CRIS Current Research Information System

MELCHIORRE, CARLO
 Distribuzione geografica
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Continente #
NA - Nord America 6.784
AS - Asia 6.022
EU - Europa 5.731
AF - Africa 468
SA - Sud America 285
Continente sconosciuto - Info sul continente non disponibili 36
OC - Oceania 19
Totale 19.345
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Nazione #
US - Stati Uniti d'America 6.700
CN - Cina 1.737
SG - Singapore 1.504
IT - Italia 1.450
VN - Vietnam 1.385
GB - Regno Unito 1.311
DE - Germania 634
UA - Ucraina 595
SE - Svezia 460
HK - Hong Kong 429
IN - India 355
FR - Francia 350
RU - Federazione Russa 288
BR - Brasile 200
CI - Costa d'Avorio 186
JP - Giappone 149
IE - Irlanda 139
EE - Estonia 95
KR - Corea 92
TG - Togo 92
NL - Olanda 88
ZA - Sudafrica 78
BD - Bangladesh 61
SC - Seychelles 57
FI - Finlandia 49
CA - Canada 47
AR - Argentina 43
BG - Bulgaria 39
ES - Italia 39
PH - Filippine 39
EU - Europa 33
TH - Thailandia 31
HR - Croazia 28
TW - Taiwan 28
IR - Iran 25
JO - Giordania 25
TR - Turchia 25
BE - Belgio 24
GR - Grecia 24
IQ - Iraq 24
MX - Messico 24
PK - Pakistan 24
CH - Svizzera 21
PL - Polonia 21
CZ - Repubblica Ceca 20
ID - Indonesia 19
AU - Australia 18
MY - Malesia 15
MA - Marocco 14
AT - Austria 13
RO - Romania 12
EC - Ecuador 10
SA - Arabia Saudita 10
LB - Libano 9
TN - Tunisia 8
AL - Albania 7
CO - Colombia 7
CL - Cile 6
IL - Israele 6
NG - Nigeria 6
PE - Perù 6
UZ - Uzbekistan 6
EG - Egitto 5
PY - Paraguay 5
AE - Emirati Arabi Uniti 4
AZ - Azerbaigian 4
HU - Ungheria 4
JM - Giamaica 4
KE - Kenya 4
VE - Venezuela 4
CM - Camerun 3
DO - Repubblica Dominicana 3
DZ - Algeria 3
KZ - Kazakistan 3
MD - Moldavia 3
NP - Nepal 3
PT - Portogallo 3
A2 - ???statistics.table.value.countryCode.A2??? 2
AO - Angola 2
BO - Bolivia 2
ET - Etiopia 2
GT - Guatemala 2
HN - Honduras 2
KG - Kirghizistan 2
LK - Sri Lanka 2
LT - Lituania 2
LV - Lettonia 2
LY - Libia 2
OM - Oman 2
SM - San Marino 2
AG - Antigua e Barbuda 1
BA - Bosnia-Erzegovina 1
BH - Bahrain 1
BY - Bielorussia 1
CG - Congo 1
CR - Costa Rica 1
DK - Danimarca 1
FK - Isole Falkland (Malvinas) 1
GH - Ghana 1
IM - Isola di Man 1
Totale 19.331
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Città #
Southend 1.124
Singapore 1.001
Ashburn 553
Fairfield 530
Jacksonville 444
San Jose 440
Hong Kong 401
Chandler 395
Santa Clara 387
Ho Chi Minh City 320
Hanoi 280
Wilmington 277
Houston 268
Woodbridge 266
Ann Arbor 246
Princeton 241
Seattle 237
Beijing 214
Hefei 213
Abidjan 186
Cambridge 185
Boardman 177
Dong Ket 151
Dublin 139
Council Bluffs 128
Tokyo 125
Padova 120
Milan 119
Bologna 117
Lauterbourg 115
Nanjing 115
Westminster 113
Los Angeles 108
Lomé 92
Berlin 87
Rome 80
Buffalo 73
Jinan 72
Mülheim 67
New York 63
Medford 60
Shenyang 60
Saint Petersburg 59
Seoul 59
Mahé 54
Guangzhou 52
Changsha 50
Nanchang 47
Haiphong 44
Dallas 43
Turin 43
Hebei 41
Helsinki 39
Sofia 39
Florence 36
Munich 36
Shanghai 36
Des Moines 32
Bari 31
Tianjin 31
Verona 30
Da Nang 29
Phoenix 28
San Diego 28
Bengaluru 27
The Dalles 27
Redmond 26
Amman 25
Zhengzhou 24
Dearborn 23
Naples 23
São Paulo 23
Palermo 22
Brussels 21
Chicago 21
Hangzhou 20
Frankfurt am Main 19
Yubileyny 19
Jiaxing 18
Redwood City 18
Redondo Beach 17
San Francisco 17
Biên Hòa 16
Can Tho 16
Cormano 16
Ferrara 16
Bangkok 15
Fuzhou 15
Toronto 15
Falls Church 14
Kunming 14
Mountain View 14
Olalla 14
Taizhou 14
Wuhan 14
Haikou 13
Mexico City 13
Montreal 13
Norwalk 13
Shenzhen 13
Totale 11.924
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Nome #
Antidepressivi e antipsicotici 771
