MELCHIORRE, CARLO
 Distribuzione geografica
Continente #
NA - Nord America 5.283
EU - Europa 4.909
AS - Asia 2.024
AF - Africa 294
Continente sconosciuto - Info sul continente non disponibili 35
OC - Oceania 14
SA - Sud America 10
Totale 12.569
Nazione #
US - Stati Uniti d'America 5.268
GB - Regno Unito 1.272
IT - Italia 1.168
CN - Cina 873
UA - Ucraina 591
DE - Germania 568
SG - Singapore 470
SE - Svezia 452
VN - Vietnam 300
IN - India 254
FR - Francia 204
RU - Federazione Russa 193
IE - Irlanda 137
EE - Estonia 95
TG - Togo 92
ZA - Sudafrica 67
CI - Costa d'Avorio 66
SC - Seychelles 55
BG - Bulgaria 38
EU - Europa 33
HR - Croazia 28
ES - Italia 24
JP - Giappone 24
FI - Finlandia 22
BE - Belgio 21
JO - Giordania 21
GR - Grecia 19
CH - Svizzera 17
NL - Olanda 17
CA - Canada 15
IR - Iran 15
AU - Australia 13
KR - Corea 12
CZ - Repubblica Ceca 11
RO - Romania 11
PK - Pakistan 8
LB - Libano 7
TR - Turchia 7
MY - Malesia 6
TW - Taiwan 6
AT - Austria 5
HK - Hong Kong 5
NG - Nigeria 5
CL - Cile 4
MA - Marocco 4
PL - Polonia 4
AL - Albania 3
IQ - Iraq 3
A2 - ???statistics.table.value.countryCode.A2??? 2
BR - Brasile 2
CM - Camerun 2
DZ - Algeria 2
HU - Ungheria 2
ID - Indonesia 2
MD - Moldavia 2
SA - Arabia Saudita 2
SM - San Marino 2
TH - Thailandia 2
UZ - Uzbekistan 2
AE - Emirati Arabi Uniti 1
AZ - Azerbaigian 1
BD - Bangladesh 1
BO - Bolivia 1
DK - Danimarca 1
EC - Ecuador 1
FK - Isole Falkland (Malvinas) 1
KG - Kirghizistan 1
LK - Sri Lanka 1
LV - Lettonia 1
MU - Mauritius 1
NZ - Nuova Zelanda 1
PE - Perù 1
SK - Slovacchia (Repubblica Slovacca) 1
Totale 12.569
Città #
Southend 1.124
Fairfield 530
Jacksonville 443
Ashburn 409
Singapore 399
Chandler 395
Santa Clara 371
Wilmington 276
Houston 266
Woodbridge 266
Ann Arbor 246
Princeton 241
Seattle 233
Cambridge 185
Boardman 173
Dong Ket 151
Dublin 137
Padova 120
Nanjing 113
Westminster 113
Bologna 105
Lomé 92
Berlin 87
Milan 87
Jinan 70
Mülheim 67
Abidjan 66
Medford 60
Saint Petersburg 59
Shenyang 56
Mahé 54
Rome 49
Nanchang 46
Changsha 42
Hebei 41
Beijing 39
Sofia 38
Los Angeles 37
Turin 36
New York 35
Des Moines 31
Guangzhou 30
San Diego 28
Verona 28
Redmond 26
Dearborn 23
Florence 23
Tianjin 23
Bari 22
Amman 21
Shanghai 21
Helsinki 20
Brussels 18
Hangzhou 18
Redwood City 18
Tokyo 18
Jiaxing 17
Cormano 16
Zhengzhou 15
Falls Church 14
Mountain View 14
Olalla 14
Taizhou 14
Ferrara 13
Haikou 13
Kunming 13
Naples 13
Norwalk 13
Barcelona 12
Lanzhou 12
Taiyuan 12
Wuhan 12
Fuzhou 11
Parma 11
Phoenix 11
Ningbo 10
Pune 10
Foshan 9
Melbourne 9
Palermo 9
San Venanzo 9
Brno 8
Chicago 8
Falkenstein 8
Livorno 8
Monza 8
Bremen 7
Madrid 7
Modena 7
Munich 7
Napoli 7
Noida 7
Paris 7
Qingdao 7
Ancona 6
Benevento 6
Bern 6
Bucharest 6
Camisano Vicentino 6
Cesena 6
Totale 8.163
Nome #
Antidepressivi e antipsicotici 461
A small molecule targeting the multifactorial nature of Alzheimer's disease 309
Progettazione e sintesi di analoghi rigidi di metoctramina nello studio dei recettori muscarinici 198
Cytotoxicity of methoctramine and methoctramine-related polyamines. 178
A new EGFR inhibitor induces apoptosis in colon cancer cells. 172
Bis(7)-tacrine Derivatives as Multitarget-Directed Ligands: Focus on Anticholinesterase and Antiamyloid Activities 164
Alzheimer's disease: new approaches to drug discovery. 160
Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 3. Effect of replacing the inner polymethylene chain with cyclic moieties 158
DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF SUSTITUTED NAPHTHALENE IMIDES AND DIIMIDES AS ANTICANCER AGENT 157
Progettazione e sintesi di poliammine a potenziale attività antitumorale 157
Rational Approach to discover multipotent anti-Alzheimer drugs 153
Design, synthesis, and biological evaluation of conformationally restricted rivastigmine analogues 153
Polyamine conjugation of curcumin analogues toward the discovery of mitochondria-directed neuroprotective agents. 147
Progettazione e sintesi di derivati poliamminici per il trattamento della malattia di Alzheimer 146
Curcumin analogs as multi-target antioxidants: focus on mitochondria. 143
A NEW EPIDERMAL GROWTH FACTOR RECEPTOR INHIBITOR IN COLON CANCER CELLS 138
Structure-activity relationships of memoquin: Influence of the chain chirality in the multi-target mechanism of action 138
Multitargeted drugs discovery: Balancing anti-amyloid and anticholinesterase capacity in a single chemical entity 134
A NEW EPIDERMAL GROWTH FACTOR RECEPTOR INHIBITOR IN COLON CANCER CELLS 134
Design, synthesis, and biological evaluation of prazosin-related derivatives as multipotent compounds 133
Multi-Target-Directed Drug Design Strategy: From a Dual Binding Site Acetylcholinesterase Inhibitor to a Trifunctional Compound against Alzheimer's Disease 129
Bivalent tacrine-based acetylcholinesterase inhibitors: role of the spacer in the recognition process of the enzyme gorge 125
Process for preparation of 1,4-benzoquinone-2,5-diamines by reaction of amines with 1,4-benzoquinones bearing leaving groups at the 2- and 5-positions 124
Design, synthesis, and biological evaluation of pirenzepine analogs bearing a 1,2-cyclohexanediamine and a perhydroquinoxaline units in exchange for the piperazine ring as antimuscarinics 124
Toward a rational design of multitarget-directed antioxidants: merging memoquin and lipoic acid molecular frameworks 124
Investigation of the photostability properties of memoquin, a quinone derivative for the treatment of Alzheimer's disease. 124
Monolithic stationary phase coupled with coulometric detection: development of an ion-pair HPLC method for the analysis of quinone-bearing compounds. 121
Memoquin: a multi-target-directed ligand as an innovative therapeutic opportunity for Alzheimer's disease 121
Novel bis(7)-tacrine derivatives as multitarget ligands: focus on anti-cholinesterase and anti-amyloid activities 121
Design, synthesis, and biological evaluation of substituted 2,3-dihydro-1H-cyclopenta[b]quinolin-9-ylamine related compounds as fructose-1,6-bisphosphatase inhibitors 121
Characterization of Cholinesterase inhibitors by means of immobilized enzyme reactor 117
Novel Class of Quinone-Bearing Polyamines as Multi-Target-Directed Ligands To Combat Alzheimer's Disease 115
Multitarget-directed ligands: Innovative chemical probes and therapeutic tools against Alzheimer's disease 115
Preparation of (hetero)aromatic (hetero)cyclic carboxamides for the treatment of Alzheimer's disease 113
Beta-secretase monolithic micro-IMER (immobilized enzyme reactor) for on-line HPLC screening of quinone-bearing polyamine inhibitors. 113
Multi-target-Directed Ligands To Combat Neurodegenerative Diseases 113
Heterocyclic inhibitors of AChE acylation and peripheral sites. 113
Dual target compounds for the treatment of Alzheimer’s disease. 112
