A review. Alzheimer's disease is a complex neurodegenerative disorder with a multifaceted pathogenesis. This fact has long halted the development of effective anti-Alzheimer drugs. Recently, however, basis for a therapeutic strategy based on multi-target-directed ligands has been formed. In this context, dual binding site acetylcholinesterase inhibitors represent a suitable starting point. The rational modification of their structures to provide them with addnl. biol. properties has emerged as a successful approach.

M. L. Bolognesi, A. Minarini, M. Rosini, V. Tumiatti, C. Melchiorre (2008). From dual binding site acetylcholinesterase inhibitors to multi-target-directed ligands (MTDLs): a step forward in the treatment of Alzheimer's disease. MINI-REVIEWS IN MEDICINAL CHEMISTRY, 8, 960-967 [10.2174/138955708785740652].

From dual binding site acetylcholinesterase inhibitors to multi-target-directed ligands (MTDLs): a step forward in the treatment of Alzheimer's disease

BOLOGNESI, MARIA LAURA;MINARINI, ANNA;ROSINI, MICHELA;TUMIATTI, VINCENZO;MELCHIORRE, CARLO
2008

Abstract

A review. Alzheimer's disease is a complex neurodegenerative disorder with a multifaceted pathogenesis. This fact has long halted the development of effective anti-Alzheimer drugs. Recently, however, basis for a therapeutic strategy based on multi-target-directed ligands has been formed. In this context, dual binding site acetylcholinesterase inhibitors represent a suitable starting point. The rational modification of their structures to provide them with addnl. biol. properties has emerged as a successful approach.
2008
M. L. Bolognesi, A. Minarini, M. Rosini, V. Tumiatti, C. Melchiorre (2008). From dual binding site acetylcholinesterase inhibitors to multi-target-directed ligands (MTDLs): a step forward in the treatment of Alzheimer's disease. MINI-REVIEWS IN MEDICINAL CHEMISTRY, 8, 960-967 [10.2174/138955708785740652].
M. L. Bolognesi; A. Minarini; M. Rosini; V. Tumiatti; C. Melchiorre
File in questo prodotto:
Eventuali allegati, non sono esposti

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/66210
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 8
  • Scopus 65
  • ???jsp.display-item.citation.isi??? 61
social impact