CRIS Current Research Information System

BISI, ALESSANDRA
 Distribuzione geografica
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Continente #
NA - Nord America 6.864
AS - Asia 6.180
EU - Europa 4.149
AF - Africa 320
SA - Sud America 296
OC - Oceania 12
Continente sconosciuto - Info sul continente non disponibili 4
Totale 17.825
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Nazione #
US - Stati Uniti d'America 6.726
VN - Vietnam 1.652
SG - Singapore 1.584
CN - Cina 1.535
IT - Italia 1.070
GB - Regno Unito 814
DE - Germania 540
HK - Hong Kong 378
SE - Svezia 328
IN - India 274
UA - Ucraina 234
FR - Francia 233
RU - Federazione Russa 209
BR - Brasile 203
NL - Olanda 144
BD - Bangladesh 140
IE - Irlanda 128
JP - Giappone 114
KR - Corea 111
JO - Giordania 104
CI - Costa d'Avorio 100
FI - Finlandia 96
CA - Canada 92
ZA - Sudafrica 89
BG - Bulgaria 61
TG - Togo 58
EE - Estonia 52
PH - Filippine 42
AR - Argentina 41
ID - Indonesia 40
ES - Italia 36
PL - Polonia 34
CH - Svizzera 33
IR - Iran 30
AT - Austria 28
SC - Seychelles 28
PK - Pakistan 26
MX - Messico 25
TH - Thailandia 25
TR - Turchia 24
IQ - Iraq 23
GR - Grecia 19
CZ - Repubblica Ceca 17
BE - Belgio 15
EC - Ecuador 14
HR - Croazia 14
MY - Malesia 14
EG - Egitto 13
CO - Colombia 11
TW - Taiwan 11
NG - Nigeria 10
SA - Arabia Saudita 10
AU - Australia 9
LB - Libano 9
LT - Lituania 9
KE - Kenya 7
KZ - Kazakistan 7
VE - Venezuela 7
HU - Ungheria 6
PT - Portogallo 6
CL - Cile 5
MD - Moldavia 5
PS - Palestinian Territory 5
DZ - Algeria 4
GT - Guatemala 4
OM - Oman 4
PE - Perù 4
PY - Paraguay 4
RS - Serbia 4
A2 - ???statistics.table.value.countryCode.A2??? 3
AE - Emirati Arabi Uniti 3
AL - Albania 3
BB - Barbados 3
BO - Bolivia 3
BY - Bielorussia 3
CR - Costa Rica 3
ET - Etiopia 3
HN - Honduras 3
NZ - Nuova Zelanda 3
PA - Panama 3
RO - Romania 3
TN - Tunisia 3
UZ - Uzbekistan 3
AO - Angola 2
GY - Guiana 2
KW - Kuwait 2
LK - Sri Lanka 2
NO - Norvegia 2
NP - Nepal 2
UY - Uruguay 2
AM - Armenia 1
AZ - Azerbaigian 1
BA - Bosnia-Erzegovina 1
CW - ???statistics.table.value.countryCode.CW??? 1
DO - Repubblica Dominicana 1
GH - Ghana 1
GI - Gibilterra 1
HT - Haiti 1
JM - Giamaica 1
KG - Kirghizistan 1
Totale 17.817
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Città #
Singapore 1.056
Southend 702
Ashburn 680
Fairfield 528
Chandler 521
San Jose 473
Santa Clara 384
Hong Kong 359
Bologna 351
Ho Chi Minh City 350
Hanoi 322
Woodbridge 298
Dong Ket 251
Hefei 248
Houston 248
Wilmington 245
Seattle 240
Cambridge 208
Beijing 198
Princeton 175
Ann Arbor 163
New York 154
Jacksonville 151
Boardman 149
Council Bluffs 138
Dublin 128
Amman 104
Abidjan 99
Seoul 99
Tokyo 94
Los Angeles 92
Dallas 88
Lauterbourg 78
Helsinki 74
Westminster 74
Buffalo 72
Nanjing 72
Padova 65
Sofia 60
Lomé 58
Munich 55
Berlin 54
Da Nang 52
Milan 50
Bremen 47
Jinan 44
Haiphong 42
San Diego 42
Shenyang 39
Redondo Beach 37
Saint Petersburg 37
Frankfurt am Main 33
Guangzhou 32
Redmond 32
Jakarta 29
São Paulo 29
Tianjin 29
Hebei 27
Mülheim 27
Nanchang 27
Quận Bình Thạnh 27
Bern 26
Shanghai 26
Bengaluru 25
Toronto 25
Changsha 24
Rimini 23
Warsaw 23
Orem 22
Chicago 21
Johannesburg 20
Nuremberg 20
The Dalles 20
Biên Hòa 19
Jiaxing 19
Montreal 19
Rome 19
Medford 18
Phoenix 18
Vienna 18
Hải Dương 17
Mahé 17
Zhengzhou 17
Can Tho 16
Des Moines 16
Olalla 16
Redwood City 16
Sant Cugat del Vallès 16
Venezia 16
Brooklyn 15
Brussels 15
London 15
Mexico City 15
Mountain View 15
Atlanta 14
Boydton 14
Dearborn 14
Kunming 14
Falkenstein 13
Turin 13
Totale 11.349
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Nome #
1,4-dihydropyridine derivatives as calcium channel modulators: the role of 3-methoxy-flavone moiety 352
