DE SIMONE, ANGELA
DE SIMONE, ANGELA
DIPARTIMENTO DI SCIENZE PER LA QUALITA' DELLA VITA
Assegnisti
(±)- BIGI-3h: Pentatarget-Directed Ligand combining Cholinesterase, Monoamine Oxidase, and Glycogen Synthase Kinase 3β Inhibition with Calcium Channel Antagonism and Antiaggregating Properties for Alzheimer's Disease
2021 Ismaili L.; Monnin J.; Etievant A.; Arribas R.L.; Viejo L.; Refouvelet B.; Soukup O.; Janockova J.; Hepnarova V.; Korabecny J.; Kucera T.; Jun D.; Andrys R.; Musilek K.; Baguet A.; Garcia-Frutos E.M.; De Simone A.; Andrisano V.; Bartolini M.; De Los Rios C.; Marco-Contelles J.; Haffen E.
- Application of an ESI-MS method enabling the discovery of new non-ATP competitive GSK-3beta inhibitors.
2016 Angela, De Simone; Andrea, Milelli; Marina, Naldi; Vincenza, Andrisano
3,4-Dihydro-1,3,5-triazin-2(1H)-ones as the First Dual BACE-1/GSK-3β Fragment Hits against Alzheimer's Disease
2015 Prati, Federica; De Simone, Angela; Armirotti, Andrea; Summa, Maria; Pizzirani, Daniela; Scarpelli, Rita; Bertozzi, Sine Mandrup; Perez, Daniel I.; Andrisano, Vincenza; Perez-Castillo, Ana; Monti, Barbara; Massenzio, Francesca; Polito, Letizia; Racchi, Marco; Sabatino, Piera; Bottegoni, Giovanni; Martinez, Ana; Cavalli, Andrea; Bolognesi, Maria L.
A multi-approach study for BACE-1 inhibitors characterization.
2010 Angela De Simone; F. Mancini; C. Bertucci; V. Andrisano
A multi-methodological approach for the investigation of β-Amyloid-CORMs interaction: an LC-ESI/MS and Circular Dichroism study.
2018 de simone a, naldi m, tedesco d, bartolini m, andrisano v
A novel class of multitarget anti-Alzheimer benzohomoadamantane‒chlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors
2019 Perez-Areales F.J.; Turcu A.L.; Barniol-Xicota M.; Pont C.; Pivetta D.; Espargaro A.; Bartolini M.; De Simone A.; Andrisano V.; Perez B.; Sabate R.; Sureda F.X.; Vazquez S.; Munoz-Torrero D.
A patent review of butyrylcholinesterase inhibitors and reactivators 2010–2017
2018 Andrisano, Vincenza*; Naldi, Marina; De Simone, Angela; Bartolini, Manuela
A small chemical library of 2-aminoimidazole derivatives as BACE-1 inhibitors: structure-based design, synthesis, and biological evaluation
2012 G. P. Chiriano; A. De Simone; F. Mancini; D. I. Perez; A. Cavalli; M. L. Bolognesi; G. Legname; A. Martinez; V. Andrisano; P. Carloni; M. Roberti
Advanced analytical methodologies in Alzheimer's disease drug discovery
2020 De Simone A.; Naldi M.; Tedesco D.; Bartolini M.; Davani L.; Andrisano V.
Amaryllidaceae alkaloids from Narcissus pseudonarcissus L. cv. Dutch Master as potential drugs in treatment of Alzheimer's disease
2019 Hulcova D.; Marikova J.; Korabecny J.; Hostalkova A.; Jun D.; Kunes J.; Chlebek J.; Opletal L.; De Simone A.; Novakova L.; Andrisano V.; Ruzicka A.; Cahlikova L.
Amyloid beta-Peptide 25-35 Self Assembly and Its Inhibition: A Model Undecapeptide System to Gain Atomistic and Secondary Structure Details of the Alzheimer's Disease Process and Treatment
2012 Naldi M.; Fiori J.; Pistolozzi M.; Drake A.F.; Bertucci C.; Wu R.; Mlynarczyk K.; Filipek S.; De Simone A.; Andrisano V.
An Advanced Multiple Receptor Conformations Virtual Ligand Screening Protocol for the Identification of Novel BACE-1 Inhibitors
2011 Kacker, Puneet; Masetti, Matteo; De Simone, Angela; Bottegoni, Giovanni; Cavalli, Andrea
An immobilized enzyme reactor based on human recombinant betasecretase (hrBACE-1-IMER) for the fast processing of substrates and screening of inhibitors
2012 Chlebek, Jakub; De Simone, Angela; Mancini, Francesca; Andrisano, Vincenza
Analytical approaches in Alzheimer’s disease Drug Discovery
2015 De Simone, Angela; Bartolini, Manuela; Fiori, Jessica; D’Urzo, Annalisa; Naldi, Marina.; Andrisano, Vincenza
Application of an ESI-MS method enabling the discovery of new non-ATP competitive GSK-3beta inhibitors.
