Inspired by the concept of bivalent ligands, we prepared a small set of analogues of the drug candidate dimebon. They were shown to inhibit AChE, Aβ42 aggregation, and NMDA receptor activation to a greater extent than dimebon. Some of these compounds also enhanced the survival of chicken neurons under apoptosis-inducing conditions.
Michela Rosini, Elena Simoni, Manuela Bartolini, Elena Soriano, José Marco-Contelles, Vincenza Andrisano, et al. (2013). The bivalent ligand approach as a tool for improving the in vitro anti-Alzheimer multitarget profile of dimebon. CHEMMEDCHEM, 8, 1276-1281 [10.1002/cmdc.201300263].
The bivalent ligand approach as a tool for improving the in vitro anti-Alzheimer multitarget profile of dimebon
ROSINI, MICHELA;SIMONI, ELENA;BARTOLINI, MANUELA;ANDRISANO, VINCENZA;MONTI, BARBARA;BOLOGNESI, MARIA LAURA
2013
Abstract
Inspired by the concept of bivalent ligands, we prepared a small set of analogues of the drug candidate dimebon. They were shown to inhibit AChE, Aβ42 aggregation, and NMDA receptor activation to a greater extent than dimebon. Some of these compounds also enhanced the survival of chicken neurons under apoptosis-inducing conditions.File in questo prodotto:
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