CRIS Current Research Information System

MELCHIORRE, CARLO
 Distribuzione geografica
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Continente #
NA - Nord America 6.884
AS - Asia 6.027
EU - Europa 5.739
AF - Africa 468
Continente sconosciuto - Info sul continente non disponibili 303
SA - Sud America 290
OC - Oceania 19
Totale 19.730
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Nazione #
US - Stati Uniti d'America 6.775
CN - Cina 1.725
SG - Singapore 1.514
IT - Italia 1.477
VN - Vietnam 1.375
GB - Regno Unito 1.305
DE - Germania 630
UA - Ucraina 590
SE - Svezia 457
HK - Hong Kong 429
IN - India 359
FR - Francia 348
RU - Federazione Russa 286
BR - Brasile 203
CI - Costa d'Avorio 185
JP - Giappone 148
IE - Irlanda 138
EE - Estonia 95
KR - Corea 93
TG - Togo 92
NL - Olanda 89
ZA - Sudafrica 76
BD - Bangladesh 74
SC - Seychelles 59
CA - Canada 56
FI - Finlandia 49
AR - Argentina 43
ES - Italia 42
BG - Bulgaria 39
PH - Filippine 39
EU - Europa 33
TH - Thailandia 30
HR - Croazia 28
TW - Taiwan 28
MX - Messico 27
IR - Iran 25
JO - Giordania 25
TR - Turchia 25
BE - Belgio 24
GR - Grecia 24
IQ - Iraq 24
PK - Pakistan 24
CH - Svizzera 21
PL - Polonia 21
CZ - Repubblica Ceca 20
ID - Indonesia 20
AU - Australia 18
MY - Malesia 15
MA - Marocco 14
AT - Austria 13
RO - Romania 12
EC - Ecuador 10
SA - Arabia Saudita 10
LB - Libano 9
CO - Colombia 8
TN - Tunisia 8
AL - Albania 7
CR - Costa Rica 7
CL - Cile 6
IL - Israele 6
NG - Nigeria 6
PE - Perù 6
UZ - Uzbekistan 6
EG - Egitto 5
PY - Paraguay 5
AE - Emirati Arabi Uniti 4
AZ - Azerbaigian 4
DZ - Algeria 4
HN - Honduras 4
HU - Ungheria 4
JM - Giamaica 4
KE - Kenya 4
VE - Venezuela 4
CM - Camerun 3
DO - Repubblica Dominicana 3
KZ - Kazakistan 3
MD - Moldavia 3
NP - Nepal 3
PT - Portogallo 3
SV - El Salvador 3
A2 - ???statistics.table.value.countryCode.A2??? 2
AO - Angola 2
BO - Bolivia 2
ET - Etiopia 2
GT - Guatemala 2
KG - Kirghizistan 2
LK - Sri Lanka 2
LT - Lituania 2
LV - Lettonia 2
LY - Libia 2
NI - Nicaragua 2
OM - Oman 2
SM - San Marino 2
UY - Uruguay 2
AG - Antigua e Barbuda 1
BA - Bosnia-Erzegovina 1
BH - Bahrain 1
BY - Bielorussia 1
CG - Congo 1
DK - Danimarca 1
Totale 19.447
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Città #
Southend 1.117
Singapore 1.014
Ashburn 553
Fairfield 529
Jacksonville 444
San Jose 439
Hong Kong 401
Santa Clara 396
Chandler 395
Ho Chi Minh City 317
Hanoi 279
Wilmington 274
Houston 268
Woodbridge 266
Ann Arbor 245
Princeton 238
Seattle 237
Hefei 213
Beijing 212
Abidjan 185
Cambridge 185
Boardman 176
Dong Ket 151
Council Bluffs 149
Dublin 138
Tokyo 124
Milan 119
Padova 119
Bologna 117
Lauterbourg 114
Nanjing 113
Westminster 112
Los Angeles 109
Lomé 92
Rome 87
Berlin 86
Buffalo 74
Jinan 72
Mülheim 66
New York 63
Seoul 60
Medford 59
Saint Petersburg 59
Shenyang 59
Mahé 54
Guangzhou 52
Changsha 49
Dallas 49
Nanchang 46
Haiphong 44
Turin 43
Hebei 41
Helsinki 39
Sofia 39
Florence 37
Shanghai 37
Munich 36
Bari 33
Des Moines 32
Bengaluru 30
Tianjin 30
Verona 30
Phoenix 29
The Dalles 29
Da Nang 28
San Diego 28
Redmond 26
Amman 25
Naples 25
Dearborn 24
Zhengzhou 24
Palermo 23
São Paulo 23
Chicago 22
Brussels 21
Hangzhou 20
Frankfurt am Main 19
Jiaxing 18
Redwood City 18
San Francisco 18
Yubileyny 18
Redondo Beach 17
Can Tho 16
Cormano 16
Ferrara 16
Biên Hòa 15
Fuzhou 15
Mexico City 15
Bangkok 14
Falls Church 14
Mountain View 14
Toronto 14
Wuhan 14
Haikou 13
Kunming 13
Montreal 13
Norwalk 13
Olalla 13
Shenzhen 13
Taiyuan 13
Totale 11.955
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Nome #
Antidepressivi e antipsicotici 788
