CRIS Current Research Information System

ROSINI, MICHELA
 Distribuzione geografica
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Continente #
NA - Nord America 5.174
EU - Europa 3.886
AS - Asia 1.606
AF - Africa 303
SA - Sud America 18
OC - Oceania 3
Totale 10.990
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Nazione #
US - Stati Uniti d'America 5.164
GB - Regno Unito 992
IT - Italia 970
CN - Cina 741
DE - Germania 442
SG - Singapore 418
SE - Svezia 390
UA - Ucraina 298
IN - India 193
RU - Federazione Russa 167
FR - Francia 159
IE - Irlanda 147
VN - Vietnam 128
CI - Costa d'Avorio 98
TG - Togo 97
EE - Estonia 77
ZA - Sudafrica 71
BG - Bulgaria 52
JO - Giordania 31
BE - Belgio 29
ES - Italia 28
SC - Seychelles 27
HR - Croazia 24
CH - Svizzera 21
FI - Finlandia 21
ID - Indonesia 17
GR - Grecia 15
JP - Giappone 13
CZ - Repubblica Ceca 10
NL - Olanda 10
RO - Romania 10
CL - Cile 9
IR - Iran 9
TR - Turchia 9
CA - Canada 8
KR - Corea 8
MY - Malesia 8
LB - Libano 7
LU - Lussemburgo 7
PK - Pakistan 7
BR - Brasile 5
NG - Nigeria 5
AT - Austria 4
BD - Bangladesh 3
HK - Hong Kong 3
PL - Polonia 3
SA - Arabia Saudita 3
UZ - Uzbekistan 3
AU - Australia 2
DZ - Algeria 2
MX - Messico 2
NO - Norvegia 2
SK - Slovacchia (Repubblica Slovacca) 2
SM - San Marino 2
TW - Taiwan 2
AE - Emirati Arabi Uniti 1
BO - Bolivia 1
CO - Colombia 1
DK - Danimarca 1
EG - Egitto 1
FK - Isole Falkland (Malvinas) 1
LK - Sri Lanka 1
LV - Lettonia 1
MD - Moldavia 1
MU - Mauritius 1
NZ - Nuova Zelanda 1
PE - Perù 1
PH - Filippine 1
PT - Portogallo 1
TN - Tunisia 1
Totale 10.990
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Città #
Southend 880
Fairfield 612
Chandler 449
Ashburn 405
Santa Clara 371
Singapore 369
Houston 294
Woodbridge 293
Seattle 261
Wilmington 257
Princeton 221
Jacksonville 207
Cambridge 206
Bologna 200
Ann Arbor 188
Dublin 147
Boardman 138
Abidjan 98
Lomé 97
Westminster 94
Nanjing 92
Padova 92
Dong Ket 82
New York 75
Berlin 72
Jinan 66
Saint Petersburg 54
Sofia 52
Shenyang 46
Medford 43
Mülheim 39
Redwood City 38
Nanchang 37
Beijing 35
Milan 35
Changsha 33
Turin 33
Amman 31
Hebei 30
San Diego 29
Tianjin 27
Brussels 26
Mahé 26
Guangzhou 25
Los Angeles 25
Dearborn 22
Des Moines 20
Falls Church 19
Hangzhou 19
Helsinki 19
Florence 17
Jakarta 17
Jiaxing 17
Mountain View 17
Shanghai 16
Siracusa 16
Zhengzhou 16
Haikou 15
Redmond 15
Barcelona 14
Olalla 14
Rome 14
Wuhan 13
Norwalk 12
Benevento 10
Catania 10
Cesena 9
Lanzhou 9
Lizzanello 9
Ningbo 9
Paris 9
Phoenix 9
Tokyo 9
Chicago 8
Cormano 8
Ferrara 8
Istanbul 8
Kunming 8
Madrid 8
Pune 8
Taiyuan 8
Taizhou 8
Angri 7
Bari 7
Falkenstein 7
Reggio Emilia 7
San Venanzo 7
Strassen 7
Verona 7
Dallas 6
Fuzhou 6
Harbin 6
London 6
Qingdao 6
Ancona 5
Bern 5
Brno 5
Caserta 5
Costa Mesa 5
Fano 5
Totale 7.506
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Nome #
Progettazione e sintesi di analoghi rigidi di metoctramina nello studio dei recettori muscarinici 198
Bis(7)-tacrine Derivatives as Multitarget-Directed Ligands: Focus on Anticholinesterase and Antiamyloid Activities 164
Alzheimer's disease: new approaches to drug discovery. 160
Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 3. Effect of replacing the inner polymethylene chain with cyclic moieties 158
Nature-Inspired Multifunctional Ligands: Focusing on Amyloid-Based Molecular Mechanisms of Alzheimer’s Disease 155
Merging memantine and ferulic acid to probe connections between NMDA receptors, oxidative stress and amyloid-β peptide in Alzheimer's disease 155
Design, synthesis, and biological evaluation of conformationally restricted rivastigmine analogues 153
Rational Approach to discover multipotent anti-Alzheimer drugs 152
Benextramine and derivatives as novel human monoamine oxidases inhibitors: an integrated approach 150
Progettazione e sintesi di derivati poliamminici per il trattamento della malattia di Alzheimer 146
Polyamine conjugation of curcumin analogues toward the discovery of mitochondria-directed neuroprotective agents. 146
Curcumin analogs as multi-target antioxidants: focus on mitochondria. 143
Structure-activity relationships of novel substituted naphthalene diimides as anticancer agents 142
Cystamine-tacrine dimer: A new multi-target-directed ligand as potential therapeutic agent for Alzheimer's disease treatment. 139
Exploring the activity of polyamine analogues on polyamine and spermine oxidase: methoctramine, a potent and selective inhibitor of polyamine oxidase 139
Structure-activity relationships of memoquin: Influence of the chain chirality in the multi-target mechanism of action 138
