CRIS Current Research Information System

DE SIMONE, ANGELA
 Distribuzione geografica
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Continente #
NA - Nord America 5.050
AS - Asia 5.016
EU - Europa 3.421
Continente sconosciuto - Info sul continente non disponibili 293
SA - Sud America 271
AF - Africa 249
OC - Oceania 6
Totale 14.306
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Nazione #
US - Stati Uniti d'America 4.959
VN - Vietnam 1.471
SG - Singapore 1.312
CN - Cina 1.220
IT - Italia 926
GB - Regno Unito 808
DE - Germania 392
HK - Hong Kong 323
SE - Svezia 309
IN - India 240
FR - Francia 202
BR - Brasile 181
RU - Federazione Russa 181
IE - Irlanda 125
KR - Corea 103
JP - Giappone 86
CI - Costa d'Avorio 80
UA - Ucraina 79
ZA - Sudafrica 70
BD - Bangladesh 67
FI - Finlandia 63
NL - Olanda 60
EE - Estonia 58
CA - Canada 50
TG - Togo 44
AR - Argentina 37
CH - Svizzera 36
BG - Bulgaria 31
BE - Belgio 29
ID - Indonesia 29
PL - Polonia 25
SC - Seychelles 25
JO - Giordania 23
ES - Italia 19
TR - Turchia 19
PH - Filippine 18
TW - Taiwan 17
TH - Thailandia 15
EC - Ecuador 14
HR - Croazia 14
MX - Messico 14
PK - Pakistan 14
CO - Colombia 11
CZ - Repubblica Ceca 11
AT - Austria 10
SA - Arabia Saudita 10
CL - Cile 9
RO - Romania 8
VE - Venezuela 8
CR - Costa Rica 7
IR - Iran 7
NG - Nigeria 7
GR - Grecia 6
HU - Ungheria 6
PY - Paraguay 6
AU - Australia 5
IL - Israele 5
IQ - Iraq 5
JM - Giamaica 5
LB - Libano 5
PT - Portogallo 5
SM - San Marino 5
UZ - Uzbekistan 5
AE - Emirati Arabi Uniti 4
EG - Egitto 4
HN - Honduras 4
MY - Malesia 4
TT - Trinidad e Tobago 4
BO - Bolivia 3
DZ - Algeria 3
KE - Kenya 3
LT - Lituania 3
MA - Marocco 3
NP - Nepal 3
PS - Palestinian Territory 3
TN - Tunisia 3
AL - Albania 2
AZ - Azerbaigian 2
BA - Bosnia-Erzegovina 2
ET - Etiopia 2
GT - Guatemala 2
MD - Moldavia 2
SK - Slovacchia (Repubblica Slovacca) 2
UY - Uruguay 2
BJ - Benin 1
BN - Brunei Darussalam 1
BS - Bahamas 1
CG - Congo 1
DK - Danimarca 1
EU - Europa 1
GM - Gambi 1
KH - Cambogia 1
KW - Kuwait 1
KZ - Kazakistan 1
LK - Sri Lanka 1
MZ - Mozambico 1
NA - Namibia 1
NI - Nicaragua 1
NZ - Nuova Zelanda 1
PA - Panama 1
Totale 14.010
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Città #
Singapore 916
Southend 694
Ashburn 485
Fairfield 384
Chandler 378
Ho Chi Minh City 351
Hong Kong 305
San Jose 300
Hanoi 283
Santa Clara 267
Dong Ket 255
Bologna 248
Houston 217
Hefei 182
Ann Arbor 181
Wilmington 180
Seattle 179
Woodbridge 172
Princeton 156
Beijing 146
Cambridge 135
Dublin 124
Boardman 117
Seoul 88
Abidjan 80
Lauterbourg 78
Dallas 75
Nanjing 73
Tokyo 71
Westminster 68
Padova 62
Los Angeles 61
New York 53
Helsinki 51
Berlin 49
Jinan 47
Milan 46
Redmond 46
Da Nang 45
Council Bluffs 44
Lomé 44
Cesena 42
Redondo Beach 40
Buffalo 37
Haiphong 36
Turin 36
Rome 33
Munich 32
Saint Petersburg 32
Tianjin 32
Guangzhou 31
Rimini 31
Medford 30
Shenyang 30
San Diego 29
Brussels 28
Changsha 27
Sofia 27
Bengaluru 26
Falls Church 26
Zhengzhou 25
Hebei 24
Amman 23
Bern 23
Forlì 22
Hangzhou 22
Hải Dương 22
Bremen 21
Carpi 21
Frankfurt am Main 21
Hyderabad 21
Phoenix 21
Biên Hòa 20
São Paulo 20
London 19
Dearborn 18
Jiaxing 18
Shanghai 18
San Francisco 17
Chicago 16
Nanchang 16
Amsterdam 15
Jacksonville 15
Jakarta 14
Nha Trang 14
Orem 14
Warsaw 14
Yubileyny 14
Haikou 13
Denver 12
Falkenstein 12
Ninh Bình 12
Norwalk 12
Nuremberg 12
Taizhou 12
Toronto 12
Can Tho 11
Ha Long 11
The Dalles 11
Thái Bình 11
Totale 9.010
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Nome #
3,4-Dihydro-1,3,5-triazin-2(1H)-ones as the First Dual BACE-1/GSK-3β Fragment Hits against Alzheimer's Disease 442
