CRIS Current Research Information System

DE SIMONE, ANGELA
 Distribuzione geografica
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Continente #
AS - Asia 4.987
NA - Nord America 4.934
EU - Europa 3.387
SA - Sud America 266
AF - Africa 245
OC - Oceania 6
Continente sconosciuto - Info sul continente non disponibili 1
Totale 13.826
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Nazione #
US - Stati Uniti d'America 4.869
VN - Vietnam 1.461
SG - Singapore 1.304
CN - Cina 1.218
IT - Italia 895
GB - Regno Unito 807
DE - Germania 392
HK - Hong Kong 320
SE - Svezia 308
IN - India 240
FR - Francia 202
RU - Federazione Russa 181
BR - Brasile 179
IE - Irlanda 125
KR - Corea 103
JP - Giappone 86
CI - Costa d'Avorio 80
UA - Ucraina 79
ZA - Sudafrica 70
FI - Finlandia 63
BD - Bangladesh 61
NL - Olanda 60
EE - Estonia 58
TG - Togo 44
CA - Canada 42
AR - Argentina 36
CH - Svizzera 36
BG - Bulgaria 31
BE - Belgio 29
ID - Indonesia 29
PL - Polonia 25
JO - Giordania 23
SC - Seychelles 22
ES - Italia 19
TR - Turchia 19
PH - Filippine 18
TW - Taiwan 17
TH - Thailandia 15
EC - Ecuador 14
HR - Croazia 14
MX - Messico 14
PK - Pakistan 14
AT - Austria 10
CO - Colombia 10
CZ - Repubblica Ceca 10
SA - Arabia Saudita 10
CL - Cile 8
RO - Romania 8
VE - Venezuela 8
IR - Iran 7
NG - Nigeria 7
GR - Grecia 6
HU - Ungheria 6
PY - Paraguay 6
AU - Australia 5
IL - Israele 5
IQ - Iraq 5
LB - Libano 5
PT - Portogallo 5
SM - San Marino 5
UZ - Uzbekistan 5
AE - Emirati Arabi Uniti 4
EG - Egitto 4
MY - Malesia 4
BO - Bolivia 3
DZ - Algeria 3
HN - Honduras 3
KE - Kenya 3
LT - Lituania 3
MA - Marocco 3
NP - Nepal 3
PS - Palestinian Territory 3
TN - Tunisia 3
AL - Albania 2
AZ - Azerbaigian 2
BA - Bosnia-Erzegovina 2
CR - Costa Rica 2
ET - Etiopia 2
MD - Moldavia 2
SK - Slovacchia (Repubblica Slovacca) 2
UY - Uruguay 2
BJ - Benin 1
BN - Brunei Darussalam 1
BS - Bahamas 1
DK - Danimarca 1
EU - Europa 1
GM - Gambi 1
JM - Giamaica 1
KH - Cambogia 1
KW - Kuwait 1
KZ - Kazakistan 1
LK - Sri Lanka 1
MZ - Mozambico 1
NA - Namibia 1
NZ - Nuova Zelanda 1
PA - Panama 1
RS - Serbia 1
SY - Repubblica araba siriana 1
TT - Trinidad e Tobago 1
Totale 13.826
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Città #
Singapore 908
Southend 694
Ashburn 480
Fairfield 384
Chandler 378
Ho Chi Minh City 346
Hong Kong 303
San Jose 297
Hanoi 281
Santa Clara 261
Dong Ket 255
Bologna 247
Houston 216
Hefei 182
Ann Arbor 181
Wilmington 180
Seattle 179
Woodbridge 172
Princeton 156
Beijing 145
Cambridge 135
Dublin 124
Boardman 117
Seoul 88
Abidjan 80
Lauterbourg 78
Dallas 74
Nanjing 73
Tokyo 71
Westminster 68
Padova 62
Los Angeles 61
New York 52
Helsinki 51
Berlin 49
Jinan 47
Redmond 46
Da Nang 44
Lomé 44
Cesena 42
Redondo Beach 40
Milan 39
Buffalo 37
Council Bluffs 37
Haiphong 36
Turin 35
Munich 32
Saint Petersburg 32
Tianjin 32
Guangzhou 31
Rimini 31
Shenyang 30
Medford 29
San Diego 29
Brussels 28
Rome 28
Changsha 27
Sofia 27
Bengaluru 26
Falls Church 26
Zhengzhou 25
Hebei 24
Amman 23
Bern 23
Forlì 22
Hangzhou 22
Hải Dương 22
Bremen 21
Carpi 21
Frankfurt am Main 21
Hyderabad 21
Phoenix 21
Biên Hòa 20
São Paulo 20
Dearborn 18
Jiaxing 18
London 18
Shanghai 18
San Francisco 17
Chicago 16
Nanchang 16
Amsterdam 15
Jacksonville 15
Jakarta 14
Nha Trang 14
Orem 14
Warsaw 14
Yubileyny 14
Haikou 13
Denver 12
Falkenstein 12
Ninh Bình 12
Norwalk 12
Nuremberg 12
Taizhou 12
Can Tho 11
Ha Long 11
The Dalles 11
Thái Bình 11
Thái Nguyên 11
Totale 8.950
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Nome #
3,4-Dihydro-1,3,5-triazin-2(1H)-ones as the First Dual BACE-1/GSK-3β Fragment Hits against Alzheimer's Disease 431
