CRIS Current Research Information System

GOBBI, SILVIA
 Distribuzione geografica
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Continente #
NA - Nord America 6.740
AS - Asia 5.740
EU - Europa 4.067
AF - Africa 309
SA - Sud America 280
OC - Oceania 12
Continente sconosciuto - Info sul continente non disponibili 4
Totale 17.152
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Nazione #
US - Stati Uniti d'America 6.609
SG - Singapore 1.490
CN - Cina 1.472
VN - Vietnam 1.434
IT - Italia 1.020
GB - Regno Unito 810
DE - Germania 534
HK - Hong Kong 343
SE - Svezia 317
IN - India 268
UA - Ucraina 245
FR - Francia 232
RU - Federazione Russa 204
BR - Brasile 188
NL - Olanda 141
BD - Bangladesh 127
IE - Irlanda 125
JP - Giappone 114
KR - Corea 112
CI - Costa d'Avorio 98
JO - Giordania 96
FI - Finlandia 91
CA - Canada 88
ZA - Sudafrica 87
BG - Bulgaria 58
TG - Togo 56
EE - Estonia 52
PH - Filippine 41
ID - Indonesia 40
AR - Argentina 39
CH - Svizzera 36
PL - Polonia 35
ES - Italia 34
AT - Austria 29
IR - Iran 29
SC - Seychelles 28
PK - Pakistan 26
TH - Thailandia 25
TR - Turchia 25
MX - Messico 24
IQ - Iraq 20
BE - Belgio 17
CZ - Repubblica Ceca 16
GR - Grecia 16
EC - Ecuador 14
MY - Malesia 14
HR - Croazia 12
EG - Egitto 11
SA - Arabia Saudita 11
TW - Taiwan 11
CO - Colombia 10
NG - Nigeria 10
AU - Australia 9
LB - Libano 8
LT - Lituania 8
CL - Cile 7
KZ - Kazakistan 7
VE - Venezuela 7
HU - Ungheria 6
PT - Portogallo 6
KE - Kenya 5
MD - Moldavia 5
PS - Palestinian Territory 5
DZ - Algeria 4
GT - Guatemala 4
OM - Oman 4
PE - Perù 4
PY - Paraguay 4
RO - Romania 4
A2 - ???statistics.table.value.countryCode.A2??? 3
AE - Emirati Arabi Uniti 3
AL - Albania 3
BO - Bolivia 3
BY - Bielorussia 3
ET - Etiopia 3
HN - Honduras 3
NP - Nepal 3
NZ - Nuova Zelanda 3
PA - Panama 3
RS - Serbia 3
UZ - Uzbekistan 3
AO - Angola 2
BB - Barbados 2
CR - Costa Rica 2
GY - Guiana 2
JM - Giamaica 2
KW - Kuwait 2
NO - Norvegia 2
TN - Tunisia 2
UY - Uruguay 2
AM - Armenia 1
AZ - Azerbaigian 1
BA - Bosnia-Erzegovina 1
CW - ???statistics.table.value.countryCode.CW??? 1
DO - Repubblica Dominicana 1
GH - Ghana 1
GI - Gibilterra 1
HT - Haiti 1
KG - Kirghizistan 1
KH - Cambogia 1
Totale 17.145
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Città #
Singapore 995
Southend 694
Ashburn 673
Fairfield 547
Chandler 521
San Jose 438
Santa Clara 347
Bologna 346
Hong Kong 330
Woodbridge 313
Ho Chi Minh City 282
Houston 263
Hefei 259
Hanoi 257
Seattle 249
Wilmington 241
Dong Ket 239
Cambridge 207
Beijing 177
Princeton 172
Ann Arbor 158
Jacksonville 158
New York 147
Boardman 139
Council Bluffs 138
Dublin 124
Seoul 100
Abidjan 98
Amman 96
Tokyo 93
Los Angeles 89
Dallas 84
Lauterbourg 77
Nanjing 73
Westminster 73
Buffalo 71
Helsinki 69
Padova 64
Sofia 57
Lomé 56
Berlin 54
Munich 54
Milan 50
Bremen 47
San Diego 43
Da Nang 42
Jinan 41
Shenyang 39
Saint Petersburg 38
Redondo Beach 34
Haiphong 33
Redmond 32
Frankfurt am Main 31
Guangzhou 31
Bern 29
Jakarta 29
Tianjin 29
Mülheim 28
Hebei 27
Bengaluru 26
Nanchang 25
Toronto 25
Shanghai 23
São Paulo 23
Warsaw 23
Orem 22
Changsha 20
Johannesburg 20
Nuremberg 20
Rimini 20
Chicago 19
Des Moines 18
Montreal 18
Phoenix 18
Quận Bình Thạnh 18
Vienna 18
Brussels 17
Jiaxing 17
Mahé 17
The Dalles 17
Zhengzhou 17
Sant Cugat del Vallès 16
Venezia 16
Brooklyn 15
Can Tho 15
London 15
Medford 15
Mexico City 15
Olalla 15
Redwood City 15
Atlanta 14
Boydton 14