Design, Synthesis, and biological evaluation of naphtalene diimides derivatives as anticancer agent 110
Combining galantamine and memantine in multitargeted, new chemical entities potentially useful in Alzheimer's disease. 110
Inhibition of Acetylcholinesterase, Beta-Amyloid Aggregation, and NMDA Receptors in Alzheimer's Disease: A Promising Direction for the Multi-target-Directed Ligands Gold Rush 109
Progress in acetylcholinesterase inhibitors for Alzheimer's disease: an update 109
Structure-activity relationships of methoctramine-related polyamines as muscarinic antagonist: Effect of replacing the inner polymethylene chain with cyclic moieties 108
Mitochondria-directed antioxidants in Alzheimer's disease. 105
Preparation of 2,5-bis-diamine-[1,4]benzoquinone derivatives for the treatment of Alzheimer's disease and a process for their preparation and intermediates thereof. 105
Memoquin: a new compound to attack Alzheimer's disease drug discovery 104
Progress in acetylcholinesterase inhibitors for Alzheimer's disease 103
Parallel synthesis and cytotoxicity evaluation of a polyamine-quinone conjugates library 102
MTDL design strategy in the context of Alzheimer's disease: from lipocrine to memoquin and beyond 102
Synthesis of Monomeric Derivatives To Probe Memoquin's Bivalent Interactions 102
Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer's disease. 102
From dual binding site acetylcholinesterase inhibitors to multi-target-directed ligands (MTDLs): a step forward in the treatment of Alzheimer's disease 101
Lipocrine, a multipotent drug for the investigation of Alzheimer's disease 100
Multitarget-directed drug design strategy: a novel molecule designed to block epidermal growth factor receptor (EGFR) and to exert proapoptotic effects 100
Design, synthesis, and biological evaluation of substituted naphtalene imides and diimides as anticancer agents 100
Methoctramine analogues inhibit responses to capsaicin and protons in rat dorsal root ganglion neurons 99
Multi-Target-Direcetd Ligands as acetylcholinesterase inhibitors and nicotinic modulators for Alzheimer's disease 98
Cystamine-tacrine dimer: a new multi-target-directed ligand as potential therapeutic agent for Alzheimer’s disease treatment 98
Polymethylene tetraamine backbone as template for the development of biologically active polyamines 97
Absolute configuration of alpha 1B-adrenoceptor antagonist (+)-cyclazosin 97
Polyamines may modulate both G protein-coupled receptors and G proteins 97
Structure-Activity Relationships of New Acetylcholinesterase Noncovalent Inhibitors Based on a Polyamine Backbone 96
CYTOTOXICITY EVALUATION OF A POLYAMINE-QUINONE LIBRARY CONJUGATES IN HUMAN COLON CARCINOMA CELLS 95
Organic compounds useful for the treatment of neurodegenerative diseases, uses and methods for the preparation thereof 95
Insight Into the Kinetic of Amyloid beta (1-42) Peptide Self-Aggregation: Elucidation of Inhibitors' Mechanism of Action 94
Novel class of quinone-bearing polyamines as multi-target-directed ligands to combat Alzheimer’s disease 94
Structure-Activity Relationships of Acetylcholinesterase Noncovalent Inhibitors Based on a Polyamine Backbone. 4. Futher Investigation on the Inner Spacer. 94
One-molecule-multiple-target strategy: a novel multifunctional molecule designed to block EGF-r and to exert pro-apoptotic effects 93
