CRIS Current Research Information System

MELCHIORRE, CARLO
 Distribuzione geografica
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Continente #
NA - Nord America 5.784
EU - Europa 5.438
AS - Asia 4.611
AF - Africa 437
SA - Sud America 240
Continente sconosciuto - Info sul continente non disponibili 35
OC - Oceania 17
Totale 16.562
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Nazione #
US - Stati Uniti d'America 5.738
CN - Cina 1.505
IT - Italia 1.365
GB - Regno Unito 1.297
SG - Singapore 1.297
VN - Vietnam 760
DE - Germania 620
UA - Ucraina 594
SE - Svezia 459
HK - Hong Kong 380
IN - India 307
RU - Federazione Russa 284
FR - Francia 228
CI - Costa d'Avorio 186
BR - Brasile 167
IE - Irlanda 138
JP - Giappone 120
EE - Estonia 95
TG - Togo 92
NL - Olanda 79
KR - Corea 78
ZA - Sudafrica 74
SC - Seychelles 57
BG - Bulgaria 39
AR - Argentina 38
ES - Italia 36
EU - Europa 33
CA - Canada 31
FI - Finlandia 31
HR - Croazia 28
IR - Iran 25
BE - Belgio 24
GR - Grecia 22
JO - Giordania 22
CZ - Repubblica Ceca 20
CH - Svizzera 18
PL - Polonia 17
TR - Turchia 17
AU - Australia 16
ID - Indonesia 14
RO - Romania 12
AT - Austria 11
MX - Messico 11
MY - Malesia 11
TW - Taiwan 11
EC - Ecuador 10
PK - Pakistan 9
MA - Marocco 8
TH - Thailandia 8
BD - Bangladesh 7
LB - Libano 7
CO - Colombia 6
IQ - Iraq 6
AL - Albania 5
CL - Cile 5
NG - Nigeria 5
PY - Paraguay 5
AE - Emirati Arabi Uniti 4
IL - Israele 4
PE - Perù 4
PH - Filippine 4
AZ - Azerbaigian 3
CM - Camerun 3
DZ - Algeria 3
UZ - Uzbekistan 3
A2 - ???statistics.table.value.countryCode.A2??? 2
AO - Angola 2
DO - Repubblica Dominicana 2
EG - Egitto 2
HU - Ungheria 2
KZ - Kazakistan 2
LK - Sri Lanka 2
LV - Lettonia 2
MD - Moldavia 2
PT - Portogallo 2
SA - Arabia Saudita 2
SM - San Marino 2
TN - Tunisia 2
VE - Venezuela 2
BH - Bahrain 1
BO - Bolivia 1
BY - Bielorussia 1
CG - Congo 1
CR - Costa Rica 1
DK - Danimarca 1
ET - Etiopia 1
FK - Isole Falkland (Malvinas) 1
GT - Guatemala 1
IM - Isola di Man 1
KG - Kirghizistan 1
LT - Lituania 1
MK - Macedonia 1
MU - Mauritius 1
NP - Nepal 1
NZ - Nuova Zelanda 1
SK - Slovacchia (Repubblica Slovacca) 1
UY - Uruguay 1
Totale 16.562
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Città #
Southend 1.124
Singapore 808
Fairfield 530
Ashburn 503
Jacksonville 443
Chandler 395
Santa Clara 379
Hong Kong 366
Wilmington 277
Houston 267
Woodbridge 266
Ann Arbor 246
Princeton 241
Seattle 236
Hefei 209
Beijing 200
Abidjan 186
Cambridge 185
Boardman 174
Ho Chi Minh City 161
Dong Ket 151
Dublin 138
Hanoi 130
Padova 120
Milan 117
Bologna 114
Nanjing 114
Westminster 113
Tokyo 111
Lomé 92
Los Angeles 92
Berlin 87
Rome 78
Buffalo 72
Jinan 72
Mülheim 67
Medford 60
Saint Petersburg 59
Seoul 59
Shenyang 57
Mahé 54
Changsha 46
Nanchang 46
New York 45
Turin 43
Hebei 41
Sofia 39
Dallas 36
Guangzhou 36
Munich 36
Florence 34
Bari 31
Des Moines 31
Verona 29
San Diego 28
Redmond 26
Bengaluru 25
Tianjin 25
Dearborn 23
Naples 23
Shanghai 23
Amman 22
Brussels 21
Helsinki 21
São Paulo 20
Zhengzhou 20
Hangzhou 19
Yubileyny 19
Haiphong 18
Jiaxing 18
Palermo 18
Redwood City 18
Chicago 17
Redondo Beach 17
Cormano 16
Phoenix 16
The Dalles 15
Falls Church 14
Kunming 14
Mountain View 14
Olalla 14
Taizhou 14
Ferrara 13
Fuzhou 13
Haikou 13
Norwalk 13
Barcelona 12
Lanzhou 12
Taiyuan 12
Wuhan 12
Falkenstein 11
Frankfurt am Main 11
Parma 11
Stockholm 11
Toronto 11
Warsaw 11
Biên Hòa 10
Boston 10
Brooklyn 10
Melbourne 10
Totale 10.390
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Nome #
Antidepressivi e antipsicotici 655
A small molecule targeting the multifactorial nature of Alzheimer's disease 465