Discovery of the First-in-Class GSK-3β/HDAC Dual Inhibitor as Disease-Modifying Agent To Combat Alzheimer's Disease. 402
AR-A014418-based dual Glycogen Synthase Kinase 3β/Histone Deacetylase inhibitors as potential therapeutics for Alzheimer's disease 312
Advanced analytical methodologies in Alzheimer's disease drug discovery 292
Correction: Discovery of the First-in-Class GSK-3β/HDAC Dual Inhibitor as Disease-Modifying Agent to Combat Alzheimer's Disease (ACS Medicinal Chemistry Letters (2019) 10: 4 (469−474) DOI: 10.1021/acsmedchemlett.8b00507) 287
A small chemical library of 2-aminoimidazole derivatives as BACE-1 inhibitors: structure-based design, synthesis, and biological evaluation 260
PROTAC-INDUCED GLYCOGEN SYNTHASE KINASE 3B DEGRADATION 237
Reversible human serum albumin binding of lipocrine: a circular dichroism study. 219
Versatility of the Curcumin Scaffold: Discovery of Potent and Balanced Dual BACE-1 and GSK-3β Inhibitors 218
Immobilized Enzyme Reactors: an Overview of Applications in Drug Discovery from 2008 to 2018 201
Naturally inspired molecules as multifunctional agents for Alzheimer's disease treatment 199
Circular dichroism in drug discovery and development: an abridged review. 198
Amaryllidaceae alkaloids from Narcissus pseudonarcissus L. cv. Dutch Master as potential drugs in treatment of Alzheimer's disease 184
Analytical characterization of fruits waste for their valorization as sources of bioactive compounds. 180
(±)- BIGI-3h: Pentatarget-Directed Ligand combining Cholinesterase, Monoamine Oxidase, and Glycogen Synthase Kinase 3β Inhibition with Calcium Channel Antagonism and Antiaggregating Properties for Alzheimer's Disease 180
Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimers Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography 175
Amyloid beta-Peptide 25-35 Self Assembly and Its Inhibition: A Model Undecapeptide System to Gain Atomistic and Secondary Structure Details of the Alzheimer's Disease Process and Treatment 171
Development of an UHPLC-diode arrays detector (DAD) method for the analysis of polydatin in human plasma 171
Application of BACE1 immobilized enzyme reactor for the characterization of multifunctional alkaloids from Corydalis cava (Fumariaceae) as Alzheimer's disease targets 170
Beta-secretase as a target for Alzheimer's disease drug discovery: an overview of in vitro methods for characterization of inhibitors. 170
Investigating in vitro amyloid peptide 1−42 aggregation: Impact of higher molecular weight stable adducts 169
Fluorinated benzophenone derivatives: balanced multipotent agents for Alzheimer's disease 168
Quinones bearing non-steroidal anti-inflammatory fragments as multitarget ligands for Alzheimer’s disease 164
Phenolic and Antioxidant Characterization of Fruit By-Products for Their Nutraceuticals and Dietary Supplements Valorization under a Circular Bio-Economy Approach 163
Human recombinant beta-secretase immobilized enzyme reactor for fast hits’ selection and characterization from a virtual screening library 162
An Advanced Multiple Receptor Conformations Virtual Ligand Screening Protocol for the Identification of Novel BACE-1 Inhibitors 160
Designing Dual Transglutaminase 2/Histone Deacetylase Inhibitors Effective at Halting Neuronal Death 159
From virtual screening hits targeting a cryptic pocket in BACE-1 to a nontoxic brain permeable multitarget anti-Alzheimer lead with disease-modifying and cognition-enhancing effects 159
Structural characterization of p53 isoforms due to the polymorphism at codon 72 by Mass Spectrometry and Circular Dichroism. 158
