CRIS Current Research Information System

ROSINI, MICHELA
 Distribuzione geografica
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Continente #
NA - Nord America 6.775
AS - Asia 5.642
EU - Europa 4.734
AF - Africa 476
SA - Sud America 271
OC - Oceania 6
Totale 17.904
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Nazione #
US - Stati Uniti d'America 6.698
CN - Cina 1.639
SG - Singapore 1.478
VN - Vietnam 1.271
IT - Italia 1.217
GB - Regno Unito 1.041
DE - Germania 518
HK - Hong Kong 436
SE - Svezia 398
UA - Ucraina 303
FR - Francia 299
IN - India 270
RU - Federazione Russa 254
CI - Costa d'Avorio 203
BR - Brasile 182
IE - Irlanda 150
NL - Olanda 130
JP - Giappone 98
TG - Togo 97
ZA - Sudafrica 97
KR - Corea 86
BD - Bangladesh 84
EE - Estonia 78
FI - Finlandia 62
BG - Bulgaria 53
CA - Canada 46
ES - Italia 43
AR - Argentina 40
ID - Indonesia 37
SC - Seychelles 37
BE - Belgio 34
JO - Giordania 34
PH - Filippine 28
HR - Croazia 25
TH - Thailandia 25
CH - Svizzera 24
TW - Taiwan 24
IQ - Iraq 22
MX - Messico 22
TR - Turchia 22
MY - Malesia 18
PK - Pakistan 17
GR - Grecia 16
AT - Austria 14
PL - Polonia 14
CL - Cile 11
EC - Ecuador 11
RO - Romania 11
CZ - Repubblica Ceca 10
IR - Iran 10
SA - Arabia Saudita 10
CO - Colombia 9
LB - Libano 8
UZ - Uzbekistan 8
LU - Lussemburgo 7
LT - Lituania 6
MA - Marocco 6
NG - Nigeria 6
PY - Paraguay 6
EG - Egitto 5
ET - Etiopia 5
PE - Perù 5
PT - Portogallo 5
AU - Australia 4
TN - Tunisia 4
DZ - Algeria 3
IL - Israele 3
KE - Kenya 3
MD - Moldavia 3
SK - Slovacchia (Repubblica Slovacca) 3
UY - Uruguay 3
AE - Emirati Arabi Uniti 2
AL - Albania 2
BY - Bielorussia 2
CG - Congo 2
CR - Costa Rica 2
GT - Guatemala 2
KZ - Kazakistan 2
LK - Sri Lanka 2
LV - Lettonia 2
LY - Libia 2
NO - Norvegia 2
NP - Nepal 2
OM - Oman 2
SM - San Marino 2
VE - Venezuela 2
AZ - Azerbaigian 1
BA - Bosnia-Erzegovina 1
BO - Bolivia 1
CM - Camerun 1
DK - Danimarca 1
DO - Repubblica Dominicana 1
FK - Isole Falkland (Malvinas) 1
GH - Ghana 1
HU - Ungheria 1
IM - Isola di Man 1
JM - Giamaica 1
KW - Kuwait 1
ME - Montenegro 1
MK - Macedonia 1
Totale 17.893
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Città #
Singapore 1.010
Southend 880
Fairfield 612
Ashburn 586
Chandler 449
Hong Kong 416
San Jose 403
Santa Clara 389
Ho Chi Minh City 333
Houston 296
Woodbridge 293
Hanoi 274
Bologna 269
Seattle 263
Wilmington 258
Hefei 224
Princeton 221
Jacksonville 209
Cambridge 206
Beijing 204
Abidjan 203
Ann Arbor 188
Dublin 149
Boardman 144
Dallas 134
Los Angeles 108
New York 108
Lauterbourg 105
Council Bluffs 104
Lomé 97
Nanjing 95
Westminster 94
Padova 92
Dong Ket 82
Tokyo 82
Berlin 73
Jinan 69
Seoul 66
Buffalo 65
Milan 55
Saint Petersburg 54
Sofia 53
Haiphong 50
Shenyang 50
Guangzhou 47
Da Nang 45
Helsinki 44
Medford 43
Changsha 41
Mülheim 39
Nanchang 38
Redwood City 38
Amman 34
Shanghai 34
Rome 33
Tianjin 33
Turin 33
Brussels 31
Hebei 30
Redondo Beach 30
San Diego 29
Munich 27
Frankfurt am Main 26
Mahé 26
Florence 24
Chicago 23
Dearborn 23
Jakarta 22
Hangzhou 21
Des Moines 20
Johannesburg 20
Verona 20
Zhengzhou 20
Falls Church 19
London 19
The Dalles 19
Phoenix 18
Yubileyny 18
Bengaluru 17
Jiaxing 17
Mountain View 17
San Francisco 17
São Paulo 17
Biên Hòa 16
Siracusa 16
Thái Nguyên 16
Haikou 15
Redmond 15
Barcelona 14
Bari 14
Brooklyn 14
Chengdu 14
Montreal 14
Olalla 14
Orem 14
Wuhan 14
Amsterdam 13
Catania 13
Chennai 13
Istanbul 13
Totale 11.429
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Nome #
Bis(7)-tacrine Derivatives as Multitarget-Directed Ligands: Focus on Anticholinesterase and Antiamyloid Activities 297
Benextramine and derivatives as novel human monoamine oxidases inhibitors: an integrated approach 271
