CRIS Current Research Information System

BISI, ALESSANDRA
 Distribuzione geografica
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Continente #
NA - Nord America 4.931
EU - Europa 3.187
AS - Asia 1.883
AF - Africa 214
SA - Sud America 13
OC - Oceania 9
Continente sconosciuto - Info sul continente non disponibili 3
Totale 10.240
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Nazione #
US - Stati Uniti d'America 4.906
GB - Regno Unito 778
IT - Italia 762
CN - Cina 670
SG - Singapore 463
DE - Germania 432
VN - Vietnam 358
SE - Svezia 322
UA - Ucraina 229
IN - India 175
RU - Federazione Russa 128
FR - Francia 124
IE - Irlanda 120
JO - Giordania 98
ZA - Sudafrica 63
CI - Costa d'Avorio 61
BG - Bulgaria 59
TG - Togo 58
EE - Estonia 52
FI - Finlandia 37
CH - Svizzera 29
IR - Iran 29
ID - Indonesia 25
CA - Canada 23
JP - Giappone 19
SC - Seychelles 17
GR - Grecia 15
BE - Belgio 14
CZ - Repubblica Ceca 14
HR - Croazia 13
ES - Italia 12
PL - Polonia 10
AT - Austria 9
NL - Olanda 9
TR - Turchia 8
LB - Libano 7
AU - Australia 6
BR - Brasile 6
HK - Hong Kong 6
NG - Nigeria 6
PT - Portogallo 6
EG - Egitto 5
PK - Pakistan 5
HU - Ungheria 4
A2 - ???statistics.table.value.countryCode.A2??? 3
BY - Bielorussia 3
DZ - Algeria 3
EC - Ecuador 3
KZ - Kazakistan 3
NZ - Nuova Zelanda 3
CL - Cile 2
IQ - Iraq 2
KR - Corea 2
KW - Kuwait 2
LK - Sri Lanka 2
MX - Messico 2
MY - Malesia 2
PH - Filippine 2
RO - Romania 2
AE - Emirati Arabi Uniti 1
AR - Argentina 1
BD - Bangladesh 1
LA - Repubblica Popolare Democratica del Laos 1
LT - Lituania 1
MD - Moldavia 1
NO - Norvegia 1
PE - Perù 1
RS - Serbia 1
SA - Arabia Saudita 1
SD - Sudan 1
UZ - Uzbekistan 1
Totale 10.240
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Città #
Southend 702
Fairfield 528
Chandler 521
Ashburn 431
Singapore 387
Santa Clara 352
Woodbridge 298
Bologna 253
Dong Ket 251
Houston 245
Wilmington 244
Seattle 239
Cambridge 207
Princeton 175
Ann Arbor 163
Jacksonville 151
Boardman 129
Dublin 120
Amman 98
New York 85
Westminster 74
Nanjing 67
Padova 62
Abidjan 61
Sofia 59
Lomé 58
Berlin 54
Bremen 45
Jinan 41
San Diego 41
Beijing 40
Saint Petersburg 37
Helsinki 35
Shenyang 35
Milan 32
Redmond 32
Hebei 27
Mülheim 27
Nanchang 27
Bern 26
Jakarta 24
Tianjin 23
Shanghai 19
Jiaxing 18
Medford 18
Tokyo 18
Changsha 17
Mahé 17
Guangzhou 16
Olalla 16
Redwood City 16
Venezia 16
Des Moines 15
Mountain View 15
Boydton 14
Brussels 14
Dearborn 14
Kunming 13
Los Angeles 13
Munich 13
Zhengzhou 12
Phoenix 11
Verona 11
Fremont 10
San Giorgio di Piano 10
Taiyuan 10
Wuhan 10
Falls Church 9
Ningbo 9
Rome 9
Turin 9
Brno 8
Haikou 8
Hangzhou 8
Norwalk 8
Casoria 7
Fuzhou 7
London 7
Pune 7
San Jose 7
Abeokuta 6
Asciano 6
Fidenza 6
Lanzhou 6
Modena 6
Ravenna 6
Rimini 6
Shenzhen 6
Urbino 6
Vienna 6
Villaurbana 6
Ancona 5
Bühl 5
Düsseldorf 5
Forlì 5
Hong Kong 5
Hyderabad 5
Madrid 5
Moscow 5
Paris 5
Totale 7.076
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Nome #
1,4-dihydropyridine derivatives as calcium channel modulators: the role of 3-methoxy-flavone moiety 276
Discovery of novel benzofuran-based compounds with neuroprotective and immunomodulatory properties for Alzheimer's disease treatment 228
Multitarget Strategy to Address Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and Computational Studies of Coumarin-Based Derivatives 197
Cholinesterase inhibitors: xanthostigmine derivatives blocking the acetylcholinesterase-induced beta-amyloid aggregation. 183
