau-Aggregation Inhibitors 126
null 123
2-Arylbenzofuran-based molecules as multipotent Alzheimer's disease modifying agents 121
null 118
Bis(7)-tacrine Derivatives as Multitarget-Directed Ligands: Focus on Anticholinesterase and Antiamyloid Activities 118
ON-LINE GLYCAN RELEASE AND ANALYSIS BY AN INTEGRATED PNGASE F-IMER LC-ESI-Q-TOF APPROACH 117
Analysis of amaryllidaceae alkaloids from Narcissus by GC-MS and capillary electrophoresis 116
Nature-Inspired Multifunctional Ligands: Focusing on Amyloid-Based Molecular Mechanisms of Alzheimer’s Disease 115
Fatty Acid Amide Hydrolase (FAAH), Acetylcholinesterase (AChE), and Butyrylcholinesterase (BuChE): Networked Targets for the Development of Carbamates as Potential Anti-Alzheimer's Disease Agents 111
Design, synthesis, and biological evaluation of conformationally restricted rivastigmine analogues 110
Benzophenone-based derivatives: A novel series of potent and selective dual inhibitors of acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation 110
Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease 109
null 108
Exploiting the chalcone scaffold to develop multifunctional agents for Alzheimer’s disease 107
Choosing the right chromatographic support in making a new acetylcholinesterase-micro-immobilised enzyme reactor for drug discovery. 104
Characterization of reversible and pseudo-irreversible Acetylcholinesterase inhibitors by means of immobilized enzyme reactor 104
Monolytic micro-immobilized-enzyme reactor with human recombinant acetylcholinesterase for on-line inhibition studies 103
Analogues of the dual acetylcholinesterase inhibitor AP2238: synthesis and SAR 103
Structure-activity relationships of memoquin: Influence of the chain chirality in the multi-target mechanism of action 103
A Fluorescent Styrylquinoline with Combined Therapeutic and Diagnostic Activities against Alzheimer's and Prion Diseases 103
Multitarget Drug Design Strategy: Quinone–Tacrine Hybrids Designed To Block Amyloid-β Aggregation and To Exert Anticholinesterase and Antioxidant Effects 103
Extensive SAR and computational studies of 3-{4-[(benzylmethylamino)methyl]phenyl}-6,7-dimethoxy-2H-2-chromenone (AP2238) derivatives. 100
Benzofuran-Based Hybrid Compounds for the Inhibition of Cholinesterase Activity, Abeta Amyloid Aggregation, and Abeta Neurotoxicity 100
Dual-Acting Cholinesterase-Human Cannabinoid Receptor 2 Ligands Show Pronounced Neuroprotection in Vitro and Overadditive and Disease-Modifying Neuroprotective Effects in Vivo 100
Design, Synthesis and Biological Evaluation of Dual Binding Site Acetylcholinesterase Inhibitors: New Disease Modifying Agents for Alzheimer's Disease 98
null 98
Multi-Target-Directed Drug Design Strategy: From a Dual Binding Site Acetylcholinesterase Inhibitor to a Trifunctional Compound against Alzheimer's Disease 96
Acetylcholinesterase oriented immobilization on nanopatterned bilayered surfaces for biosensing devices 96
Cystamine-tacrine dimer: A new multi-target-directed ligand as potential therapeutic agent for Alzheimer's disease treatment. 96
CHOLINESTERASE INHIBITORS: SAR AND ENZYME INHIBITORY ACTIVITY OF 3-[omega-(BENZYLMETHYLAMINO)ALKOXY]XANTHEN-9-ONES 95
Toward a rational design of multitarget-directed antioxidants: merging memoquin and lipoic acid molecular frameworks 94
Fluorinated benzophenone derivatives: balanced multipotent agents for Alzheimer's disease 94
Novel Class of Quinone-Bearing Polyamines as Multi-Target-Directed Ligands To Combat Alzheimer's Disease 94
Bivalent tacrine-based acetylcholinesterase inhibitors: role of the spacer in the recognition process of the enzyme gorge 93
Multitargeted drugs discovery: Balancing anti-amyloid and anticholinesterase capacity in a single chemical entity 93
Sustainable Drug Discovery of Multi-Target-Directed Ligands for Alzheimer's Disease 93
IMMOBILIZED ENZYMES AS TOOLS IN DRUG DISCOVERY 92
Heterocyclic inhibitors of AChE acylation and peripheral sites. 92
null 91
Immobilized Enzyme Reactors: an Overview of Applications in Drug Discovery from 2008 to 2018 90
The role of Li(+), Na(+), and K(+) in the ligand binding inside the human acetylcholinesterase gorge 89
Synthesis and multitarget biological profiling of a novel family of rhein derivatives as disease-modifying anti-Alzheimer agents. 89
Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease. 88
A MULTI-METHODOLOGICAL APPROACH FOR BETA-AMYLOID AGGREGATION AND INHIBITION STUDIES 87
Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimers Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography 87
Synthesis of Monomeric Derivatives To Probe Memoquin's Bivalent Interactions 86
From the dual function lead AP2238 to AP2469, a multi-target-directed ligand for the treatment of Alzheimer’s disease 86
