| Nome |
# |
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Exploiting the chalcone scaffold to develop multifunctional agents for Alzheimer’s disease, file e1dcb331-d54f-7715-e053-1705fe0a6cc9
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135
|
|
Targeting SMYD3 to Sensitize Homologous Recombination-Proficient Tumors to PARP-Mediated Synthetic Lethality, file e1dcb337-0af0-7715-e053-1705fe0a6cc9
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110
|
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New tacrine dimers with antioxidant linkers as dual drugs: Anti-Alzheimer's and antiproliferative agents, file e1dcb339-6ebb-7715-e053-1705fe0a6cc9
|
92
|
|
From the dual function lead AP2238 to AP2469, a multi-target-directed ligand for the treatment of Alzheimer’s disease, file e1dcb32f-ba56-7715-e053-1705fe0a6cc9
|
89
|
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Increasing polarity in tacrine and huprine derivatives: Potent anticholinesterase agents for the treatment of myasthenia gravis, file e1dcb333-22b6-7715-e053-1705fe0a6cc9
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85
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Discovery of novel benzofuran-based compounds with neuroprotective and immunomodulatory properties for Alzheimer's disease treatment, file e1dcb338-f369-7715-e053-1705fe0a6cc9
|
81
|
|
Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimers Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography, file e1dcb339-e25c-7715-e053-1705fe0a6cc9
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69
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Determination of Effective Albumin in Patients With Decompensated Cirrhosis: Clinical and Prognostic Implications, file e1dcb339-453d-7715-e053-1705fe0a6cc9
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68
|
|
Fatty Acid Amide Hydrolase (FAAH), Acetylcholinesterase (AChE), and Butyrylcholinesterase (BuChE): Networked Targets for the Development of Carbamates as Potential Anti-Alzheimer's Disease Agents, file e1dcb339-79eb-7715-e053-1705fe0a6cc9
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66
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|
Towards automation in protein digestion: Development of a monolithic trypsin immobilized reactor for highly efficient on-line digestion and analysis, file e1dcb339-5163-7715-e053-1705fe0a6cc9
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65
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Dual-Acting Cholinesterase-Human Cannabinoid Receptor 2 Ligands Show Pronounced Neuroprotection in Vitro and Overadditive and Disease-Modifying Neuroprotective Effects in Vivo, file e1dcb339-ae9a-7715-e053-1705fe0a6cc9
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65
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Imidazopyranotacrines as Non-Hepatotoxic, Selective Acetylcholinesterase Inhibitors, and Antioxidant Agents for Alzheimer's Disease Therapy, file e1dcb334-c8a3-7715-e053-1705fe0a6cc9
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61
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Investigating in vitro amyloid peptide 1−42 aggregation: Impact of higher molecular weight stable adducts, file e1dcb333-059a-7715-e053-1705fe0a6cc9
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60
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Multitarget Strategy to Address Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and Computational Studies of Coumarin-Based Derivatives, file e1dcb339-5e2a-7715-e053-1705fe0a6cc9
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57
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No G-Quadruplex Structures in the DNA of Parvovirus B19: Experimental Evidence versus Bioinformatic Predictions, file e1dcb335-9301-7715-e053-1705fe0a6cc9
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56
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Quinoxalinetacrine QT78, a cholinesterase inhibitor as a potential ligand for Alzheimer’s disease therapy, file e1dcb334-1340-7715-e053-1705fe0a6cc9
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54
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Extraction of human serum albumin for functional studies using novel immunoaffinity-based CIMac-αHSA monolithic columns, file e1dcb331-6d45-7715-e053-1705fe0a6cc9
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25
