CRIS Current Research Information System

BARTOLINI, MANUELA
 Distribuzione geografica
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Continente #
NA - Nord America 10.744
EU - Europa 8.954
AS - Asia 4.426
AF - Africa 532
SA - Sud America 46
Continente sconosciuto - Info sul continente non disponibili 36
OC - Oceania 24
Totale 24.762
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Nazione #
US - Stati Uniti d'America 10.666
GB - Regno Unito 2.233
IT - Italia 2.185
CN - Cina 1.729
DE - Germania 1.109
SG - Singapore 979
SE - Svezia 852
VN - Vietnam 811
UA - Ucraina 660
IN - India 538
FR - Francia 374
RU - Federazione Russa 346
IE - Irlanda 317
EE - Estonia 174
ZA - Sudafrica 158
CI - Costa d'Avorio 154
TG - Togo 145
CH - Svizzera 100
BG - Bulgaria 89
FI - Finlandia 84
CA - Canada 64
ES - Italia 61
KR - Corea 60
HR - Croazia 58
JO - Giordania 58
SC - Seychelles 57
IR - Iran 56
BE - Belgio 47
GR - Grecia 37
ID - Indonesia 37
EU - Europa 35
JP - Giappone 35
AT - Austria 31
PL - Polonia 30
PT - Portogallo 29
BR - Brasile 28
NL - Olanda 27
CZ - Repubblica Ceca 26
RO - Romania 26
TR - Turchia 24
HK - Hong Kong 22
PK - Pakistan 19
AU - Australia 18
LB - Libano 13
DK - Danimarca 12
CL - Cile 11
MX - Messico 10
NG - Nigeria 10
NO - Norvegia 9
HU - Ungheria 8
TW - Taiwan 8
SI - Slovenia 7
BD - Bangladesh 6
NZ - Nuova Zelanda 6
IQ - Iraq 5
LT - Lituania 5
PH - Filippine 5
CU - Cuba 4
LV - Lettonia 4
EG - Egitto 3
LK - Sri Lanka 3
MD - Moldavia 3
MK - Macedonia 3
MY - Malesia 3
SK - Slovacchia (Repubblica Slovacca) 3
UZ - Uzbekistan 3
AL - Albania 2
AR - Argentina 2
AZ - Azerbaigian 2
CO - Colombia 2
DZ - Algeria 2
MU - Mauritius 2
OM - Oman 2
RS - Serbia 2
SA - Arabia Saudita 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AE - Emirati Arabi Uniti 1
BO - Bolivia 1
EC - Ecuador 1
FK - Isole Falkland (Malvinas) 1
IL - Israele 1
KW - Kuwait 1
KZ - Kazakistan 1
LA - Repubblica Popolare Democratica del Laos 1
SM - San Marino 1
SN - Senegal 1
TH - Thailandia 1
Totale 24.762
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Città #
Southend 2.008
Fairfield 1.045
Chandler 1.029
Ashburn 866
Singapore 857
Santa Clara 673
Houston 575
Wilmington 575
Bologna 539
Woodbridge 523
Princeton 494
Dong Ket 461
Jacksonville 455
Seattle 448
Ann Arbor 390
Cambridge 378
Dublin 317
Boardman 310
Nanjing 221
Westminster 209
Padova 178
Berlin 170
Milan 155
Abidjan 154
Lomé 145
Jinan 141
Medford 104
Shenyang 102
Saint Petersburg 97
Sofia 85
Mülheim 78
Beijing 75
Bern 75
Helsinki 74
Turin 72
Changsha 69
Nanchang 67
Falls Church 66
Hebei 65
Redmond 65
San Diego 62
New York 60
Guangzhou 59
Amman 58
Tianjin 56
Rome 55
Mahé 54
Redwood City 54
Shanghai 49
Jiaxing 48
Des Moines 44
Dearborn 43
Haikou 43
Los Angeles 43
Zhengzhou 43
Brussels 41
Hangzhou 38
Bremen 36
Jakarta 36
Norwalk 34
Taiyuan 32
Olalla 31
Verona 28
Kunming 25
Fremont 24
Taizhou 24
Ningbo 22
Paris 22
Tokyo 22
Vienna 22
Phoenix 21
Ottawa 20
Lanzhou 19
Pune 19
Catania 17
Florence 17
Fuzhou 17
London 17
Madrid 17
Mountain View 17
Barcelona 16
Bühl 16
Chicago 16
Hyderabad 16
Falkenstein 15
Hong Kong 15
Lisbon 15
Shenzhen 15
Wuhan 15
Boydton 14
Seoul 14
Xi'an 14
Bengaluru 13
Munich 13
Ravenna 13
San Jose 13
Toronto 13
Bari 12
Brno 12
Athens 11
Totale 16.080
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Nome #
Preparazione del campione - metodi estrattivi 430
A small molecule targeting the multifactorial nature of Alzheimer's disease 305
Discovery of novel benzofuran-based compounds with neuroprotective and immunomodulatory properties for Alzheimer's disease treatment 228
null 222
Advanced analytical methodologies in Alzheimer's disease drug discovery 221