Discovery of the First-in-Class GSK-3β/HDAC Dual Inhibitor as Disease-Modifying Agent To Combat Alzheimer's Disease. 412
AR-A014418-based dual Glycogen Synthase Kinase 3β/Histone Deacetylase inhibitors as potential therapeutics for Alzheimer's disease 326
Advanced analytical methodologies in Alzheimer's disease drug discovery 293
Correction: Discovery of the First-in-Class GSK-3β/HDAC Dual Inhibitor as Disease-Modifying Agent to Combat Alzheimer's Disease (ACS Medicinal Chemistry Letters (2019) 10: 4 (469−474) DOI: 10.1021/acsmedchemlett.8b00507) 289
A small chemical library of 2-aminoimidazole derivatives as BACE-1 inhibitors: structure-based design, synthesis, and biological evaluation 261
PROTAC-INDUCED GLYCOGEN SYNTHASE KINASE 3B DEGRADATION 242
Versatility of the Curcumin Scaffold: Discovery of Potent and Balanced Dual BACE-1 and GSK-3β Inhibitors 222
Reversible human serum albumin binding of lipocrine: a circular dichroism study. 221
Immobilized Enzyme Reactors: an Overview of Applications in Drug Discovery from 2008 to 2018 206
Circular dichroism in drug discovery and development: an abridged review. 199
Naturally inspired molecules as multifunctional agents for Alzheimer's disease treatment 199
Amaryllidaceae alkaloids from Narcissus pseudonarcissus L. cv. Dutch Master as potential drugs in treatment of Alzheimer's disease 185
(±)- BIGI-3h: Pentatarget-Directed Ligand combining Cholinesterase, Monoamine Oxidase, and Glycogen Synthase Kinase 3β Inhibition with Calcium Channel Antagonism and Antiaggregating Properties for Alzheimer's Disease 183
Analytical characterization of fruits waste for their valorization as sources of bioactive compounds. 181
Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimers Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography 180
Development of an UHPLC-diode arrays detector (DAD) method for the analysis of polydatin in human plasma 177
Beta-secretase as a target for Alzheimer's disease drug discovery: an overview of in vitro methods for characterization of inhibitors. 174
Amyloid beta-Peptide 25-35 Self Assembly and Its Inhibition: A Model Undecapeptide System to Gain Atomistic and Secondary Structure Details of the Alzheimer's Disease Process and Treatment 172
Investigating in vitro amyloid peptide 1−42 aggregation: Impact of higher molecular weight stable adducts 172
Application of BACE1 immobilized enzyme reactor for the characterization of multifunctional alkaloids from Corydalis cava (Fumariaceae) as Alzheimer's disease targets 170
Fluorinated benzophenone derivatives: balanced multipotent agents for Alzheimer's disease 169
Phenolic and Antioxidant Characterization of Fruit By-Products for Their Nutraceuticals and Dietary Supplements Valorization under a Circular Bio-Economy Approach 167
Quinones bearing non-steroidal anti-inflammatory fragments as multitarget ligands for Alzheimer’s disease 166
Designing Dual Transglutaminase 2/Histone Deacetylase Inhibitors Effective at Halting Neuronal Death 162
Human recombinant beta-secretase immobilized enzyme reactor for fast hits’ selection and characterization from a virtual screening library 162
From virtual screening hits targeting a cryptic pocket in BACE-1 to a nontoxic brain permeable multitarget anti-Alzheimer lead with disease-modifying and cognition-enhancing effects 162
An Advanced Multiple Receptor Conformations Virtual Ligand Screening Protocol for the Identification of Novel BACE-1 Inhibitors 160
Surface plasmon resonance, fluorescence, and circular dichroism studies for the characterization of the binding of BACE-1 inhibitors 159
