CRIS Current Research Information System

BOLOGNESI, MARIA LAURA
 Distribuzione geografica
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Continente #
NA - Nord America 10.161
EU - Europa 8.951
AS - Asia 2.500
AF - Africa 619
SA - Sud America 95
Continente sconosciuto - Info sul continente non disponibili 34
OC - Oceania 10
Totale 22.370
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Nazione #
US - Stati Uniti d'America 10.115
IT - Italia 2.382
GB - Regno Unito 2.154
DE - Germania 1.088
CN - Cina 1.044
SE - Svezia 809
UA - Ucraina 626
IN - India 551
VN - Vietnam 517
FR - Francia 353
IE - Irlanda 315
RU - Federazione Russa 293
TG - Togo 185
CI - Costa d'Avorio 184
EE - Estonia 164
SG - Singapore 159
ZA - Sudafrica 157
HR - Croazia 143
ES - Italia 101
BG - Bulgaria 84
BR - Brasile 72
CH - Svizzera 62
SC - Seychelles 59
GR - Grecia 57
PT - Portogallo 51
BE - Belgio 47
PL - Polonia 42
FI - Finlandia 41
JO - Giordania 37
CA - Canada 36
EU - Europa 30
KR - Corea 30
JP - Giappone 29
RO - Romania 29
CZ - Repubblica Ceca 25
NL - Olanda 24
NG - Nigeria 23
IR - Iran 22
TR - Turchia 22
PK - Pakistan 21
AT - Austria 14
CL - Cile 14
LB - Libano 12
NO - Norvegia 11
SI - Slovenia 9
AU - Australia 8
IQ - Iraq 8
HK - Hong Kong 7
IL - Israele 7
TW - Taiwan 7
BD - Bangladesh 6
MX - Messico 6
DK - Danimarca 5
LV - Lettonia 5
A2 - ???statistics.table.value.countryCode.A2??? 4
CU - Cuba 4
HU - Ungheria 4
ID - Indonesia 4
MY - Malesia 4
AE - Emirati Arabi Uniti 3
AL - Albania 3
CO - Colombia 3
EG - Egitto 3
MD - Moldavia 3
MU - Mauritius 3
PE - Perù 3
SM - San Marino 3
UZ - Uzbekistan 3
AR - Argentina 2
CM - Camerun 2
DZ - Algeria 2
LU - Lussemburgo 2
NZ - Nuova Zelanda 2
TH - Thailandia 2
AM - Armenia 1
BO - Bolivia 1
KZ - Kazakistan 1
LK - Sri Lanka 1
LY - Libia 1
PH - Filippine 1
RS - Serbia 1
SA - Arabia Saudita 1
SK - Slovacchia (Repubblica Slovacca) 1
Totale 22.370
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Città #
Southend 1.892
Fairfield 1.283
Chandler 955
Ashburn 820
Woodbridge 639
Wilmington 616
Houston 613
Ann Arbor 568
Bologna 566
Seattle 538
Princeton 494
Cambridge 484
Jacksonville 418
Dublin 315
Dong Ket 250
Westminster 203
Nanjing 194
Padova 189
Lomé 185
Abidjan 184
Berlin 179
Milan 148
Singapore 111
Jinan 108
Saint Petersburg 103
Medford 92
Turin 89
Mülheim 83
Nanchang 83
Redmond 82
San Diego 82
Shenyang 80
New York 75
Sofia 75
Dearborn 71
Hebei 71
Changsha 70
Redwood City 66
Des Moines 65
Boardman 58
Falls Church 56
Los Angeles 54
Rome 53
Mahé 52
Beijing 51
Hyderabad 46
Stockholm 42
Brussels 39
Amman 37
Florence 37
Jiaxing 36
Helsinki 34
Tianjin 33
Bern 30
Bremen 30
Madrid 30
Olalla 30
London 29
Siracusa 29
Haikou 27
Verona 27
Lisbon 26
Norwalk 26
Zhengzhou 26
Guangzhou 25
Hangzhou 25
Chicago 23
Mountain View 23
São Paulo 23
Kunming 20
Taizhou 20
Ningbo 19
Cesena 18
Cormano 18
Dallas 18
Fremont 18
Lanzhou 18
Barcelona 17
Gallarate 17
Hefei 17
Paris 17
Ponta Delgada 17
Rimini 17
Taiyuan 17
Piacenza 15
Abeokuta 14
Bengaluru 14
Cagliari 14
Forlì 14
San Venanzo 14
Tokyo 14
Varanasi 14
Athens 13
Brno 13
Phoenix 13
Ravenna 13
Washington 13
Bari 12
Ferrara 12
Lodz 12
Totale 14.678
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Nome #
3,4-Dihydro-1,3,5-triazin-2(1H)-ones as the First Dual BACE-1/GSK-3β Fragment Hits against Alzheimer's Disease 242
A Focused Library of Psychotropic Analogues with Neuroprotective and Neuroregenerative Potential 223
A small molecule targeting the multifactorial nature of Alzheimer's disease 218
Progettazione e sintesi di analoghi rigidi di metoctramina nello studio dei recettori muscarinici 188
