MILELLI, ANDREA
MILELLI, ANDREA
DIPARTIMENTO DI SCIENZE PER LA QUALITA' DELLA VITA
Docenti di ruolo di IIa fascia
First in Class Dual Non-ATP-Competitive Glycogen Synthase Kinase 3β/Histone Deacetylase Inhibitors as a Potential Therapeutic to Treat Alzheimer’s Disease
2024 Santini A.; Tassinari E.; Poeta E.; Loi M.; Ciani E.; Trazzi S.; Piccarducci R.; Daniele S.; Martini C.; Pagliarani B.; Tarozzi A.; Bersani M.; Spyrakis F.; Danková D.; Olsen C.A.; Soldati R.; Tumiatti V.; Montanari S.; De Simone A.; Milelli A.
Integrating a quinone substructure into histone deacetylase inhibitors to cope with Alzheimer's disease and cancer
2024 Guardigni M.; Greco G.; Poeta E.; Santini A.; Tassinari E.; Bergamini C.; Zalambani C.; De Simone A.; Andrisano V.; Uliassi E.; Monti B.; Bolognesi M.L.; Fimognari C.; Milelli A.
From Monoamine Oxidase Inhibition to Antiproliferative Activity: New Biological Perspectives for Polyamine Analogs
2023 Nordio G.; Piazzola F.; Cozza G.; Rossetto M.; Cervelli M.; Minarini A.; Basagni F.; Tassinari E.; Dalla Via L.; Milelli A.; Di Paolo M.L.
PROTAC-Induced Glycogen Synthase Kinase 3β Degradation as a Potential Therapeutic Strategy for Alzheimer’s Disease
2023 Guardigni M.; Pruccoli L.; Santini A.; Simone A.D.; Bersani M.; Spyrakis F.; Frabetti F.; Uliassi E.; Andrisano V.; Pagliarani B.; Fernández-Gómez P.; Palomo V.; Bolognesi M.L.; Tarozzi A.; Milelli A.
Targeted Protein Degradation for Infectious Diseases: from Basic Biology to Drug Discovery
2023 Rocío Marisol Espinoza Chávez; Salerno A.; Liuzzi A.; Ilari A.; Milelli A.; Uliassi E.; Bolognesi M.L.
Asymmetric Organocatalysis: A Survival Guide to Medicinal Chemists
2022 EFRAIM REYES; Liher Prieto; ANDREA MILELLI
Bovine Serum Amine Oxidase and Polyamine Analogues: Chemical Synthesis and Biological Evaluation Integrated with Molecular Docking and 3-D QSAR Studies
2022 Ragno, Rino; Minarini, Anna; Proia, Eleonora; Lorenzo, Antonini; Milelli, Andrea; Tumiatti, Vincenzo; Fiore, Marco; Fino, Pasquale; Rutigliano, Lavinia; Fioravanti, Rossella; Tahara, Tomoaki; Pacella, Elena; Greco, Antonio; Canettieri, Gianluca; Di Paolo, Maria Luisa; Agostinelli, Enzo
Enriching Proteolysis Targeting Chimeras with a Second Modality: When Two Are Better Than One
2022 Salerno, Alessandra; Seghetti, Francesca; Caciolla, Jessica; Uliassi, Elisa; Testi, Eleonora; Guardigni, Melissa; Roberti, Marinella; Milelli, Andrea; Bolognesi, Maria Laura
PROTAC-INDUCED GLYCOGEN SYNTHASE KINASE 3B DEGRADATION
2022 Santini, A.; Pruccoli, L.; Guardigni, M.; De Simone, A.; Spyrakis, F.; Frabetti, F.; Andrisano, V.; Bolognesi, M. L.; Tarozzi, A.; Milelli, A.
Glycogen Synthase Kinase 3β: A New Gold Rush in Anti-Alzheimer’s Disease Multitarget Drug Discovery?
2021 Angela De Simone, Vincenzo Tumiatti, VIncenza Andrisano, Andrea Milelli
Treatment with a GSK-3β/HDAC Dual Inhibitor Restores Neuronal Survival and Maturation in an In Vitro and In Vivo Model of CDKL5 Deficiency Disorder
2021 Loi, Manuela; Gennaccaro, Laura; Fuchs, Claudia; Trazzi, Stefania; Medici, Giorgio; Galvani, Giuseppe; Mottolese, Nicola; Tassinari, Marianna; Giorgini, Roberto Rimondini; Milelli, Andrea; Ciani, Elisabetta
Targeting topoisomerase II with trypthantrin derivatives: Discovery of 7-((2-(dimethylamino)ethyl)amino)indolo[2,1-b]quinazoline-6,12-dione as an antiproliferative agent and to treat cancer
2020 Catanzaro E.; Betari N.; Arencibia J.M.; Montanari S.; Sissi C.; De Simone A.; Vassura I.; Santini A.; Andrisano V.; Tumiatti V.; De Vivo M.; Krysko D.V.; Rocchi M.B.L.; Fimognari C.; Milelli A.