Discovery of novel benzofuran-based compounds with neuroprotective and immunomodulatory properties for Alzheimer's disease treatment 340
Chalcones induce apoptosis, autophagy and reduce spreading in osteosarcoma 3D models 300
Multitarget Strategy to Address Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and Computational Studies of Coumarin-Based Derivatives 297
Benzofuran-Based Hybrid Compounds for the Inhibition of Cholinesterase Activity, Abeta Amyloid Aggregation, and Abeta Neurotoxicity 285
Cholinesterase inhibitors: xanthostigmine derivatives blocking the acetylcholinesterase-induced beta-amyloid aggregation. 252
Structure-Activity Relationships and Binding Mode in the Human Acetylcholinesterase Active Site of Pseudo-Irreversible Inhibitors Related to Xanthostigmine 252
Progettazione e sintesi di derivati benzofuranici per la malattia di Alzheimer 241
Design, synthesis and biological profile of new inhibitors of multidrug resistance associated proteins carrying a polycyclic scaffold 227
Targeting neuronal calcium channels and GSK3β for Alzheimer's disease with naturally-inspired Diels-Alder adducts 224
Analogues of the dual acetylcholinesterase inhibitor AP2238: synthesis and SAR 221
Versatility of the Curcumin Scaffold: Discovery of Potent and Balanced Dual BACE-1 and GSK-3β Inhibitors 220
Benzophenones as xanthone-open model CYP11B1 inhibitors potentially useful for promoting wound healing 220
Identification of chalcone-based antileishmanial agents targeting trypanothione reductase 218
Balanced dual acting compounds targeting aromatase and estrogen receptor α as an emerging therapeutic opportunity to counteract estrogen responsive breast cancer 216
Exploiting the chalcone scaffold to develop multifunctional agents for Alzheimer’s disease 215
Fatty Acid Amide Hydrolase (FAAH), Acetylcholinesterase (AChE), and Butyrylcholinesterase (BuChE): Networked Targets for the Development of Carbamates as Potential Anti-Alzheimer's Disease Agents 214
Identification of a new tamoxifen-xanthene hybrid as pro-apoptotic anticancer agent 209
Natural-like Chalcones with Antitumor Activity on Human MG63 Osteosarcoma Cells 209
Targeting the multifaceted neurotoxicity of Alzheimer's disease by tailored functionalisation of the curcumin scaffold 208
2-Arylbenzofuran-based molecules as multipotent Alzheimer's disease modifying agents 208
Extensive SAR and computational studies of 3-{4-[(benzylmethylamino)methyl]phenyl}-6,7-dimethoxy-2H-2-chromenone (AP2238) derivatives. 200
SAR and binding mode at the h-AChE active site of pseudo-irreversible inhibitors related to Xanthostigmine 200
Naturally inspired molecules as multifunctional agents for Alzheimer's disease treatment 199
Benzophenone-based derivatives: A novel series of potent and selective dual inhibitors of acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation 197
Interplay Between Endocannabinoid System and Neurodegeneration: Focus on Polypharmacology 195
Cardiovascular profile of xanthone-based 1,4 dihydropyridines bearing a lidoflazine pharmacophore fragment 193
Curcumin-1,2,3-triazole conjugation for targeting the cancer apoptosis machinery. 192
Novel Curcumin-Diethyl Fumarate Hybrid as a Dualistic GSK-3β Inhibitor/Nrf2 Inducer for the Treatment of Parkinson's Disease 191
CHOLINESTERASE INHIBITORS: SAR AND ENZYME INHIBITORY ACTIVITY OF 3-[omega-(BENZYLMETHYLAMINO)ALKOXY]XANTHEN-9-ONES 186
Enantioselective nonsteroidal aromatase inhibitors identified through a multidisciplinary medicinal chemistry approach 182
Single-digit nanomolar inhibitors lock the aromatase active site via a dualsteric targeting strategy 176
