CRIS Current Research Information System

BISI, ALESSANDRA
 Distribuzione geografica
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Continente #
NA - Nord America 6.325
AS - Asia 6.028
EU - Europa 4.011
AF - Africa 317
SA - Sud America 286
OC - Oceania 12
Continente sconosciuto - Info sul continente non disponibili 4
Totale 16.983
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Nazione #
US - Stati Uniti d'America 6.218
VN - Vietnam 1.643
SG - Singapore 1.573
CN - Cina 1.524
IT - Italia 941
GB - Regno Unito 810
DE - Germania 540
HK - Hong Kong 371
SE - Svezia 328
IN - India 269
UA - Ucraina 234
FR - Francia 233
RU - Federazione Russa 209
BR - Brasile 195
NL - Olanda 142
IE - Irlanda 128
JP - Giappone 114
KR - Corea 111
JO - Giordania 104
CI - Costa d'Avorio 100
FI - Finlandia 96
ZA - Sudafrica 89
CA - Canada 71
BG - Bulgaria 61
TG - Togo 58
EE - Estonia 52
PH - Filippine 42
AR - Argentina 41
ID - Indonesia 40
ES - Italia 36
PL - Polonia 34
BD - Bangladesh 33
CH - Svizzera 33
IR - Iran 30
AT - Austria 28
SC - Seychelles 28
PK - Pakistan 25
TH - Thailandia 25
TR - Turchia 24
IQ - Iraq 23
MX - Messico 21
GR - Grecia 18
CZ - Repubblica Ceca 17
BE - Belgio 15
EC - Ecuador 14
MY - Malesia 14
HR - Croazia 13
CO - Colombia 10
EG - Egitto 10
NG - Nigeria 10
SA - Arabia Saudita 10
TW - Taiwan 10
AU - Australia 9
LB - Libano 9
LT - Lituania 9
KE - Kenya 7
KZ - Kazakistan 7
VE - Venezuela 7
HU - Ungheria 6
PT - Portogallo 6
CL - Cile 5
PS - Palestinian Territory 5
DZ - Algeria 4
GT - Guatemala 4
MD - Moldavia 4
OM - Oman 4
PE - Perù 4
PY - Paraguay 4
RS - Serbia 4
A2 - ???statistics.table.value.countryCode.A2??? 3
AE - Emirati Arabi Uniti 3
AL - Albania 3
BO - Bolivia 3
BY - Bielorussia 3
ET - Etiopia 3
HN - Honduras 3
NZ - Nuova Zelanda 3
PA - Panama 3
RO - Romania 3
TN - Tunisia 3
UZ - Uzbekistan 3
AO - Angola 2
KW - Kuwait 2
LK - Sri Lanka 2
NO - Norvegia 2
NP - Nepal 2
UY - Uruguay 2
AM - Armenia 1
AZ - Azerbaigian 1
BA - Bosnia-Erzegovina 1
BB - Barbados 1
CR - Costa Rica 1
CW - ???statistics.table.value.countryCode.CW??? 1
DO - Repubblica Dominicana 1
GH - Ghana 1
GI - Gibilterra 1
GY - Guiana 1
JM - Giamaica 1
KG - Kirghizistan 1
KH - Cambogia 1
Totale 16.977
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Città #
Singapore 1.047
Southend 702
Ashburn 643
Fairfield 528
Chandler 521
Santa Clara 370
Hong Kong 352
Ho Chi Minh City 349
San Jose 335
Bologna 332
Hanoi 318
Woodbridge 298
Dong Ket 251
Hefei 248
Houston 247
Wilmington 245
Seattle 240
Cambridge 207
Beijing 196
Princeton 175
Ann Arbor 163
Jacksonville 151
Boardman 134
Dublin 128
New York 113
Amman 104
Abidjan 99
Seoul 99
Tokyo 94
Council Bluffs 90
Los Angeles 80
Dallas 79
Lauterbourg 78
Helsinki 74
Westminster 74
Nanjing 72
Padova 65
Sofia 60
Lomé 58
Buffalo 56
Munich 55
Berlin 54
Da Nang 52
Bremen 47
Jinan 44
Haiphong 42
Milan 41
San Diego 41
Shenyang 39
Redondo Beach 37
Saint Petersburg 37
Frankfurt am Main 33
Guangzhou 32
Redmond 32
Jakarta 29
Tianjin 29
Hebei 27
Mülheim 27
Nanchang 27
Quận Bình Thạnh 27
Bern 26
Shanghai 25
São Paulo 25
Bengaluru 24
Changsha 24
Warsaw 23
Orem 21
Johannesburg 20
Nuremberg 20
Biên Hòa 19
Jiaxing 19
Medford 18
Montreal 18
Vienna 18
Hải Dương 17
Mahé 17
Zhengzhou 17
Can Tho 16
Des Moines 16
Olalla 16
Phoenix 16
Redwood City 16
Sant Cugat del Vallès 16
Toronto 16
Venezia 16
Brussels 15
Chicago 15
London 15
Mountain View 15
Boydton 14
Dearborn 14
Kunming 14
Atlanta 13
Brooklyn 13
Falkenstein 13
Wuhan 13
Amsterdam 12
Hangzhou 12
The Dalles 12
Thái Nguyên 12
Totale 10.908
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Nome #