A small chemical library of 2-aminoimidazole derivatives as BACE-1 inhibitors: structure-based design, synthesis, and biological evaluation 188
Accelerating Drug Discovery Efforts for Trypanosomatidic Infections Using an Integrated Transnational Academic Drug Discovery Platform 164
Tau-Centric Multitarget Approach for Alzheimer's Disease: Development of First-in-Class Dual Glycogen Synthase Kinase 3β and Tau-Aggregation Inhibitors 162
A new EGFR inhibitor induces apoptosis in colon cancer cells. 156
Discovery of Sustainable Drugs for Neglected Tropical Diseases: Cashew Nut Shell Liquid (CNSL)-Based Hybrids Target Mitochondrial Function and ATP Production in Trypanosoma brucei 156
Changing paradigm to target microglia in neurodegenerative diseases: from anti-inflammatory strategy to active immunomodulation. 154
Alzheimer's disease: new approaches to drug discovery. 152
BACE-1 Inhibitors: From Recent Single-Target Molecules to Multitarget Compounds for Alzheimer's Disease 150
Bis(7)-tacrine Derivatives as Multitarget-Directed Ligands: Focus on Anticholinesterase and Antiamyloid Activities 150
Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease 150
Novel Sustainable-by-Design HDAC Inhibitors for the Treatment of Alzheimer's Disease 150
Progettazione e sintesi di poliammine a potenziale attività antitumorale 147
Development of a Focused Library of Triazole-Linked Privileged-Structure-Based Conjugates Leading to the Discovery of Novel Phenotypic Hits against Protozoan Parasitic Infections 146
From combinations to multitarget-directed ligands: A continuum in Alzheimer's disease polypharmacology 146
Nutritional and Pharmacological Strategies to Regulate Microglial Polarization in Cognitive Aging and Alzheimer's Disease. 144
null 144
Rational Approach to discover multipotent anti-Alzheimer drugs 142
Design, synthesis, and biological evaluation of conformationally restricted rivastigmine analogues 141
Capitolo 2. Proprietà chimico-fisiche e attività biologica 140
Sustainable Drug Discovery of Multi-Target-Directed Ligands for Alzheimer's Disease 140
Polyamine conjugation of curcumin analogues toward the discovery of mitochondria-directed neuroprotective agents. 138
PROTAC-Induced Glycogen Synthase Kinase 3β Degradation as a Potential Therapeutic Strategy for Alzheimer’s Disease 134
A General Protocol for the Solvent- and Catalyst-Free Synthesis of 2-Styrylquinolines under Focused Microwave Irradiation 133
Curcumin analogs as multi-target antioxidants: focus on mitochondria. 132
A Fluorescent Styrylquinoline with Combined Therapeutic and Diagnostic Activities against Alzheimer's and Prion Diseases 132
Multitarget Drug Design Strategy: Quinone–Tacrine Hybrids Designed To Block Amyloid-β Aggregation and To Exert Anticholinesterase and Antioxidant Effects 132
Enriching Proteolysis Targeting Chimeras with a Second Modality: When Two Are Better Than One 128
Structure-activity relationships of memoquin: Influence of the chain chirality in the multi-target mechanism of action 128
Cystamine-tacrine dimer: A new multi-target-directed ligand as potential therapeutic agent for Alzheimer's disease treatment. 128
Complementary medicinal chemistry-driven strategies toward new antitrypanosomal and antileishmanial lead drug candidates 127
Parallel Synthesis, Evaluation, and Preliminary Structure-Activity Relationship of 2,5-Diamino-1,4-benzoquinones as a Novel Class of Bivalent Anti-Prion Compound. 126
A NEW EPIDERMAL GROWTH FACTOR RECEPTOR INHIBITOR IN COLON CANCER CELLS 124
Progettazione e sintesi di derivati poliamminici per il trattamento della malattia di Alzheimer 123
