CRIS Current Research Information System

MELCHIORRE, CARLO
 Distribuzione geografica
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Continente #
NA - Nord America 6.358
AS - Asia 5.943
EU - Europa 5.686
AF - Africa 468
SA - Sud America 276
Continente sconosciuto - Info sul continente non disponibili 36
OC - Oceania 18
Totale 18.785
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Nazione #
US - Stati Uniti d'America 6.297
CN - Cina 1.726
SG - Singapore 1.487
IT - Italia 1.414
VN - Vietnam 1.385
GB - Regno Unito 1.311
DE - Germania 632
UA - Ucraina 595
SE - Svezia 460
HK - Hong Kong 421
IN - India 352
FR - Francia 350
RU - Federazione Russa 288
BR - Brasile 191
CI - Costa d'Avorio 186
JP - Giappone 149
IE - Irlanda 139
EE - Estonia 95
KR - Corea 92
TG - Togo 92
NL - Olanda 87
ZA - Sudafrica 78
SC - Seychelles 57
FI - Finlandia 49
AR - Argentina 43
BG - Bulgaria 39
ES - Italia 39
PH - Filippine 39
CA - Canada 35
EU - Europa 33
TH - Thailandia 31
HR - Croazia 28
TW - Taiwan 28
IR - Iran 25
JO - Giordania 25
TR - Turchia 25
BD - Bangladesh 24
BE - Belgio 24
GR - Grecia 24
IQ - Iraq 24
PK - Pakistan 22
CZ - Repubblica Ceca 20
CH - Svizzera 19
ID - Indonesia 19
PL - Polonia 19
AU - Australia 17
MX - Messico 15
MY - Malesia 15
MA - Marocco 14
AT - Austria 13
RO - Romania 12
EC - Ecuador 10
SA - Arabia Saudita 10
LB - Libano 9
TN - Tunisia 8
AL - Albania 7
CO - Colombia 7
CL - Cile 6
IL - Israele 6
NG - Nigeria 6
PE - Perù 6
UZ - Uzbekistan 6
EG - Egitto 5
PY - Paraguay 5
AE - Emirati Arabi Uniti 4
AZ - Azerbaigian 4
HU - Ungheria 4
KE - Kenya 4
VE - Venezuela 4
CM - Camerun 3
DO - Repubblica Dominicana 3
DZ - Algeria 3
JM - Giamaica 3
KZ - Kazakistan 3
NP - Nepal 3
PT - Portogallo 3
A2 - ???statistics.table.value.countryCode.A2??? 2
AO - Angola 2
BO - Bolivia 2
ET - Etiopia 2
GT - Guatemala 2
KG - Kirghizistan 2
LK - Sri Lanka 2
LT - Lituania 2
LV - Lettonia 2
LY - Libia 2
MD - Moldavia 2
OM - Oman 2
SM - San Marino 2
AG - Antigua e Barbuda 1
BA - Bosnia-Erzegovina 1
BH - Bahrain 1
BY - Bielorussia 1
CG - Congo 1
CR - Costa Rica 1
DK - Danimarca 1
FK - Isole Falkland (Malvinas) 1
GH - Ghana 1
HN - Honduras 1
IM - Isola di Man 1
Totale 18.773
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Città #
Southend 1.124
Singapore 986
Ashburn 534
Fairfield 530
Jacksonville 443
Chandler 395
Hong Kong 393
Santa Clara 385
San Jose 352
Ho Chi Minh City 320
Hanoi 280
Wilmington 277
Houston 268
Woodbridge 266
Ann Arbor 246
Princeton 241
Seattle 236
Hefei 213
Beijing 208
Abidjan 186
Cambridge 185
Boardman 174
Dong Ket 151
Dublin 139
Tokyo 125
Padova 120
Milan 119
Bologna 116
Lauterbourg 115
Nanjing 115
Westminster 113
Los Angeles 97
Lomé 92
Berlin 87
Rome 79
Buffalo 72
Jinan 72
Mülheim 67
Medford 60
Shenyang 60
Saint Petersburg 59
Seoul 59
Mahé 54
New York 54
Guangzhou 52
Changsha 50
Nanchang 47
Haiphong 44
Turin 43
Hebei 41
Dallas 40
Helsinki 39
Sofia 39
Florence 36
Munich 36
Shanghai 36
Des Moines 32
Bari 31
Tianjin 31
Da Nang 29
Verona 29
San Diego 28
Bengaluru 27
The Dalles 27
Redmond 26
Amman 25
Zhengzhou 24
Dearborn 23
Naples 23
São Paulo 23
Brussels 21
Hangzhou 20
Phoenix 20
Frankfurt am Main 19
Palermo 19
Yubileyny 19
Jiaxing 18
Redwood City 18
Chicago 17
Redondo Beach 17
Biên Hòa 16
Can Tho 16
Cormano 16
Ferrara 16
Bangkok 15
Fuzhou 15
Falls Church 14
Kunming 14
Mountain View 14
Olalla 14
Taizhou 14
Wuhan 14
Haikou 13
Norwalk 13
Shenzhen 13
Taiyuan 13
Toronto 13
Warsaw 13
Baghdad 12
Barcelona 12
Totale 11.616
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Nome #
Antidepressivi e antipsicotici 721
A small molecule targeting the multifactorial nature of Alzheimer's disease 511
