The purpose of this study was to investigate correlations between brain proton magnetic resonance spectroscopy (1 H-MRS) findings with serum biomarkers and heteroplasmy of mitochondrial DNA (mtDNA) mutations. This study enrolled patients carrying mtDNA mutations associated with Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like episodes (MELAS), and MELAS-Spectrum Syndrome (MSS).
Brain MRS correlates with mitochondrial dysfunction biomarkers in MELAS-associated mtDNA mutations / Gramegna, Laura L; Evangelisti, Stefania; Di Vito, Lidia; La Morgia, Chiara; Maresca, Alessandra; Caporali, Leonardo; Amore, Giulia; Talozzi, Lia; Bianchini, Claudio; Testa, Claudia; Manners, David N; Cortesi, Irene; Valentino, Maria L; Liguori, Rocco; Carelli, Valerio; Tonon, Caterina; Lodi, Raffaele. - In: ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY. - ISSN 2328-9503. - STAMPA. - 8:6(2021), pp. 1200-1211. [10.1002/acn3.51329]
Brain MRS correlates with mitochondrial dysfunction biomarkers in MELAS-associated mtDNA mutations
Gramegna, Laura L;Evangelisti, Stefania;La Morgia, Chiara;Maresca, Alessandra;Caporali, Leonardo;Talozzi, Lia;Bianchini, Claudio;Testa, Claudia;Manners, David N;Valentino, Maria L;Liguori, Rocco;Carelli, Valerio;Tonon, Caterina;Lodi, Raffaele
2021
Abstract
The purpose of this study was to investigate correlations between brain proton magnetic resonance spectroscopy (1 H-MRS) findings with serum biomarkers and heteroplasmy of mitochondrial DNA (mtDNA) mutations. This study enrolled patients carrying mtDNA mutations associated with Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like episodes (MELAS), and MELAS-Spectrum Syndrome (MSS).| File | Dimensione | Formato | |
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