CRIS Current Research Information System

ROSINI, MICHELA
 Distribuzione geografica
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Continente #
NA - Nord America 5.828
EU - Europa 4.387
AS - Asia 4.095
AF - Africa 437
SA - Sud America 232
OC - Oceania 5
Totale 14.984
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Nazione #
US - Stati Uniti d'America 5.781
CN - Cina 1.430
SG - Singapore 1.267
IT - Italia 1.087
GB - Regno Unito 1.014
DE - Germania 505
VN - Vietnam 485
SE - Svezia 397
HK - Hong Kong 394
UA - Ucraina 301
RU - Federazione Russa 251
IN - India 233
CI - Costa d'Avorio 203
FR - Francia 185
BR - Brasile 159
IE - Irlanda 148
NL - Olanda 118
TG - Togo 97
ZA - Sudafrica 79
EE - Estonia 77
KR - Corea 73
JP - Giappone 71
BG - Bulgaria 53
ES - Italia 42
FI - Finlandia 42
SC - Seychelles 37
AR - Argentina 33
BE - Belgio 32
JO - Giordania 31
ID - Indonesia 28
CA - Canada 24
HR - Croazia 24
CH - Svizzera 23
MX - Messico 19
GR - Grecia 15
AT - Austria 14
MY - Malesia 12
TR - Turchia 12
CL - Cile 11
BD - Bangladesh 10
CZ - Repubblica Ceca 10
IR - Iran 10
PL - Polonia 10
RO - Romania 10
EC - Ecuador 9
CO - Colombia 7
LB - Libano 7
LU - Lussemburgo 7
PK - Pakistan 7
PY - Paraguay 6
NG - Nigeria 5
IQ - Iraq 4
LT - Lituania 4
PE - Perù 4
UZ - Uzbekistan 4
AU - Australia 3
DZ - Algeria 3
MA - Marocco 3
SA - Arabia Saudita 3
SK - Slovacchia (Repubblica Slovacca) 3
TW - Taiwan 3
AE - Emirati Arabi Uniti 2
CG - Congo 2
EG - Egitto 2
LK - Sri Lanka 2
LV - Lettonia 2
MD - Moldavia 2
NO - Norvegia 2
PT - Portogallo 2
SM - San Marino 2
TN - Tunisia 2
AL - Albania 1
BO - Bolivia 1
BY - Bielorussia 1
CM - Camerun 1
CR - Costa Rica 1
DK - Danimarca 1
DO - Repubblica Dominicana 1
ET - Etiopia 1
FK - Isole Falkland (Malvinas) 1
IL - Israele 1
IM - Isola di Man 1
KW - Kuwait 1
KZ - Kazakistan 1
MK - Macedonia 1
ML - Mali 1
MQ - Martinica 1
MU - Mauritius 1
NP - Nepal 1
NZ - Nuova Zelanda 1
PH - Filippine 1
PS - Palestinian Territory 1
SV - El Salvador 1
TH - Thailandia 1
TV - Tuvalu 1
UY - Uruguay 1
Totale 14.984
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Città #
Southend 880
Singapore 826
Fairfield 612
Ashburn 527
Chandler 449
Hong Kong 390
Santa Clara 377
Houston 295
Woodbridge 293
Seattle 263
Wilmington 258
Bologna 227
Hefei 221
Princeton 221
Jacksonville 207
Cambridge 206
Abidjan 203
Beijing 195
Ann Arbor 188
Dublin 147
Boardman 140
Ho Chi Minh City 128
Dallas 127
Hanoi 97
Lomé 97
Westminster 94
Nanjing 93
New York 92
Padova 92
Los Angeles 88
Dong Ket 82
Berlin 72
Jinan 69
Tokyo 67
Seoul 66
Buffalo 60
Saint Petersburg 54
Sofia 53
Milan 52
Shenyang 47
Medford 43
Changsha 39
Mülheim 39
Redwood City 38
Nanchang 37
Turin 33
Guangzhou 32
Amman 31
Hebei 30
Redondo Beach 30
Brussels 29
San Diego 29
Tianjin 29
Munich 27
Helsinki 26
Mahé 26
Rome 23
Shanghai 23
Dearborn 22
Jakarta 21
Des Moines 20
Florence 20
Chicago 19
Falls Church 19
Frankfurt am Main 19
Hangzhou 19
Verona 18
Yubileyny 18
Zhengzhou 18
Bengaluru 17
Jiaxing 17
Mountain View 17
Siracusa 16
Haikou 15
Redmond 15
Barcelona 14
Bari 14
Olalla 14
São Paulo 14
Haiphong 13
Madrid 13
Phoenix 13
Wuhan 13
Norwalk 12
Brooklyn 11
Falkenstein 11
London 11
Benevento 10
Boston 10
Catania 10
Ningbo 10
The Dalles 10
Turku 10
Cesena 9
Kunming 9
Lanzhou 9
Lizzanello 9
Paris 9
Qingdao 9
San Francisco 9
Totale 9.805
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Nome #
Bis(7)-tacrine Derivatives as Multitarget-Directed Ligands: Focus on Anticholinesterase and Antiamyloid Activities 278
Progettazione e sintesi di analoghi rigidi di metoctramina nello studio dei recettori muscarinici 226
Benextramine and derivatives as novel human monoamine oxidases inhibitors: an integrated approach 219