A small molecule targeting the multifactorial nature of Alzheimer's disease 533
Rational approach to discover multipotent anti-Alzheimer drugs 297
Bis(7)-tacrine Derivatives as Multitarget-Directed Ligands: Focus on Anticholinesterase and Antiamyloid Activities 297
Progettazione e sintesi di analoghi rigidi di metoctramina nello studio dei recettori muscarinici 239
A NEW EPIDERMAL GROWTH FACTOR RECEPTOR INHIBITOR IN COLON CANCER CELLS 239
Cytotoxicity of methoctramine and methoctramine-related polyamines. 231
Progettazione e sintesi di poliammine a potenziale attività antitumorale 228
Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 3. Effect of replacing the inner polymethylene chain with cyclic moieties 224
DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF SUSTITUTED NAPHTHALENE IMIDES AND DIIMIDES AS ANTICANCER AGENT 224
A new EGFR inhibitor induces apoptosis in colon cancer cells. 218
Rational Approach to discover multipotent anti-Alzheimer drugs 217
Polyamine conjugation of curcumin analogues toward the discovery of mitochondria-directed neuroprotective agents. 208
Curcumin analogs as multi-target antioxidants: focus on mitochondria. 208
Design, synthesis, and biological evaluation of conformationally restricted rivastigmine analogues 206
Progettazione e sintesi di derivati poliamminici per il trattamento della malattia di Alzheimer 202
Alzheimer's disease: new approaches to drug discovery. 198
Multitargeted drugs discovery: Balancing anti-amyloid and anticholinesterase capacity in a single chemical entity 194
A NEW EPIDERMAL GROWTH FACTOR RECEPTOR INHIBITOR IN COLON CANCER CELLS 190
Design, synthesis, and biological evaluation of prazosin-related derivatives as multipotent compounds 187
Structure-activity relationships of memoquin: Influence of the chain chirality in the multi-target mechanism of action 183
Design, Synthesis, and biological evaluation of naphtalene diimides derivatives as anticancer agent 178
Toward a rational design of multitarget-directed antioxidants: merging memoquin and lipoic acid molecular frameworks 177
Bivalent tacrine-based acetylcholinesterase inhibitors: role of the spacer in the recognition process of the enzyme gorge 176
Multi-Target-Directed Drug Design Strategy: From a Dual Binding Site Acetylcholinesterase Inhibitor to a Trifunctional Compound against Alzheimer's Disease 176
Novel bis(7)-tacrine derivatives as multitarget ligands: focus on anti-cholinesterase and anti-amyloid activities 176
Process for preparation of 1,4-benzoquinone-2,5-diamines by reaction of amines with 1,4-benzoquinones bearing leaving groups at the 2- and 5-positions 175
Design, synthesis, and biological evaluation of pirenzepine analogs bearing a 1,2-cyclohexanediamine and a perhydroquinoxaline units in exchange for the piperazine ring as antimuscarinics 170
Design, synthesis, and biological evaluation of substituted naphtalene imides and diimides as anticancer agents 167
Dual target compounds for the treatment of Alzheimer’s disease. 166
Multitarget-directed ligands: Innovative chemical probes and therapeutic tools against Alzheimer's disease 166
Inhibition of Acetylcholinesterase, Beta-Amyloid Aggregation, and NMDA Receptors in Alzheimer's Disease: A Promising Direction for the Multi-target-Directed Ligands Gold Rush 163
Doxazosin-related alpha1-adrenoceptor antagonists with prostate antitumor activity 163
Combining galantamine and memantine in multitargeted, new chemical entities potentially useful in Alzheimer's disease. 163
Preparation of (hetero)aromatic (hetero)cyclic carboxamides for the treatment of Alzheimer's disease 161