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Nature-Inspired Multifunctional Ligands: Focusing on Amyloid-Based Molecular Mechanisms of Alzheimer’s Disease, file e1dcb339-6e2e-7715-e053-1705fe0a6cc9
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25
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From combinations to single-molecule polypharmacology—cromolyn-ibuprofen conjugates for alzheimer’s disease, file e1dcb339-0623-7715-e053-1705fe0a6cc9
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22
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Application of the SMALP technology to the isolation of GPCRs from low-yielding cell lines, file 54bef1d3-34df-494d-a4c5-f911ae0ad2f2
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16
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Lipid bilayer nanodiscs: a promising system for in-solution studies on GPCR binding, file e1dcb331-3de1-7715-e053-1705fe0a6cc9
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16
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Determination of Effective Albumin in Patients With Decompensated Cirrhosis: Clinical and Prognostic Implications, file e1dcb339-78ae-7715-e053-1705fe0a6cc9
|
16
|
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Bio-guided fractionation of stem bark extracts from phyllanthus muellarianus: Identification of phytocomponents with anti-cholinesterase activity, file e1dcb339-4a63-7715-e053-1705fe0a6cc9
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15
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Dual-Acting Cholinesterase-Human Cannabinoid Receptor 2 Ligands Show Pronounced Neuroprotection in Vitro and Overadditive and Disease-Modifying Neuroprotective Effects in Vivo, file e1dcb334-7138-7715-e053-1705fe0a6cc9
|
11
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New Coumarin derivatives as cholinergic and cannabinoid system modulators, file e1dcb338-093f-7715-e053-1705fe0a6cc9
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10
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Sustainable Drug Discovery of Multi-Target-Directed Ligands for Alzheimer's Disease, file e1dcb337-faf2-7715-e053-1705fe0a6cc9
|
9
|
|
Preparation of GPR55 nanoparticles for ligand binding studies, file e1dcb331-1669-7715-e053-1705fe0a6cc9
|
8
|
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Discovery of novel benzofuran-based compounds with neuroprotective and immunomodulatory properties for Alzheimer's disease treatment, file e1dcb334-1a5a-7715-e053-1705fe0a6cc9
|
7
|
|
Nature-Inspired Multifunctional Ligands: Focusing on Amyloid-Based Molecular Mechanisms of Alzheimer’s Disease, file e1dcb334-7045-7715-e053-1705fe0a6cc9
|
7
|
|
Application of the SMALP technology to the isolation of GPCRs from low-yielding cell lines, file e1dcb339-559b-7715-e053-1705fe0a6cc9
|
7
|
|
From virtual screening hits targeting a cryptic pocket in BACE-1 to a nontoxic brain permeable multitarget anti-Alzheimer lead with disease-modifying and cognition-enhancing effects, file e1dcb338-ec2c-7715-e053-1705fe0a6cc9
|
6
|
|
HSA-Binding Prodrugs-Based Nanoparticles Endowed with Chemo and Photo-Toxicity against Breast Cancer, file 253692ee-b0ce-4207-947e-4dbc00093c23
|
5
|
|
Targeting neuronal calcium channels and GSK3β for Alzheimer's disease with naturally-inspired Diels-Alder adducts, file b91aa2fe-9e85-4dd2-bd98-dcaea8c93f4e
|
5
|
|
null, file e1dcb333-d418-7715-e053-1705fe0a6cc9
|
5
|
|
null, file e1dcb334-6293-7715-e053-1705fe0a6cc9
|
5
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null, file e1dcb334-73f2-7715-e053-1705fe0a6cc9
|
5
|
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Analytical methods for the determination of folic acid in a polymeric micellar carrier, file 1de9a806-79a5-4bbf-b164-63b1d04dc2f8
|
4
|
|
Discovery of sustainable drugs for Alzheimer's disease: cardanol-derived cholinesterase inhibitors with antioxidant and anti-amyloid properties, file cb8635de-1e66-46ad-8581-75ee02a5eb49
|
4
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|
Fatty Acid Amide Hydrolase (FAAH), Acetylcholinesterase (AChE), and Butyrylcholinesterase (BuChE): Networked Targets for the Development of Carbamates as Potential Anti-Alzheimer's Disease Agents, file e1dcb333-f4bc-7715-e053-1705fe0a6cc9
|
4
|
|
null, file e1dcb334-4980-7715-e053-1705fe0a6cc9
|
4
|
|
