CRIS Current Research Information System

GOBBI, SILVIA
 Distribuzione geografica
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Continente #
NA - Nord America 4.913
EU - Europa 3.135
AS - Asia 1.822
AF - Africa 206
SA - Sud America 13
OC - Oceania 10
Continente sconosciuto - Info sul continente non disponibili 3
Totale 10.102
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Nazione #
US - Stati Uniti d'America 4.889
GB - Regno Unito 775
IT - Italia 725
CN - Cina 636
SG - Singapore 431
DE - Germania 424
VN - Vietnam 376
SE - Svezia 313
UA - Ucraina 240
IN - India 172
RU - Federazione Russa 128
FR - Francia 125
IE - Irlanda 117
JO - Giordania 92
ZA - Sudafrica 61
CI - Costa d'Avorio 59
BG - Bulgaria 56
TG - Togo 56
EE - Estonia 52
FI - Finlandia 35
CH - Svizzera 32
IR - Iran 28
ID - Indonesia 25
CA - Canada 22
JP - Giappone 20
SC - Seychelles 17
BE - Belgio 16
CZ - Repubblica Ceca 13
GR - Grecia 13
ES - Italia 11
HR - Croazia 11
PL - Polonia 11
AT - Austria 9
NL - Olanda 9
TR - Turchia 8
AU - Australia 7
BR - Brasile 6
LB - Libano 6
NG - Nigeria 6
PT - Portogallo 6
PK - Pakistan 5
HU - Ungheria 4
A2 - ???statistics.table.value.countryCode.A2??? 3
BY - Bielorussia 3
DZ - Algeria 3
EC - Ecuador 3
EG - Egitto 3
HK - Hong Kong 3
KZ - Kazakistan 3
NZ - Nuova Zelanda 3
PH - Filippine 3
RO - Romania 3
CL - Cile 2
IQ - Iraq 2
KR - Corea 2
KW - Kuwait 2
MX - Messico 2
MY - Malesia 2
AE - Emirati Arabi Uniti 1
AR - Argentina 1
BD - Bangladesh 1
LA - Repubblica Popolare Democratica del Laos 1
LK - Sri Lanka 1
LT - Lituania 1
MD - Moldavia 1
NO - Norvegia 1
PE - Perù 1
RS - Serbia 1
SA - Arabia Saudita 1
SD - Sudan 1
UZ - Uzbekistan 1
Totale 10.102
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Città #
Southend 694
Fairfield 547
Chandler 521
Ashburn 436
Singapore 371
Santa Clara 322
Woodbridge 313
Houston 261
Seattle 248
Bologna 246
Wilmington 240
Dong Ket 239
Cambridge 207
Princeton 172
Ann Arbor 158
Jacksonville 158
Boardman 121
Dublin 116
Amman 92
New York 83
Westminster 73
Nanjing 68
Padova 61
Abidjan 59
Lomé 56
Sofia 56
Berlin 54
Bremen 45
San Diego 42
Jinan 38
Saint Petersburg 38
Beijing 37
Shenyang 35
Milan 34
Helsinki 33
Redmond 32
Bern 29
Mülheim 28
Hebei 27
Nanchang 25
Jakarta 24
Tianjin 24
Tokyo 19
Des Moines 17
Jiaxing 17
Mahé 17
Shanghai 17
Brussels 16
Venezia 16
Changsha 15
Medford 15
Olalla 15
Redwood City 15
Boydton 14
Dearborn 14
Guangzhou 14
Mountain View 14
Kunming 13
Munich 13
Verona 13
Los Angeles 12
Zhengzhou 12
Phoenix 11
San Giorgio di Piano 10
Taiyuan 10
Falls Church 9
Fremont 9
Ningbo 9
Norwalk 9
Brno 8
Hangzhou 8
Turin 8
Casoria 7
Fuzhou 7
Haikou 7
London 7
Shenzhen 7
Wuhan 7
Abeokuta 6
Asciano 6
Fidenza 6
Lanzhou 6
Modena 6
Pune 6
Ravenna 6
San Jose 6
Urbino 6
Vienna 6
Ancona 5
Bühl 5
Forlì 5
Hyderabad 5
Madrid 5
Moscow 5
Paris 5
Toronto 5
Valsamoggia 5
Bentivoglio 4
Delhi 4
Dongguan 4
Totale 7.011
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Nome #
1,4-dihydropyridine derivatives as calcium channel modulators: the role of 3-methoxy-flavone moiety 276
Discovery of novel benzofuran-based compounds with neuroprotective and immunomodulatory properties for Alzheimer's disease treatment 228
Multitarget Strategy to Address Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and Computational Studies of Coumarin-Based Derivatives 196
Cholinesterase inhibitors: xanthostigmine derivatives blocking the acetylcholinesterase-induced beta-amyloid aggregation. 183