Novel Class of Quinone-Bearing Polyamines as Multi-Target-Directed Ligands To Combat Alzheimer's Disease 161
Synthesis of Monomeric Derivatives To Probe Memoquin's Bivalent Interactions 159
Lipocrine, a multipotent drug for the investigation of Alzheimer's disease 158
Investigation of the photostability properties of memoquin, a quinone derivative for the treatment of Alzheimer's disease. 157
Mitochondria-directed antioxidants in Alzheimer's disease. 157
Progress in acetylcholinesterase inhibitors for Alzheimer's disease: an update 157
Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer's disease. 157
Analysis of the muscarinic receptor subtype mediating inhibition of the neurogenic contractions in rabbit isolated vas deferens by a series of polymethylene tetra-amines 156
Characterization of Cholinesterase inhibitors by means of immobilized enzyme reactor 156
Memoquin: a new therapeutic poly-agent for Alzheimer's disease 155
CYTOTOXICITY EVALUATION OF A POLYAMINE-QUINONE LIBRARY CONJUGATES IN HUMAN COLON CARCINOMA CELLS 155
Design, synthesis, and biological evaluation of substituted 2,3-dihydro-1H-cyclopenta[b]quinolin-9-ylamine related compounds as fructose-1,6-bisphosphatase inhibitors 155
New quinazoline compounds as non-peptidomimetic BACE-1 inhibitors in the treatment of Alzheimer's disease 154
Cystamine-tacrine dimer: a new multi-target-directed ligand as potential therapeutic agent for Alzheimer’s disease treatment 153
Beta-secretase monolithic micro-IMER (immobilized enzyme reactor) for on-line HPLC screening of quinone-bearing polyamine inhibitors. 152
Memoquin: a new compound to attack Alzheimer's disease drug discovery 151
One-molecule-multiple-target strategy: a novel multifunctional molecule designed to block EGF-r and to exert pro-apoptotic effects 151
Monolithic stationary phase coupled with coulometric detection: development of an ion-pair HPLC method for the analysis of quinone-bearing compounds. 151
Multi-target-Directed Ligands To Combat Neurodegenerative Diseases 149
Heterocyclic inhibitors of AChE acylation and peripheral sites. 148
Multi-target-directed drug design strategy: quinone derivatives designed to block amyloid-beta aggregation and to exert antioxidant effects 147
Memoquin: a multi-target-directed ligand as an innovative therapeutic opportunity for Alzheimer's disease 147
Structure-activity relationships of methoctramine-related polyamines as muscarinic antagonist: Effect of replacing the inner polymethylene chain with cyclic moieties 146
Multitarget-directed drug design strategy: a novel molecule designed to block epidermal growth factor receptor (EGFR) and to exert proapoptotic effects 146
Preparation of 2,5-bis-diamine-[1,4]benzoquinone derivatives for the treatment of Alzheimer's disease and a process for their preparation and intermediates thereof. 145
Combining galantamine and memantine in dual-target new chemical entities for the treatment of Alzheimer’s disease 145
POLYPHARMACOLOGY: CREATING SELECTIVE NON-SELECTIVITY 144
Progress in acetylcholinesterase inhibitors for Alzheimer's disease 143
Structure-Activity Relationships of Acetylcholinesterase Noncovalent Inhibitors Based on a Polyamine Backbone. 4. Futher Investigation on the Inner Spacer. 142
MTDL design strategy in the context of Alzheimer's disease: from lipocrine to memoquin and beyond 142
MEMOQUIN: A MULTIPOTENT ACETYLCHOLINESTERASE INHIBITOR WITH EXCELLENT IN VIVO ACTIVITY 140
Parallel synthesis and cytotoxicity evaluation of a polyamine-quinone conjugates library 140
Multi-Target-Direcetd Ligands as acetylcholinesterase inhibitors and nicotinic modulators for Alzheimer's disease 140