2-Arylbenzofuran-based molecules as multipotent Alzheimer's disease modifying agents 167
Design, synthesis and biological profile of new inhibitors of multidrug resistance associated proteins carrying a polycyclic scaffold 156
Benzofuran-Based Hybrid Compounds for the Inhibition of Cholinesterase Activity, Abeta Amyloid Aggregation, and Abeta Neurotoxicity 155
Analogues of the dual acetylcholinesterase inhibitor AP2238: synthesis and SAR 154
Benzophenones as xanthone-open model CYP11B1 inhibitors potentially useful for promoting wound healing 152
Benzophenone-based derivatives: A novel series of potent and selective dual inhibitors of acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation 151
Versatility of the Curcumin Scaffold: Discovery of Potent and Balanced Dual BACE-1 and GSK-3β Inhibitors 151
Cardiovascular profile of xanthone-based 1,4 dihydropyridines bearing a lidoflazine pharmacophore fragment 150
Exploiting the chalcone scaffold to develop multifunctional agents for Alzheimer’s disease 147
Fatty Acid Amide Hydrolase (FAAH), Acetylcholinesterase (AChE), and Butyrylcholinesterase (BuChE): Networked Targets for the Development of Carbamates as Potential Anti-Alzheimer's Disease Agents 147
Extensive SAR and computational studies of 3-{4-[(benzylmethylamino)methyl]phenyl}-6,7-dimethoxy-2H-2-chromenone (AP2238) derivatives. 144
Anthracene Based Compounds as New L-type Ca2+ Channel Blockers: Design, Synthesis, and Full Biological Profile 142
Identification of chalcone-based antileishmanial agents targeting trypanothione reductase 136
Emerging targets in neurodegeneration: new opportunities for Alzheimer's disease treatment? 135
A Computational Assay of Estrogen Receptor α Antagonists Reveals the Key Common Structural Traits of Drugs Effectively Fighting Refractory Breast Cancers 135
CHOLINESTERASE INHIBITORS: SAR AND ENZYME INHIBITORY ACTIVITY OF 3-[omega-(BENZYLMETHYLAMINO)ALKOXY]XANTHEN-9-ONES 135
Identification of a new tamoxifen-xanthene hybrid as pro-apoptotic anticancer agent 131
Enantioselective nonsteroidal aromatase inhibitors identified through a multidisciplinary medicinal chemistry approach 130
null 123
Fluorinated benzophenone derivatives: balanced multipotent agents for Alzheimer's disease 122
Naturally inspired molecules as multifunctional agents for Alzheimer's disease treatment 121
null 118
Polycyclic maleimide-based derivatives as first dual modulators of neuronal calcium channels and GSK-3β for Alzheimer's disease treatment 118
Imidazolylmethylbenzophenones as highly potent aromatase inhibitors. 117
Design, synthesis, and evaluation of benzophenone derivatives as novel acetylcholinesterase inhibitors 117
Antitumor profile of new phenothiazine derivatives 116
Homopterocarpanes as bridged triarylethylene analogues: synthesis and antagonistic effects in human MCF-7 breast cancer cells 116
Structure-Activity Relationships and Binding Mode in the Human Acetylcholinesterase Active Site of Pseudo-Irreversible Inhibitors Related to Xanthostigmine 114
Lead optimization providing a series of flavone derivatives as potent nonsteroidal inhibitors of the cytochrome P450 aromatase enzyme 113
Benzophenone derivatives as Inhibitors of Acetylcholinesterase 113
Curcumin-1,2,3-triazole conjugation for targeting the cancer apoptosis machinery. 113
Novel Curcumin-Diethyl Fumarate Hybrid as a Dualistic GSK-3β Inhibitor/Nrf2 Inducer for the Treatment of Parkinson's Disease 113
