Tacrine is no longer used for the treatment of Alzheimer's disease (AD) as oral acetylcholinesterase (AChE) inhibitor (AChEI) mainly due to its hepatotoxic effects. Notwithstanding, it is still one of the most famous drugs. Indeed, since the discovery of the "non-cholinergic" AChE's activities and the seminal paper from Pang and coworkers reporting the discovery of a tacrine-dimer, bis(7)-tacrine, tacrine has been used from legions of medicinal chemists as a starting point to develop new multi target ligands (MTLs), able to interfere with biochemical pathways and targets whose dysregulation seems to be involved in the development of AD. This is the third review of a series concerning tacrine-based MTLs; in particular, in the present, we will summarize and discuss the most intriguing examples of tacrine-based MTLs published since 2013 until now.
Milelli, A., De Simone, A., Ticchi, N., Chen, H.H., Betari, N., Andrisano, V., et al. (2017). Tacrine-based Multifunctional Agents in Alzheimer's Disease: an Old Story in Continuous Development. CURRENT MEDICINAL CHEMISTRY, 24(32), 3522-3546 [10.2174/0929867324666170309123920].
Tacrine-based Multifunctional Agents in Alzheimer's Disease: an Old Story in Continuous Development
MILELLI, ANDREA;DE SIMONE, ANGELA;TICCHI, NICOLE;BETARI, NIBAL;ANDRISANO, VINCENZA;TUMIATTI, VINCENZO
2017
Abstract
Tacrine is no longer used for the treatment of Alzheimer's disease (AD) as oral acetylcholinesterase (AChE) inhibitor (AChEI) mainly due to its hepatotoxic effects. Notwithstanding, it is still one of the most famous drugs. Indeed, since the discovery of the "non-cholinergic" AChE's activities and the seminal paper from Pang and coworkers reporting the discovery of a tacrine-dimer, bis(7)-tacrine, tacrine has been used from legions of medicinal chemists as a starting point to develop new multi target ligands (MTLs), able to interfere with biochemical pathways and targets whose dysregulation seems to be involved in the development of AD. This is the third review of a series concerning tacrine-based MTLs; in particular, in the present, we will summarize and discuss the most intriguing examples of tacrine-based MTLs published since 2013 until now.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