Bis(7)-tacrine Derivatives as Multitarget-Directed Ligands: Focus on Anticholinesterase and Antiamyloid Activities 297
Rational approach to discover multipotent anti-Alzheimer drugs 294
Progettazione e sintesi di analoghi rigidi di metoctramina nello studio dei recettori muscarinici 237
Cytotoxicity of methoctramine and methoctramine-related polyamines. 228
A NEW EPIDERMAL GROWTH FACTOR RECEPTOR INHIBITOR IN COLON CANCER CELLS 227
Progettazione e sintesi di poliammine a potenziale attività antitumorale 226
DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF SUSTITUTED NAPHTHALENE IMIDES AND DIIMIDES AS ANTICANCER AGENT 221
A new EGFR inhibitor induces apoptosis in colon cancer cells. 216
Rational Approach to discover multipotent anti-Alzheimer drugs 214
Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 3. Effect of replacing the inner polymethylene chain with cyclic moieties 208
Curcumin analogs as multi-target antioxidants: focus on mitochondria. 207
Polyamine conjugation of curcumin analogues toward the discovery of mitochondria-directed neuroprotective agents. 203
Design, synthesis, and biological evaluation of conformationally restricted rivastigmine analogues 199
Progettazione e sintesi di derivati poliamminici per il trattamento della malattia di Alzheimer 193
Alzheimer's disease: new approaches to drug discovery. 193
Multitargeted drugs discovery: Balancing anti-amyloid and anticholinesterase capacity in a single chemical entity 192
A NEW EPIDERMAL GROWTH FACTOR RECEPTOR INHIBITOR IN COLON CANCER CELLS 189
Design, synthesis, and biological evaluation of prazosin-related derivatives as multipotent compounds 184
Structure-activity relationships of memoquin: Influence of the chain chirality in the multi-target mechanism of action 179
Design, Synthesis, and biological evaluation of naphtalene diimides derivatives as anticancer agent 177
Novel bis(7)-tacrine derivatives as multitarget ligands: focus on anti-cholinesterase and anti-amyloid activities 173
Bivalent tacrine-based acetylcholinesterase inhibitors: role of the spacer in the recognition process of the enzyme gorge 171
Toward a rational design of multitarget-directed antioxidants: merging memoquin and lipoic acid molecular frameworks 171
Multi-Target-Directed Drug Design Strategy: From a Dual Binding Site Acetylcholinesterase Inhibitor to a Trifunctional Compound against Alzheimer's Disease 169
Design, synthesis, and biological evaluation of pirenzepine analogs bearing a 1,2-cyclohexanediamine and a perhydroquinoxaline units in exchange for the piperazine ring as antimuscarinics 165
Process for preparation of 1,4-benzoquinone-2,5-diamines by reaction of amines with 1,4-benzoquinones bearing leaving groups at the 2- and 5-positions 164
Design, synthesis, and biological evaluation of substituted naphtalene imides and diimides as anticancer agents 164
Doxazosin-related alpha1-adrenoceptor antagonists with prostate antitumor activity 163
Multitarget-directed ligands: Innovative chemical probes and therapeutic tools against Alzheimer's disease 163
Combining galantamine and memantine in multitargeted, new chemical entities potentially useful in Alzheimer's disease. 161
Inhibition of Acetylcholinesterase, Beta-Amyloid Aggregation, and NMDA Receptors in Alzheimer's Disease: A Promising Direction for the Multi-target-Directed Ligands Gold Rush 160
Dual target compounds for the treatment of Alzheimer’s disease. 159
Novel Class of Quinone-Bearing Polyamines as Multi-Target-Directed Ligands To Combat Alzheimer's Disease 158