Tau-Centric Multitarget Approach for Alzheimer's Disease: Development of First-in-Class Dual Glycogen Synthase Kinase 3β and Tau-Aggregation Inhibitors, file e1dcb334-70a8-7715-e053-1705fe0a6cc9
|
4
|
|
Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimers Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography, file e1dcb334-c31b-7715-e053-1705fe0a6cc9
|
4
|
|
Towards automation in protein digestion: Development of a monolithic trypsin immobilized reactor for highly efficient on-line digestion and analysis, file e1dcb333-c6a9-7715-e053-1705fe0a6cc9
|
3
|
|
Multitarget Strategy to Address Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and Computational Studies of Coumarin-Based Derivatives, file e1dcb333-dcda-7715-e053-1705fe0a6cc9
|
3
|
|
null, file e1dcb334-46e0-7715-e053-1705fe0a6cc9
|
3
|
|
null, file e1dcb334-528d-7715-e053-1705fe0a6cc9
|
3
|
|
Turning Donepezil into a Multi-Target-Directed Ligand through a Merging Strategy, file e1dcb336-7247-7715-e053-1705fe0a6cc9
|
3
|
|
N-1,2,3-triazole-isatin derivatives for cholinesterase and β-amyloid aggregation inhibition: A comprehensive bioassay study, file e1dcb336-ad3a-7715-e053-1705fe0a6cc9
|
3
|
|
Inhibition of β-Amyloid Aggregation in Alzheimer's Disease: The Key Role of (Pro)electrophilic Warheads, file da976549-2a95-403f-a738-cb5a7bfaad71
|
2
|
|
Polyamine Conjugation as a Promising Strategy To Target Amyloid Aggregation in the Framework of Alzheimer’s Disease, file e1dcb32f-a31c-7715-e053-1705fe0a6cc9
|
2
|
|
Advanced analytical methodologies in Alzheimer's disease drug discovery, file e1dcb334-10fe-7715-e053-1705fe0a6cc9
|
2
|
|
Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3, file e1dcb334-11cb-7715-e053-1705fe0a6cc9
|
2
|
|
Tacripyrimidines, the first tacrine-dihydropyrimidine hybrids, as multi-target-directed ligands for Alzheimer's disease, file e1dcb334-6edf-7715-e053-1705fe0a6cc9
|
2
|
|
Tacrine-O-protected phenolics heterodimers as multitarget-directed ligands against Alzheimer's disease: Selective subnanomolar BuChE inhibitors, file e1dcb334-a042-7715-e053-1705fe0a6cc9
|
2
|
|
New tacrine dimers with antioxidant linkers as dual drugs: Anti-Alzheimer's and antiproliferative agents, file e1dcb334-bea3-7715-e053-1705fe0a6cc9
|
2
|
|
Evaluation of the effects of acetylcholinesterase inhibitors in the zebrafish touch-evoked response: quantitative vs. qualitative assessment, file e1dcb336-d608-7715-e053-1705fe0a6cc9
|
2
|
|
Centrally Active Multitarget Anti-Alzheimer Agents Derived from the Antioxidant Lead CR-6, file e1dcb337-0274-7715-e053-1705fe0a6cc9
|
2
|
|
Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice, file e1dcb337-4347-7715-e053-1705fe0a6cc9
|
2
|
|
Discovery of Dual Aβ/Tau Inhibitors and Evaluation of Their Therapeutic Effect on a Drosophila Model of Alzheimer's Disease, file 721d29a7-64b1-41b6-843e-8e38731db9ae
|
1
|
|
Turning Donepezil into a Multi-Target-Directed Ligand through a Merging Strategy, file 72b52ca1-cef8-4532-9585-6b8ebe0be929
|
1
|
|
Cystamine-tacrine dimer: A new multi-target-directed ligand as potential therapeutic agent for Alzheimer's disease treatment., file e1dcb32c-2553-7715-e053-1705fe0a6cc9
|
1
|
|
Fluorescence biosensing micropatterned surfaces based on immobilized human acetylcholinesterase, file e1dcb32d-3eae-7715-e053-1705fe0a6cc9
|
1
|
|
null, file e1dcb333-cb2c-7715-e053-1705fe0a6cc9
|
1
|
|
A novel class of multitarget anti-Alzheimer benzohomoadamantane‒chlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors, file e1dcb333-e881-7715-e053-1705fe0a6cc9
|
1
|
|
Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase, file e1dcb333-e896-7715-e053-1705fe0a6cc9
|
1
|
|
null, file e1dcb334-15e2-7715-e053-1705fe0a6cc9
|
1
|
|
null, file e1dcb334-5921-7715-e053-1705fe0a6cc9
|
1
|
|
null, file e1dcb334-7880-7715-e053-1705fe0a6cc9
|
1
|
|
Solid lipid microparticles for oral delivery of catalase: focus on the protein integrity and gastric protection, file e1dcb336-7889-7715-e053-1705fe0a6cc9
|
1
|
|
Discovery of an Allosteric Ligand Binding Site in SMYD3 Lysine Methyltransferase, file e1dcb336-e260-7715-e053-1705fe0a6cc9
|
1
|
|
Solid Lipid Microparticles for Oral Delivery of Catalase: Focus on the Protein Structural Integrity and Gastric Protection, file e1dcb337-0537-7715-e053-1705fe0a6cc9
|
1
|
|
Phenothiazine-Tacrine Heterodimers: Pursuing Multitarget Directed Approach in Alzheimer's Disease, file e1dcb337-d9ff-7715-e053-1705fe0a6cc9
|
1
|
| Totale |
1514 |