Rational Approach to discover multipotent anti-Alzheimer drugs 204
Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 3. Effect of replacing the inner polymethylene chain with cyclic moieties 201
Reversible human serum albumin binding of lipocrine: a circular dichroism study. 197
Merging memantine and ferulic acid to probe connections between NMDA receptors, oxidative stress and amyloid-β peptide in Alzheimer's disease 197
Design, synthesis, and biological evaluation of conformationally restricted rivastigmine analogues 193
Nature-Inspired Multifunctional Ligands: Focusing on Amyloid-Based Molecular Mechanisms of Alzheimer’s Disease 191
Curcumin analogs as multi-target antioxidants: focus on mitochondria. 185
Alzheimer's disease: new approaches to drug discovery. 182
Polyamine conjugation of curcumin analogues toward the discovery of mitochondria-directed neuroprotective agents. 179
Polypharmacology: the rise of multitarget drugs over combination therapies 176
Progettazione e sintesi di derivati poliamminici per il trattamento della malattia di Alzheimer 175
Farmaci per le malattie neurodegenerative 174
Structure-activity relationships of novel substituted naphthalene diimides as anticancer agents 173
Immunomodulators inspired by nature: A review on curcumin and Echinacea 172
Exploring the activity of polyamine analogues on polyamine and spermine oxidase: methoctramine, a potent and selective inhibitor of polyamine oxidase 172
Design, synthesis, and biological evaluation of prazosin-related derivatives as multipotent compounds 166
Cystamine-tacrine dimer: A new multi-target-directed ligand as potential therapeutic agent for Alzheimer's disease treatment. 165
Multitargeted drugs discovery: Balancing anti-amyloid and anticholinesterase capacity in a single chemical entity 164
Bivalent tacrine-based acetylcholinesterase inhibitors: role of the spacer in the recognition process of the enzyme gorge 162
Design and synthesis of new multitarget agents for the study of neuroinflammation in Alzheimer's disease 161
Structure-activity relationships of memoquin: Influence of the chain chirality in the multi-target mechanism of action 159
Toward a rational design of multitarget-directed antioxidants: merging memoquin and lipoic acid molecular frameworks 156
Galantamine-memantine hybrids for Alzheimer's disease: The influence of linker rigidity in biological activity and pharmacokinetic properties 154
Hybrid Lipoic Acid Derivatives to Attack Prion Disease on Multiple Fronts 154
Multi-Target-Directed Drug Design Strategy: From a Dual Binding Site Acetylcholinesterase Inhibitor to a Trifunctional Compound against Alzheimer's Disease 153
Design, synthesis, and biological evaluation of pirenzepine analogs bearing a 1,2-cyclohexanediamine and a perhydroquinoxaline units in exchange for the piperazine ring as antimuscarinics 153
Novel bis(7)-tacrine derivatives as multitarget ligands: focus on anti-cholinesterase and anti-amyloid activities 152
Lights and shadows of electrophile signaling: Focus on the Nrf2-Keap1 pathway 151
In vivo characterization of ARN14140, a memantine/galantamine-based multi-target compound for Alzheimer's disease 149
Memantine Derivatives as Multitarget Agents in Alzheimer’s Disease 149
Exploiting RNA as a new biomolecular target for synthetic polyamines 143
Polyamine Conjugation as a Promising Strategy To Target Amyloid Aggregation in the Framework of Alzheimer’s Disease 143
Mitochondria-directed antioxidants in Alzheimer's disease. 142
Double Attack to Oxidative Stress in Neurodegenerative Disorders: MAO-B and Nrf2 as Elected Targets 141