New potent P-glycoprotein inhibitors carrying a polycyclic scaffold 110
Derivati a struttura benzofenonica come inibitori dell'acetilcolinesterasi 109
Multi-target strategy to address Alzheimer’s disease: Design, synthesis and biological evaluation of new tacrine-based dimers 109
null 105
New derivatives of xanthenone-4-acetic acid: synthesis, pharmacological profile and effect on TNF-alpha and NO production by human immune cells 104
In vitro studies of flavon-8-acetic acid analogues 103
Hybrid drugs for Alzheimer's disease: new indanone derivatives bearing a pharmacophoric fragment of AP2238 103
Novel Aldosterone Synthase Inhibitors with Extended Carbocyclic Skeleton by a Combined Ligand-Based and Structure-Based Drug Design Approach 103
Natural-like Chalcones with Antitumor Activity on Human MG63 Osteosarcoma Cells 103
Design of Multifunctional Compounds for Cardiovascular Disease: From Natural Scaffolds to “Classical” Multitarget Approach 102
New Coumarin derivatives as cholinergic and cannabinoid system modulators 102
Design, Synthesis, and Biological and Crystallographic Evaluation of Novel Inhibitors ofPlasmodium falciparumEnoyl-ACP-reductase (PfFabI) 101
Functionalization of the chalcone scaffold for the discovery of novel lead compounds targeting fungal infections 100
In vitro biological activity of new analogues of flavon-8-acetic acid 98
Nonsteroidal Aromatase inhibitors: synthesis and evaluation of new flavone derivatives 98
Hybrid-Based Multi-Target Ligands for the Treatment of Alzheimer's Disease 98
PREPARATION AND STEREOCHEMICAL CHARACTERIZATION OF ENANTIOMERIC HOMOISOFLAVONES ACTIVE AS AROMATASE INHIBITORS 96
Novel highly potent and selective nonsteroidal aromatase inhibitors: synthesis, biological evaluation and structure-activity relationships investigation 96
Progettazione e sintesi di derivati benzofuranici per la malattia di Alzheimer 95
Multidrug resistance reverting activity and antitumor profile of new phenothiazine derivatives 95
Balanced dual acting compounds targeting aromatase and estrogen receptor α as an emerging therapeutic opportunity to counteract estrogen responsive breast cancer 95
Targeting the Bacterial Membrane with a New Polycyclic Privileged Structure: A Powerful Tool To Face Staphylococcus aureus Infections 94
Reconsidering Aromatase for Breast Cancer Treatment: New Roles for an Old Target 94
Modulation of Cytochromes P450 with Xanthone-Based Molecules: From Aromatase to Aldosterone Synthase and Steroid 11β-Hydroxylase Inhibition 92
Nonsteroidal aromatase inhibitors for the treatment of breast cancer: an update. 92
Studies on cytostatic and cytotoxic activity of new flavopiridol analogues 91
The first dual ChE/FAAH inhibitors: new perspectives for Alzheimer's disease? 91
Improved eradication efficacy of a combination of newly identified antimicrobial agents in C. albicans and S. aureus mixed-species biofilm 89
Polycyclic Maleimide-based Scaffold as New Privileged Structure for Navigating the Cannabinoid System Opportunities 87
Mono- or di-fluorinated analogues of Flavone-8-acetic acid: synthesis and in vitro biological activity 85
Multifaceted activity of polyciclic MDR revertant agents in drug-resistant leukemic cells: Role of the spacer 85
Imidazolylmethylxanthones as potent inhibitors of cytochrome P450 aromatase 84
From nonsteroidal aromatase inhibitors to multifunctional drug candidates: classic and innovative strategies for the treatment of breast cancer. 84