Rational approach to discover multipotent anti-Alzheimer drugs 287
Bis(7)-tacrine Derivatives as Multitarget-Directed Ligands: Focus on Anticholinesterase and Antiamyloid Activities 278
Progettazione e sintesi di analoghi rigidi di metoctramina nello studio dei recettori muscarinici 226
Cytotoxicity of methoctramine and methoctramine-related polyamines. 205
Rational Approach to discover multipotent anti-Alzheimer drugs 204
Progettazione e sintesi di poliammine a potenziale attività antitumorale 202
Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 3. Effect of replacing the inner polymethylene chain with cyclic moieties 201
A new EGFR inhibitor induces apoptosis in colon cancer cells. 201
DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF SUSTITUTED NAPHTHALENE IMIDES AND DIIMIDES AS ANTICANCER AGENT 194
Design, synthesis, and biological evaluation of conformationally restricted rivastigmine analogues 193
Curcumin analogs as multi-target antioxidants: focus on mitochondria. 185
A NEW EPIDERMAL GROWTH FACTOR RECEPTOR INHIBITOR IN COLON CANCER CELLS 183
Alzheimer's disease: new approaches to drug discovery. 182
Polyamine conjugation of curcumin analogues toward the discovery of mitochondria-directed neuroprotective agents. 179
Progettazione e sintesi di derivati poliamminici per il trattamento della malattia di Alzheimer 175
Design, synthesis, and biological evaluation of prazosin-related derivatives as multipotent compounds 166
Multitargeted drugs discovery: Balancing anti-amyloid and anticholinesterase capacity in a single chemical entity 164
A NEW EPIDERMAL GROWTH FACTOR RECEPTOR INHIBITOR IN COLON CANCER CELLS 164
Bivalent tacrine-based acetylcholinesterase inhibitors: role of the spacer in the recognition process of the enzyme gorge 162
Structure-activity relationships of memoquin: Influence of the chain chirality in the multi-target mechanism of action 159
Toward a rational design of multitarget-directed antioxidants: merging memoquin and lipoic acid molecular frameworks 155
Multi-Target-Directed Drug Design Strategy: From a Dual Binding Site Acetylcholinesterase Inhibitor to a Trifunctional Compound against Alzheimer's Disease 153
Design, synthesis, and biological evaluation of pirenzepine analogs bearing a 1,2-cyclohexanediamine and a perhydroquinoxaline units in exchange for the piperazine ring as antimuscarinics 153
Novel bis(7)-tacrine derivatives as multitarget ligands: focus on anti-cholinesterase and anti-amyloid activities 152
Process for preparation of 1,4-benzoquinone-2,5-diamines by reaction of amines with 1,4-benzoquinones bearing leaving groups at the 2- and 5-positions 148
Design, Synthesis, and biological evaluation of naphtalene diimides derivatives as anticancer agent 146
Doxazosin-related alpha1-adrenoceptor antagonists with prostate antitumor activity 143
Investigation of the photostability properties of memoquin, a quinone derivative for the treatment of Alzheimer's disease. 142
Mitochondria-directed antioxidants in Alzheimer's disease. 142
Novel Class of Quinone-Bearing Polyamines as Multi-Target-Directed Ligands To Combat Alzheimer's Disease 141
Multitarget-directed ligands: Innovative chemical probes and therapeutic tools against Alzheimer's disease 141
Memoquin: a multi-target-directed ligand as an innovative therapeutic opportunity for Alzheimer's disease 140
Design, synthesis, and biological evaluation of substituted 2,3-dihydro-1H-cyclopenta[b]quinolin-9-ylamine related compounds as fructose-1,6-bisphosphatase inhibitors 140
Design, synthesis, and biological evaluation of substituted naphtalene imides and diimides as anticancer agents 140
