Distribuzione geografica
Continente #
NA - Nord America 3.716
EU - Europa 3.085
AS - Asia 622
AF - Africa 156
Continente sconosciuto - Info sul continente non disponibili 7
SA - Sud America 7
OC - Oceania 5
Totale 7.598
Nazione #
US - Stati Uniti d'America 3.706
GB - Regno Unito 736
IT - Italia 648
SE - Svezia 413
DE - Germania 399
CN - Cina 287
CH - Svizzera 188
IE - Irlanda 181
UA - Ucraina 180
IN - India 137
VN - Vietnam 124
FR - Francia 103
TG - Togo 96
RU - Federazione Russa 72
BE - Belgio 52
ZA - Sudafrica 45
EE - Estonia 40
JO - Giordania 27
FI - Finlandia 23
BG - Bulgaria 15
TR - Turchia 12
SC - Seychelles 11
JP - Giappone 10
CA - Canada 9
ID - Indonesia 9
NL - Olanda 7
EU - Europa 6
GR - Grecia 6
RO - Romania 6
AU - Australia 5
CI - Costa d'Avorio 4
HR - Croazia 4
MY - Malesia 4
BR - Brasile 3
DK - Danimarca 3
KR - Corea 3
CL - Cile 2
CZ - Repubblica Ceca 2
ES - Italia 2
LB - Libano 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AR - Argentina 1
AT - Austria 1
BD - Bangladesh 1
HU - Ungheria 1
IR - Iran 1
JM - Giamaica 1
KZ - Kazakistan 1
LA - Repubblica Popolare Democratica del Laos 1
NO - Norvegia 1
PE - Perù 1
PL - Polonia 1
PT - Portogallo 1
SG - Singapore 1
TH - Thailandia 1
UZ - Uzbekistan 1
Totale 7.598
Città #
Southend 654
Fairfield 501
Chandler 476
Ashburn 297
Woodbridge 226
Princeton 200
Ann Arbor 197
Houston 188
Seattle 186
Wilmington 185
Dublin 180
Bologna 168
Bern 156
Cambridge 151
Jacksonville 129
Lomé 96
Dong Ket 94
Berlin 76
New York 69
Turin 65
Westminster 57
Bremen 55
Brussels 52
Padova 51
Nanjing 49
Milan 38
Redmond 38
Jinan 33
San Diego 32
Bulle 29
Amman 27
Beijing 24
Helsinki 23
Mülheim 22
Nanchang 22
Saint Petersburg 22
Changsha 21
Hebei 21
Shenyang 19
Olalla 17
Redwood City 16
Medford 15
Sofia 15
Des Moines 13
Boardman 12
Tianjin 12
London 11
Mahé 11
Pune 11
Dearborn 10
Istanbul 10
Jiaxing 10
Guangzhou 9
Jakarta 9
Tokyo 9
Los Angeles 8
Norwalk 8
Paris 8
Rimini 8
Taizhou 8
Boydton 7
Falls Church 7
Lanzhou 7
Phoenix 7
Zhengzhou 7
Brescia 6
Casalecchio di Reno 6
Chicago 6
Ningbo 6
Novate Milanese 6
Verona 6
Hangzhou 5
Mountain View 5
Napoli 5
Abidjan 4
Acate 4
Cesenatico 4
Forlì 4
Haikou 4
Kunming 4
San Francisco 4
San Venanzo 4
Taiyuan 4
Toronto 4
Cesena 3
Costa Mesa 3
Groningen 3
Imola 3
Leawood 3
Rovigo 3
Somerville 3
São Paulo 3
Zevio 3
Acton 2
Amsterdam 2
Andover 2
Bochum 2
Casaleone 2
Changchun 2
Chiswick 2
Totale 5.326
Nome #
Rescue, Purification, and Characterization of a Recombinant HSV Expressing a Transgenic Protein 172
A heptad repeat in herpes simplex virus-1 gH, located downstream of the α-helix with attributes of a fusion peptide, is critical for virus entry and fusion. 162
Retargeting strategies for oncolytic herpes simplex viruses 162
Eradication of glioblastoma by immuno-virotherapy with a retargeted oncolytic HSV in a preclinical model 155
Rethinking herpes simplex virus: the way to oncolytic agents. 153
oHSV Genome Editing by Means of galK Recombineering 153
Preclinical therapy of disseminated HER-2+ ovarian and breast carcinomas with a HER-2-retargeted oncolytic herpesvirus. 147
HSV as A Platform for the Generation of Retargeted, Armed, and Reporter-Expressing Oncolytic Viruses 147
The ectodomain of herpes simplex virus glycoprotein H contains a membrane alpha-helix with attributes of an internal fusion peptide, positionally conserved in the herpesviridae family. 144
Systemic delivery of HER2-retargeted oncolytic-HSV by mesenchymal stromal cells protects from lung and brain metastases 138
A herpes simplex virus recombinant that exhibits a single-chain antibody to HER2/neu enters cells through the mammary tumor receptor, independently of the gD receptors. 133
The simultaneous insertion of two ligands in gD for the cultivation of oncolytic HSVs in non-cancer cells and the retargeting to cancer receptors 133