Analytical approaches in Alzheimer’s disease Drug Discovery 156
Multifunctional activity of some isoquinoline alkaloids from Corydalis cava tubers on Alzheimer's disease targets 156
A patent review of butyrylcholinesterase inhibitors and reactivators 2010–2017 156
Surface plasmon resonance, fluorescence, and circular dichroism studies for the characterization of the binding of BACE-1 inhibitors 154
Uleine disrupts key enzymatic and non-enzymatic biomarkers that leads to Alzheimer's disease 154
Functionalized aromatic esters of the Amaryllidaceae alkaloid haemanthamine and their in vitro and in silico biological activity connected to Alzheimer's disease 154
Combined Methodologies for Determining In Vitro Bioavailability of Drugs and Prediction of In Vivo Bioequivalence From Pharmaceutical Oral Formulations 153
Histone Deacetylase Inhibitors as Multitarget Ligands: New Players in Alzheimer's Disease Drug Discovery? 152
From AChE to BACE1 inhibitors: The role of the amine on the indanone scaffold 148
Integrated analytical approaches for the characterization of nutraceutical bioactives in microalgae 147
Curcumin derivatives as beta-secretase (BACE1) inhibitors. 147
Protein Flexibility in Virtual Screening: The BACE-1 Case Study 145
Aß42 peptide toxicity on neuronal cells: a lipidomic study in view of Alzheimer’s Disease drug discovery 142
Circular Dichroism: a Study of Reversible Binding HSA Binding of Lipocrine. 142
The role of Chromatography in Alzheimer’s Disease Drug Discovery. 140
Fentanyl pharmacokinetics in blood of cancer patients by Gas Chromatography - Mass Spectrometry 140
Pyridinylimidazoles as GSK3β Inhibitors: The Impact of Tautomerism on Compound Activity via Water Networks 139
Hydroxy-substituted trans-cinnamoyl derivatives as multifunctional tools in the context of Alzheimer's disease 138
Synthesis and multitarget biological profiling of a novel family of rhein derivatives as disease-modifying anti-Alzheimer agents. 136
A multi-methodological approach for the investigation of β-Amyloid-CORMs interaction: an LC-ESI/MS and Circular Dichroism study. 135
null 135
Application of an ESI-QTOF method for the detailed characterization of GSK-3β inhibitors 134
- Application of an ESI-MS method enabling the discovery of new non-ATP competitive GSK-3beta inhibitors. 133
Application of an ESI-MS method enabling the discovery of new non-ATP competitive GSK-3beta inhibitors. 128
Characterization of polyphenolic composition in Leccinum Scabrum and Leccinum Versipelle mushrooms 127
Valorization of by-products from agro-foods for pharmaceutical, cosmetic, nutraceutical applications 127
Design, synthesis, in silico and in vitro screening of 1,2,4-thiadiazole analogues as non-peptide inhibitors of beta-secretase. 127
Micro-immobilized enzyme reactor based on human recombinant beta secretase (hrBACE-1-microIMER) for liquid chromatography fast screening of inhibitors. 126
Application of ESI-MS method for detailed characterization of GSK-3β inhibitors by monitoring GSM peptide phosphorylation.Angelini Farmaceutici. 126
Design of Experiments and Optimization of Monacolin K Green Extraction from Red Yeast Rice by Ultra-High-Performance Liquid Chromatography 125
Identification of Novel BACE-1 Inhibitors through an Advanced Structure-Based Virtual Screening Protocol. 125
β-Amyloid-CORMs interaction monitoring by LC-ESI/MS and Circular Dichroism studies 124
null 123
A multi-approach study for BACE-1 inhibitors characterization. 123
ESI-MS and UHPLC combined analytical approaches for determining the kinetics of Glycogen Synthase Kinase-3β 120