A small molecule targeting the multifactorial nature of Alzheimer's disease 534
Bis(7)-tacrine Derivatives as Multitarget-Directed Ligands: Focus on Anticholinesterase and Antiamyloid Activities 299
Rational approach to discover multipotent anti-Alzheimer drugs 298
A NEW EPIDERMAL GROWTH FACTOR RECEPTOR INHIBITOR IN COLON CANCER CELLS 245
Progettazione e sintesi di analoghi rigidi di metoctramina nello studio dei recettori muscarinici 239
Cytotoxicity of methoctramine and methoctramine-related polyamines. 232
Progettazione e sintesi di poliammine a potenziale attività antitumorale 230
Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 3. Effect of replacing the inner polymethylene chain with cyclic moieties 226
DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF SUSTITUTED NAPHTHALENE IMIDES AND DIIMIDES AS ANTICANCER AGENT 226
Rational Approach to discover multipotent anti-Alzheimer drugs 220
A new EGFR inhibitor induces apoptosis in colon cancer cells. 220
Design, synthesis, and biological evaluation of conformationally restricted rivastigmine analogues 209
Polyamine conjugation of curcumin analogues toward the discovery of mitochondria-directed neuroprotective agents. 209
Curcumin analogs as multi-target antioxidants: focus on mitochondria. 209
Progettazione e sintesi di derivati poliamminici per il trattamento della malattia di Alzheimer 203
Alzheimer's disease: new approaches to drug discovery. 199
Multitargeted drugs discovery: Balancing anti-amyloid and anticholinesterase capacity in a single chemical entity 195
A NEW EPIDERMAL GROWTH FACTOR RECEPTOR INHIBITOR IN COLON CANCER CELLS 194
Design, synthesis, and biological evaluation of prazosin-related derivatives as multipotent compounds 187
Structure-activity relationships of memoquin: Influence of the chain chirality in the multi-target mechanism of action 185
Bivalent tacrine-based acetylcholinesterase inhibitors: role of the spacer in the recognition process of the enzyme gorge 178
Process for preparation of 1,4-benzoquinone-2,5-diamines by reaction of amines with 1,4-benzoquinones bearing leaving groups at the 2- and 5-positions 178
Design, Synthesis, and biological evaluation of naphtalene diimides derivatives as anticancer agent 178
Toward a rational design of multitarget-directed antioxidants: merging memoquin and lipoic acid molecular frameworks 177
Multi-Target-Directed Drug Design Strategy: From a Dual Binding Site Acetylcholinesterase Inhibitor to a Trifunctional Compound against Alzheimer's Disease 176
Novel bis(7)-tacrine derivatives as multitarget ligands: focus on anti-cholinesterase and anti-amyloid activities 176
Design, synthesis, and biological evaluation of pirenzepine analogs bearing a 1,2-cyclohexanediamine and a perhydroquinoxaline units in exchange for the piperazine ring as antimuscarinics 172
Dual target compounds for the treatment of Alzheimer’s disease. 169
Design, synthesis, and biological evaluation of substituted naphtalene imides and diimides as anticancer agents 168
Inhibition of Acetylcholinesterase, Beta-Amyloid Aggregation, and NMDA Receptors in Alzheimer's Disease: A Promising Direction for the Multi-target-Directed Ligands Gold Rush 166
Multitarget-directed ligands: Innovative chemical probes and therapeutic tools against Alzheimer's disease 166
Preparation of (hetero)aromatic (hetero)cyclic carboxamides for the treatment of Alzheimer's disease 164
Doxazosin-related alpha1-adrenoceptor antagonists with prostate antitumor activity 164
Combining galantamine and memantine in multitargeted, new chemical entities potentially useful in Alzheimer's disease. 163