Multitargeted drugs discovery: Balancing anti-amyloid and anticholinesterase capacity in a single chemical entity 134
Polypharmacology: the rise of multitarget drugs over combination therapies 132
Design, synthesis, and biological evaluation of prazosin-related derivatives as multipotent compounds 131
Hybrid Lipoic Acid Derivatives to Attack Prion Disease on Multiple Fronts 130
Multi-Target-Directed Drug Design Strategy: From a Dual Binding Site Acetylcholinesterase Inhibitor to a Trifunctional Compound against Alzheimer's Disease 129
Design and synthesis of new multitarget agents for the study of neuroinflammation in Alzheimer's disease 128
Bivalent tacrine-based acetylcholinesterase inhibitors: role of the spacer in the recognition process of the enzyme gorge 124
Design, synthesis, and biological evaluation of pirenzepine analogs bearing a 1,2-cyclohexanediamine and a perhydroquinoxaline units in exchange for the piperazine ring as antimuscarinics 124
Toward a rational design of multitarget-directed antioxidants: merging memoquin and lipoic acid molecular frameworks 123
Lights and shadows of electrophile signaling: Focus on the Nrf2-Keap1 pathway 122
Novel bis(7)-tacrine derivatives as multitarget ligands: focus on anti-cholinesterase and anti-amyloid activities 121
Design, synthesis, and biological evaluation of substituted 2,3-dihydro-1H-cyclopenta[b]quinolin-9-ylamine related compounds as fructose-1,6-bisphosphatase inhibitors 121
Farmaci per le malattie neurodegenerative 121
In vivo characterization of ARN14140, a memantine/galantamine-based multi-target compound for Alzheimer's disease 121
Novel Class of Quinone-Bearing Polyamines as Multi-Target-Directed Ligands To Combat Alzheimer's Disease 115
Multitarget-directed ligands: Innovative chemical probes and therapeutic tools against Alzheimer's disease 115
Multi-target Design Strategies in the Context of Alzheimer's Disease: Acetylcholinesterase Inhibition and NMDA Receptor Antagonism as the Driving Forces 114
Exploiting RNA as a new biomolecular target for synthetic polyamines 114
Polyamine Conjugation as a Promising Strategy To Target Amyloid Aggregation in the Framework of Alzheimer’s Disease 114
Heterocyclic inhibitors of AChE acylation and peripheral sites. 113
Preparation of (hetero)aromatic (hetero)cyclic carboxamides for the treatment of Alzheimer's disease 112
Multi-target-Directed Ligands To Combat Neurodegenerative Diseases 112
Immunomodulators inspired by nature: A review on curcumin and Echinacea 111
Dual target compounds for the treatment of Alzheimer’s disease. 110
Combining galantamine and memantine in multitargeted, new chemical entities potentially useful in Alzheimer's disease. 110
An optimized polyamine moiety boosts the potency of human type II topoisomerase poisons as quantified by comparative analysis centered on the clinical candidate F14512 110
Inhibition of Acetylcholinesterase, Beta-Amyloid Aggregation, and NMDA Receptors in Alzheimer's Disease: A Promising Direction for the Multi-target-Directed Ligands Gold Rush 109
Progress in acetylcholinesterase inhibitors for Alzheimer's disease: an update 109
Memantine Derivatives as Multitarget Agents in Alzheimer’s Disease 109
Structure-activity relationships of methoctramine-related polyamines as muscarinic antagonist: Effect of replacing the inner polymethylene chain with cyclic moieties 108
Oxidative stress in Alzheimer’s disease: are we connecting the dots? 107
Benextramine derivatives as probes to target human monoamine oxidases 106
Mitochondria-directed antioxidants in Alzheimer's disease. 105
Multifunctional Tacrine Derivatives in Alzheimer’s Disease 103
The bivalent ligand approach as a tool for improving the in vitro anti-Alzheimer multitarget profile of dimebon 103
MTDL design strategy in the context of Alzheimer's disease: from lipocrine to memoquin and beyond 102
Synthesis of Monomeric Derivatives To Probe Memoquin's Bivalent Interactions 102
From dual binding site acetylcholinesterase inhibitors to multi-target-directed ligands (MTDLs): a step forward in the treatment of Alzheimer's disease 101
Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer's disease. 101
Multitarget-directed drug design strategy: a novel molecule designed to block epidermal growth factor receptor (EGFR) and to exert proapoptotic effects 99
Lipocrine, a multipotent drug for the investigation of Alzheimer's disease 98
Multi-Target-Direcetd Ligands as acetylcholinesterase inhibitors and nicotinic modulators for Alzheimer's disease 98