Polymethylene tetraamine backbone as template for the development of biologically active polyamines 139
Discovery of Memoquin, a Multitarget-Directed Ligand (MTDL) for the Treatment of Alzheimer’s Disease 139
Propidium-based polyamine ligands as potent inhibitors of acetylcholinesterase and acetylcholinesterase-induced amyloid beta aggregaation 137
Methoctramine-related polyamines as antinociceptive agents 136
Polyamines may modulate both G protein-coupled receptors and G proteins 136
Insight Into the Kinetic of Amyloid beta (1-42) Peptide Self-Aggregation: Elucidation of Inhibitors' Mechanism of Action 135
Structure-Activity Relationships of New Acetylcholinesterase Noncovalent Inhibitors Based on a Polyamine Backbone 135
Methoctramine analogues inhibit responses to capsaicin and protons in rat dorsal root ganglion neurons 135
Synthesis and alpha-1 adrenoceptor antagonist activity of derivatives and isosters of the furan portion of (+)-cyclazosin 134
Absolute configuration of alpha 1B-adrenoceptor antagonist (+)-cyclazosin 134
Methoctramine analogues inhibit responses to capsaicin in DRG neurons and cloned TRPV1 132
From dual binding site acetylcholinesterase inhibitors to multi-target-directed ligands (MTDLs): a step forward in the treatment of Alzheimer's disease 132
Recent advances in alpha1-adrenoreceptor antagonists as pharmacological tools and therapeutic agents. 131
Polyamines in Drug Discovery: From the Universal Template Approach to the Multitarget-Directed Ligand Design Strategy 130
Novel class of quinone-bearing polyamines as multi-target-directed ligands to combat Alzheimer’s disease 129
Discovery of multipotent drugs for the teratment of Alzheimer's disease 129
Memoquin: an up-date on preclinical studies 128
A rational approach to multi-site-directed ligands for the treatment of Alzheimer’s disease 128
Rational design of multitarget-directed antioxidants: merging memoquin and lipocrine molecular frameworks 128
Organic compounds useful for the treatment of neurodegenerative diseases, uses and methods for the preparation thereof 127
Quinone-bearing polyamines are AChE inhibitors endowed with multifunctional properties 126
Synthetic polyamines: an overview of their multiple biological activities. 126
HPLC screening of a chemical library for Alzheimer's disease drug discovery 124
Polyaminoquinones Binding to Human Serum Albumin: a Biochromatography and Circular Dichroism Study 123
Studio della configurazione dell'antagonista alfa 1B-adrenergico (+)-cyclazosin 122
Studio farmacologico del (+)-cyclazosin, un antagonista selettivo del recettore alfa 1B-adrenergico 119
Strategie farmacologiche per il trattamento della malattia di Alzheimer 118
Tacrine Derivatives and Alzheimer's Disease 118
Synthesis and α1-adrenoceptor antagonist activity of tamsulosin analogues 116
Discovery of Multi-Target Agents for Neurological Diseases via Ligand Design 116
Multi-functional drugs and Alzheimer's disease 115
Lipoic acid, a lead structure for multi-target-directed drugs for neurodegeneration 115
Totale 16.922
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Categoria #
all - tutte 53.044
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 53.044
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021356 0 0 0 0 0 0 0 0 0 0 0 356
2021/20222.104 188 83 122 197 167 165 53 129 55 206 374 365
2022/20231.997 222 311 106 249 111 127 88 99 309 55 213 107
2023/2024869 47 103 67 64 75 141 46 90 24 65 75 72
2024/20252.768 143 369 300 197 607 182 144 91 73 103 95 464
2025/20265.880 593 550 593 482 704 349 512 162 1.093 375 263 204
Totale 19.613