Inhibition of Acetylcholinesterase, Beta-Amyloid Aggregation, and NMDA Receptors in Alzheimer's Disease: A Promising Direction for the Multi-target-Directed Ligands Gold Rush 139
Progress in acetylcholinesterase inhibitors for Alzheimer's disease: an update 139
Lipocrine, a multipotent drug for the investigation of Alzheimer's disease 138
Monolithic stationary phase coupled with coulometric detection: development of an ion-pair HPLC method for the analysis of quinone-bearing compounds. 138
Memoquin: a new compound to attack Alzheimer's disease drug discovery 137
Characterization of Cholinesterase inhibitors by means of immobilized enzyme reactor 137
Analysis of the muscarinic receptor subtype mediating inhibition of the neurogenic contractions in rabbit isolated vas deferens by a series of polymethylene tetra-amines 135
Beta-secretase monolithic micro-IMER (immobilized enzyme reactor) for on-line HPLC screening of quinone-bearing polyamine inhibitors. 134
Multi-target-Directed Ligands To Combat Neurodegenerative Diseases 134
Combining galantamine and memantine in multitargeted, new chemical entities potentially useful in Alzheimer's disease. 134
Preparation of (hetero)aromatic (hetero)cyclic carboxamides for the treatment of Alzheimer's disease 133
Dual target compounds for the treatment of Alzheimer’s disease. 133
Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer's disease. 133
Structure-activity relationships of methoctramine-related polyamines as muscarinic antagonist: Effect of replacing the inner polymethylene chain with cyclic moieties 130
Heterocyclic inhibitors of AChE acylation and peripheral sites. 130
Synthesis of Monomeric Derivatives To Probe Memoquin's Bivalent Interactions 130
Memoquin: a new therapeutic poly-agent for Alzheimer's disease 129
Cystamine-tacrine dimer: a new multi-target-directed ligand as potential therapeutic agent for Alzheimer’s disease treatment 128
CYTOTOXICITY EVALUATION OF A POLYAMINE-QUINONE LIBRARY CONJUGATES IN HUMAN COLON CARCINOMA CELLS 126
Parallel synthesis and cytotoxicity evaluation of a polyamine-quinone conjugates library 126
Preparation of 2,5-bis-diamine-[1,4]benzoquinone derivatives for the treatment of Alzheimer's disease and a process for their preparation and intermediates thereof. 126
Progress in acetylcholinesterase inhibitors for Alzheimer's disease 125
Multi-Target-Direcetd Ligands as acetylcholinesterase inhibitors and nicotinic modulators for Alzheimer's disease 125
Multitarget-directed drug design strategy: a novel molecule designed to block epidermal growth factor receptor (EGFR) and to exert proapoptotic effects 124
One-molecule-multiple-target strategy: a novel multifunctional molecule designed to block EGF-r and to exert pro-apoptotic effects 123
Insight Into the Kinetic of Amyloid beta (1-42) Peptide Self-Aggregation: Elucidation of Inhibitors' Mechanism of Action 123
New quinazoline compounds as non-peptidomimetic BACE-1 inhibitors in the treatment of Alzheimer's disease 123
MTDL design strategy in the context of Alzheimer's disease: from lipocrine to memoquin and beyond 123
MEMOQUIN: A MULTIPOTENT ACETYLCHOLINESTERASE INHIBITOR WITH EXCELLENT IN VIVO ACTIVITY 122
From dual binding site acetylcholinesterase inhibitors to multi-target-directed ligands (MTDLs): a step forward in the treatment of Alzheimer's disease 121
Polymethylene tetraamine backbone as template for the development of biologically active polyamines 121
Structure-Activity Relationships of Acetylcholinesterase Noncovalent Inhibitors Based on a Polyamine Backbone. 4. Futher Investigation on the Inner Spacer. 120