Novel Class of Quinone-Bearing Polyamines as Multi-Target-Directed Ligands To Combat Alzheimer's Disease 163
Lipocrine, a multipotent drug for the investigation of Alzheimer's disease 159
Synthesis of Monomeric Derivatives To Probe Memoquin's Bivalent Interactions 159
Analysis of the muscarinic receptor subtype mediating inhibition of the neurogenic contractions in rabbit isolated vas deferens by a series of polymethylene tetra-amines 158
Characterization of Cholinesterase inhibitors by means of immobilized enzyme reactor 158
New quinazoline compounds as non-peptidomimetic BACE-1 inhibitors in the treatment of Alzheimer's disease 158
Mitochondria-directed antioxidants in Alzheimer's disease. 158
Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer's disease. 158
Investigation of the photostability properties of memoquin, a quinone derivative for the treatment of Alzheimer's disease. 157
Progress in acetylcholinesterase inhibitors for Alzheimer's disease: an update 157
Memoquin: a new therapeutic poly-agent for Alzheimer's disease 156
Design, synthesis, and biological evaluation of substituted 2,3-dihydro-1H-cyclopenta[b]quinolin-9-ylamine related compounds as fructose-1,6-bisphosphatase inhibitors 156
CYTOTOXICITY EVALUATION OF A POLYAMINE-QUINONE LIBRARY CONJUGATES IN HUMAN COLON CARCINOMA CELLS 155
Memoquin: a new compound to attack Alzheimer's disease drug discovery 153
Monolithic stationary phase coupled with coulometric detection: development of an ion-pair HPLC method for the analysis of quinone-bearing compounds. 153
Cystamine-tacrine dimer: a new multi-target-directed ligand as potential therapeutic agent for Alzheimer’s disease treatment 153
One-molecule-multiple-target strategy: a novel multifunctional molecule designed to block EGF-r and to exert pro-apoptotic effects 152
Beta-secretase monolithic micro-IMER (immobilized enzyme reactor) for on-line HPLC screening of quinone-bearing polyamine inhibitors. 152
Heterocyclic inhibitors of AChE acylation and peripheral sites. 151
Multi-target-Directed Ligands To Combat Neurodegenerative Diseases 149
Memoquin: a multi-target-directed ligand as an innovative therapeutic opportunity for Alzheimer's disease 149
Multi-target-directed drug design strategy: quinone derivatives designed to block amyloid-beta aggregation and to exert antioxidant effects 148
Multitarget-directed drug design strategy: a novel molecule designed to block epidermal growth factor receptor (EGFR) and to exert proapoptotic effects 147
Structure-activity relationships of methoctramine-related polyamines as muscarinic antagonist: Effect of replacing the inner polymethylene chain with cyclic moieties 146
Preparation of 2,5-bis-diamine-[1,4]benzoquinone derivatives for the treatment of Alzheimer's disease and a process for their preparation and intermediates thereof. 146
Combining galantamine and memantine in dual-target new chemical entities for the treatment of Alzheimer’s disease 146
Progress in acetylcholinesterase inhibitors for Alzheimer's disease 145
POLYPHARMACOLOGY: CREATING SELECTIVE NON-SELECTIVITY 145
MTDL design strategy in the context of Alzheimer's disease: from lipocrine to memoquin and beyond 143
Parallel synthesis and cytotoxicity evaluation of a polyamine-quinone conjugates library 142
Structure-Activity Relationships of Acetylcholinesterase Noncovalent Inhibitors Based on a Polyamine Backbone. 4. Futher Investigation on the Inner Spacer. 142
MEMOQUIN: A MULTIPOTENT ACETYLCHOLINESTERASE INHIBITOR WITH EXCELLENT IN VIVO ACTIVITY 140
Multi-Target-Direcetd Ligands as acetylcholinesterase inhibitors and nicotinic modulators for Alzheimer's disease 140