Anthracene Based Compounds as New L-type Ca2+ Channel Blockers: Design, Synthesis, and Full Biological Profile 176
A Computational Assay of Estrogen Receptor α Antagonists Reveals the Key Common Structural Traits of Drugs Effectively Fighting Refractory Breast Cancers 176
New Coumarin derivatives as cholinergic and cannabinoid system modulators 175
Polycyclic maleimide-based derivatives as first dual modulators of neuronal calcium channels and GSK-3β for Alzheimer's disease treatment 174
Lead optimization providing a series of flavone derivatives as potent nonsteroidal inhibitors of the cytochrome P450 aromatase enzyme 173
Emerging targets in neurodegeneration: new opportunities for Alzheimer's disease treatment? 172
Nonsteroidal Aromatase inhibitors: synthesis and evaluation of new flavone derivatives 171
Homopterocarpanes as bridged triarylethylene analogues: synthesis and antagonistic effects in human MCF-7 breast cancer cells 171
Derivati a struttura benzofenonica come inibitori dell'acetilcolinesterasi 169
Multifaceted activity of polyciclic MDR revertant agents in drug-resistant leukemic cells: Role of the spacer 169
Fluorinated benzophenone derivatives: balanced multipotent agents for Alzheimer's disease 168
Design, synthesis, and evaluation of benzophenone derivatives as novel acetylcholinesterase inhibitors 166
Antitumor profile of new phenothiazine derivatives 165
Imidazolylmethylbenzophenones as highly potent aromatase inhibitors. 162
Reconsidering Aromatase for Breast Cancer Treatment: New Roles for an Old Target 162
PREPARATION AND STEREOCHEMICAL CHARACTERIZATION OF ENANTIOMERIC HOMOISOFLAVONES ACTIVE AS AROMATASE INHIBITORS 159
Improved eradication efficacy of a combination of newly identified antimicrobial agents in C. albicans and S. aureus mixed-species biofilm 157
In vitro studies of flavon-8-acetic acid analogues 155
New derivatives of xanthenone-4-acetic acid: synthesis, pharmacological profile and effect on TNF-alpha and NO production by human immune cells 155
Naturally Inspired Coumarin Derivatives in Alzheimer’s Disease Drug Discovery: Latest Advances and Current Challenges 153
Switching from Aromatase Inhibitors to Dual Targeting Flavonoid-Based Compounds for Breast Cancer Treatment 153
Studies on cytostatic and cytotoxic activity of new flavopiridol analogues 153
Hybrid drugs for Alzheimer's disease: new indanone derivatives bearing a pharmacophoric fragment of AP2238 153
Benzophenone derivatives as Inhibitors of Acetylcholinesterase 153
From AChE to BACE1 inhibitors: The role of the amine on the indanone scaffold 152
In vitro biological activity of new analogues of flavon-8-acetic acid 151
Functionalization of the chalcone scaffold for the discovery of novel lead compounds targeting fungal infections 151
Targeting Orthosteric and Allosteric Pockets of Aromatase via Dual-Mode Novel Azole Inhibitors 147
Flavonoid-inspired vascular disrupting agents: Exploring flavone-8-acetic acid and derivatives in the new century 147
Design, Synthesis, and Biological and Crystallographic Evaluation of Novel Inhibitors ofPlasmodium falciparumEnoyl-ACP-reductase (PfFabI) 146
Multi-target strategy to address Alzheimer’s disease: Design, synthesis and biological evaluation of new tacrine-based dimers 146
Hitting drug-resistant malaria infection with triazole-linked flavonoid–chloroquine hybrid compounds 145
New potent P-glycoprotein inhibitors carrying a polycyclic scaffold 145
Polycyclic Maleimide-based Scaffold as New Privileged Structure for Navigating the Cannabinoid System Opportunities 145
Targeting the Bacterial Membrane with a New Polycyclic Privileged Structure: A Powerful Tool To Face Staphylococcus aureus Infections 142