Preparation of (hetero)aromatic (hetero)cyclic carboxamides for the treatment of Alzheimer's disease 156
Mitochondria-directed antioxidants in Alzheimer's disease. 156
Progress in acetylcholinesterase inhibitors for Alzheimer's disease: an update 155
Design, synthesis, and biological evaluation of substituted 2,3-dihydro-1H-cyclopenta[b]quinolin-9-ylamine related compounds as fructose-1,6-bisphosphatase inhibitors 154
Synthesis of Monomeric Derivatives To Probe Memoquin's Bivalent Interactions 154
Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer's disease. 154
Analysis of the muscarinic receptor subtype mediating inhibition of the neurogenic contractions in rabbit isolated vas deferens by a series of polymethylene tetra-amines 153
Investigation of the photostability properties of memoquin, a quinone derivative for the treatment of Alzheimer's disease. 153
Characterization of Cholinesterase inhibitors by means of immobilized enzyme reactor 152
Lipocrine, a multipotent drug for the investigation of Alzheimer's disease 151
Cystamine-tacrine dimer: a new multi-target-directed ligand as potential therapeutic agent for Alzheimer’s disease treatment 151
Memoquin: a new therapeutic poly-agent for Alzheimer's disease 150
CYTOTOXICITY EVALUATION OF A POLYAMINE-QUINONE LIBRARY CONJUGATES IN HUMAN COLON CARCINOMA CELLS 150
New quinazoline compounds as non-peptidomimetic BACE-1 inhibitors in the treatment of Alzheimer's disease 149
One-molecule-multiple-target strategy: a novel multifunctional molecule designed to block EGF-r and to exert pro-apoptotic effects 147
Multi-target-Directed Ligands To Combat Neurodegenerative Diseases 147
Memoquin: a new compound to attack Alzheimer's disease drug discovery 146
Monolithic stationary phase coupled with coulometric detection: development of an ion-pair HPLC method for the analysis of quinone-bearing compounds. 146
Beta-secretase monolithic micro-IMER (immobilized enzyme reactor) for on-line HPLC screening of quinone-bearing polyamine inhibitors. 145
Memoquin: a multi-target-directed ligand as an innovative therapeutic opportunity for Alzheimer's disease 145
Heterocyclic inhibitors of AChE acylation and peripheral sites. 143
Combining galantamine and memantine in dual-target new chemical entities for the treatment of Alzheimer’s disease 143
Structure-Activity Relationships of Acetylcholinesterase Noncovalent Inhibitors Based on a Polyamine Backbone. 4. Futher Investigation on the Inner Spacer. 142
MTDL design strategy in the context of Alzheimer's disease: from lipocrine to memoquin and beyond 141
Multitarget-directed drug design strategy: a novel molecule designed to block epidermal growth factor receptor (EGFR) and to exert proapoptotic effects 141
Preparation of 2,5-bis-diamine-[1,4]benzoquinone derivatives for the treatment of Alzheimer's disease and a process for their preparation and intermediates thereof. 140
Structure-activity relationships of methoctramine-related polyamines as muscarinic antagonist: Effect of replacing the inner polymethylene chain with cyclic moieties 139
Parallel synthesis and cytotoxicity evaluation of a polyamine-quinone conjugates library 138
MEMOQUIN: A MULTIPOTENT ACETYLCHOLINESTERASE INHIBITOR WITH EXCELLENT IN VIVO ACTIVITY 137
Multi-target-directed drug design strategy: quinone derivatives designed to block amyloid-beta aggregation and to exert antioxidant effects 137
Multi-Target-Direcetd Ligands as acetylcholinesterase inhibitors and nicotinic modulators for Alzheimer's disease 137
Progress in acetylcholinesterase inhibitors for Alzheimer's disease 136