Novel Class of Quinone-Bearing Polyamines as Multi-Target-Directed Ligands To Combat Alzheimer's Disease 141
Multitarget-directed ligands: Innovative chemical probes and therapeutic tools against Alzheimer's disease 141
Design, synthesis, and biological evaluation of substituted 2,3-dihydro-1H-cyclopenta[b]quinolin-9-ylamine related compounds as fructose-1,6-bisphosphatase inhibitors 140
Inhibition of Acetylcholinesterase, Beta-Amyloid Aggregation, and NMDA Receptors in Alzheimer's Disease: A Promising Direction for the Multi-target-Directed Ligands Gold Rush 139
Multi-target Design Strategies in the Context of Alzheimer's Disease: Acetylcholinesterase Inhibition and NMDA Receptor Antagonism as the Driving Forces 139
Progress in acetylcholinesterase inhibitors for Alzheimer's disease: an update 139
Lipocrine, a multipotent drug for the investigation of Alzheimer's disease 138
Eye-Light on Age-Related Macular Degeneration: Targeting Nrf2-Pathway as a Novel Therapeutic Strategy for Retinal Pigment Epithelium 137
Inhibition of β-Amyloid Aggregation in Alzheimer's Disease: The Key Role of (Pro)electrophilic Warheads 136
An optimized polyamine moiety boosts the potency of human type II topoisomerase poisons as quantified by comparative analysis centered on the clinical candidate F14512 136
Analysis of the muscarinic receptor subtype mediating inhibition of the neurogenic contractions in rabbit isolated vas deferens by a series of polymethylene tetra-amines 135
Combining galantamine and memantine in multitargeted, new chemical entities potentially useful in Alzheimer's disease. 135
Multi-target-Directed Ligands To Combat Neurodegenerative Diseases 134
Preparation of (hetero)aromatic (hetero)cyclic carboxamides for the treatment of Alzheimer's disease 133
Dual target compounds for the treatment of Alzheimer’s disease. 133
The bivalent ligand approach as a tool for improving the in vitro anti-Alzheimer multitarget profile of dimebon 133
Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer's disease. 133
Multifunctional Tacrine Derivatives in Alzheimer’s Disease 132
Oxidative stress in Alzheimer’s disease: are we connecting the dots? 131
Structure-activity relationships of methoctramine-related polyamines as muscarinic antagonist: Effect of replacing the inner polymethylene chain with cyclic moieties 130
Heterocyclic inhibitors of AChE acylation and peripheral sites. 130
Synthesis of Monomeric Derivatives To Probe Memoquin's Bivalent Interactions 130
Benextramine derivatives as probes to target human monoamine oxidases 128
Multi-Target-Direcetd Ligands as acetylcholinesterase inhibitors and nicotinic modulators for Alzheimer's disease 125
Modulation of Keap1/Nrf2/ARE signaling pathway by curcuma- And garlic-derived hybrids 125
Multitarget-directed drug design strategy: a novel molecule designed to block epidermal growth factor receptor (EGFR) and to exert proapoptotic effects 124
One-molecule-multiple-target strategy: a novel multifunctional molecule designed to block EGF-r and to exert pro-apoptotic effects 123
New quinazoline compounds as non-peptidomimetic BACE-1 inhibitors in the treatment of Alzheimer's disease 123
MTDL design strategy in the context of Alzheimer's disease: from lipocrine to memoquin and beyond 123
From dual binding site acetylcholinesterase inhibitors to multi-target-directed ligands (MTDLs): a step forward in the treatment of Alzheimer's disease 121
Polymethylene tetraamine backbone as template for the development of biologically active polyamines 121
Structure-Activity Relationships of Acetylcholinesterase Noncovalent Inhibitors Based on a Polyamine Backbone. 4. Futher Investigation on the Inner Spacer. 120