Galantamine-memantine hybrids for Alzheimer's disease: The influence of linker rigidity in biological activity and pharmacokinetic properties 270
Progettazione e sintesi di analoghi rigidi di metoctramina nello studio dei recettori muscarinici 239
Merging memantine and ferulic acid to probe connections between NMDA receptors, oxidative stress and amyloid-β peptide in Alzheimer's disease 229
Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 3. Effect of replacing the inner polymethylene chain with cyclic moieties 224
Reversible human serum albumin binding of lipocrine: a circular dichroism study. 219
Rational Approach to discover multipotent anti-Alzheimer drugs 217
Nature-Inspired Multifunctional Ligands: Focusing on Amyloid-Based Molecular Mechanisms of Alzheimer’s Disease 217
Polyamine conjugation of curcumin analogues toward the discovery of mitochondria-directed neuroprotective agents. 208
Curcumin analogs as multi-target antioxidants: focus on mitochondria. 208
Design, synthesis, and biological evaluation of conformationally restricted rivastigmine analogues 206
Cystamine-tacrine dimer: A new multi-target-directed ligand as potential therapeutic agent for Alzheimer's disease treatment. 206
Farmaci per le malattie neurodegenerative 205
Exploring the activity of polyamine analogues on polyamine and spermine oxidase: methoctramine, a potent and selective inhibitor of polyamine oxidase 205
Immunomodulators inspired by nature: A review on curcumin and Echinacea 203
Eye-Light on Age-Related Macular Degeneration: Targeting Nrf2-Pathway as a Novel Therapeutic Strategy for Retinal Pigment Epithelium 203
Progettazione e sintesi di derivati poliamminici per il trattamento della malattia di Alzheimer 202
Design and synthesis of new multitarget agents for the study of neuroinflammation in Alzheimer's disease 199
Alzheimer's disease: new approaches to drug discovery. 198
Multitargeted drugs discovery: Balancing anti-amyloid and anticholinesterase capacity in a single chemical entity 194
Structure-activity relationships of novel substituted naphthalene diimides as anticancer agents 194
Design, synthesis, and biological evaluation of prazosin-related derivatives as multipotent compounds 187
Structure-activity relationships of memoquin: Influence of the chain chirality in the multi-target mechanism of action 183
Memantine Derivatives as Multitarget Agents in Alzheimer’s Disease 183
Lights and shadows of electrophile signaling: Focus on the Nrf2-Keap1 pathway 182
In vivo characterization of ARN14140, a memantine/galantamine-based multi-target compound for Alzheimer's disease 182
Double Attack to Oxidative Stress in Neurodegenerative Disorders: MAO-B and Nrf2 as Elected Targets 181
Inhibition of β-Amyloid Aggregation in Alzheimer's Disease: The Key Role of (Pro)electrophilic Warheads 181
Polypharmacology: the rise of multitarget drugs over combination therapies 180
Toward a rational design of multitarget-directed antioxidants: merging memoquin and lipoic acid molecular frameworks 177
Bivalent tacrine-based acetylcholinesterase inhibitors: role of the spacer in the recognition process of the enzyme gorge 176
Multi-Target-Directed Drug Design Strategy: From a Dual Binding Site Acetylcholinesterase Inhibitor to a Trifunctional Compound against Alzheimer's Disease 176
Novel bis(7)-tacrine derivatives as multitarget ligands: focus on anti-cholinesterase and anti-amyloid activities 176
Polyamine Conjugation as a Promising Strategy To Target Amyloid Aggregation in the Framework of Alzheimer’s Disease 176
Design, synthesis, and biological evaluation of pirenzepine analogs bearing a 1,2-cyclohexanediamine and a perhydroquinoxaline units in exchange for the piperazine ring as antimuscarinics 170
