A review. The authors review the investigations reported in the past decade that illustrate the ability of medicinal chemists to design multi-target-directed ligands (MTDLs) to confront neurodegenerative diseases. The authors briefly illustrate the multifactorial nature of these diseases before discussing the possible development of MTDLs in light of the known mol. bases of the main neurodegenerative pathologies.
Multi-target-Directed Ligands To Combat Neurodegenerative Diseases / A. Cavalli; M. L. Bolognesi; A. Minarini; M.Rosini; V. Tumiatti; M. Recanatini; C. Melchiorre. - In: JOURNAL OF MEDICINAL CHEMISTRY. - ISSN 0022-2623. - STAMPA. - 51:(2008), pp. 347-372. [10.1021/jm7009364]
Multi-target-Directed Ligands To Combat Neurodegenerative Diseases
CAVALLI, ANDREA;BOLOGNESI, MARIA LAURA;MINARINI, ANNA;ROSINI, MICHELA;TUMIATTI, VINCENZO;RECANATINI, MAURIZIO;MELCHIORRE, CARLO
2008
Abstract
A review. The authors review the investigations reported in the past decade that illustrate the ability of medicinal chemists to design multi-target-directed ligands (MTDLs) to confront neurodegenerative diseases. The authors briefly illustrate the multifactorial nature of these diseases before discussing the possible development of MTDLs in light of the known mol. bases of the main neurodegenerative pathologies.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