Structural characterization of p53 isoforms due to the polymorphism at codon 72 by Mass Spectrometry and Circular Dichroism. 158
A patent review of butyrylcholinesterase inhibitors and reactivators 2010–2017 158
Analytical approaches in Alzheimer’s disease Drug Discovery 156
Multifunctional activity of some isoquinoline alkaloids from Corydalis cava tubers on Alzheimer's disease targets 156
Functionalized aromatic esters of the Amaryllidaceae alkaloid haemanthamine and their in vitro and in silico biological activity connected to Alzheimer's disease 155
From AChE to BACE1 inhibitors: The role of the amine on the indanone scaffold 154
Uleine disrupts key enzymatic and non-enzymatic biomarkers that leads to Alzheimer's disease 154
Histone Deacetylase Inhibitors as Multitarget Ligands: New Players in Alzheimer's Disease Drug Discovery? 154
Combined Methodologies for Determining In Vitro Bioavailability of Drugs and Prediction of In Vivo Bioequivalence From Pharmaceutical Oral Formulations 153
Integrated analytical approaches for the characterization of nutraceutical bioactives in microalgae 149
Curcumin derivatives as beta-secretase (BACE1) inhibitors. 147
Protein Flexibility in Virtual Screening: The BACE-1 Case Study 146
Pyridinylimidazoles as GSK3β Inhibitors: The Impact of Tautomerism on Compound Activity via Water Networks 145
Aß42 peptide toxicity on neuronal cells: a lipidomic study in view of Alzheimer’s Disease drug discovery 143
Circular Dichroism: a Study of Reversible Binding HSA Binding of Lipocrine. 143
The role of Chromatography in Alzheimer’s Disease Drug Discovery. 142
Hydroxy-substituted trans-cinnamoyl derivatives as multifunctional tools in the context of Alzheimer's disease 142
Fentanyl pharmacokinetics in blood of cancer patients by Gas Chromatography - Mass Spectrometry 142
Application of an ESI-QTOF method for the detailed characterization of GSK-3β inhibitors 138
A multi-methodological approach for the investigation of β-Amyloid-CORMs interaction: an LC-ESI/MS and Circular Dichroism study. 137
Synthesis and multitarget biological profiling of a novel family of rhein derivatives as disease-modifying anti-Alzheimer agents. 137
null 135
Design of Experiments and Optimization of Monacolin K Green Extraction from Red Yeast Rice by Ultra-High-Performance Liquid Chromatography 133
- Application of an ESI-MS method enabling the discovery of new non-ATP competitive GSK-3beta inhibitors. 133
Characterization of polyphenolic composition in Leccinum Scabrum and Leccinum Versipelle mushrooms 130
Application of an ESI-MS method enabling the discovery of new non-ATP competitive GSK-3beta inhibitors. 128
Valorization of by-products from agro-foods for pharmaceutical, cosmetic, nutraceutical applications 127
Design, synthesis, in silico and in vitro screening of 1,2,4-thiadiazole analogues as non-peptide inhibitors of beta-secretase. 127
β-Amyloid-CORMs interaction monitoring by LC-ESI/MS and Circular Dichroism studies 127
Micro-immobilized enzyme reactor based on human recombinant beta secretase (hrBACE-1-microIMER) for liquid chromatography fast screening of inhibitors. 126
Identification of Novel BACE-1 Inhibitors through an Advanced Structure-Based Virtual Screening Protocol. 126
Application of ESI-MS method for detailed characterization of GSK-3β inhibitors by monitoring GSM peptide phosphorylation.Angelini Farmaceutici. 126
A multi-approach study for BACE-1 inhibitors characterization. 125
null 123
Monitoring GSM peptide phosphorylation by Glycogen Synthase Kinase-3β using Electrospray Ionization Ion Trap Mass Spectrometry (ESI-IT-MS). 121
