CRIS Current Research Information System

DE SIMONE, ANGELA
 Distribuzione geografica
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Continente #
NA - Nord America 3.180
EU - Europa 2.547
AS - Asia 982
AF - Africa 148
SA - Sud America 22
OC - Oceania 6
Continente sconosciuto - Info sul continente non disponibili 1
Totale 6.886
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Nazione #
US - Stati Uniti d'America 3.170
GB - Regno Unito 748
IT - Italia 595
CN - Cina 384
VN - Vietnam 313
DE - Germania 312
SE - Svezia 298
IN - India 179
IE - Irlanda 119
FR - Francia 97
RU - Federazione Russa 82
UA - Ucraina 72
EE - Estonia 58
ZA - Sudafrica 58
TG - Togo 44
SG - Singapore 38
CI - Costa d'Avorio 37
CH - Svizzera 32
BG - Bulgaria 31
BE - Belgio 26
JO - Giordania 22
FI - Finlandia 18
HR - Croazia 13
BR - Brasile 9
NL - Olanda 8
TR - Turchia 8
CL - Cile 7
IR - Iran 7
KR - Corea 7
RO - Romania 7
NG - Nigeria 6
PL - Polonia 6
AU - Australia 5
CA - Canada 5
CZ - Repubblica Ceca 5
GR - Grecia 5
LB - Libano 5
ES - Italia 4
JP - Giappone 4
PT - Portogallo 4
CO - Colombia 3
EC - Ecuador 3
HK - Hong Kong 3
MX - Messico 3
SC - Seychelles 3
HU - Ungheria 2
ID - Indonesia 2
IL - Israele 2
MD - Moldavia 2
PK - Pakistan 2
AL - Albania 1
AT - Austria 1
AZ - Azerbaigian 1
BD - Bangladesh 1
BN - Brunei Darussalam 1
CR - Costa Rica 1
EU - Europa 1
KW - Kuwait 1
NZ - Nuova Zelanda 1
SM - San Marino 1
TT - Trinidad e Tobago 1
TW - Taiwan 1
UZ - Uzbekistan 1
Totale 6.886
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Città #
Southend 694
Fairfield 383
Chandler 378
Dong Ket 255
Ashburn 250
Houston 211
Bologna 196
Ann Arbor 181
Wilmington 180
Seattle 176
Woodbridge 172
Princeton 156
Cambridge 133
Dublin 118
Westminster 68
Nanjing 66
Padova 60
Berlin 48
Redmond 46
Lomé 44
Jinan 38
Abidjan 37
Turin 35
Saint Petersburg 32
Beijing 31
Cesena 30
Medford 29
Singapore 29
Boardman 28
San Diego 28
Shenyang 28
Sofia 27
Brussels 26
Falls Church 26
Changsha 24
Hebei 24
Bern 23
Amman 22
Tianjin 22
Bremen 21
Forlì 21
New York 20
Dearborn 18
Jiaxing 18
Helsinki 17
Hyderabad 15
Nanchang 15
Milan 14
Haikou 13
Hangzhou 13
Jacksonville 13
Zhengzhou 13
Guangzhou 12
Norwalk 12
Taizhou 12
Redwood City 10
Phoenix 9
Rimini 9
Rome 9
Bühl 8
Lanzhou 8
London 8
New Haven 8
Olalla 8
Costa Mesa 7
Des Moines 7
Mohali 7
Fremont 6
Mirandola 6
Taiyuan 6
Torino 6
Abeokuta 5
Amsterdam 5
Cervia 5
Lausanne 5
Naples 5
Ningbo 5
Ravenna 5
São Paulo 5
Tappahannock 5
Bengaluru 4
Bergamo 4
Delhi 4
Hefei 4
Hradec Králové 4
Kunming 4
Leeds 4
Mülheim 4
Nagold 4
San Francisco 4
San Jose 4
Siena 4
Arese 3
Brescia 3
Castel San Giorgio 3
Cecina 3
Frankfurt am Main 3
Fuzhou 3
Genova 3
Kashan 3
Totale 4.840
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Nome #
3,4-Dihydro-1,3,5-triazin-2(1H)-ones as the First Dual BACE-1/GSK-3β Fragment Hits against Alzheimer's Disease 241
Discovery of the First-in-Class GSK-3β/HDAC Dual Inhibitor as Disease-Modifying Agent To Combat Alzheimer's Disease. 230
Advanced analytical methodologies in Alzheimer's disease drug discovery 208
A small chemical library of 2-aminoimidazole derivatives as BACE-1 inhibitors: structure-based design, synthesis, and biological evaluation 188
Versatility of the Curcumin Scaffold: Discovery of Potent and Balanced Dual BACE-1 and GSK-3β Inhibitors 135
null 135
Circular dichroism in drug discovery and development: an abridged review. 129
null 123
Immobilized Enzyme Reactors: an Overview of Applications in Drug Discovery from 2008 to 2018 120
Amyloid beta-Peptide 25-35 Self Assembly and Its Inhibition: A Model Undecapeptide System to Gain Atomistic and Secondary Structure Details of the Alzheimer's Disease Process and Treatment 117
Application of BACE1 immobilized enzyme reactor for the characterization of multifunctional alkaloids from Corydalis cava (Fumariaceae) as Alzheimer's disease targets 113
Fluorinated benzophenone derivatives: balanced multipotent agents for Alzheimer's disease 112
Beta-secretase as a target for Alzheimer's disease drug discovery: an overview of in vitro methods for characterization of inhibitors. 112
Analytical approaches in Alzheimer’s disease Drug Discovery 111
null 108
An Advanced Multiple Receptor Conformations Virtual Ligand Screening Protocol for the Identification of Novel BACE-1 Inhibitors 107
null 106