Methoctramine analogues inhibit responses to capsaicin and protons in rat dorsal root ganglion neurons 98
Polymethylene tetraamine backbone as template for the development of biologically active polyamines 97
Polyamines may modulate both G protein-coupled receptors and G proteins 97
Structure-Activity Relationships of New Acetylcholinesterase Noncovalent Inhibitors Based on a Polyamine Backbone 96
Circular Dichroism: a Study of Reversible Binding HSA Binding of Lipocrine. 95
Structure-Activity Relationships of Acetylcholinesterase Noncovalent Inhibitors Based on a Polyamine Backbone. 4. Futher Investigation on the Inner Spacer. 94
One-molecule-multiple-target strategy: a novel multifunctional molecule designed to block EGF-r and to exert pro-apoptotic effects 93
Discovery of multipotent drugs for the teratment of Alzheimer's disease 93
Synthetic polyamines: an overview of their multiple biological activities. 91
Rational design of multitarget-directed antioxidants: merging memoquin and lipocrine molecular frameworks 91
Reversible human serum albumin binding of lipocrine: a circular dichroism study. 90
Modulation of Keap1/Nrf2/ARE signaling pathway by curcuma- And garlic-derived hybrids 90
New quinazoline compounds as non-peptidomimetic BACE-1 inhibitors in the treatment of Alzheimer's disease 87
Tacrine Derivatives and Alzheimer's Disease 87
Combining galantamine and memantine in dual-target new chemical entities for the treatment of Alzheimer’s disease 87
Polyamines in Drug Discovery: From the Universal Template Approach to the Multitarget-Directed Ligand Design Strategy 86
Novel targets for “old” polyamine analogues: monoamine oxidases and benextramine derivatives 85
Recent advances in alpha1-adrenoreceptor antagonists as pharmacological tools and therapeutic agents. 84
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EVALUATION OF NOVEL POLYAMINE AND MEMANTINE-DERIVATIVE COMPOUNDS TARGETING NMDA RECEPTORS FOR ALZHEIMER'S DISEASE TREATMENT 80
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Methoctramine-related polyamines as antinociceptive agents 78
Methoctramine analogues inhibit responses to capsaicin in DRG neurons and cloned TRPV1 78
Eye-Light on Age-Related Macular Degeneration: Targeting Nrf2-Pathway as a Novel Therapeutic Strategy for Retinal Pigment Epithelium 78
Methoctramine analogues inhibit capsaicin induced currents in dorsal root ganglia and Xenopus oocytes expressing TRPV1 77
Natural-product-inspired modulators of Alzheimer’s disease: focus on amyloid and oxidative stress 77
Reversible HSA binding of lipocrine: a circular dichroism study. 74
Synthesis of monomeric derivatives to probe Memoquin bivalent interactions 74
A nature‐inspired nrf2 activator protects retinal explants from oxidative stress and neurodegeneration 74
In vitro methods for characterizing new multi-potent compounds for Alzheimer’s disease 73
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Nature-inspired Nrf2 activators in retinal pigment epithelial cells: a source for therapeutics in age-related macular degeneration 73
NRF2 and PPAR-γ Pathways in Oligodendrocyte Progenitors: Focus on Ros Protection, Mitochondrial Biogenesis and Promotion of Cell Differentiation 70
Rational design of dimebon bivalent ligands against Alzheimer’s disease 67
Multitarget-directed drug design strategy: novel hybrid compounds between lipocrine and carvedilol 67
Exploiting RNA as anticancer target for synthetic polyamines 67
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Targeting Cytokine Release Through the Differential Modulation of Nrf2 and NF-κB Pathways by Electrophilic/Non-Electrophilic Compounds 66
Controlled Iontophoretic Delivery in Vitro and in Vivo of ARN14140 - A Multitarget Compound for Alzheimer's Disease 64
Inhibition of β-Amyloid Aggregation in Alzheimer's Disease: The Key Role of (Pro)electrophilic Warheads 57
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Totale 10.584
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Categoria #
all - tutte 30.786
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 30.786
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20201.802 0 0 0 0 0 260 351 393 331 200 122 145
2020/20211.469 317 100 28 73 49 122 26 136 155 102 105 256
2021/20221.920 104 80 124 140 165 126 40 160 67 194 348 372
2022/20231.916 217 287 100 239 112 136 82 95 367 48 168 65
2023/2024775 37 105 49 54 71 217 41 61 26 44 40 30
2024/20251.491 142 287 254 182 528 98 0 0 0 0 0 0
Totale 11.278