Aims: We sought to investigate the thrombogenicity of different DES and BMS in an in vitro system of stent perfusion. Material and methods: The experimental model consisted of a peristaltic pump connected to 4 parallel silicone tubes in which different stents were deployed. Blood was drawn from healthy volunteers and the amount of stent surfaced-induced thrombus deposition was determined using 125I-fibrinogen. Results: Compared to Resolute, Biomatrix and Vision, Xience was associated with the lowest amount of stent surface-induced thrombus formation, with a significant difference compared to Vision (125I-fibrinogen median value deposition [IQ range]: 50 ng [25–98] versus 560 ng [320–1520], respectively, p < 0.05), but not to other DES. In the second set of experiments Fluoropolymer-coated BMS not eluting drug was associated with a significant 3-fold reduction in 125I-fibrinogen deposition (245 ng [80–300]) compared to Vision (625 ng [320–760], p < 0.05), but a 7-fold increase compared to Xience (35 ng [20–60], p < 0.05). Finally Xience was associated with a significantly greater absorption of albumin compared to BMS. Conclusions: In an in vitro system of stent perfusion, Xience was associated with the lowest amount of stent surface-induced thrombus formation compared with Resolute, Biomatrix and Vision, with a noted synergistic effect between the fluoropolymer and the drug.

In vitro thrombogenicity of drug-eluting and bare metal stents

Palmerini, Tullio;Barozzi, Chiara;Tomasi, Luciana;Riva, Diego Della;Marengo, Mario;Bruno, Antonio G.;Bacchi-Reggiani, Maria-Letizia;Naldi, Marina;Bartolini, Manuela;Fanti, Stefano;Galiè, Nazzareno;
2020

Abstract

Aims: We sought to investigate the thrombogenicity of different DES and BMS in an in vitro system of stent perfusion. Material and methods: The experimental model consisted of a peristaltic pump connected to 4 parallel silicone tubes in which different stents were deployed. Blood was drawn from healthy volunteers and the amount of stent surfaced-induced thrombus deposition was determined using 125I-fibrinogen. Results: Compared to Resolute, Biomatrix and Vision, Xience was associated with the lowest amount of stent surface-induced thrombus formation, with a significant difference compared to Vision (125I-fibrinogen median value deposition [IQ range]: 50 ng [25–98] versus 560 ng [320–1520], respectively, p < 0.05), but not to other DES. In the second set of experiments Fluoropolymer-coated BMS not eluting drug was associated with a significant 3-fold reduction in 125I-fibrinogen deposition (245 ng [80–300]) compared to Vision (625 ng [320–760], p < 0.05), but a 7-fold increase compared to Xience (35 ng [20–60], p < 0.05). Finally Xience was associated with a significantly greater absorption of albumin compared to BMS. Conclusions: In an in vitro system of stent perfusion, Xience was associated with the lowest amount of stent surface-induced thrombus formation compared with Resolute, Biomatrix and Vision, with a noted synergistic effect between the fluoropolymer and the drug.
Palmerini, Tullio; Barozzi, Chiara; Tomasi, Luciana; Riva, Diego Della; Marengo, Mario; Cicoria, Gianfranco; Bruno, Antonio G.; Bacchi-Reggiani, Maria-Letizia; Naldi, Marina; Bartolini, Manuela; Fanti, Stefano; Galiè, Nazzareno; Stone, Gregg W.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11585/746064
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