Histone Deacetylase Inhibitors as Multitarget Ligands: New Players in Alzheimer's Disease Drug Discovery? 104
Correction: Discovery of the First-in-Class GSK-3β/HDAC Dual Inhibitor as Disease-Modifying Agent to Combat Alzheimer's Disease (ACS Medicinal Chemistry Letters (2019) 10: 4 (469−474) DOI: 10.1021/acsmedchemlett.8b00507) 104
Human recombinant beta-secretase immobilized enzyme reactor for fast hits’ selection and characterization from a virtual screening library 103
Uleine disrupts key enzymatic and non-enzymatic biomarkers that leads to Alzheimer's disease 102
Naturally inspired molecules as multifunctional agents for Alzheimer's disease treatment 102
Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimers Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography 102
Quinones bearing non-steroidal anti-inflammatory fragments as multitarget ligands for Alzheimer’s disease 101
Multifunctional activity of some isoquinoline alkaloids from Corydalis cava tubers on Alzheimer's disease targets 100
null 99
Synthesis and multitarget biological profiling of a novel family of rhein derivatives as disease-modifying anti-Alzheimer agents. 99
Designing Dual Transglutaminase 2/Histone Deacetylase Inhibitors Effective at Halting Neuronal Death 98
Structural characterization of p53 isoforms due to the polymorphism at codon 72 by Mass Spectrometry and Circular Dichroism. 93
A patent review of butyrylcholinesterase inhibitors and reactivators 2010–2017 93
- Application of an ESI-MS method enabling the discovery of new non-ATP competitive GSK-3beta inhibitors. 92
null 91
Protein Flexibility in Virtual Screening: The BACE-1 Case Study 90
Application of an ESI-MS method enabling the discovery of new non-ATP competitive GSK-3beta inhibitors. 89
Application of ESI-MS method for detailed characterization of GSK-3β inhibitors by monitoring GSM peptide phosphorylation.Angelini Farmaceutici. 88
Surface plasmon resonance, fluorescence, and circular dichroism studies for the characterization of the binding of BACE-1 inhibitors 87
Optical Biosensors and Applications to Drug Discovery and Development in Cancer Research 87
Design, synthesis, in silico and in vitro screening of 1,2,4-thiadiazole analogues as non-peptide inhibitors of beta-secretase. 85
Investigating in vitro amyloid peptide 1−42 aggregation: Impact of higher molecular weight stable adducts 85
Circular Dichroism: a Study of Reversible Binding HSA Binding of Lipocrine. 82
Reversible human serum albumin binding of lipocrine: a circular dichroism study. 80
Curcumin derivatives as beta-secretase (BACE1) inhibitors. 80
Pyridinylimidazoles as GSK3β Inhibitors: The Impact of Tautomerism on Compound Activity via Water Networks 80
The role of Chromatography in Alzheimer’s Disease Drug Discovery. 78
null 77
Characterization of essential oil components in cosmetic products by GC-MS. 76
Monitoring GSM peptide phosphorylation by Glycogen Synthase Kinase-3β using Electrospray Ionization Ion Trap Mass Spectrometry (ESI-IT-MS). 72
Combined Methodologies for Determining In Vitro Bioavailability of Drugs and Prediction of In Vivo Bioequivalence From Pharmaceutical Oral Formulations 72
Synthesis, in vitro biological profiling and in vivo efficacy studies of novel multitarget disease-modifyng anti-Alzheimer drug candidates. 69
Amaryllidaceae alkaloids from Narcissus pseudonarcissus L. cv. Dutch Master as potential drugs in treatment of Alzheimer's disease 69
ESI-MS and UHPLC combined analytical approaches for determining the kinetics of Glycogen Synthase Kinase-3β 68
Liquid chromatographic enzymatic studies with on-line Beta-secretase immobilized enzyme reactor and 4-(4-dimethylaminophenylazo) benzoic acid/5-[(2-aminoethyl) amino] naphthalene-1-sulfonic acid as fluorogenic substrate 65
Identification of Novel BACE-1 Inhibitors through an Advanced Structure-Based Virtual Screening Protocol. 64
A multi-methodological approach for the investigation of β-Amyloid-CORMs interaction: an LC-ESI/MS and Circular Dichroism study. 64
Structural characterization of recombinant therapeutic proteins by circular dichroism. 63
Development of an UHPLC-diode arrays detector (DAD) method for the analysis of polydatin in human plasma 62
Design, Synthesis and Biological profiling of a promising new family of multitarget directed ligands for the treatment of Alzheimer Disease. 60
β-Amyloid-CORMs interaction monitoring by LC-ESI/MS and Circular Dichroism studies 60
