The complex etiology of Alzheimer’s disease (AD) prompts scientists to develop multitarget strategies to combat causes and symptoms. We therefore designed, synthesized, and tested new hybrid molecules linking a benzofuran ring to a N-methyl-N-benzylamine through a heptyloxy chain, affording a series of potential multifunctional drugs for AD. The cholinesterase inhibitory activity was extended to the inhibition of Abeta fibril formation for 1, 3, and 5. Compound 3 showed an additional neuroprotective effect.

Benzofuran-Based Hybrid Compounds for the Inhibition of Cholinesterase Activity, Abeta Amyloid Aggregation, and Abeta Neurotoxicity

RIZZO, STEFANO;PIAZZI, LORNA;BISI, ALESSANDRA;GOBBI, SILVIA;BARTOLINI, MANUELA;ANDRISANO, VINCENZA;MORRONI, FABIANA;TAROZZI, ANDREA;RAMPA, ANGELA
2008

Abstract

The complex etiology of Alzheimer’s disease (AD) prompts scientists to develop multitarget strategies to combat causes and symptoms. We therefore designed, synthesized, and tested new hybrid molecules linking a benzofuran ring to a N-methyl-N-benzylamine through a heptyloxy chain, affording a series of potential multifunctional drugs for AD. The cholinesterase inhibitory activity was extended to the inhibition of Abeta fibril formation for 1, 3, and 5. Compound 3 showed an additional neuroprotective effect.
S. Rizzo; C. Riviere; L. Piazzi; A. Bisi; S. Gobbi; M. Bartolini; V. Andrisano; F. Morroni; A. Tarozzi; J. P. Monti; A. Rampa
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/61192
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