1,4-dihydropyridine derivatives as calcium channel modulators: the role of 3-methoxy-flavone moiety 348
Discovery of novel benzofuran-based compounds with neuroprotective and immunomodulatory properties for Alzheimer's disease treatment 325
Multitarget Strategy to Address Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and Computational Studies of Coumarin-Based Derivatives 287
Benzofuran-Based Hybrid Compounds for the Inhibition of Cholinesterase Activity, Abeta Amyloid Aggregation, and Abeta Neurotoxicity 281
Cholinesterase inhibitors: xanthostigmine derivatives blocking the acetylcholinesterase-induced beta-amyloid aggregation. 250
Structure-Activity Relationships and Binding Mode in the Human Acetylcholinesterase Active Site of Pseudo-Irreversible Inhibitors Related to Xanthostigmine 244
Progettazione e sintesi di derivati benzofuranici per la malattia di Alzheimer 236
Chalcones induce apoptosis, autophagy and reduce spreading in osteosarcoma 3D models 229
Design, synthesis and biological profile of new inhibitors of multidrug resistance associated proteins carrying a polycyclic scaffold 218
Analogues of the dual acetylcholinesterase inhibitor AP2238: synthesis and SAR 216
Benzophenones as xanthone-open model CYP11B1 inhibitors potentially useful for promoting wound healing 215
Targeting neuronal calcium channels and GSK3β for Alzheimer's disease with naturally-inspired Diels-Alder adducts 214
Versatility of the Curcumin Scaffold: Discovery of Potent and Balanced Dual BACE-1 and GSK-3β Inhibitors 214
Identification of chalcone-based antileishmanial agents targeting trypanothione reductase 210
Fatty Acid Amide Hydrolase (FAAH), Acetylcholinesterase (AChE), and Butyrylcholinesterase (BuChE): Networked Targets for the Development of Carbamates as Potential Anti-Alzheimer's Disease Agents 210
Exploiting the chalcone scaffold to develop multifunctional agents for Alzheimer’s disease 209
2-Arylbenzofuran-based molecules as multipotent Alzheimer's disease modifying agents 206
Identification of a new tamoxifen-xanthene hybrid as pro-apoptotic anticancer agent 203
Targeting the multifaceted neurotoxicity of Alzheimer's disease by tailored functionalisation of the curcumin scaffold 200
SAR and binding mode at the h-AChE active site of pseudo-irreversible inhibitors related to Xanthostigmine 199
Balanced dual acting compounds targeting aromatase and estrogen receptor α as an emerging therapeutic opportunity to counteract estrogen responsive breast cancer 199
Extensive SAR and computational studies of 3-{4-[(benzylmethylamino)methyl]phenyl}-6,7-dimethoxy-2H-2-chromenone (AP2238) derivatives. 197
Benzophenone-based derivatives: A novel series of potent and selective dual inhibitors of acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation 196
Naturally inspired molecules as multifunctional agents for Alzheimer's disease treatment 195
Natural-like Chalcones with Antitumor Activity on Human MG63 Osteosarcoma Cells 194
Cardiovascular profile of xanthone-based 1,4 dihydropyridines bearing a lidoflazine pharmacophore fragment 192
Interplay Between Endocannabinoid System and Neurodegeneration: Focus on Polypharmacology 189
Curcumin-1,2,3-triazole conjugation for targeting the cancer apoptosis machinery. 189
CHOLINESTERASE INHIBITORS: SAR AND ENZYME INHIBITORY ACTIVITY OF 3-[omega-(BENZYLMETHYLAMINO)ALKOXY]XANTHEN-9-ONES 186
Novel Curcumin-Diethyl Fumarate Hybrid as a Dualistic GSK-3β Inhibitor/Nrf2 Inducer for the Treatment of Parkinson's Disease 186
Enantioselective nonsteroidal aromatase inhibitors identified through a multidisciplinary medicinal chemistry approach 179