Novel multi target-directed ligands targeting 5-HT4 receptors with in cellulo antioxidant properties as promising leads in Alzheimer's disease 123
A NEW EPIDERMAL GROWTH FACTOR RECEPTOR INHIBITOR IN COLON CANCER CELLS 122
α-linolenic acid-valproic acid conjugates: Toward single-molecule polypharmacology for multiple sclerosis 122
Discovery of sustainable drugs for Alzheimer's disease: cardanol-derived cholinesterase inhibitors with antioxidant and anti-amyloid properties 122
null 121
The concept of privileged structures in rational drug design: Focus on acridine and quinoline scaffolds in neurodegenerative and protozoan diseases 119
Molecular hybridization as a tool for designing multitarget drug candidates for complex diseases 118
Design and in vitro study of a dual drug-loaded delivery system produced by electrospinning for the treatment of acute injuries of the central nervous system 118
Medicinal Chemistry of Hybrids for Neurodegenerative Diseases 117
Design, synthesis, and biological evaluation of pirenzepine analogs bearing a 1,2-cyclohexanediamine and a perhydroquinoxaline units in exchange for the piperazine ring as antimuscarinics 116
Toward a rational design of multitarget-directed antioxidants: merging memoquin and lipoic acid molecular frameworks 116
Multitargeted drugs discovery: Balancing anti-amyloid and anticholinesterase capacity in a single chemical entity 116
Multitargeted drugs for the treatment of Alzheimer's disease 116
Journal of Medicinal Chemistry 116
Process for preparation of 1,4-benzoquinone-2,5-diamines by reaction of amines with 1,4-benzoquinones bearing leaving groups at the 2- and 5-positions 114
Investigation of the photostability properties of memoquin, a quinone derivative for the treatment of Alzheimer's disease. 114
Bivalent tacrine-based acetylcholinesterase inhibitors: role of the spacer in the recognition process of the enzyme gorge 113
Multi-Target-Directed Drug Design Strategy: From a Dual Binding Site Acetylcholinesterase Inhibitor to a Trifunctional Compound against Alzheimer's Disease 113
Drug Discovery Strategies for the Generation of Multitarget Ligands against Neglected Tropical Diseases 113
Memoquin: a multi-target-directed ligand as an innovative therapeutic opportunity for Alzheimer's disease 112
Hybrid Lipoic Acid Derivatives to Attack Prion Disease on Multiple Fronts 111
Design, synthesis, and biological evaluation of substituted 2,3-dihydro-1H-cyclopenta[b]quinolin-9-ylamine related compounds as fructose-1,6-bisphosphatase inhibitors 111
Characterization of Cholinesterase inhibitors by means of immobilized enzyme reactor 109
Novel bis(7)-tacrine derivatives as multitarget ligands: focus on anti-cholinesterase and anti-amyloid activities 108
Multitarget Drug Discovery and Polypharmacology 108
STUDY OF THE ANTI-INFLAMMATORY ACTIVITY OF NOVEL TACRINE DERIVATIVES WITH LIPIDS EXTRACTED FROM CASHEW NUT SHELL LIQUID 108
Novel Class of Quinone-Bearing Polyamines as Multi-Target-Directed Ligands To Combat Alzheimer's Disease 108
New tacrine dimers with antioxidant linkers as dual drugs: Anti-Alzheimer's and antiproliferative agents 107
A perspective on multi-target drug discovery and design for complex diseases 107
Monolithic stationary phase coupled with coulometric detection: development of an ion-pair HPLC method for the analysis of quinone-bearing compounds. 106
Docking ligands on protein surfaces: the case study of prion protein. 106
Neglected tropical diseases: multi-target-directed ligands in the search for novel lead candidates against Trypanosoma and Leishmania 106
Remembering Marie Curie's legacy 106