Farmaci cardiaci 83
The ability of coumarin-, flavanon- and flavonol-analogues of flavone acetic acid to stimulate human monocytes. 82
null 82
Small-molecule inhibitors/modulators of amyloid-β peptide aggregation and toxicity for the treatment of Alzheimer's disease: a patent review (2010 – 2012) 81
null 79
New potent inhibitors of cytochrome P450 aromatase 78
SAR and binding mode at the h-AChE active site of pseudo-irreversible inhibitors related to Xanthostigmine 77
null 76
Targeting Orthosteric and Allosteric Pockets of Aromatase via Dual-Mode Novel Azole Inhibitors 74
null 70
Targeting neuronal calcium channels and GSK3β for Alzheimer's disease with naturally-inspired Diels-Alder adducts 69
null 67
Chalcone-based carbamates for Alzheimer's disease treatment 65
Coumarin derivatives as potential antitumor agents: Growth inhibition, apoptosis induction and multidrug resistance reverting activity 61
Tackling Alzheimer's Disease with Existing Drugs:A Promising Strategy for Bypassing Obstacles 61
Flavonoid-inspired vascular disrupting agents: Exploring flavone-8-acetic acid and derivatives in the new century 60
null 58
From AChE to BACE1 inhibitors: The role of the amine on the indanone scaffold 55
Targeting the multifaceted neurotoxicity of Alzheimer's disease by tailored functionalisation of the curcumin scaffold 53
Single-digit nanomolar inhibitors lock the aromatase active site via a dualsteric targeting strategy 49
Chalcones induce apoptosis, autophagy and reduce spreading in osteosarcoma 3D models 48
New approaches to the treatment of Alzheimer's disease. 47
Hitting drug-resistant malaria infection with triazole-linked flavonoid–chloroquine hybrid compounds 46
Interplay Between Endocannabinoid System and Neurodegeneration: Focus on Polypharmacology 46
3-(4-{[benzyl(methyl)amino]methyl}-phenyl)-6,7-dimethoxy-2H-2-chromenone (AP2238) inhibits both acetylcholinesterase and acetylcholinesterase-induced β-amyloid aggregation: A dual function lead for Alzheimer's disease therapy 42
Recent progress on curcumin-based therapeutics: a patent review (2012-2016). Part II: curcumin derivatives in cancer and neurodegeneration 40
Acetylcholinesterase inhibitors: SAR and kinetic studies on ω-[N-methyl-N-(3-alkylcarbamoyloxyphenyl]methyl] aminoalkoxyaryl derivatives 37
Recent progress on curcumin-based therapeutics: a patent review (2012-2016). Part I: Curcumin 37
Chromone-based small molecules for multistep shutdown of arachidonate pathway: Simultaneous inhibition of COX-2, 15-LOX and mPGES-1 enzymes 34
Cardiovascular hybrid drugs: New benzazepinone derivatives as bradycardic agents endowed with selective β1-Non-competitive antagonism 33
Acetylcholinesterase inhibitors for potential use in Alzheimer's disease: Molecular modeling, synthesis and kinetic evaluation of 11H-indeno-[1,2-b]-quinolin-10-ylamine derivatives 28
Totale 10.147
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Categoria #
all - tutte 29.666
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 29.666
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20201.338 0 0 0 0 0 0 292 331 313 162 106 134
2020/20211.382 271 86 22 62 26 76 28 132 100 72 93 414
2021/20221.620 146 42 102 86 133 84 47 158 91 126 308 297
2022/20232.205 199 241 92 269 160 168 66 130 469 68 166 177
2023/2024704 37 81 40 93 53 204 41 32 14 35 35 39
2024/20251.580 85 356 282 140 544 139 34 0 0 0 0 0
Totale 10.551