Polycyclic maleimide-based derivatives as first dual modulators of neuronal calcium channels and GSK-3β for Alzheimer's disease treatment 173
A Computational Assay of Estrogen Receptor α Antagonists Reveals the Key Common Structural Traits of Drugs Effectively Fighting Refractory Breast Cancers 171
Anthracene Based Compounds as New L-type Ca2+ Channel Blockers: Design, Synthesis, and Full Biological Profile 170
New Coumarin derivatives as cholinergic and cannabinoid system modulators 170
Lead optimization providing a series of flavone derivatives as potent nonsteroidal inhibitors of the cytochrome P450 aromatase enzyme 168
Multifaceted activity of polyciclic MDR revertant agents in drug-resistant leukemic cells: Role of the spacer 168
Emerging targets in neurodegeneration: new opportunities for Alzheimer's disease treatment? 167
Single-digit nanomolar inhibitors lock the aromatase active site via a dualsteric targeting strategy 166
Nonsteroidal Aromatase inhibitors: synthesis and evaluation of new flavone derivatives 166
Derivati a struttura benzofenonica come inibitori dell'acetilcolinesterasi 164
Homopterocarpanes as bridged triarylethylene analogues: synthesis and antagonistic effects in human MCF-7 breast cancer cells 163
Fluorinated benzophenone derivatives: balanced multipotent agents for Alzheimer's disease 162
Design, synthesis, and evaluation of benzophenone derivatives as novel acetylcholinesterase inhibitors 161
Reconsidering Aromatase for Breast Cancer Treatment: New Roles for an Old Target 160
Antitumor profile of new phenothiazine derivatives 158
Imidazolylmethylbenzophenones as highly potent aromatase inhibitors. 158
PREPARATION AND STEREOCHEMICAL CHARACTERIZATION OF ENANTIOMERIC HOMOISOFLAVONES ACTIVE AS AROMATASE INHIBITORS 156
New derivatives of xanthenone-4-acetic acid: synthesis, pharmacological profile and effect on TNF-alpha and NO production by human immune cells 151
Improved eradication efficacy of a combination of newly identified antimicrobial agents in C. albicans and S. aureus mixed-species biofilm 151
Naturally Inspired Coumarin Derivatives in Alzheimer’s Disease Drug Discovery: Latest Advances and Current Challenges 150
In vitro studies of flavon-8-acetic acid analogues 150
Studies on cytostatic and cytotoxic activity of new flavopiridol analogues 150
Functionalization of the chalcone scaffold for the discovery of novel lead compounds targeting fungal infections 149
In vitro biological activity of new analogues of flavon-8-acetic acid 148
Benzophenone derivatives as Inhibitors of Acetylcholinesterase 148
Switching from Aromatase Inhibitors to Dual Targeting Flavonoid-Based Compounds for Breast Cancer Treatment 147
Hybrid drugs for Alzheimer's disease: new indanone derivatives bearing a pharmacophoric fragment of AP2238 147
From AChE to BACE1 inhibitors: The role of the amine on the indanone scaffold 145
Multi-target strategy to address Alzheimer’s disease: Design, synthesis and biological evaluation of new tacrine-based dimers 145
Design, Synthesis, and Biological and Crystallographic Evaluation of Novel Inhibitors ofPlasmodium falciparumEnoyl-ACP-reductase (PfFabI) 144
Flavonoid-inspired vascular disrupting agents: Exploring flavone-8-acetic acid and derivatives in the new century 144
New potent P-glycoprotein inhibitors carrying a polycyclic scaffold 143
Targeting Orthosteric and Allosteric Pockets of Aromatase via Dual-Mode Novel Azole Inhibitors 143
Polycyclic Maleimide-based Scaffold as New Privileged Structure for Navigating the Cannabinoid System Opportunities 142
Targeting the Bacterial Membrane with a New Polycyclic Privileged Structure: A Powerful Tool To Face Staphylococcus aureus Infections 137