Viral and cellular contributions to herpes simplex virus entry into the cell 130
Inhibition of human tumor growth in mice by an oncolytic herpes simplex virus designed to target solely HER-2-positive cells. 130
The herpes simplex virus JMP mutant enters receptor-negative J cells through a novel pathway independent of the known receptors nectin1, HveA, and nectin2. 129
Coexpression of UL20p and gK inhibits cell-cell fusion mediated by herpes simplex virus glycoproteins gD, gH-gL, and wild-type gB or an endocytosis-defective gB mutant and downmodulates their cell surface expression. 128
Oncolytic herpes virus retargeted to HER-2. 126
A fully-virulent retargeted oncolytic HSV armed with IL-12 elicits local immunity and vaccine therapy towards distant tumors 126
Construction of a fully retargeted herpes simplex virus 1 recombinant capable of entering cells solely via human epidermal growth factor receptor 2 125
Alphaherpes viral genes and their functions 123
Insertion of a ligand to HER2 in gB retargets HSV tropism and obviates the need for activation of the other entry glycoproteins 120
Herpes Simplex Virus Glycoproteins gH/gL and gB Bind Toll-Like Receptor 2, and Soluble gH/gL Is Sufficient To Activate NF-kB. 119
Herpes simplex virus gD forms distinct complexes with fusion executors gB and gH/gL in part through the C-terminal profusion domain. 117
Cross talk among the glycoproteins involved in herpes simplex virus entry and fusion: the interaction between gB and gH/gL does not necessarily require gD. 115
Dual Ligand Insertion in gB and gD of Oncolytic Herpes Simplex Viruses for Retargeting to a Producer Vero Cell Line and to Cancer Cells 115
Herpes simplex virus glycoproteins H/L bind to cells independently of alpha V- beta 3 integrin and inhibit virus entry, and their constitutive expression restricts infection. 114
Dissociation of HSV gL from gH by αvβ6- or αvβ8-integrin promotes gH activation and virus entry 113
Entry of alphaherpesviruses into the cell 112
Herpesviruses as oncolytic agents 112
A strategy for cultivation of retargeted oncolytic herpes simplex viruses in non-cancer cells 112
alphav-beta3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1. 109
alphaV-beta3-Integrin Relocalizes nectin1 and Routes Herpes Simplex Virus to Lipid Rafts 109
The multipartite system that mediates entry of herpes simplex virus into the cell 105
The soluble ectodomain of herpes simplex virus gD contains a membrane-proximal pro-fusion domain and suffices to mediate virus entry. 105
αvβ3-integrin regulates PD-L1 expression and is involved in cancer immune evasion 102
Entry of herpes simplex virus mediated by chimeric forms of nectin1 retargeted to endosomes or to lipid rafts occurs through acidic endosomes. 100
Type I Interferon and NF- B Activation Elicited by Herpes Simplex Virus gH/gL via  v 3 Integrin in Epithelial and Neuronal Cell Lines 100
The Engineering of a Novel Ligand in gH Confers to HSV an Expanded Tropism Independent of gD Activation by Its Receptors 100
The molecular basis of herpesviruses as oncolytic agents. 99
The pro-fusion domain of herpes simplex virus glycoprotein D (gD) interacts with the gD N terminus and is displaced by soluble forms of viral receptors. 98
The Epithelial αvβ3-Integrin Boosts the MYD88-Dependent TLR2 Signaling in Response to Viral and Bacterial Components 98
αvβ3 Integrin boosts the innate immune response elicited in epithelial cells through plasma membrane and endosomal Toll-like receptors 98
null 98
The egress of alphaherpesviruses from the cell 97
Heptad repeat 2 in herpes simplex virus 1 gH interacts with heptad repeat 1 and is critical for virus entry and fusion. 96
Towards a precision medicine approach and in situ vaccination against prostate cancer by psma-retargeted ohsv 96