Structural characterization of recombinant therapeutic proteins by circular dichroism. 121
A novel class of multitarget anti-Alzheimer benzohomoadamantane‒chlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors 121
ESI-MS and UHPLC combined analytical approaches for determining the kinetics of Glycogen Synthase Kinase-3β 120
Optical Biosensors and Applications to Drug Discovery and Development in Cancer Research 120
Characterization of essential oil components in cosmetic products by GC-MS. 116
Surface plasmon resonance assay for BACE-1 inhibitors’ characterization. 115
Synthesis, in vitro biological profiling and in vivo efficacy studies of novel multitarget disease-modifyng anti-Alzheimer drug candidates. 115
Integrated analytical methodologies for Alzheimer's disease drug discovery 115
An immobilized enzyme reactor based on human recombinant betasecretase (hrBACE-1-IMER) for the fast processing of substrates and screening of inhibitors 115
Tacrine-benzofunan hybrids as multi-target directed ligands for Alzheimer´s disease treatment 113
Synthesis and pharmacological evaluation of a novel class of multi target Huprine-based anti-Alzheimer hybrids 113
Liquid chromatographic enzymatic studies with on-line Beta-secretase immobilized enzyme reactor and 4-(4-dimethylaminophenylazo) benzoic acid/5-[(2-aminoethyl) amino] naphthalene-1-sulfonic acid as fluorogenic substrate 112
Design, synthesis and multitarget biological profiling of second-generation anti-Alzheimer rhein-huprine hybrids 111
Uleine an indole alkaloid from Himatanthus lancifolius as acetylcholinesterase, butyrylcholinesterase, beta-secretase and beta-amyloid(1-42) spontaneous aggregation inhibitor. 108
Direct determination of GSK-3β activity and inhibition by UHPLC-UV-vis diode arrays detector (DAD) 108
null 108
null 106
Design, Synthesis and Biological profiling of a promising new family of multitarget directed ligands for the treatment of Alzheimer Disease. 106
LIPIDOMICS STUDY OF NEUROBLASTOMA CELLS UNDER Aβ1-42 TOXIC INSULT 103
null 99
Synthesis, molecular modelling, in vitro biological profiling, and in vivo efficacy studies of a novel family of huprine-based multi-target anti-alzheimer compounds. 99
Simultaneous Multiple MS Binding Assays for the Dopamine, Norepinephrine, and Serotonin Transporters 97
Lipidomics of neuroblastoma cells under Aß1-42 toxic insult 94
null 91
Optimization of natural compounds on-line screening by immobilized enzyme reactor based on human recombinant betasecretase (hrBACE-1-IMER). 90
Simultaneous MS Binding Assays for Monoamine Transporters. 83
MICROALGAE: BIOACTIVES EXTRACTION AND CHARACTERIZATION FOR NUTRACEUTICAL USAGE 82
Valorization of by-products from agri-foods for pharmaceutical, cosmetic, nutraceutical applications 81
Tacrine-based Multifunctional Agents in Alzheimer's Disease: an Old Story in Continuous Development 81
null 77
Multitarget drug discovery for Alzheimer's disease: triazinones as BACE-1 and GSK-3β inhibitors. 77
Totale 14.306
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Categoria #
all - tutte 37.896
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 37.896
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20221.297 0 40 78 43 130 75 27 108 136 79 314 267
2022/20231.598 154 218 107 227 140 116 37 103 265 63 97 71
2023/2024535 37 79 41 52 43 101 48 36 23 23 32 20
2024/20251.941 77 272 213 138 371 64 167 90 11 88 88 362
2025/20265.167 374 687 426 350 498 308 762 168 890 281 214 209
2026/2027146 105 41 0 0 0 0 0 0 0 0 0 0
Totale 14.306