Benextramine and derivatives as novel human monoamine oxidases inhibitors: an integrated approach
2019 Di Paolo, Maria Luisa; Cozza, Giorgio; Milelli, Andrea; Zonta, Francesca; Sarno, Stefania; Minniti, Elirosa; Ursini, Fulvio; Rosini, Michela; Minarini, Anna
COMPOSTI ISOTIOCIANATI E ISOSELENCIANATI
2019 Fimognari C, Sestili P, Milelli A
Correction: Discovery of the First-in-Class GSK-3β/HDAC Dual Inhibitor as Disease-Modifying Agent to Combat Alzheimer's Disease (ACS Medicinal Chemistry Letters (2019) 10: 4 (469−474) DOI: 10.1021/acsmedchemlett.8b00507)
2019 De Simone A.; La Pietra V.; Betari N.; Petragnani N.; Conte M.; Daniele S.; Pietrobono D.; Martini C.; Petralla S.; Casadei R.; Davani L.; Frabetti F.; Russomanno P.; Novellino E.; Montanari S.; Tumiatti V.; Ballerini P.; Sarno F.; Nebbioso A.; Altucci L.; Monti B.; Andrisano V.; Milelli A.
Deuterium Incorporation Protects Cells from Oxidative Damage
2019 Sestili P.; Brigotti M.; Calcabrini C.; Turrini E.; Arfilli V.; Carnicelli D.; Lucarini M.; Mazzanti A.; Milelli A.; Righi V.; Fimognari C.
Discovery of the First-in-Class GSK-3β/HDAC Dual Inhibitor as Disease-Modifying Agent To Combat Alzheimer's Disease.
2019 De Simone A, La Pietra V, Betari N, Petragnani N, Conte M, Daniele S, Pietrobono D, Martini C, Petralla S, Casadei R, Davani L, Frabetti F, Russomanno P, Novellino E, Montanari S, Tumiatti V, Ballerini P, Sarno F, Nebbioso A, Altucci L, Monti B, Andrisano V, Milelli A.
Distinct biological responses of metastatic castration resistant prostate cancer cells upon exposure to G-quadruplex interacting naphthalenediimide derivatives
2019 Recagni M.; Greco M.L.; Milelli A.; Minarini A.; Zaffaroni N.; Folini M.; Sissi C.
Exploring the activity of polyamine analogues on polyamine and spermine oxidase: methoctramine, a potent and selective inhibitor of polyamine oxidase
2019 Di Paolo, Maria Luisa; Cervelli, Manuela; Mariottini, Paolo; Leonetti, Alessia; Polticelli, Fabio; Rosini, Michela; Milelli, Andrea; Basagni, Filippo; Venerando, Rina; Agostinelli, Enzo; Minarini, Anna
Histone Deacetylase Inhibitors as Multitarget Ligands: New Players in Alzheimer's Disease Drug Discovery?
2019 De Simone Angela; Milelli Andrea
| Titolo | Autore(i) | Anno | Periodico | Editore | Tipo | File |
|---|---|---|---|---|---|---|
| First in Class Dual Non-ATP-Competitive Glycogen Synthase Kinase 3β/Histone Deacetylase Inhibitors as a Potential Therapeutic to Treat Alzheimer’s Disease | Santini A.; Tassinari E.; Poeta E.; Loi M.; Ciani E.; Trazzi S.; Piccarducci R.; Daniele S.; Mart...ini C.; Pagliarani B.; Tarozzi A.; Bersani M.; Spyrakis F.; Danková D.; Olsen C.A.; Soldati R.; Tumiatti V.; Montanari S.; De Simone A.; Milelli A. | 2024-01-01 | ACS CHEMICAL NEUROSCIENCE | - | 1.01 Articolo in rivista | acs-cn.pdf; cn4c00061_si_001.pdf |
| Integrating a quinone substructure into histone deacetylase inhibitors to cope with Alzheimer's disease and cancer | Guardigni M.; Greco G.; Poeta E.; Santini A.; Tassinari E.; Bergamini C.; Zalambani C.; De Simone... A.; Andrisano V.; Uliassi E.; Monti B.; Bolognesi M.L.; Fimognari C.; Milelli A. | 2024-01-01 | RSC MEDICINAL CHEMISTRY | - | 1.01 Articolo in rivista | d4md00175c.pdf; d4md00175c1.pdf |