Synthesis, molecular modelling, in vitro biological profiling, and in vivo efficacy studies of a novel family of huprine-based multi-target anti-alzheimer compounds. 60
Micro-immobilized enzyme reactor based on human recombinant beta secretase (hrBACE-1-microIMER) for liquid chromatography fast screening of inhibitors. 59
Simultaneous Multiple MS Binding Assays for the Dopamine, Norepinephrine, and Serotonin Transporters 58
A novel class of multitarget anti-Alzheimer benzohomoadamantane‒chlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors 58
From virtual screening hits targeting a cryptic pocket in BACE-1 to a nontoxic brain permeable multitarget anti-Alzheimer lead with disease-modifying and cognition-enhancing effects 58
A multi-approach study for BACE-1 inhibitors characterization. 57
Surface plasmon resonance assay for BACE-1 inhibitors’ characterization. 56
An immobilized enzyme reactor based on human recombinant betasecretase (hrBACE-1-IMER) for the fast processing of substrates and screening of inhibitors 56
null 56
Uleine an indole alkaloid from Himatanthus lancifolius as acetylcholinesterase, butyrylcholinesterase, beta-secretase and beta-amyloid(1-42) spontaneous aggregation inhibitor. 55
Synthesis and pharmacological evaluation of a novel class of multi target Huprine-based anti-Alzheimer hybrids 55
Integrated analytical methodologies for Alzheimer's disease drug discovery 53
PROTAC-INDUCED GLYCOGEN SYNTHASE KINASE 3B DEGRADATION 51
Tacrine-benzofunan hybrids as multi-target directed ligands for Alzheimer´s disease treatment 51
Optimization of natural compounds on-line screening by immobilized enzyme reactor based on human recombinant betasecretase (hrBACE-1-IMER). 50
Functionalized aromatic esters of the Amaryllidaceae alkaloid haemanthamine and their in vitro and in silico biological activity connected to Alzheimer's disease 49
Simultaneous MS Binding Assays for Monoamine Transporters. 48
Fentanyl pharmacokinetics in blood of cancer patients by Gas Chromatography - Mass Spectrometry 46
Application of an ESI-QTOF method for the detailed characterization of GSK-3β inhibitors 45
From AChE to BACE1 inhibitors: The role of the amine on the indanone scaffold 41
Direct determination of GSK-3β activity and inhibition by UHPLC-UV-vis diode arrays detector (DAD) 39
(±)- BIGI-3h: Pentatarget-Directed Ligand combining Cholinesterase, Monoamine Oxidase, and Glycogen Synthase Kinase 3β Inhibition with Calcium Channel Antagonism and Antiaggregating Properties for Alzheimer's Disease 34
Hydroxy-substituted trans-cinnamoyl derivatives as multifunctional tools in the context of Alzheimer's disease 32
Valorization of by-products from agro-foods for pharmaceutical, cosmetic, nutraceutical applications 24
Aß42 peptide toxicity on neuronal cells: a lipidomic study in view of Alzheimer’s Disease drug discovery 19
Design, synthesis and multitarget biological profiling of second-generation anti-Alzheimer rhein-huprine hybrids 19
Integrated analytical approaches for the characterization of nutraceutical bioactives in microalgae 17
Multitarget drug discovery for Alzheimer's disease: triazinones as BACE-1 and GSK-3β inhibitors. 17
Tacrine-based Multifunctional Agents in Alzheimer's Disease: an Old Story in Continuous Development 16
Analytical characterization of fruits waste for their valorization as sources of bioactive compounds. 9
MICROALGAE: BIOACTIVES EXTRACTION AND CHARACTERIZATION FOR NUTRACEUTICAL USAGE 8
Lipidomics of neuroblastoma cells under Aß1-42 toxic insult 4
Characterization of polyphenolic composition in Leccinum Scabrum and Leccinum Versipelle mushrooms 4
LIPIDOMICS STUDY OF NEUROBLASTOMA CELLS UNDER Aβ1-42 TOXIC INSULT 4
Valorization of by-products from agri-foods for pharmaceutical, cosmetic, nutraceutical applications 2
Totale 7.140
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Categoria #
all - tutte 17.842
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 17.842
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20201.820 285 48 10 82 172 156 198 286 255 151 93 84
2020/20211.016 249 58 21 21 32 37 12 72 122 45 41 306
2021/20221.484 187 40 78 43 130 75 27 108 136 79 314 267
2022/20231.598 154 218 107 227 140 116 37 103 265 63 97 71
2023/2024560 37 79 41 52 43 101 48 36 23 35 43 22
2024/202563 63 0 0 0 0 0 0 0 0 0 0 0
Totale 7.140