2-Arylbenzofuran-based molecules as multipotent Alzheimer's disease modifying agents 167
Characterization and Heterologous Expression of the Oxalyl Coenzyme A Decarboxylase Gene from Bifidobacterium lactis 160
Design, synthesis and biological profile of new inhibitors of multidrug resistance associated proteins carrying a polycyclic scaffold 155
Benzofuran-Based Hybrid Compounds for the Inhibition of Cholinesterase Activity, Abeta Amyloid Aggregation, and Abeta Neurotoxicity 155
Analogues of the dual acetylcholinesterase inhibitor AP2238: synthesis and SAR 154
Benzophenones as xanthone-open model CYP11B1 inhibitors potentially useful for promoting wound healing 152
Versatility of the Curcumin Scaffold: Discovery of Potent and Balanced Dual BACE-1 and GSK-3β Inhibitors 151
Cardiovascular profile of xanthone-based 1,4 dihydropyridines bearing a lidoflazine pharmacophore fragment 150
Exploiting the chalcone scaffold to develop multifunctional agents for Alzheimer’s disease 147
Fatty Acid Amide Hydrolase (FAAH), Acetylcholinesterase (AChE), and Butyrylcholinesterase (BuChE): Networked Targets for the Development of Carbamates as Potential Anti-Alzheimer's Disease Agents 147
Extensive SAR and computational studies of 3-{4-[(benzylmethylamino)methyl]phenyl}-6,7-dimethoxy-2H-2-chromenone (AP2238) derivatives. 144
Anthracene Based Compounds as New L-type Ca2+ Channel Blockers: Design, Synthesis, and Full Biological Profile 142
Identification of chalcone-based antileishmanial agents targeting trypanothione reductase 136
Emerging targets in neurodegeneration: new opportunities for Alzheimer's disease treatment? 135
CHOLINESTERASE INHIBITORS: SAR AND ENZYME INHIBITORY ACTIVITY OF 3-[omega-(BENZYLMETHYLAMINO)ALKOXY]XANTHEN-9-ONES 135
A Computational Assay of Estrogen Receptor α Antagonists Reveals the Key Common Structural Traits of Drugs Effectively Fighting Refractory Breast Cancers 134
Identification of a new tamoxifen-xanthene hybrid as pro-apoptotic anticancer agent 131
Enantioselective nonsteroidal aromatase inhibitors identified through a multidisciplinary medicinal chemistry approach 130
Clobenpropit analogs as dual activity ligands for the histamine H3 and H4 receptors: synthesis, pharmacological evaluation, and cross-target QSAR studies. 129
null 123
Fluorinated benzophenone derivatives: balanced multipotent agents for Alzheimer's disease 122
Naturally inspired molecules as multifunctional agents for Alzheimer's disease treatment 121
Targeting Alzheimer’s disease: Novel indanone hybrids bearing a pharmacophoric fragment of AP2238 119
null 118
Imidazolylmethylbenzophenones as highly potent aromatase inhibitors. 117
Design, synthesis, and evaluation of benzophenone derivatives as novel acetylcholinesterase inhibitors 117
Polycyclic maleimide-based derivatives as first dual modulators of neuronal calcium channels and GSK-3β for Alzheimer's disease treatment 117
Antitumor profile of new phenothiazine derivatives 116
Homopterocarpanes as bridged triarylethylene analogues: synthesis and antagonistic effects in human MCF-7 breast cancer cells 116
Lead optimization providing a series of flavone derivatives as potent nonsteroidal inhibitors of the cytochrome P450 aromatase enzyme 113
Benzophenone derivatives as Inhibitors of Acetylcholinesterase 113
Novel Curcumin-Diethyl Fumarate Hybrid as a Dualistic GSK-3β Inhibitor/Nrf2 Inducer for the Treatment of Parkinson's Disease 113
Curcumin-1,2,3-triazole conjugation for targeting the cancer apoptosis machinery. 111