Structural characterization of recombinant therapeutic proteins by circular dichroism. 120
A novel class of multitarget anti-Alzheimer benzohomoadamantane‒chlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors 120
Optical Biosensors and Applications to Drug Discovery and Development in Cancer Research 120
Monitoring GSM peptide phosphorylation by Glycogen Synthase Kinase-3β using Electrospray Ionization Ion Trap Mass Spectrometry (ESI-IT-MS). 119
Characterization of essential oil components in cosmetic products by GC-MS. 115
An immobilized enzyme reactor based on human recombinant betasecretase (hrBACE-1-IMER) for the fast processing of substrates and screening of inhibitors 115
Surface plasmon resonance assay for BACE-1 inhibitors’ characterization. 113
Synthesis, in vitro biological profiling and in vivo efficacy studies of novel multitarget disease-modifyng anti-Alzheimer drug candidates. 113
Liquid chromatographic enzymatic studies with on-line Beta-secretase immobilized enzyme reactor and 4-(4-dimethylaminophenylazo) benzoic acid/5-[(2-aminoethyl) amino] naphthalene-1-sulfonic acid as fluorogenic substrate 112
Integrated analytical methodologies for Alzheimer's disease drug discovery 112
Synthesis and pharmacological evaluation of a novel class of multi target Huprine-based anti-Alzheimer hybrids 112
Tacrine-benzofunan hybrids as multi-target directed ligands for Alzheimer´s disease treatment 111
Uleine an indole alkaloid from Himatanthus lancifolius as acetylcholinesterase, butyrylcholinesterase, beta-secretase and beta-amyloid(1-42) spontaneous aggregation inhibitor. 108
null 108
null 106
Design, Synthesis and Biological profiling of a promising new family of multitarget directed ligands for the treatment of Alzheimer Disease. 106
Direct determination of GSK-3β activity and inhibition by UHPLC-UV-vis diode arrays detector (DAD) 105
Design, synthesis and multitarget biological profiling of second-generation anti-Alzheimer rhein-huprine hybrids 105
LIPIDOMICS STUDY OF NEUROBLASTOMA CELLS UNDER Aβ1-42 TOXIC INSULT 101
null 99
Synthesis, molecular modelling, in vitro biological profiling, and in vivo efficacy studies of a novel family of huprine-based multi-target anti-alzheimer compounds. 98
Simultaneous Multiple MS Binding Assays for the Dopamine, Norepinephrine, and Serotonin Transporters 95
Lipidomics of neuroblastoma cells under Aß1-42 toxic insult 93
null 91
Optimization of natural compounds on-line screening by immobilized enzyme reactor based on human recombinant betasecretase (hrBACE-1-IMER). 89
Simultaneous MS Binding Assays for Monoamine Transporters. 83
Tacrine-based Multifunctional Agents in Alzheimer's Disease: an Old Story in Continuous Development 81
Valorization of by-products from agri-foods for pharmaceutical, cosmetic, nutraceutical applications 80
MICROALGAE: BIOACTIVES EXTRACTION AND CHARACTERIZATION FOR NUTRACEUTICAL USAGE 80
null 77
Multitarget drug discovery for Alzheimer's disease: triazinones as BACE-1 and GSK-3β inhibitors. 75
Totale 14.118
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Categoria #
all - tutte 36.706
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 36.706
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021306 0 0 0 0 0 0 0 0 0 0 0 306
2021/20221.484 187 40 78 43 130 75 27 108 136 79 314 267
2022/20231.598 154 218 107 227 140 116 37 103 265 63 97 71
2023/2024535 37 79 41 52 43 101 48 36 23 23 32 20
2024/20251.941 77 272 213 138 371 64 167 90 11 88 88 362
2025/20265.125 374 687 426 350 498 308 762 168 890 281 214 167
Totale 14.118