Hybrid Lipoic Acid Derivatives to Attack Prion Disease on Multiple Fronts 168
Dual target compounds for the treatment of Alzheimer’s disease. 168
Multitarget-directed ligands: Innovative chemical probes and therapeutic tools against Alzheimer's disease 166
Exploiting RNA as a new biomolecular target for synthetic polyamines 165
Inhibition of Acetylcholinesterase, Beta-Amyloid Aggregation, and NMDA Receptors in Alzheimer's Disease: A Promising Direction for the Multi-target-Directed Ligands Gold Rush 163
Combining galantamine and memantine in multitargeted, new chemical entities potentially useful in Alzheimer's disease. 163
Preparation of (hetero)aromatic (hetero)cyclic carboxamides for the treatment of Alzheimer's disease 161
Novel Class of Quinone-Bearing Polyamines as Multi-Target-Directed Ligands To Combat Alzheimer's Disease 161
Lipocrine, a multipotent drug for the investigation of Alzheimer's disease 159
Synthesis of Monomeric Derivatives To Probe Memoquin's Bivalent Interactions 159
Analysis of the muscarinic receptor subtype mediating inhibition of the neurogenic contractions in rabbit isolated vas deferens by a series of polymethylene tetra-amines 157
Mitochondria-directed antioxidants in Alzheimer's disease. 157
Progress in acetylcholinesterase inhibitors for Alzheimer's disease: an update 157
Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer's disease. 157
Design, synthesis, and biological evaluation of substituted 2,3-dihydro-1H-cyclopenta[b]quinolin-9-ylamine related compounds as fructose-1,6-bisphosphatase inhibitors 155
An optimized polyamine moiety boosts the potency of human type II topoisomerase poisons as quantified by comparative analysis centered on the clinical candidate F14512 155
New quinazoline compounds as non-peptidomimetic BACE-1 inhibitors in the treatment of Alzheimer's disease 154
Multifunctional Tacrine Derivatives in Alzheimer’s Disease 152
Oxidative stress in Alzheimer’s disease: are we connecting the dots? 152
Multi-target Design Strategies in the Context of Alzheimer's Disease: Acetylcholinesterase Inhibition and NMDA Receptor Antagonism as the Driving Forces 152
Exploration of the Neuromodulatory Properties of Fyn and GSK-3β Kinases Exploiting 7-Azaindole-Based Inhibitors 151
One-molecule-multiple-target strategy: a novel multifunctional molecule designed to block EGF-r and to exert pro-apoptotic effects 151
Polyamine–Drug Conjugates: Do They Boost Drug Activity? 150
The bivalent ligand approach as a tool for improving the in vitro anti-Alzheimer multitarget profile of dimebon 150
Multi-target-Directed Ligands To Combat Neurodegenerative Diseases 149
Nature-Inspired Hybrids (NIH) Improve Proteostasis by Activating Nrf2-Mediated Protective Pathways in Retinal Pigment Epithelial Cells 148
Heterocyclic inhibitors of AChE acylation and peripheral sites. 148
Modulation of Keap1/Nrf2/ARE signaling pathway by curcuma- And garlic-derived hybrids 148
Novel targets for “old” polyamine analogues: monoamine oxidases and benextramine derivatives 147
Structure-activity relationships of methoctramine-related polyamines as muscarinic antagonist: Effect of replacing the inner polymethylene chain with cyclic moieties 146
Multitarget-directed drug design strategy: a novel molecule designed to block epidermal growth factor receptor (EGFR) and to exert proapoptotic effects 146
Combining galantamine and memantine in dual-target new chemical entities for the treatment of Alzheimer’s disease 145
MTDL design strategy in the context of Alzheimer's disease: from lipocrine to memoquin and beyond 143