Novel Aldosterone Synthase Inhibitors with Extended Carbocyclic Skeleton by a Combined Ligand-Based and Structure-Based Drug Design Approach 141
Design of Multifunctional Compounds for Cardiovascular Disease: From Natural Scaffolds to “Classical” Multitarget Approach 139
New potent inhibitors of cytochrome P450 aromatase 134
Novel highly potent and selective nonsteroidal aromatase inhibitors: synthesis, biological evaluation and structure-activity relationships investigation 133
The ability of coumarin-, flavanon- and flavonol-analogues of flavone acetic acid to stimulate human monocytes. 130
Imidazolylmethylxanthones as potent inhibitors of cytochrome P450 aromatase 129
Chalcone-based carbamates for Alzheimer's disease treatment 129
Farmaci cardiaci 127
Hybrid-Based Multi-Target Ligands for the Treatment of Alzheimer's Disease 126
Multidrug resistance reverting activity and antitumor profile of new phenothiazine derivatives 126
Coumarin derivatives as potential antitumor agents: Growth inhibition, apoptosis induction and multidrug resistance reverting activity 125
Exploiting acylaminopyrazole scaffold for polypharmacology approach in Alzheimer's disease 124
The first dual ChE/FAAH inhibitors: new perspectives for Alzheimer's disease? 124
null 123
Extended Antimicrobial Profile of Chromone–Butenafine Hybrids 122
Nonsteroidal aromatase inhibitors for the treatment of breast cancer: an update. 122
Tackling Alzheimer's Disease with Existing Drugs:A Promising Strategy for Bypassing Obstacles 122
Modulation of Cytochromes P450 with Xanthone-Based Molecules: From Aromatase to Aldosterone Synthase and Steroid 11β-Hydroxylase Inhibition 121
Mono- or di-fluorinated analogues of Flavone-8-acetic acid: synthesis and in vitro biological activity 121
null 118
From nonsteroidal aromatase inhibitors to multifunctional drug candidates: classic and innovative strategies for the treatment of breast cancer. 114
Small-molecule inhibitors/modulators of amyloid-β peptide aggregation and toxicity for the treatment of Alzheimer's disease: a patent review (2010 – 2012) 112
Chromone-based small molecules for multistep shutdown of arachidonate pathway: Simultaneous inhibition of COX-2, 15-LOX and mPGES-1 enzymes 107
null 105
Recent progress on curcumin-based therapeutics: a patent review (2012-2016). Part I: Curcumin 92
Recent progress on curcumin-based therapeutics: a patent review (2012-2016). Part II: curcumin derivatives in cancer and neurodegeneration 92
SAR of 9-amino-1,2,3-4-tetrahydroacridine-based acetylcholinesterase inhibitors: Synthesis, enzyme inhibitory activity, QSAR, and structure-based CoMFA of tacrine analogues 89
New approaches to the treatment of Alzheimer's disease. 85
null 82
3-(4-{[benzyl(methyl)amino]methyl}-phenyl)-6,7-dimethoxy-2H-2-chromenone (AP2238) inhibits both acetylcholinesterase and acetylcholinesterase-induced β-amyloid aggregation: A dual function lead for Alzheimer's disease therapy 79
null 79
null 76
Cardiovascular hybrid drugs: New benzazepinone derivatives as bradycardic agents endowed with selective β1-Non-competitive antagonism 75
Totale 16.519
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Categoria #
all - tutte 50.426
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 50.426
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021414 0 0 0 0 0 0 0 0 0 0 0 414
2021/20221.620 146 42 102 86 133 84 47 158 91 126 308 297
2022/20232.205 199 241 92 269 160 168 66 130 469 68 166 177
2023/2024704 37 81 40 93 53 204 41 32 14 35 35 39
2024/20252.615 85 356 282 140 544 139 218 70 61 186 148 386
2025/20266.627 720 553 601 455 652 302 582 281 1.210 525 444 302
Totale 18.213