Structure-Activity Relationships of Acetylcholinesterase Noncovalent Inhibitors Based on a Polyamine Backbone. 4. Futher Investigation on the Inner Spacer.

Tumiatti, Vincenzo; Milelli, Andrea; Minarini, Anna; Rosini, Michela; Bolognesi, Maria Laura; Micco, M.; Andrisano, Vincenza; Bartolini, Manuela; Mancini, Francesco; Recanatini, Maurizio; Cavalli, Andrea; Melchiorre, Carlo

doi:10.1021/jm8009684

Novel multi-target-directed ligands were designed by replacing the inner dipiperidino function of 3 with less flexible or completely rigid moieties to obtain compounds endowed with multiple biological properties that might be relevant to Alzheimer’s disease. 15 was the most interesting, inhibiting AChE in the nanomolar range and inhibiting AChE-induced and self-promoted beta-amyloid aggregation in the micromolar range.

Titolo:	Structure-Activity Relationships of Acetylcholinesterase Noncovalent Inhibitors Based on a Polyamine Backbone. 4. Futher Investigation on the Inner Spacer.
Autore/i:	TUMIATTI, VINCENZO; MILELLI, ANDREA; MINARINI, ANNA; ROSINI, MICHELA; BOLOGNESI, MARIA LAURA; M. Micco; ANDRISANO, VINCENZA; BARTOLINI, MANUELA; MANCINI, FRANCESCO; RECANATINI, MAURIZIO; CAVALLI, ANDREA; MELCHIORRE, CARLO
Autore/i Unibo:	TUMIATTI, VINCENZO MILELLI, ANDREA MINARINI, ANNA ROSINI, MICHELA BOLOGNESI, MARIA LAURA M. Micco ANDRISANO, VINCENZA BARTOLINI, MANUELA MANCINI, FRANCESCO RECANATINI, MAURIZIO CAVALLI, ANDREA MELCHIORRE, CARLO mostra contributor esterni nascondi contributor esterni
Anno:	2008
Rivista:	JOURNAL OF MEDICINAL CHEMISTRY
Digital Object Identifier (DOI):	http://dx.doi.org/10.1021/jm8009684
Abstract:	Novel multi-target-directed ligands were designed by replacing the inner dipiperidino function of 3 with less flexible or completely rigid moieties to obtain compounds endowed with multiple biological properties that might be relevant to Alzheimer’s disease. 15 was the most interesting, inhibiting AChE in the nanomolar range and inhibiting AChE-induced and self-promoted beta-amyloid aggregation in the micromolar range.
Data prodotto definitivo in UGOV:	2008-12-03 18:14:12
Appare nelle tipologie:	1.01 Articolo in rivista

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http://hdl.handle.net/11585/66207

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