New pentacyclic inhibitors of the P-glycoprotein carrying nitrogen-containing alkyl chains were synthesized and evaluated for MDR reverting activity on mouse lymphoma cells infected with pHa MDR1/A retrovirus. The activity of the compounds proved to be up to 5-fold higher than verapamil, used as reference compound.
Bisi A., Gobbi S., Rampa A., Belluti F., Piazzi L., Valenti P., et al. (2006). New potent P-glycoprotein inhibitors carrying a polycyclic scaffold. JOURNAL OF MEDICINAL CHEMISTRY, 49, 3049-3051 [10.1021/jm060056p].
New potent P-glycoprotein inhibitors carrying a polycyclic scaffold
BISI, ALESSANDRA;GOBBI, SILVIA;RAMPA, ANGELA;BELLUTI, FEDERICA;PIAZZI, LORNA;VALENTI, PIERO;
2006
Abstract
New pentacyclic inhibitors of the P-glycoprotein carrying nitrogen-containing alkyl chains were synthesized and evaluated for MDR reverting activity on mouse lymphoma cells infected with pHa MDR1/A retrovirus. The activity of the compounds proved to be up to 5-fold higher than verapamil, used as reference compound.File in questo prodotto:
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