| From Monoamine Oxidase Inhibition to Antiproliferative Activity: New Biological Perspectives for Polyamine Analogs | Nordio G.; Piazzola F.; Cozza G.; Rossetto M.; Cervelli M.; Minarini A.; Basagni F.; Tassinari E....; Dalla Via L.; Milelli A.; Di Paolo M.L. | 2023-01-01 | MOLECULES | - | 1.01 Articolo in rivista | molecules-28-06329-v3.pdf; molecules-2562834-supplementary.pdf |
| PROTAC-Induced Glycogen Synthase Kinase 3β Degradation as a Potential Therapeutic Strategy for Alzheimer’s Disease | Guardigni M.; Pruccoli L.; Santini A.; Simone A.D.; Bersani M.; Spyrakis F.; Frabetti F.; Uliassi... E.; Andrisano V.; Pagliarani B.; Fernández-Gómez P.; Palomo V.; Bolognesi M.L.; Tarozzi A.; Milelli A. | 2023-01-01 | ACS CHEMICAL NEUROSCIENCE | - | 1.01 Articolo in rivista | acschemneuro.3c00096.pdf; cn3c00096_si_001.pdf |
| Targeted Protein Degradation for Infectious Diseases: from Basic Biology to Drug Discovery | Rocío Marisol Espinoza Chávez; Salerno A.; Liuzzi A.; Ilari A.; Milelli A.; Uliassi E.; Bolognesi... M.L. | 2023-01-01 | ACS BIO & MED CHEM AU | - | 1.01 Articolo in rivista | acsbiomedchemau.2c00063.pdf |
| Asymmetric Organocatalysis: A Survival Guide to Medicinal Chemists | EFRAIM REYES; Liher Prieto; ANDREA MILELLI | 2022-01-01 | MOLECULES | - | 1.01 Articolo in rivista | molecules-28-00271 (1).pdf |
| Bovine Serum Amine Oxidase and Polyamine Analogues: Chemical Synthesis and Biological Evaluation Integrated with Molecular Docking and 3-D QSAR Studies | Ragno, Rino; Minarini, Anna; Proia, Eleonora; Lorenzo, Antonini; Milelli, Andrea; Tumiatti, Vince...nzo; Fiore, Marco; Fino, Pasquale; Rutigliano, Lavinia; Fioravanti, Rossella; Tahara, Tomoaki; Pacella, Elena; Greco, Antonio; Canettieri, Gianluca; Di Paolo, Maria Luisa; Agostinelli, Enzo | 2022-01-01 | JOURNAL OF CHEMICAL INFORMATION AND MODELING | - | 1.01 Articolo in rivista | Accepted.20220504_con link.pdf; SI JCIM 2022.pdf; ci2c00559_si_002.xlsx |
| Enriching Proteolysis Targeting Chimeras with a Second Modality: When Two Are Better Than One | Salerno, Alessandra; Seghetti, Francesca; Caciolla, Jessica; Uliassi, Elisa; Testi, Eleonora; Gua...rdigni, Melissa; Roberti, Marinella; Milelli, Andrea; Bolognesi, Maria Laura | 2022-01-01 | JOURNAL OF MEDICINAL CHEMISTRY | - | 1.01 Articolo in rivista | acs.jmedchem.2c00302.pdf |
| PROTAC-INDUCED GLYCOGEN SYNTHASE KINASE 3B DEGRADATION | Santini, A.; Pruccoli, L.; Guardigni, M.; De Simone, A.; Spyrakis, F.; Frabetti, F.; Andrisano, V....; Bolognesi, M. L.; Tarozzi, A.; Milelli, A. | 2022-01-01 | - | - | 4.03 Poster | - |
| Glycogen Synthase Kinase 3β: A New Gold Rush in Anti-Alzheimer’s Disease Multitarget Drug Discovery? |
Angela De Simone, Vincenzo Tumiatti, VIncenza Andrisano, Andrea Milelli |
2021-01-01 | JOURNAL OF MEDICINAL CHEMISTRY | - | 1.01 Articolo in rivista | acs.jmedchem.0c00931.pdf |
| Treatment with a GSK-3β/HDAC Dual Inhibitor Restores Neuronal Survival and Maturation in an In Vitro and In Vivo Model of CDKL5 Deficiency Disorder | Loi, Manuela; Gennaccaro, Laura; Fuchs, Claudia; Trazzi, Stefania; Medici, Giorgio; Galvani, Gius...eppe; Mottolese, Nicola; Tassinari, Marianna; Giorgini, Roberto Rimondini; Milelli, Andrea; Ciani, Elisabetta | 2021-01-01 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - | 1.01 Articolo in rivista | Loi et al 2021.pdf; ijms-1212824-supplementary.pdf |