The egress of herpesviruses from cells: the unanswered questions. 95
null 95
αvβ6- and αvβ8-Integrins Serve As Interchangeable Receptors for HSV gH/gL to Promote Endocytosis and Activation of Membrane Fusion 92
{alpha}V{beta}3-integrin routes herpes simplex virus to an entry pathway dependent on cholesterol-rich lipid rafts and dynamin2. 92
Herpes simplex virus (HSV) with modified tropism, uses and process of preparation thereof. 88
Glycoprotein D of bovine herpesvirus 5 (BoHV-5) confers an extended host range to BoHV-1 but does not contribute to invasion of the brain. 86
Hydrophobic alpha-helices 1 and 2 of herpes simplex virus gH interact with lipids, and their mimetic peptides enhance virus infection and fusion. 84
HSV glycoproteins and their roles in virus entry and egress 84
Intracellular Trafficking and Maturation of Herpes Simplex Virus Type 1 gB and Virus Egress Require Functional Biogenesis of Multivesicular Bodies. 72
Immunocompetent C57BL/6 mouse, engineered to be tolerant to the human HER2 receptor, as a model for the study of retargeted fully-virulent oncolytic Herpes Virus (HSV) 72
Specificity, safety, efficacy of egfrviii-retargeted oncolytic hsv for xenotransplanted human glioblastoma 64
Genotype of Immunologically Hot or Cold Tumors Determines the Antitumor Immune Response and Efficacy by Fully Virulent Retargeted oHSV 61
Immunotherapeutic efficacy of retargeted ohsvs designed for propagation in an ad hoc cell line 60
Fundamentals of Molecular Virology 53
Comparison of murine and human nectin1 binding to herpes simplex virus glycoprotein D (gD) reveals a weak interaction of murine nectin1 to gD and a gD-dependent pathway of entry 45
Critical residues in the CC′ ridge of the human nectin1 receptor V domain enable herpes simplex virus entry into the cell and act synergistically with the downstream region 44
Integrins as Herpesvirus Receptors and Mediators of the Host Signalosome 40
Chimeric nectin1-poliovirus receptor molecules identify a nectin1 region functional in herpes simplex virus entry 40
Cell-to-cell spread of wild-type herpes simplex virus type 1, but not of syncytial strains, is mediated by the immunoglobulin-like receptors that mediate virion entry, Nectin1 (PRR1/HveC/HIgR) and Nectin2 (PRR2/HveB) 39
Conservation of the architecture of the Golgi apparatus related to a differential organization of microtubules in polykaryocytes induced by syn- mutants of herpes simplex virus 1 36
Herpes simplex virus (HSV) glycoprotein h is partially processed in a cell line that expresses the glycoprotein and fully processed in cells infected with deletion or is mutants in the known hsv glycoproteins 36
The V domain of herpesvirus Ig-like receptor (HIgR) contains a major functional region in herpes simplex virus-1 entry into cells and interacts physically with the viral glycoprotein D 35
CD68+ cells of monocyte/macrophage lineage in the environment of AIDS-associated and classic-sporadic Kaposi sarcoma are singly or doubly infected with human herpesviruses 7 and 6B 35
Complexes between Herpes Simplex Virus Glycoproteins gD, gB, and gH Detected in Cells by Complementation of Split Enhanced Green Fluorescent Protein. 34
Human herpesvirus 6: An emerging pathogen 34
Nectin2α (PRR2α or HveB) and nectin2δ are low-efficiency mediators for entry of herpes simplex virus mutants carrying the Leu25Pro substitution in glycoprotein D 32
The murine homolog of human Nectin1δ serves as a species nonspecific mediator for entry of human and animal αherpesviruses in a pathway independent of a detectable binding to gD 32
Glycoprotein C-dependent attachment of herpes simplex virus to susceptible cells leading to productive infection 28
The domains of glycoprotein D required to block apoptosis induced by herpes simplex virus 1 are largely distinct from those involved in cell-cell fusion and binding to nectin1 27