Development of immobilized enzyme reactors based on human recombinant cytochrome P450 enzymes for phase I drug metabolism studies. 85
Tacrine-based dual binding site acetylcholinesterase inhibitors as potential disease-modifying anti-Alzheimer drug candidates 85
null 85
null 85
New tacrine dimers with antioxidant linkers as dual drugs: Anti-Alzheimer's and antiproliferative agents 85
Fluorescence biosensing micropatterned surfaces based on immobilized human acetylcholinesterase 85
null 85
Batch-wise covalent immobilisation of human acetylcholinesterase: kinetic and inhibition spectrophotometric studies 84
CHOOSING THE RIGHT CHROMATOGRAPHIC SUPPORT FOR ENZYME-BASED MICRO-IMERS. 84
Preparation of (hetero)aromatic (hetero)cyclic carboxamides for the treatment of Alzheimer's disease 84
Design, synthesis, and evaluation of benzophenone derivatives as novel acetylcholinesterase inhibitors 84
AMYLOID-b-PEPTIDE SELF ASSEMBLY KINETICS BY AFM AND MALDI-TOF MASS SPECTROMETRY 84
The bivalent ligand approach as a tool for improving the in vitro anti-Alzheimer multitarget profile of dimebon 84
Chemical and Pharmacological Studies on Enantiomerically Pure p-Methoxytacripyrines, Promising Multi-Target-Directed Ligands for the Treatment of Alzheimer's Disease 84
Uleine disrupts key enzymatic and non-enzymatic biomarkers that leads to Alzheimer's disease 84
null 83
Solid Lipid Microparticles for Oral Delivery of Catalase: Focus on the Protein Structural Integrity and Gastric Protection 83
Characterization of Cholinesterase inhibitors by means of immobilized enzyme reactor 82
Immobilized butyrylcholinesterase in the characterization of new inhibitors that could ease Alzheimer's disease. 82
Increasing polarity in tacrine and huprine derivatives: Potent anticholinesterase agents for the treatment of myasthenia gravis 82
Unveiling the Biochemistry of the Epigenetic Regulator SMYD3 82
Kinetic characterization of amyloid-beta 1-42 aggregation with a multimethodological approach. 81
null 81
null 81
Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer's disease. 80
Circular dichroism investigation on amyloid bata(1-42) peptide self-aggregation 79
ALZHEIMER'S DISEASE DRUG DISCOVERY: NEW ANALYTICAL APPROACHES FOR LEAD SELECTION AND OPTIMIZATION PBA 2009 (20h International Symposium on Pharmaceutical and Biomedical Analysis), Agra, India 01-04 Marzo 2009 79
Structure-Activity Relationships and Binding Mode in the Human Acetylcholinesterase Active Site of Pseudo-Irreversible Inhibitors Related to Xanthostigmine 79
Multi-target strategy to address Alzheimer’s disease: Design, synthesis and biological evaluation of new tacrine-based dimers 79
Imidazopyranotacrines as Non-Hepatotoxic, Selective Acetylcholinesterase Inhibitors, and Antioxidant Agents for Alzheimer's Disease Therapy 79
Combination of human acetylcholinesterase and serum albumin sensing surfaces as highly informative analytical tool for inhibitor screening 79
Multi-target-directed coumarin derivatives: hAChE and BAC1 inhibitors as potential anti-Alzheimer compounds 78
Targeting Alzheimer’s disease: Novel indanone hybrids bearing a pharmacophoric fragment of AP2238 78
Polyamine Conjugation as a Promising Strategy To Target Amyloid Aggregation in the Framework of Alzheimer’s Disease 78
New insights into the altered binding capacity of pharmaceutical-grade human serum albumin: site-specific binding studies by induced circular dichroism spectroscopy 78
Quinones bearing non-steroidal anti-inflammatory fragments as multitarget ligands for Alzheimer’s disease 77
MTDL design strategy in the context of Alzheimer's disease: from lipocrine to memoquin and beyond 77
Towards automation in protein digestion: Development of a monolithic trypsin immobilized reactor for highly efficient on-line digestion and analysis 77
null 77
null 77
METODI ANALITICI INTEGRATI PER LA VALUTAZIONE DEL PROFILO D’AZIONE DI NUOVI FARMACI ANTI-ALZHEIMER. 76
Inhibition of Acetylcholinesterase, Beta-Amyloid Aggregation, and NMDA Receptors in Alzheimer's Disease: A Promising Direction for the Multi-target-Directed Ligands Gold Rush 76
ANALYTICAL STRATEGIES FOR THE CHARACTERIZATION OF PROTEIN AGGREGATION AND INHIBITION IN HUMAN DISEASES 76
Preparation of 2,5-bis-diamine-[1,4]benzoquinone derivatives for the treatment of Alzheimer's disease and a process for their preparation and intermediates thereof. 76
Totale 9723
Categoria #
all - tutte 21776
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 21776


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2017/2018470 0000 825 16 0040129
2018/20191638 8420329224 40171 10185 128259105209
2019/20205321 868141122309 445484 568736 655425258310
2020/20213561 708186120186 79220 135304 284199181959
2021/20224376 434157215262 468272 88374 194332843737
2022/20231399 48961026337 00 00 0000
Totale 16918