Polymethylene tetraamine backbone as template for the development of biologically active polyamines 139
Discovery of Memoquin, a Multitarget-Directed Ligand (MTDL) for the Treatment of Alzheimer’s Disease 139
Propidium-based polyamine ligands as potent inhibitors of acetylcholinesterase and acetylcholinesterase-induced amyloid beta aggregaation 139
Insight Into the Kinetic of Amyloid beta (1-42) Peptide Self-Aggregation: Elucidation of Inhibitors' Mechanism of Action 138
Methoctramine-related polyamines as antinociceptive agents 136
Polyamines may modulate both G protein-coupled receptors and G proteins 136
Synthesis and alpha-1 adrenoceptor antagonist activity of derivatives and isosters of the furan portion of (+)-cyclazosin 135
Absolute configuration of alpha 1B-adrenoceptor antagonist (+)-cyclazosin 135
Structure-Activity Relationships of New Acetylcholinesterase Noncovalent Inhibitors Based on a Polyamine Backbone 135
Methoctramine analogues inhibit responses to capsaicin and protons in rat dorsal root ganglion neurons 135
Memoquin: an up-date on preclinical studies 134
Methoctramine analogues inhibit responses to capsaicin in DRG neurons and cloned TRPV1 132
From dual binding site acetylcholinesterase inhibitors to multi-target-directed ligands (MTDLs): a step forward in the treatment of Alzheimer's disease 132
Discovery of multipotent drugs for the teratment of Alzheimer's disease 132
Polyamines in Drug Discovery: From the Universal Template Approach to the Multitarget-Directed Ligand Design Strategy 132
Rational design of multitarget-directed antioxidants: merging memoquin and lipocrine molecular frameworks 131
Recent advances in alpha1-adrenoreceptor antagonists as pharmacological tools and therapeutic agents. 131
Novel class of quinone-bearing polyamines as multi-target-directed ligands to combat Alzheimer’s disease 129
Quinone-bearing polyamines are AChE inhibitors endowed with multifunctional properties 128
A rational approach to multi-site-directed ligands for the treatment of Alzheimer’s disease 128
Synthetic polyamines: an overview of their multiple biological activities. 128
HPLC screening of a chemical library for Alzheimer's disease drug discovery 127
Organic compounds useful for the treatment of neurodegenerative diseases, uses and methods for the preparation thereof 127
Polyaminoquinones Binding to Human Serum Albumin: a Biochromatography and Circular Dichroism Study 124
Studio della configurazione dell'antagonista alfa 1B-adrenergico (+)-cyclazosin 122
Studio farmacologico del (+)-cyclazosin, un antagonista selettivo del recettore alfa 1B-adrenergico 121
Strategie farmacologiche per il trattamento della malattia di Alzheimer 120
Tacrine Derivatives and Alzheimer's Disease 120
Discovery of Multi-Target Agents for Neurological Diseases via Ligand Design 118
Multi-functional drugs and Alzheimer's disease 117
Synthesis and α1-adrenoceptor antagonist activity of tamsulosin analogues 117
Lipoic acid, a lead structure for multi-target-directed drugs for neurodegeneration 116
Totale 17.069
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Categoria #
all - tutte 54.408
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 54.408
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20221.903 0 81 122 197 166 164 53 128 54 204 372 362
2022/20231.985 220 310 104 249 111 127 88 98 308 54 209 107
2023/2024864 46 103 67 64 75 139 46 90 24 65 75 70
2024/20252.753 142 368 298 197 602 182 143 91 73 102 94 461
2025/20265.868 592 546 588 479 700 347 510 162 1.079 373 260 232
2026/2027202 105 97 0 0 0 0 0 0 0 0 0 0
Totale 19.730