| Targeting topoisomerase II with trypthantrin derivatives: Discovery of 7-((2-(dimethylamino)ethyl)amino)indolo[2,1-b]quinazoline-6,12-dione as an antiproliferative agent and to treat cancer | Catanzaro E.; Betari N.; Arencibia J.M.; Montanari S.; Sissi C.; De Simone A.; Vassura I.; Santin...i A.; Andrisano V.; Tumiatti V.; De Vivo M.; Krysko D.V.; Rocchi M.B.L.; Fimognari C.; Milelli A. | 2020-01-01 | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - | 1.01 Articolo in rivista | Draft_revised_Milelli no copertina.pdf |
| Benextramine and derivatives as novel human monoamine oxidases inhibitors: an integrated approach | Di Paolo, Maria Luisa; Cozza, Giorgio; Milelli, Andrea; Zonta, Francesca; Sarno, Stefania; Minnit...i, Elirosa; Ursini, Fulvio; Rosini, Michela; Minarini, Anna | 2019-01-01 | THE FEBS JOURNAL | - | 1.01 Articolo in rivista | - |
| COMPOSTI ISOTIOCIANATI E ISOSELENCIANATI | Fimognari C, Sestili P, Milelli A | 2019-01-01 | - | - | 6.01 Brevetto | - |
| Correction: Discovery of the First-in-Class GSK-3β/HDAC Dual Inhibitor as Disease-Modifying Agent to Combat Alzheimer's Disease (ACS Medicinal Chemistry Letters (2019) 10: 4 (469−474) DOI: 10.1021/acsmedchemlett.8b00507) | De Simone A.; La Pietra V.; Betari N.; Petragnani N.; Conte M.; Daniele S.; Pietrobono D.; Martin...i C.; Petralla S.; Casadei R.; Davani L.; Frabetti F.; Russomanno P.; Novellino E.; Montanari S.; Tumiatti V.; Ballerini P.; Sarno F.; Nebbioso A.; Altucci L.; Monti B.; Andrisano V.; Milelli A. | 2019-01-01 | ACS MEDICINAL CHEMISTRY LETTERS | - | 1.01 Articolo in rivista | - |
| Deuterium Incorporation Protects Cells from Oxidative Damage | Sestili P.; Brigotti M.; Calcabrini C.; Turrini E.; Arfilli V.; Carnicelli D.; Lucarini M.; Mazza...nti A.; Milelli A.; Righi V.; Fimognari C. | 2019-01-01 | OXIDATIVE MEDICINE AND CELLULAR LONGEVITY | - | 1.01 Articolo in rivista | SestiliEtAl_2019_OxidativeMedCellLong.pdf |
| Discovery of the First-in-Class GSK-3β/HDAC Dual Inhibitor as Disease-Modifying Agent To Combat Alzheimer's Disease. | De Simone A, La Pietra V, Betari N, Petragnani N, Conte M, Daniele S, Pietrobono D, Martini C, Pe...tralla S, Casadei R, Davani L, Frabetti F, Russomanno P, Novellino E, Montanari S, Tumiatti V, Ballerini P, Sarno F, Nebbioso A, Altucci L, Monti B, Andrisano V, Milelli A. | 2019-01-01 | ACS MEDICINAL CHEMISTRY LETTERS | - | 1.01 Articolo in rivista | AM11585-685764.pdf |
| Distinct biological responses of metastatic castration resistant prostate cancer cells upon exposure to G-quadruplex interacting naphthalenediimide derivatives | Recagni M.; Greco M.L.; Milelli A.; Minarini A.; Zaffaroni N.; Folini M.; Sissi C. | 2019-01-01 | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - | 1.01 Articolo in rivista | - |
| Exploring the activity of polyamine analogues on polyamine and spermine oxidase: methoctramine, a potent and selective inhibitor of polyamine oxidase | Di Paolo, Maria Luisa; Cervelli, Manuela; Mariottini, Paolo; Leonetti, Alessia; Polticelli, Fabio...; Rosini, Michela; Milelli, Andrea; Basagni, Filippo; Venerando, Rina; Agostinelli, Enzo; Minarini, Anna | 2019-01-01 | JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | - | 1.01 Articolo in rivista | 99. J.Enz. Inhib. Med Chem 2019.pdf |
| Histone Deacetylase Inhibitors as Multitarget Ligands: New Players in Alzheimer's Disease Drug Discovery? | De Simone Angela; Milelli Andrea | 2019-01-01 | CHEMMEDCHEM | - | 1.01 Articolo in rivista | - |