Multitarget Strategy to Address Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and Computational Studies of Coumarin-Based Derivatives 194
Cholinesterase inhibitors: xanthostigmine derivatives blocking the acetylcholinesterase-induced beta-amyloid aggregation. 183
Tau-Centric Multitarget Approach for Alzheimer's Disease: Development of First-in-Class Dual Glycogen Synthase Kinase 3β and Tau-Aggregation Inhibitors 175
2-Arylbenzofuran-based molecules as multipotent Alzheimer's disease modifying agents 167
Bis(7)-tacrine Derivatives as Multitarget-Directed Ligands: Focus on Anticholinesterase and Antiamyloid Activities 164
Dual-Acting Cholinesterase-Human Cannabinoid Receptor 2 Ligands Show Pronounced Neuroprotection in Vitro and Overadditive and Disease-Modifying Neuroprotective Effects in Vivo 160
Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease 159
Sustainable Drug Discovery of Multi-Target-Directed Ligands for Alzheimer's Disease 159
Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 3. Effect of replacing the inner polymethylene chain with cyclic moieties 158
Nature-Inspired Multifunctional Ligands: Focusing on Amyloid-Based Molecular Mechanisms of Alzheimer’s Disease 155
Benzofuran-Based Hybrid Compounds for the Inhibition of Cholinesterase Activity, Abeta Amyloid Aggregation, and Abeta Neurotoxicity 155
Analogues of the dual acetylcholinesterase inhibitor AP2238: synthesis and SAR 154
Design, synthesis, and biological evaluation of conformationally restricted rivastigmine analogues 153
Rational Approach to discover multipotent anti-Alzheimer drugs 152
Analysis of amaryllidaceae alkaloids from Narcissus by GC-MS and capillary electrophoresis 152
Benzophenone-based derivatives: A novel series of potent and selective dual inhibitors of acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation 150
Exploiting the chalcone scaffold to develop multifunctional agents for Alzheimer’s disease 147
Fatty Acid Amide Hydrolase (FAAH), Acetylcholinesterase (AChE), and Butyrylcholinesterase (BuChE): Networked Targets for the Development of Carbamates as Potential Anti-Alzheimer's Disease Agents 147
Progettazione e sintesi di derivati poliamminici per il trattamento della malattia di Alzheimer 146
Extensive SAR and computational studies of 3-{4-[(benzylmethylamino)methyl]phenyl}-6,7-dimethoxy-2H-2-chromenone (AP2238) derivatives. 144
ON-LINE GLYCAN RELEASE AND ANALYSIS BY AN INTEGRATED PNGASE F-IMER LC-ESI-Q-TOF APPROACH 144
Multitarget Drug Design Strategy: Quinone–Tacrine Hybrids Designed To Block Amyloid-β Aggregation and To Exert Anticholinesterase and Antioxidant Effects 140
Cystamine-tacrine dimer: A new multi-target-directed ligand as potential therapeutic agent for Alzheimer's disease treatment. 139
Structure-activity relationships of memoquin: Influence of the chain chirality in the multi-target mechanism of action 138
A Fluorescent Styrylquinoline with Combined Therapeutic and Diagnostic Activities against Alzheimer's and Prion Diseases 138
Discovery of sustainable drugs for Alzheimer's disease: cardanol-derived cholinesterase inhibitors with antioxidant and anti-amyloid properties 137
Choosing the right chromatographic support in making a new acetylcholinesterase-micro-immobilised enzyme reactor for drug discovery. 136
CHOLINESTERASE INHIBITORS: SAR AND ENZYME INHIBITORY ACTIVITY OF 3-[omega-(BENZYLMETHYLAMINO)ALKOXY]XANTHEN-9-ONES 135
Multitargeted drugs discovery: Balancing anti-amyloid and anticholinesterase capacity in a single chemical entity 134
A MULTI-METHODOLOGICAL APPROACH FOR BETA-AMYLOID AGGREGATION AND INHIBITION STUDIES 134
Characterization of reversible and pseudo-irreversible Acetylcholinesterase inhibitors by means of immobilized enzyme reactor 132