Design of Multifunctional Compounds for Cardiovascular Disease: From Natural Scaffolds to “Classical” Multitarget Approach 135
Novel Aldosterone Synthase Inhibitors with Extended Carbocyclic Skeleton by a Combined Ligand-Based and Structure-Based Drug Design Approach 134
Novel highly potent and selective nonsteroidal aromatase inhibitors: synthesis, biological evaluation and structure-activity relationships investigation 133
New potent inhibitors of cytochrome P450 aromatase 131
Imidazolylmethylxanthones as potent inhibitors of cytochrome P450 aromatase 127
The ability of coumarin-, flavanon- and flavonol-analogues of flavone acetic acid to stimulate human monocytes. 126
Hybrid-Based Multi-Target Ligands for the Treatment of Alzheimer's Disease 125
Multidrug resistance reverting activity and antitumor profile of new phenothiazine derivatives 125
Chalcone-based carbamates for Alzheimer's disease treatment 125
null 123
The first dual ChE/FAAH inhibitors: new perspectives for Alzheimer's disease? 122
Farmaci cardiaci 122
Nonsteroidal aromatase inhibitors for the treatment of breast cancer: an update. 121
Mono- or di-fluorinated analogues of Flavone-8-acetic acid: synthesis and in vitro biological activity 121
Modulation of Cytochromes P450 with Xanthone-Based Molecules: From Aromatase to Aldosterone Synthase and Steroid 11β-Hydroxylase Inhibition 119
Coumarin derivatives as potential antitumor agents: Growth inhibition, apoptosis induction and multidrug resistance reverting activity 118
null 118
Tackling Alzheimer's Disease with Existing Drugs:A Promising Strategy for Bypassing Obstacles 116
From nonsteroidal aromatase inhibitors to multifunctional drug candidates: classic and innovative strategies for the treatment of breast cancer. 112
Hitting drug-resistant malaria infection with triazole-linked flavonoid–chloroquine hybrid compounds 111
Small-molecule inhibitors/modulators of amyloid-β peptide aggregation and toxicity for the treatment of Alzheimer's disease: a patent review (2010 – 2012) 110
null 105
Chromone-based small molecules for multistep shutdown of arachidonate pathway: Simultaneous inhibition of COX-2, 15-LOX and mPGES-1 enzymes 101
Extended Antimicrobial Profile of Chromone–Butenafine Hybrids 96
Recent progress on curcumin-based therapeutics: a patent review (2012-2016). Part I: Curcumin 88
Recent progress on curcumin-based therapeutics: a patent review (2012-2016). Part II: curcumin derivatives in cancer and neurodegeneration 86
New approaches to the treatment of Alzheimer's disease. 83
null 82
Exploiting acylaminopyrazole scaffold for polypharmacology approach in Alzheimer's disease 81
null 79
3-(4-{[benzyl(methyl)amino]methyl}-phenyl)-6,7-dimethoxy-2H-2-chromenone (AP2238) inhibits both acetylcholinesterase and acetylcholinesterase-induced β-amyloid aggregation: A dual function lead for Alzheimer's disease therapy 76
null 76
Cardiovascular hybrid drugs: New benzazepinone derivatives as bradycardic agents endowed with selective β1-Non-competitive antagonism 72
null 70
Totale 15.920
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Categoria #
all - tutte 47.027
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 47.027
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021579 0 0 0 0 0 0 0 0 0 72 93 414
2021/20221.620 146 42 102 86 133 84 47 158 91 126 308 297
2022/20232.205 199 241 92 269 160 168 66 130 469 68 166 177
2023/2024704 37 81 40 93 53 204 41 32 14 35 35 39
2024/20252.615 85 356 282 140 544 139 218 70 61 186 148 386
2025/20265.778 720 553 601 455 652 302 582 281 1.210 422 0 0
Totale 17.364