Circular Dichroism: a Study of Reversible Binding HSA Binding of Lipocrine. 120
Novel targets for “old” polyamine analogues: monoamine oxidases and benextramine derivatives 120
Methoctramine analogues inhibit responses to capsaicin and protons in rat dorsal root ganglion neurons 118
Polyamines may modulate both G protein-coupled receptors and G proteins 117
Methoctramine analogues inhibit responses to capsaicin in DRG neurons and cloned TRPV1 115
Structure-Activity Relationships of New Acetylcholinesterase Noncovalent Inhibitors Based on a Polyamine Backbone 115
Methoctramine-related polyamines as antinociceptive agents 114
Combining galantamine and memantine in dual-target new chemical entities for the treatment of Alzheimer’s disease 114
Synthetic polyamines: an overview of their multiple biological activities. 113
Rational design of multitarget-directed antioxidants: merging memoquin and lipocrine molecular frameworks 113
Discovery of multipotent drugs for the teratment of Alzheimer's disease 112
Natural-product-inspired modulators of Alzheimer’s disease: focus on amyloid and oxidative stress 112
Polyamines in Drug Discovery: From the Universal Template Approach to the Multitarget-Directed Ligand Design Strategy 110
Polyamine–Drug Conjugates: Do They Boost Drug Activity? 109
Recent advances in alpha1-adrenoreceptor antagonists as pharmacological tools and therapeutic agents. 108
NRF2 and PPAR-γ Pathways in Oligodendrocyte Progenitors: Focus on Ros Protection, Mitochondrial Biogenesis and Promotion of Cell Differentiation 107
EVALUATION OF NOVEL POLYAMINE AND MEMANTINE-DERIVATIVE COMPOUNDS TARGETING NMDA RECEPTORS FOR ALZHEIMER'S DISEASE TREATMENT 106
Nature-Inspired Hybrids (NIH) Improve Proteostasis by Activating Nrf2-Mediated Protective Pathways in Retinal Pigment Epithelial Cells 104
Tacrine Derivatives and Alzheimer's Disease 104
Targeting Cytokine Release Through the Differential Modulation of Nrf2 and NF-κB Pathways by Electrophilic/Non-Electrophilic Compounds 104
A nature‐inspired nrf2 activator protects retinal explants from oxidative stress and neurodegeneration 104
Nature-inspired Nrf2 activators in retinal pigment epithelial cells: a source for therapeutics in age-related macular degeneration 102
Reversible HSA binding of lipocrine: a circular dichroism study. 100
Methoctramine analogues inhibit capsaicin induced currents in dorsal root ganglia and Xenopus oocytes expressing TRPV1 99
Synthesis of monomeric derivatives to probe Memoquin bivalent interactions 98
In vitro methods for characterizing new multi-potent compounds for Alzheimer’s disease 93
Exploiting RNA as anticancer target for synthetic polyamines 92
Rational design of dimebon bivalent ligands against Alzheimer’s disease 91
Controlled Iontophoretic Delivery in Vitro and in Vivo of ARN14140 - A Multitarget Compound for Alzheimer's Disease 91
Role of Fyn Kinase Inhibitors in Switching Neuroinflammatory Pathways 89
Functionalized Cannabinoid Subtype 2 Receptor Ligands: Fluorescent, PET, Photochromic and Covalent Molecular Probes 86
Totale 13.899
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Categoria #
all - tutte 43.868
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 43.868
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021902 0 0 0 0 0 122 26 136 155 102 105 256
2021/20221.920 104 80 124 140 165 126 40 160 67 194 348 372
2022/20231.916 217 287 100 239 112 136 82 95 367 48 168 65
2023/2024775 37 105 49 54 71 217 41 61 26 44 40 30
2024/20252.444 142 287 254 182 528 118 144 78 32 145 110 424
2025/20263.061 413 656 637 460 729 166 0 0 0 0 0 0
Totale 15.292