New potent P-glycoprotein inhibitors carrying a polycyclic scaffold 110
Derivati a struttura benzofenonica come inibitori dell'acetilcolinesterasi 109
Multi-target strategy to address Alzheimer’s disease: Design, synthesis and biological evaluation of new tacrine-based dimers 109
null 105
New derivatives of xanthenone-4-acetic acid: synthesis, pharmacological profile and effect on TNF-alpha and NO production by human immune cells 104
In vitro studies of flavon-8-acetic acid analogues 103
Hybrid drugs for Alzheimer's disease: new indanone derivatives bearing a pharmacophoric fragment of AP2238 103
Novel Aldosterone Synthase Inhibitors with Extended Carbocyclic Skeleton by a Combined Ligand-Based and Structure-Based Drug Design Approach 103
Natural-like Chalcones with Antitumor Activity on Human MG63 Osteosarcoma Cells 102
Design, Synthesis, and Biological and Crystallographic Evaluation of Novel Inhibitors ofPlasmodium falciparumEnoyl-ACP-reductase (PfFabI) 101
New Coumarin derivatives as cholinergic and cannabinoid system modulators 101
Functionalization of the chalcone scaffold for the discovery of novel lead compounds targeting fungal infections 100
In vitro biological activity of new analogues of flavon-8-acetic acid 98
Nonsteroidal Aromatase inhibitors: synthesis and evaluation of new flavone derivatives 98
Hybrid-Based Multi-Target Ligands for the Treatment of Alzheimer's Disease 98
Design of Multifunctional Compounds for Cardiovascular Disease: From Natural Scaffolds to “Classical” Multitarget Approach 97
PREPARATION AND STEREOCHEMICAL CHARACTERIZATION OF ENANTIOMERIC HOMOISOFLAVONES ACTIVE AS AROMATASE INHIBITORS 96
Novel highly potent and selective nonsteroidal aromatase inhibitors: synthesis, biological evaluation and structure-activity relationships investigation 96
Progettazione e sintesi di derivati benzofuranici per la malattia di Alzheimer 95
Multidrug resistance reverting activity and antitumor profile of new phenothiazine derivatives 95
Targeting the Bacterial Membrane with a New Polycyclic Privileged Structure: A Powerful Tool To Face Staphylococcus aureus Infections 94
Reconsidering Aromatase for Breast Cancer Treatment: New Roles for an Old Target 94
Balanced dual acting compounds targeting aromatase and estrogen receptor α as an emerging therapeutic opportunity to counteract estrogen responsive breast cancer 94
Modulation of Cytochromes P450 with Xanthone-Based Molecules: From Aromatase to Aldosterone Synthase and Steroid 11β-Hydroxylase Inhibition 92
Nonsteroidal aromatase inhibitors for the treatment of breast cancer: an update. 92
Studies on cytostatic and cytotoxic activity of new flavopiridol analogues 91
The first dual ChE/FAAH inhibitors: new perspectives for Alzheimer's disease? 91
Improved eradication efficacy of a combination of newly identified antimicrobial agents in C. albicans and S. aureus mixed-species biofilm 88
Immune-modulating and anti-vascular activities of two xanthenone acetic acid analogues: a comparative study to DMXAA. 87
Polycyclic Maleimide-based Scaffold as New Privileged Structure for Navigating the Cannabinoid System Opportunities 87
Mono- or di-fluorinated analogues of Flavone-8-acetic acid: synthesis and in vitro biological activity 85
Imidazolylmethylxanthones as potent inhibitors of cytochrome P450 aromatase 84
From nonsteroidal aromatase inhibitors to multifunctional drug candidates: classic and innovative strategies for the treatment of breast cancer. 84
