The purpose of this study was to investigate correlations between brain proton magnetic resonance spectroscopy (1 H-MRS) findings with serum biomarkers and heteroplasmy of mitochondrial DNA (mtDNA) mutations. This study enrolled patients carrying mtDNA mutations associated with Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like episodes (MELAS), and MELAS-Spectrum Syndrome (MSS).
Brain MRS correlates with mitochondrial dysfunction biomarkers in MELAS-associated mtDNA mutations
Gramegna, Laura L;Evangelisti, Stefania;La Morgia, Chiara;Maresca, Alessandra;Talozzi, Lia;Bianchini, Claudio;Testa, Claudia;Manners, David N;Valentino, Maria L;Liguori, Rocco;Carelli, Valerio;Tonon, Caterina;Lodi, Raffaele
2021
Abstract
The purpose of this study was to investigate correlations between brain proton magnetic resonance spectroscopy (1 H-MRS) findings with serum biomarkers and heteroplasmy of mitochondrial DNA (mtDNA) mutations. This study enrolled patients carrying mtDNA mutations associated with Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like episodes (MELAS), and MELAS-Spectrum Syndrome (MSS).File in questo prodotto:
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