Acetylcholinesterase oriented immobilization on nanopatterned bilayered surfaces for biosensing devices 131
Immobilized Enzyme Reactors: an Overview of Applications in Drug Discovery from 2008 to 2018 130
Determination of Effective Albumin in Patients With Decompensated Cirrhosis: Clinical and Prognostic Implications 130
Multi-Target-Directed Drug Design Strategy: From a Dual Binding Site Acetylcholinesterase Inhibitor to a Trifunctional Compound against Alzheimer's Disease 129
ALZHEIMER'S DISEASE DRUG DISCOVERY: NEW ANALYTICAL APPROACHES FOR LEAD SELECTION AND OPTIMIZATION PBA 2009 (20h International Symposium on Pharmaceutical and Biomedical Analysis), Agra, India 01-04 Marzo 2009 129
New insights into the altered binding capacity of pharmaceutical-grade human serum albumin: site-specific binding studies by induced circular dichroism spectroscopy 129
New tacrine dimers with antioxidant linkers as dual drugs: Anti-Alzheimer's and antiproliferative agents 127
Monolytic micro-immobilized-enzyme reactor with human recombinant acetylcholinesterase for on-line inhibition studies 125
Bivalent tacrine-based acetylcholinesterase inhibitors: role of the spacer in the recognition process of the enzyme gorge 124
null 123
Toward a rational design of multitarget-directed antioxidants: merging memoquin and lipoic acid molecular frameworks 123
Tacrine-based dual binding site acetylcholinesterase inhibitors as potential disease-modifying anti-Alzheimer drug candidates 122
Analytical approaches in Alzheimer’s disease Drug Discovery 122
Fluorinated benzophenone derivatives: balanced multipotent agents for Alzheimer's disease 122
Novel bis(7)-tacrine derivatives as multitarget ligands: focus on anti-cholinesterase and anti-amyloid activities 121
From the dual function lead AP2238 to AP2469, a multi-target-directed ligand for the treatment of Alzheimer’s disease 121
AMYLOID-b-PEPTIDE SELF ASSEMBLY KINETICS BY AFM AND MALDI-TOF MASS SPECTROMETRY 119
Targeting Alzheimer’s disease: Novel indanone hybrids bearing a pharmacophoric fragment of AP2238 119
Unveiling the Biochemistry of the Epigenetic Regulator SMYD3 119
Solid Lipid Microparticles for Oral Delivery of Catalase: Focus on the Protein Structural Integrity and Gastric Protection 119
null 118
CHOOSING THE RIGHT CHROMATOGRAPHIC SUPPORT FOR ENZYME-BASED MICRO-IMERS. 117
Characterization of Cholinesterase inhibitors by means of immobilized enzyme reactor 117
Design, synthesis, and evaluation of benzophenone derivatives as novel acetylcholinesterase inhibitors 117
IMMOBILIZED ENZYMES AS TOOLS IN DRUG DISCOVERY 116
Phenothiazine-Tacrine Heterodimers: Pursuing Multitarget Directed Approach in Alzheimer's Disease 116
Batch-wise covalent immobilisation of human acetylcholinesterase: kinetic and inhibition spectrophotometric studies 115
Novel Class of Quinone-Bearing Polyamines as Multi-Target-Directed Ligands To Combat Alzheimer's Disease 115
Uleine disrupts key enzymatic and non-enzymatic biomarkers that leads to Alzheimer's disease 114
Polyamine Conjugation as a Promising Strategy To Target Amyloid Aggregation in the Framework of Alzheimer’s Disease 114
Preparation of (hetero)aromatic (hetero)cyclic carboxamides for the treatment of Alzheimer's disease 113
The role of Li(+), Na(+), and K(+) in the ligand binding inside the human acetylcholinesterase gorge 113
Benzophenone derivatives as Inhibitors of Acetylcholinesterase 113
Heterocyclic inhibitors of AChE acylation and peripheral sites. 113
Discovery of Dual Aβ/Tau Inhibitors and Evaluation of Their Therapeutic Effect on a Drosophila Model of Alzheimer's Disease 112
Design, Synthesis and Biological Evaluation of Dual Binding Site Acetylcholinesterase Inhibitors: New Disease Modifying Agents for Alzheimer's Disease 112