Herpes simplex virus glycoprotein K, but not its syncytial allele, inhibits cell-cell fusion mediated by the four fusogenic glycoproteins, gD, gB, gH, and gL 27
Prominent role of the Ig-like V domain in trans-interactions of nectins. Nectin3 and nectin4 bind to the predicted C-C′-C″-D β-strands of the nectin1 V domain 25
U(L)27.5 Is a novel γ2 gene antisense to the herpes simplex virus 1 gene encoding glycoprotein B 25
Redistribution of microtubules and Golgi apparatus in herpes simplex virus-infected cells and their role in viral exocytosis 25
Individual herpes simplex virus 1 glycoproteins display characteristic rates of maturation from precursor to mature form both in infected cells and in cells that constitutively express the glycoproteins 25
Localization and putative function of the U(L)20 membrane protein in cells infected with herpes simplex virus 1 25
The herpes simplex virus U(L)20 protein compensates for the differential disruption of exocytosis of virions and viral membrane glycoproteins associated with fragmentation of the Golgi apparatus 25
The novel receptors that mediate the entry of herpes simplex viruses and animal alphaherpesviruses into cells 24
Herpes simplex virus glycoprotein D is sufficient to induce spontaneous pH-independent fusion in a cell line that constitutively expresses the glycoprotein 24
Identification of an 85 kDa phosphoprotein as an immunodominant protein specific for human herpesvirus 7-infected cells 24
Novel, soluble isoform of the herpes simplex virus (HSV) receptor nectin1 (or PRR1-HIgR-HveC) modulates positively and negatively susceptibility to HSV infection 24
Efficacy of Systemically Administered Retargeted Oncolytic Herpes Simplex Viruses—Clearance and Biodistribution in Naïve and HSV-Preimmune Mice 23
The biology and natural history of two emerging pathogens: Human herpesviruses 6 and 7 23
The ectodomain of a novel member of the immunoglobulin subfamily related to the poliovirus receptor has the attributes of a bona fide receptor for herpes simplex virus types 1 and 2 in human cells 22
Glycoprotein D of herpes simplex virus encodes a domain which precludes penetration of cells expressing the glycoprotein by superinfecting herpes simplex virus 22
Selection of a monoclonal antibody specific for variant B human herpesvirus 6-infected mononuclear cells 20
Innovative retargeted oncolytic herpesvirus against nectin4-positive cancers 18
Substitution in the murine nectin1 receptor of a single conserved amino acid at a position distal from the herpes simplex virus gD binding site confers high-affinity binding to gD 16
Characterization of N- and O-linked oligosaccharides of glycoprotein 350 from Epstein-Barr virus 15
Targeted Delivery of IL-12 Adjuvants Immunotherapy by Oncolytic Viruses 15
Trafficking to the plasma membrane of the seven-transmembrane protein encoded by human herpesvirus 6 U51 gene involves a cell-specific function present in T lymphocytes 14
Persistence of human herpesvirus 7 in normal tissues detected by expression of a structural antigen 14
Comparative study on O-linked oligosaccharides of glycoprotein D of herpes simplex virus types 1 and 2 13
N-acetylgalactosaminyltransferase activity involved in O-glycosylation of herpes simplex virus type 1 glycoproteins 12
Totale 7.816
Categoria #
all - tutte 18.838
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 18.838

Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/2019320 0 0 0 0 0 56 25 26 48 69 35 61
2019/20201.824 227 41 28 108 184 186 250 239 247 130 73 111
2020/20211.057 234 78 41 52 54 102 21 58 94 68 64 191
2021/20221.496 103 40 122 88 108 78 65 137 93 92 315 255
2022/20232.173 225 280 96 229 158 154 65 144 363 72 191 196
2023/2024557 54 131 65 97 87 123 0 0 0 0 0 0
Totale 7.860