A rational approach to multi-site-directed ligands for the treatment of Alzheimer’s disease 93
Discovery of multipotent drugs for the teratment of Alzheimer's disease 93
Propidium-based polyamine ligands as potent inhibitors of acetylcholinesterase and acetylcholinesterase-induced amyloid beta aggregaation 93
Lipoic acid, a lead structure for multi-target-directed drugs for neurodegeneration 93
Memoquin: a new therapeutic poly-agent for Alzheimer's disease 92
Synthetic polyamines: an overview of their multiple biological activities. 92
Rational approach to discover multipotent anti-Alzheimer drugs 91
Doxazosin-related alpha1-adrenoceptor antagonists with prostate antitumor activity 91
Rational design of multitarget-directed antioxidants: merging memoquin and lipocrine molecular frameworks 91
MEMOQUIN: A MULTIPOTENT ACETYLCHOLINESTERASE INHIBITOR WITH EXCELLENT IN VIVO ACTIVITY 90
Synthesis and α1-adrenoceptor antagonist activity of tamsulosin analogues 90
Synthesis and alpha-1 adrenoceptor antagonist activity of derivatives and isosters of the furan portion of (+)-cyclazosin 89
Quinone-bearing polyamines are AChE inhibitors endowed with multifunctional properties 88
New quinazoline compounds as non-peptidomimetic BACE-1 inhibitors in the treatment of Alzheimer's disease 88
Discovery of Memoquin, a Multitarget-Directed Ligand (MTDL) for the Treatment of Alzheimer’s Disease 88
Tacrine Derivatives and Alzheimer's Disease 88
POLYPHARMACOLOGY: CREATING SELECTIVE NON-SELECTIVITY 87
Combining galantamine and memantine in dual-target new chemical entities for the treatment of Alzheimer’s disease 87
Polyaminoquinones Binding to Human Serum Albumin: a Biochromatography and Circular Dichroism Study 87
Polyamines in Drug Discovery: From the Universal Template Approach to the Multitarget-Directed Ligand Design Strategy 86
Recent advances in the design and synthesis of prazosin derivatives 85
(+)- Cyclazosin derivatives as alpha 1-adrenoceptor antagonists 84
Recent advances in alpha1-adrenoreceptor antagonists as pharmacological tools and therapeutic agents. 84
Multi-target-directed drug design strategy: quinone derivatives designed to block amyloid-beta aggregation and to exert antioxidant effects 83
Rational approach to discover multipotent anti-Alzheimer drugs 81
Methoctramine-related polyamines as antinociceptive agents 78
Methoctramine analogues inhibit responses to capsaicin in DRG neurons and cloned TRPV1 78
Methoctramine analogues inhibit capsaicin induced currents in dorsal root ganglia and Xenopus oocytes expressing TRPV1 77
Synthesis of doxazosin analogues as alpha-1 adrenoceptor antagonists with prostate antitumor activity 77
Studio della configurazione dell'antagonista alfa 1B-adrenergico (+)-cyclazosin 75
Reversible HSA binding of lipocrine: a circular dichroism study. 75
Synthesis of monomeric derivatives to probe Memoquin bivalent interactions 75
Totale 11.446
Categoria #
all - tutte 33.259
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 33.259


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20201.549 0 0 0 0 0 0 330 376 290 214 123 216
2020/20211.721 403 117 46 114 23 140 35 156 117 109 105 356
2021/20222.104 188 83 122 197 167 165 53 129 55 206 374 365
2022/20231.997 222 311 106 249 111 127 88 99 309 55 213 107
2023/2024869 47 103 67 64 75 141 46 90 24 65 75 72
2024/20251.846 143 369 300 197 607 182 48 0 0 0 0 0
Totale 12.811