2016 De Simone, A; Milelli, A; Naldi, M; Andrisano, V.
Application of an ESI-QTOF method for the detailed characterization of GSK-3β inhibitors
2017 De Simone, Angela; Fiori, Jessica; Naldi, Marina; D'Urzo, Annalisa; Tumiatti, Vincenzo; Milelli, Andrea; Andrisano, Vincenza
Application of BACE1 immobilized enzyme reactor for the characterization of multifunctional alkaloids from Corydalis cava (Fumariaceae) as Alzheimer's disease targets
2016 Chlebek, Jakub; De Simone, Angela; Hoš͗álková, Anna; Opletal, Lubomír; Pérez, Concepción; Pérez, Daniel I.; Havlíková, Lucie; Cahlíková, Lucie; Andrisano, Vincenza
Application of ESI-MS method for detailed characterization of GSK-3β inhibitors by monitoring GSM peptide phosphorylation.Angelini Farmaceutici.
2016 De Simone, A; Naldi, M; Milelli, A; Andrisano, V
Aß42 peptide toxicity on neuronal cells: a lipidomic study in view of Alzheimer’s Disease drug discovery
2021 Lara Davani, Xiaoqing Fu, Angela De Simone, Peng Li, Serena Montanari, Michael Lämmerhofer, Vincenza Andrisano
Beta-secretase as a target for Alzheimer's disease drug discovery: an overview of in vitro methods for characterization of inhibitors.
2011 F. Mancini; A. De Simone; V. Andrisano
| Titolo | Autore(i) | Anno | Periodico | Editore | Tipo | File |
|---|---|---|---|---|---|---|
| (±)- BIGI-3h: Pentatarget-Directed Ligand combining Cholinesterase, Monoamine Oxidase, and Glycogen Synthase Kinase 3β Inhibition with Calcium Channel Antagonism and Antiaggregating Properties for Alzheimer's Disease | Ismaili L.; Monnin J.; Etievant A.; Arribas R.L.; Viejo L.; Refouvelet B.; Soukup O.; Janockova J....; Hepnarova V.; Korabecny J.; Kucera T.; Jun D.; Andrys R.; Musilek K.; Baguet A.; Garcia-Frutos E.M.; De Simone A.; Andrisano V.; Bartolini M.; De Los Rios C.; Marco-Contelles J.; Haffen E. | 2021-01-01 | ACS CHEMICAL NEUROSCIENCE | - | 1.01 Articolo in rivista | - |
| - Application of an ESI-MS method enabling the discovery of new non-ATP competitive GSK-3beta inhibitors. | Angela, De Simone; Andrea, Milelli; Marina, Naldi; Vincenza, Andrisano | 2016-01-01 | - | - | 4.03 Poster | - |
| 3,4-Dihydro-1,3,5-triazin-2(1H)-ones as the First Dual BACE-1/GSK-3β Fragment Hits against Alzheimer's Disease | Prati, Federica; De Simone, Angela; Armirotti, Andrea; Summa, Maria; Pizzirani, Daniela; Scarpell...i, Rita; Bertozzi, Sine Mandrup; Perez, Daniel I.; Andrisano, Vincenza; Perez-Castillo, Ana; Monti, Barbara; Massenzio, Francesca; Polito, Letizia; Racchi, Marco; Sabatino, Piera; Bottegoni, Giovanni; Martinez, Ana; Cavalli, Andrea; Bolognesi, Maria L. | 2015-01-01 | ACS CHEMICAL NEUROSCIENCE | - | 1.01 Articolo in rivista | accepted11585-546374.pdf |
| A multi-approach study for BACE-1 inhibitors characterization. | Angela De Simone; F. Mancini; C. Bertucci; V. Andrisano | 2010-01-01 | - | - | 4.01 Contributo in Atti di convegno | - |
| A multi-methodological approach for the investigation of β-Amyloid-CORMs interaction: an LC-ESI/MS and Circular Dichroism study. | de simone a, naldi m, tedesco d, bartolini m, andrisano v | 2018-01-01 | - | - | 4.01 Contributo in Atti di convegno | - |
| A novel class of multitarget anti-Alzheimer benzohomoadamantane‒chlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors | Perez-Areales F.J.; Turcu A.L.; Barniol-Xicota M.; Pont C.; Pivetta D.; Espargaro A.; Bartolini M....; De Simone A.; Andrisano V.; Perez B.; Sabate R.; Sureda F.X.; Vazquez S.; Munoz-Torrero D. | 2019-01-01 | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - | 1.01 Articolo in rivista | - |
| A patent review of butyrylcholinesterase inhibitors and reactivators 2010–2017 | Andrisano, Vincenza*; Naldi, Marina; De Simone, Angela; Bartolini, Manuela | 2018-01-01 | EXPERT OPINION ON THERAPEUTIC PATENTS | - | 1.01 Articolo in rivista | - |