Propidium-based polyamine ligands as potent inhibitors of acetylcholinesterase and acetylcholinesterase-induced amyloid beta aggregaation 118
Methoctramine analogues inhibit responses to capsaicin and protons in rat dorsal root ganglion neurons 118
Polyamines may modulate both G protein-coupled receptors and G proteins 117
Methoctramine analogues inhibit responses to capsaicin in DRG neurons and cloned TRPV1 115
Memoquin: an up-date on preclinical studies 115
Novel class of quinone-bearing polyamines as multi-target-directed ligands to combat Alzheimer’s disease 115
Discovery of Memoquin, a Multitarget-Directed Ligand (MTDL) for the Treatment of Alzheimer’s Disease 115
Structure-Activity Relationships of New Acetylcholinesterase Noncovalent Inhibitors Based on a Polyamine Backbone 115
Methoctramine-related polyamines as antinociceptive agents 114
POLYPHARMACOLOGY: CREATING SELECTIVE NON-SELECTIVITY 114
Combining galantamine and memantine in dual-target new chemical entities for the treatment of Alzheimer’s disease 114
Synthesis and alpha-1 adrenoceptor antagonist activity of derivatives and isosters of the furan portion of (+)-cyclazosin 113
Synthetic polyamines: an overview of their multiple biological activities. 113
Rational design of multitarget-directed antioxidants: merging memoquin and lipocrine molecular frameworks 113
Discovery of multipotent drugs for the teratment of Alzheimer's disease 112
Absolute configuration of alpha 1B-adrenoceptor antagonist (+)-cyclazosin 110
Polyamines in Drug Discovery: From the Universal Template Approach to the Multitarget-Directed Ligand Design Strategy 110
Studio della configurazione dell'antagonista alfa 1B-adrenergico (+)-cyclazosin 109
A rational approach to multi-site-directed ligands for the treatment of Alzheimer’s disease 108
Recent advances in alpha1-adrenoreceptor antagonists as pharmacological tools and therapeutic agents. 108
Multi-target-directed drug design strategy: quinone derivatives designed to block amyloid-beta aggregation and to exert antioxidant effects 107
Quinone-bearing polyamines are AChE inhibitors endowed with multifunctional properties 106
Lipoic acid, a lead structure for multi-target-directed drugs for neurodegeneration 106
Organic compounds useful for the treatment of neurodegenerative diseases, uses and methods for the preparation thereof 105
HPLC screening of a chemical library for Alzheimer's disease drug discovery 104
Studio farmacologico del (+)-cyclazosin, un antagonista selettivo del recettore alfa 1B-adrenergico 104
Synthesis and α1-adrenoceptor antagonist activity of tamsulosin analogues 104
Tacrine Derivatives and Alzheimer's Disease 104
Polyaminoquinones Binding to Human Serum Albumin: a Biochromatography and Circular Dichroism Study 102
Reversible HSA binding of lipocrine: a circular dichroism study. 100
Recent advances in the design and synthesis of prazosin derivatives 100
Methoctramine analogues inhibit capsaicin induced currents in dorsal root ganglia and Xenopus oocytes expressing TRPV1 99
Totale 14.712
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Categoria #
all - tutte 45.844
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 45.844
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/20211.018 0 0 0 0 0 140 35 156 117 109 105 356
2021/20222.104 188 83 122 197 167 165 53 129 55 206 374 365
2022/20231.997 222 311 106 249 111 127 88 99 309 55 213 107
2023/2024869 47 103 67 64 75 141 46 90 24 65 75 72
2024/20252.768 143 369 300 197 607 182 144 91 73 103 95 464
2025/20263.071 593 550 593 482 704 149 0 0 0 0 0 0
Totale 16.804