Quinones bearing non-steroidal anti-inflammatory fragments as multitarget ligands for Alzheimer’s disease 112
Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimers Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography 112
Immobilized enzyme-based analytical tools in the -omics era: recent advances 112
Turning Donepezil into a Multi-Target-Directed Ligand through a Merging Strategy 112
Circular dichroism investigation on amyloid bata(1-42) peptide self-aggregation 111
Structure-Activity Relationships and Binding Mode in the Human Acetylcholinesterase Active Site of Pseudo-Irreversible Inhibitors Related to Xanthostigmine 111
Combination of human acetylcholinesterase and serum albumin sensing surfaces as highly informative analytical tool for inhibitor screening 111
Increasing polarity in tacrine and huprine derivatives: Potent anticholinesterase agents for the treatment of myasthenia gravis 111
In vitro thrombogenicity of drug-eluting and bare metal stents 111
Fluorescence biosensing micropatterned surfaces based on immobilized human acetylcholinesterase 110
Derivati a struttura benzofenonica come inibitori dell'acetilcolinesterasi 109
Multi-target-directed coumarin derivatives: hAChE and BAC1 inhibitors as potential anti-Alzheimer compounds 109
Inhibition of Acetylcholinesterase, Beta-Amyloid Aggregation, and NMDA Receptors in Alzheimer's Disease: A Promising Direction for the Multi-target-Directed Ligands Gold Rush 109
Multi-target strategy to address Alzheimer’s disease: Design, synthesis and biological evaluation of new tacrine-based dimers 109
ANALYTICAL STRATEGIES FOR THE CHARACTERIZATION OF PROTEIN AGGREGATION AND INHIBITION IN HUMAN DISEASES 108
null 108
N-1,2,3-triazole-isatin derivatives for cholinesterase and β-amyloid aggregation inhibition: A comprehensive bioassay study 108
Tacripyrimidines, the first tacrine-dihydropyrimidine hybrids, as multi-target-directed ligands for Alzheimer's disease 107
Synthesis and multitarget biological profiling of a novel family of rhein derivatives as disease-modifying anti-Alzheimer agents. 106
High-throughput screening of beta-secretase inhibitors by multiwell FRET assay 105
Memoquin: a new compound to attack Alzheimer's disease drug discovery 104
Immobilized butyrylcholinesterase in the characterization of new inhibitors that could ease Alzheimer's disease. 104
Preparation of 2,5-bis-diamine-[1,4]benzoquinone derivatives for the treatment of Alzheimer's disease and a process for their preparation and intermediates thereof. 104
Hybrid drugs for Alzheimer's disease: new indanone derivatives bearing a pharmacophoric fragment of AP2238 103
The bivalent ligand approach as a tool for improving the in vitro anti-Alzheimer multitarget profile of dimebon 103
MTDL design strategy in the context of Alzheimer's disease: from lipocrine to memoquin and beyond 102
Synthesis of Monomeric Derivatives To Probe Memoquin's Bivalent Interactions 102
Towards automation in protein digestion: Development of a monolithic trypsin immobilized reactor for highly efficient on-line digestion and analysis 102
Totale 13.421
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Categoria #
all - tutte 66.559
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 66.559
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20203.436 0 0 0 0 0 484 568 736 655 425 258 310
2020/20213.561 708 186 120 186 79 220 135 304 284 199 181 959
2021/20224.376 434 157 215 262 468 272 88 374 194 332 843 737
2022/20234.771 489 610 263 594 316 309 147 318 789 205 399 332
2023/20241.729 115 248 109 122 149 308 128 123 76 127 129 95
2024/20253.451 274 848 609 395 1.061 264 0 0 0 0 0 0
Totale 25.470