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An integrated structural approach reveals novel insights on the BRCA2 - RAD51 interaction

An integrative approach is well suited for the study of highly challenging systems displaying complex conformational dynamics, such as intrinsically disordered proteins like the BRCA2-RAD51 complexes. In this project we would like to couple SAXS, cross-linking mass spectrometry (XL-MS) data, AlphaFold2 predictions, and molecular dynamics (MD) simulations to refine the studies on these complexes. Indeed, SAXS experiments can provide insights into the conformational dynamics in solution, while ...

A chemical biology probe identified through 19F NMR screening stimulates RAD51 oligomerization and disrupts BRC4 binding

The BRCA2–RAD51 interaction is essential to ensure high-fidelity repair of deleterious DNA double strand-breaks within Homologous Recombination (HR) [1,2]. BRCA2 engages RAD51 through eight repetitive sequences, named BRC-repeats, which mediate proper cytosolic RAD51 recruitment and promote its nuclear translocation [1,2]. Disruption of this crucial interaction impairs HR (BRCAness) and sensitizes cancer cells to PARP inhibitors (PARP-is), making it a compelling therapeutic target [3]. Indeed...

Randomized comparative study of 5-Fluorouracil 4%, tirbanibulin, and photodynamic therapy for relapsing actinic keratoses

Background: Actinic keratosis (AK) reflects a field cancerization process in chronically sun-damaged skin, and relapse after diclofenac therapy is a frequent clinical scenario. Field-directed treatments such as 5-fluorouracil (5-FU), tirbanibulin, and photodynamic therapy (PDT) are widely used, yet comparative data in post-diclofenac relapse and the contribution of reflectance confocal microscopy (RCM) to therapeutic monitoring remain limited. Objectives: To compare the clinical efficacy, tol...

«E cominciai a travagliare sì come farnetica persona» (Vita nova XXIII, 4 / 14, 4). Note per una storia culturale della frenesia

Partendo dall’indizio lessicale di una condizione patologica associata a stati alterati di coscien- za, si tenterà di esaminarne lo spessore storico-semantico in relazione ai registri discorsivi e rituali della religione e della malattia, con particolare attenzione al connotato diabolico e divi- natorio della condizione dei frenetici nel cristianesimo tardoantico e medievale. Il caso di studio consente di evidenziare i rischi di un approccio filologico-testuale alla storia delle pratiche e de...

Semantics

This chapter reviews key topics in the semantic description of Italian, which have significantly contributed to the theoretical analysis and to the elaboration of models of cross-linguistic variation. The focus is on the meaning of grammatical categories: determiners and quantifiers (including articles and quantifiers), tense and aspect (including deictic and anaphoric tense, aoristic drift, reference time vs event time vs speech time, passato prossimo and passato remoto, imperfective vs perf...

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Tipologia
  • 1 - Contributo in rivista194268
  • 4 - Contributo in Atti di convegno62943
  • 2 - Contributo in volume61823
  • 3 - Libro17276
  • 8 - Attività collegate direttamen...7344
  • 7 - Altra tipologia4336
  • 5 - Traduzione1954
  • 6 - Brevetto838
Autore
  • CASTRO, ANDREA1799
  • ROVELLI, TIZIANO1479
  • BONACORSI, DANIELE1469
  • BENINI, LUCA1456
  • VILLA, MAURO1432
  • CUFFIANI, MARCO1431
  • FANFANI, ALESSANDRA1423
  • SIROLI, GIAN PIERO1418
  • ZOCCOLI, ANTONIO1399
  • GUIDUCCI, LUIGI1387
Data di pubblicazione
  • In stampa/Attività in corso3025
  • 2020 - 202799304
  • 2010 - 2019150010
  • 2000 - 200994211
  • 1990 - 19993621
  • 1980 - 1989575
  • 1970 - 197930
  • 1967 - 19691
Editore
  • s.n8475
  • Springer2771
  • IEEE2198
  • Il Mulino1968
  • Institute of Electrical and Elect...1929
  • Bononia University Press1854
  • Franco Angeli1542
  • FrancoAngeli1446
  • Carocci1282
  • Giappichelli1165
Rivista
  • ASTRONOMY & ASTROPHYSICS1778
  • JOURNAL OF HIGH ENERGY PHYSICS1325
  • MONTHLY NOTICES OF THE ROYAL ASTR...1223
  • PHYSICAL REVIEW LETTERS1171
  • PHYSICS LETTERS. SECTION B974
  • THE ASTROPHYSICAL JOURNAL943
  • PLOS ONE931
  • PHYSICAL REVIEW D, PARTICLES, FIE...825
  • SCIENTIFIC REPORTS824
  • THE EUROPEAN PHYSICAL JOURNAL. C,...792
Serie
  • LECTURE NOTES IN COMPUTER SCIENCE841
  • CEUR WORKSHOP PROCEEDINGS366
  • LECTURE NOTES IN ARTIFICIAL INTEL...201
  • BREVIARIA IURIS191
  • LE FONTI DEL DIRITTO ITALIANO133
  • STUDI SUPERIORI133
  • INDO-IRANICA ET ORIENTALIA, SERIE...129
  • PROCEEDINGS OF SPIE, THE INTERNAT...114
  • SOCIETÀ ITALIANA DI PEDAGOGIA114
  • IFAC-PAPERSONLINE103
Keyword
  • Humans6491
  • Female3245
  • Male3082
  • Italy2306
  • Middle Aged1860
  • Adult1844
  • Aged1602
  • LHC1473
  • COVID-191397
  • HEP1316
Lingua
  • eng219038
  • ita114522
  • fre4504
  • spa3684
  • ger2028
  • por910
  • rus447
  • lat312
  • grc180
  • chi146
Accesso al fulltext
  • no fulltext277996
  • open63766
  • reserved7438
  • embargoed861
  • partially open703
  • mixed13