Editorial: Multi-target-directed ligands (MTDL) as challenging research tools in drug discovery: From design to pharmacological evaluation 106
Conjugation of Quinones with Natural Polyamines: Toward an Expanded Antitrypanosomatid Profile 105
Phenothiazine-Tacrine Heterodimers: Pursuing Multitarget Directed Approach in Alzheimer's Disease 105
Heterocyclic inhibitors of AChE acylation and peripheral sites. 104
Navigating the Chemical Space of Multitarget-Directed Ligands: From Hybrids to Fragments in Alzheimer's Disease 104
Turning Donepezil into a Multi-Target-Directed Ligand through a Merging Strategy 104
Multitarget-directed ligands: Innovative chemical probes and therapeutic tools against Alzheimer's disease 104
Multitarget Ligands in the Search for Novel Lead Candidates against Trypanosoma and Leishmania 103
Quinones bearing non-steroidal anti-inflammatory fragments as multitarget ligands for Alzheimer’s disease 103
Amyloid Chemical Probes and Theranostics: Steps Toward Personalized Medicine in Neurodegenerative DiseasesMedicinal Chemistry Approaches to Personalized Medicine 103
Beta-secretase monolithic micro-IMER (immobilized enzyme reactor) for on-line HPLC screening of quinone-bearing polyamine inhibitors. 102
Privileged structure-guided synthesis of quinazoline derivatives as inhibitors of trypanothione reductase 102
Synthesis and evaluation of a library of 2,5-bisdiamino-benzoquinone derivatives as probes to modulate protein-protein interactions in prions 102
Trypanocidal activity of quinoxaline 1,4 Di-N-oxide derivatives as trypanothione reductase inhibitors 102
Multi-target-Directed Ligands To Combat Neurodegenerative Diseases 100
Progress in acetylcholinesterase inhibitors for Alzheimer's disease: an update 100
Tacripyrimidines, the first tacrine-dihydropyrimidine hybrids, as multi-target-directed ligands for Alzheimer's disease 100
Progress in acetylcholinesterase inhibitors for Alzheimer's disease 98
null 98
Bifunctional carbazole derivatives for simultaneous therapy and fluorescence imaging in prion disease murine cell models 97
Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer's disease. 97
Inhibition of Acetylcholinesterase, Beta-Amyloid Aggregation, and NMDA Receptors in Alzheimer's Disease: A Promising Direction for the Multi-target-Directed Ligands Gold Rush 96
Discovery of a Class of Diketopiperazines as Antiprion Compounds 96
Preparation of 2,5-bis-diamine-[1,4]benzoquinone derivatives for the treatment of Alzheimer's disease and a process for their preparation and intermediates thereof. 96
Synthesis of Monomeric Derivatives To Probe Memoquin's Bivalent Interactions 96
Repurposing of Drugs Targeting YAP-TEAD Functions 96
Tackling neurodegeneration with multi-target and theranostic small molecules 95
Targeted Protein Degradation for Infectious Diseases: from Basic Biology to Drug Discovery 94
Discovery of Dual Aβ/Tau Inhibitors and Evaluation of Their Therapeutic Effect on a Drosophila Model of Alzheimer's Disease 94
Harnessing Polypharmacology with Medicinal Chemistry 94
Totale 12.316
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Categoria #
all - tutte 60.668
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 166
Totale 60.834
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20204.976 0 152 118 343 562 598 719 788 744 383 226 343
2020/20213.429 707 219 152 192 74 308 163 243 265 235 193 678
2021/20224.476 519 137 255 273 451 337 134 296 223 294 798 759
2022/20234.776 478 680 274 532 334 335 201 352 705 154 458 273
2023/20242.004 131 243 156 174 167 301 119 137 98 176 167 135
2024/2025416 395 21 0 0 0 0 0 0 0 0 0 0
Totale 23.032