Discovery of Memoquin, a Multitarget-Directed Ligand (MTDL) for the Treatment of Alzheimer’s Disease 135
POLYPHARMACOLOGY: CREATING SELECTIVE NON-SELECTIVITY 135
Propidium-based polyamine ligands as potent inhibitors of acetylcholinesterase and acetylcholinesterase-induced amyloid beta aggregaation 135
Polymethylene tetraamine backbone as template for the development of biologically active polyamines 134
Structure-Activity Relationships of New Acetylcholinesterase Noncovalent Inhibitors Based on a Polyamine Backbone 134
Absolute configuration of alpha 1B-adrenoceptor antagonist (+)-cyclazosin 133
Insight Into the Kinetic of Amyloid beta (1-42) Peptide Self-Aggregation: Elucidation of Inhibitors' Mechanism of Action 132
Polyamines may modulate both G protein-coupled receptors and G proteins 131
Synthesis and alpha-1 adrenoceptor antagonist activity of derivatives and isosters of the furan portion of (+)-cyclazosin 130
From dual binding site acetylcholinesterase inhibitors to multi-target-directed ligands (MTDLs): a step forward in the treatment of Alzheimer's disease 130
Methoctramine analogues inhibit responses to capsaicin and protons in rat dorsal root ganglion neurons 130
Methoctramine-related polyamines as antinociceptive agents 129
Methoctramine analogues inhibit responses to capsaicin in DRG neurons and cloned TRPV1 129
Polyamines in Drug Discovery: From the Universal Template Approach to the Multitarget-Directed Ligand Design Strategy 127
Memoquin: an up-date on preclinical studies 126
Novel class of quinone-bearing polyamines as multi-target-directed ligands to combat Alzheimer’s disease 126
Organic compounds useful for the treatment of neurodegenerative diseases, uses and methods for the preparation thereof 126
Discovery of multipotent drugs for the teratment of Alzheimer's disease 125
Rational design of multitarget-directed antioxidants: merging memoquin and lipocrine molecular frameworks 125
Synthetic polyamines: an overview of their multiple biological activities. 124
A rational approach to multi-site-directed ligands for the treatment of Alzheimer’s disease 123
Recent advances in alpha1-adrenoreceptor antagonists as pharmacological tools and therapeutic agents. 123
Quinone-bearing polyamines are AChE inhibitors endowed with multifunctional properties 121
Polyaminoquinones Binding to Human Serum Albumin: a Biochromatography and Circular Dichroism Study 121
HPLC screening of a chemical library for Alzheimer's disease drug discovery 120
Studio della configurazione dell'antagonista alfa 1B-adrenergico (+)-cyclazosin 120
Tacrine Derivatives and Alzheimer's Disease 116
Studio farmacologico del (+)-cyclazosin, un antagonista selettivo del recettore alfa 1B-adrenergico 114
Synthesis and α1-adrenoceptor antagonist activity of tamsulosin analogues 114
Discovery of Multi-Target Agents for Neurological Diseases via Ligand Design 114
Lipoic acid, a lead structure for multi-target-directed drugs for neurodegeneration 113
Multi-functional drugs and Alzheimer's disease 112
Strategie farmacologiche per il trattamento della malattia di Alzheimer 112
Totale 16.464
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Categoria #
all - tutte 50.157
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 50.157
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021570 0 0 0 0 0 0 0 0 0 109 105 356
2021/20222.104 188 83 122 197 167 165 53 129 55 206 374 365
2022/20231.997 222 311 106 249 111 127 88 99 309 55 213 107
2023/2024869 47 103 67 64 75 141 46 90 24 65 75 72
2024/20252.768 143 369 300 197 607 182 144 91 73 103 95 464
2025/20265.320 593 550 593 482 704 349 512 162 1.093 282 0 0
Totale 19.053