Targeting Cytokine Release Through the Differential Modulation of Nrf2 and NF-κB Pathways by Electrophilic/Non-Electrophilic Compounds 143
Structure-Activity Relationships of Acetylcholinesterase Noncovalent Inhibitors Based on a Polyamine Backbone. 4. Futher Investigation on the Inner Spacer. 142
Circular Dichroism: a Study of Reversible Binding HSA Binding of Lipocrine. 142
Multi-Target-Direcetd Ligands as acetylcholinesterase inhibitors and nicotinic modulators for Alzheimer's disease 140
Benextramine derivatives as probes to target human monoamine oxidases 140
NRF2 and PPAR-γ Pathways in Oligodendrocyte Progenitors: Focus on Ros Protection, Mitochondrial Biogenesis and Promotion of Cell Differentiation 140
Polymethylene tetraamine backbone as template for the development of biologically active polyamines 139
Methoctramine-related polyamines as antinociceptive agents 136
Polyamines may modulate both G protein-coupled receptors and G proteins 136
Natural-product-inspired modulators of Alzheimer’s disease: focus on amyloid and oxidative stress 136
Structure-Activity Relationships of New Acetylcholinesterase Noncovalent Inhibitors Based on a Polyamine Backbone 135
Methoctramine analogues inhibit responses to capsaicin and protons in rat dorsal root ganglion neurons 135
A nature‐inspired nrf2 activator protects retinal explants from oxidative stress and neurodegeneration 135
Methoctramine analogues inhibit responses to capsaicin in DRG neurons and cloned TRPV1 132
From dual binding site acetylcholinesterase inhibitors to multi-target-directed ligands (MTDLs): a step forward in the treatment of Alzheimer's disease 132
Nature-inspired Nrf2 activators in retinal pigment epithelial cells: a source for therapeutics in age-related macular degeneration 132
Recent advances in alpha1-adrenoreceptor antagonists as pharmacological tools and therapeutic agents. 131
Role of Fyn Kinase Inhibitors in Switching Neuroinflammatory Pathways 131
EVALUATION OF NOVEL POLYAMINE AND MEMANTINE-DERIVATIVE COMPOUNDS TARGETING NMDA RECEPTORS FOR ALZHEIMER'S DISEASE TREATMENT 130
Polyamines in Drug Discovery: From the Universal Template Approach to the Multitarget-Directed Ligand Design Strategy 130
Discovery of multipotent drugs for the teratment of Alzheimer's disease 129
Rational design of multitarget-directed antioxidants: merging memoquin and lipocrine molecular frameworks 128
Synthetic polyamines: an overview of their multiple biological activities. 126
Controlled Iontophoretic Delivery in Vitro and in Vivo of ARN14140 - A Multitarget Compound for Alzheimer's Disease 121
In vitro methods for characterizing new multi-potent compounds for Alzheimer’s disease 120
Tacrine Derivatives and Alzheimer's Disease 118
Methoctramine analogues inhibit capsaicin induced currents in dorsal root ganglia and Xenopus oocytes expressing TRPV1 113
Rational design of dimebon bivalent ligands against Alzheimer’s disease 113
Reversible HSA binding of lipocrine: a circular dichroism study. 112
Exploiting RNA as anticancer target for synthetic polyamines 111
Multitarget drug design strategy in Alzheimer's disease: focus on cholinergic transmission and amyloid-beta aggregation 111
Totale 16.446
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Categoria #
all - tutte 51.060
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 51.060
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021256 0 0 0 0 0 0 0 0 0 0 0 256
2021/20221.920 104 80 124 140 165 126 40 160 67 194 348 372
2022/20231.916 217 287 100 239 112 136 82 95 367 48 168 65
2023/2024775 37 105 49 54 71 217 41 61 26 44 40 30
2024/20252.444 142 287 254 182 528 118 144 78 32 145 110 424
2025/20266.015 413 656 637 460 729 330 600 148 1.173 394 268 207
Totale 18.246