Multifaceted activity of polyciclic MDR revertant agents in drug-resistant leukemic cells: Role of the spacer 84
The ability of coumarin-, flavanon- and flavonol-analogues of flavone acetic acid to stimulate human monocytes. 82
null 82
Small-molecule inhibitors/modulators of amyloid-β peptide aggregation and toxicity for the treatment of Alzheimer's disease: a patent review (2010 – 2012) 81
null 79
New potent inhibitors of cytochrome P450 aromatase 78
null 76
Targeting Orthosteric and Allosteric Pockets of Aromatase via Dual-Mode Novel Azole Inhibitors 74
null 70
Targeting neuronal calcium channels and GSK3β for Alzheimer's disease with naturally-inspired Diels-Alder adducts 68
null 67
Chalcone-based carbamates for Alzheimer's disease treatment 65
Coumarin derivatives as potential antitumor agents: Growth inhibition, apoptosis induction and multidrug resistance reverting activity 61
Tackling Alzheimer's Disease with Existing Drugs:A Promising Strategy for Bypassing Obstacles 60
Flavonoid-inspired vascular disrupting agents: Exploring flavone-8-acetic acid and derivatives in the new century 59
null 58
From AChE to BACE1 inhibitors: The role of the amine on the indanone scaffold 55
Targeting the multifaceted neurotoxicity of Alzheimer's disease by tailored functionalisation of the curcumin scaffold 52
Single-digit nanomolar inhibitors lock the aromatase active site via a dualsteric targeting strategy 48
Chalcones induce apoptosis, autophagy and reduce spreading in osteosarcoma 3D models 48
Interplay Between Endocannabinoid System and Neurodegeneration: Focus on Polypharmacology 45
Hitting drug-resistant malaria infection with triazole-linked flavonoid–chloroquine hybrid compounds 43
3-(4-{[benzyl(methyl)amino]methyl}-phenyl)-6,7-dimethoxy-2H-2-chromenone (AP2238) inhibits both acetylcholinesterase and acetylcholinesterase-induced β-amyloid aggregation: A dual function lead for Alzheimer's disease therapy 42
Recent progress on curcumin-based therapeutics: a patent review (2012-2016). Part II: curcumin derivatives in cancer and neurodegeneration 40
Acetylcholinesterase inhibitors: SAR and kinetic studies on ω-[N-methyl-N-(3-alkylcarbamoyloxyphenyl]methyl] aminoalkoxyaryl derivatives 37
Recent progress on curcumin-based therapeutics: a patent review (2012-2016). Part I: Curcumin 37
Cardiovascular hybrid drugs: New benzazepinone derivatives as bradycardic agents endowed with selective β1-Non-competitive antagonism 33
Chromone-based small molecules for multistep shutdown of arachidonate pathway: Simultaneous inhibition of COX-2, 15-LOX and mPGES-1 enzymes 33
Acetylcholinesterase inhibitors for potential use in Alzheimer's disease: Molecular modeling, synthesis and kinetic evaluation of 11H-indeno-[1,2-b]-quinolin-10-ylamine derivatives 28
A new class of nonsteroidal aromatase inhibitors: Design and synthesis of chromone and xanthone derivatives and inhibition of the P450 enzymes aromatase and 17α-hydroxylase/C17,20-lyase 26
Totale 10.170
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Categoria #
all - tutte 28.433
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 28.433
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20201.371 0 0 0 0 0 0 297 342 323 165 107 137
2020/20211.413 276 88 26 61 26 77 27 128 103 76 94 431
2021/20221.612 144 39 108 86 134 82 48 159 90 125 303 294
2022/20232.157 197 247 92 262 168 169 53 129 448 59 156 177
2023/2024663 34 78 33 86 48 191 40 32 14 34 34 39
2024/20251.446 83 341 263 133 500 122 4 0 0 0 0 0
Totale 10.399