In recent years, the investigation of acetylcholinesterase (AChE) inhibitors has gained further interest, because the involvement of the peripheral site of the enzyme in the β-amyloid (Aβ) aggregation process has been disclosed. We present here, for the first time, a direct evidence of the Aβ antiaggregating action of an AChE inhibitor (AP2238) purposely designed to bind at both the catalytic and the peripheral sites of the human enzyme.

3-(4-{[benzyl(methyl)amino]methyl}-phenyl)-6,7-dimethoxy-2H-2-chromenone (AP2238) inhibits both acetylcholinesterase and acetylcholinesterase-induced β-amyloid aggregation: A dual function lead for Alzheimer's disease therapy

Piazzi L.;Rampa A.;Bisi A.;Gobbi S.;Belluti F.;Cavalli A.;Bartolini M.;Andrisano V.;Valenti P.;Recanatini M.
2003

Abstract

In recent years, the investigation of acetylcholinesterase (AChE) inhibitors has gained further interest, because the involvement of the peripheral site of the enzyme in the β-amyloid (Aβ) aggregation process has been disclosed. We present here, for the first time, a direct evidence of the Aβ antiaggregating action of an AChE inhibitor (AP2238) purposely designed to bind at both the catalytic and the peripheral sites of the human enzyme.
Piazzi L.; Rampa A.; Bisi A.; Gobbi S.; Belluti F.; Cavalli A.; Bartolini M.; Andrisano V.; Valenti P.; Recanatini M.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/903725
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