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EnglishThe complex etiology of Alzheimer’s disease (AD) prompts scientists to develop multitarget strategies to combat causes and symptoms. We therefore designed, synthesized, and tested new hybrid molecules linking a benzofuran ring to a N-methyl-N-benzylamine through a heptyloxy chain, affording a series of potential multifunctional drugs for AD. The cholinesterase inhibitory activity was extended to the inhibition of Abeta fibril formation for 1, 3, and 5. Compound 3 showed an additional neuroprotective effect.
| Titolo: | Benzofuran-Based Hybrid Compounds for the Inhibition of Cholinesterase Activity, Abeta Amyloid Aggregation, and Abeta Neurotoxicity | |
| Autore/i: | RIZZO, STEFANO; C. Riviere; PIAZZI, LORNA; BISI, ALESSANDRA; GOBBI, SILVIA; BARTOLINI, MANUELA; ANDRISANO, VINCENZA; MORRONI, FABIANA; TAROZZI, ANDREA; J. P. Monti; RAMPA, ANGELA | |
| Autore/i Unibo: | ||
| Anno: | 2008 | |
| Rivista: | ||
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1021/jm8002747 | |
| Abstract: | The complex etiology of Alzheimer’s disease (AD) prompts scientists to develop multitarget strategies to combat causes and symptoms. We therefore designed, synthesized, and tested new hybrid molecules linking a benzofuran ring to a N-methyl-N-benzylamine through a heptyloxy chain, affording a series of potential multifunctional drugs for AD. The cholinesterase inhibitory activity was extended to the inhibition of Abeta fibril formation for 1, 3, and 5. Compound 3 showed an additional neuroprotective effect. | |
| Data prodotto definitivo in UGOV: | 2008-06-16 12:27:09 | |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
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