| A small chemical library of 2-aminoimidazole derivatives as BACE-1 inhibitors: structure-based design, synthesis, and biological evaluation | G. P. Chiriano; A. De Simone; F. Mancini; D. I. Perez; A. Cavalli; M. L. Bolognesi; G. Legname; A.... Martinez; V. Andrisano; P. Carloni; M. Roberti | 2012-01-01 | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - | 1.01 Articolo in rivista | - |
| Advanced analytical methodologies in Alzheimer's disease drug discovery | De Simone A.; Naldi M.; Tedesco D.; Bartolini M.; Davani L.; Andrisano V. | 2020-01-01 | JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | - | 1.01 Articolo in rivista | - |
| Amaryllidaceae alkaloids from Narcissus pseudonarcissus L. cv. Dutch Master as potential drugs in treatment of Alzheimer's disease | Hulcova D.; Marikova J.; Korabecny J.; Hostalkova A.; Jun D.; Kunes J.; Chlebek J.; Opletal L.; D...e Simone A.; Novakova L.; Andrisano V.; Ruzicka A.; Cahlikova L. | 2019-01-01 | PHYTOCHEMISTRY | - | 1.01 Articolo in rivista | - |
| Amyloid beta-Peptide 25-35 Self Assembly and Its Inhibition: A Model Undecapeptide System to Gain Atomistic and Secondary Structure Details of the Alzheimer's Disease Process and Treatment | Naldi M.; Fiori J.; Pistolozzi M.; Drake A.F.; Bertucci C.; Wu R.; Mlynarczyk K.; Filipek S.; De ...Simone A.; Andrisano V. | 2012-01-01 | ACS CHEMICAL NEUROSCIENCE | - | 1.01 Articolo in rivista | - |
| An Advanced Multiple Receptor Conformations Virtual Ligand Screening Protocol for the Identification of Novel BACE-1 Inhibitors | Kacker, Puneet; Masetti, Matteo; De Simone, Angela; Bottegoni, Giovanni; Cavalli, Andrea | 2011-01-01 | - | - | 4.03 Poster | - |
| An immobilized enzyme reactor based on human recombinant betasecretase (hrBACE-1-IMER) for the fast processing of substrates and screening of inhibitors | Chlebek, Jakub; De Simone, Angela; Mancini, Francesca; Andrisano, Vincenza | 2012-01-01 | - | - | 4.03 Poster | - |
| Analytical approaches in Alzheimer’s disease Drug Discovery | De Simone, Angela; Bartolini, Manuela; Fiori, Jessica; D’Urzo, Annalisa; Naldi, Marina.; Andrisan...o, Vincenza | 2015-01-01 | - | - | 4.01 Contributo in Atti di convegno | - |
| Application of an ESI-MS method enabling the discovery of new non-ATP competitive GSK-3beta inhibitors. | De Simone, A; Milelli, A; Naldi, M; Andrisano, V. | 2016-01-01 | - | - | 4.03 Poster | - |
| Application of an ESI-QTOF method for the detailed characterization of GSK-3β inhibitors | De Simone, Angela; Fiori, Jessica; Naldi, Marina; D'Urzo, Annalisa; Tumiatti, Vincenzo; Milelli, ...Andrea; Andrisano, Vincenza | 2017-01-01 | JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | - | 1.01 Articolo in rivista | - |
| Application of BACE1 immobilized enzyme reactor for the characterization of multifunctional alkaloids from Corydalis cava (Fumariaceae) as Alzheimer's disease targets | Chlebek, Jakub; De Simone, Angela; Hoš͗álková, Anna; Opletal, Lubomír; Pérez, Concepción; Pérez, ...Daniel I.; Havlíková, Lucie; Cahlíková, Lucie; Andrisano, Vincenza | 2016-01-01 | FITOTERAPIA | - | 1.01 Articolo in rivista | - |
| Application of ESI-MS method for detailed characterization of GSK-3β inhibitors by monitoring GSM peptide phosphorylation.Angelini Farmaceutici. | De Simone, A; Naldi, M; Milelli, A; Andrisano, V | 2016-01-01 | - | - | 4.01 Contributo in Atti di convegno | - |
| Aß42 peptide toxicity on neuronal cells: a lipidomic study in view of Alzheimer’s Disease drug discovery | Lara Davani, Xiaoqing Fu, Angela De Simone, Peng Li, Serena Montanari, Michael Lämmerhofer, Vince...nza Andrisano | 2021-01-01 | - | - | 4.03 Poster | - |
| Beta-secretase as a target for Alzheimer's disease drug discovery: an overview of in vitro methods for characterization of inhibitors. | F. Mancini; A. De Simone; V. Andrisano | 2011-01-01 | ANALYTICAL AND BIOANALYTICAL CHEMISTRY | - | 1.01 Articolo in rivista | - |