Dearborn 14
Hải Dương 14
Kunming 14
Mountain View 14
Rome 14
Verona 14
Biên Hòa 13
Falkenstein 13
Totale 10.941
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Nome #
1,4-dihydropyridine derivatives as calcium channel modulators: the role of 3-methoxy-flavone moiety 352
Discovery of novel benzofuran-based compounds with neuroprotective and immunomodulatory properties for Alzheimer's disease treatment 337
Chalcones induce apoptosis, autophagy and reduce spreading in osteosarcoma 3D models 299
Multitarget Strategy to Address Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and Computational Studies of Coumarin-Based Derivatives 292
Benzofuran-Based Hybrid Compounds for the Inhibition of Cholinesterase Activity, Abeta Amyloid Aggregation, and Abeta Neurotoxicity 285
Cholinesterase inhibitors: xanthostigmine derivatives blocking the acetylcholinesterase-induced beta-amyloid aggregation. 252
Progettazione e sintesi di derivati benzofuranici per la malattia di Alzheimer 241
Characterization and Heterologous Expression of the Oxalyl Coenzyme A Decarboxylase Gene from Bifidobacterium lactis 227
Design, synthesis and biological profile of new inhibitors of multidrug resistance associated proteins carrying a polycyclic scaffold 227
Targeting neuronal calcium channels and GSK3β for Alzheimer's disease with naturally-inspired Diels-Alder adducts 223
Analogues of the dual acetylcholinesterase inhibitor AP2238: synthesis and SAR 221
Benzophenones as xanthone-open model CYP11B1 inhibitors potentially useful for promoting wound healing 220
Versatility of the Curcumin Scaffold: Discovery of Potent and Balanced Dual BACE-1 and GSK-3β Inhibitors 218
Identification of chalcone-based antileishmanial agents targeting trypanothione reductase 218
Balanced dual acting compounds targeting aromatase and estrogen receptor α as an emerging therapeutic opportunity to counteract estrogen responsive breast cancer 216
Exploiting the chalcone scaffold to develop multifunctional agents for Alzheimer’s disease 215
Fatty Acid Amide Hydrolase (FAAH), Acetylcholinesterase (AChE), and Butyrylcholinesterase (BuChE): Networked Targets for the Development of Carbamates as Potential Anti-Alzheimer's Disease Agents 214
Identification of a new tamoxifen-xanthene hybrid as pro-apoptotic anticancer agent 209
Natural-like Chalcones with Antitumor Activity on Human MG63 Osteosarcoma Cells 209
Targeting the multifaceted neurotoxicity of Alzheimer's disease by tailored functionalisation of the curcumin scaffold 208
2-Arylbenzofuran-based molecules as multipotent Alzheimer's disease modifying agents 208
Extensive SAR and computational studies of 3-{4-[(benzylmethylamino)methyl]phenyl}-6,7-dimethoxy-2H-2-chromenone (AP2238) derivatives. 200
Naturally inspired molecules as multifunctional agents for Alzheimer's disease treatment 199
Interplay Between Endocannabinoid System and Neurodegeneration: Focus on Polypharmacology 195
Cardiovascular profile of xanthone-based 1,4 dihydropyridines bearing a lidoflazine pharmacophore fragment 193
Curcumin-1,2,3-triazole conjugation for targeting the cancer apoptosis machinery. 192
Novel Curcumin-Diethyl Fumarate Hybrid as a Dualistic GSK-3β Inhibitor/Nrf2 Inducer for the Treatment of Parkinson's Disease 191
CHOLINESTERASE INHIBITORS: SAR AND ENZYME INHIBITORY ACTIVITY OF 3-[omega-(BENZYLMETHYLAMINO)ALKOXY]XANTHEN-9-ONES 186
Enantioselective nonsteroidal aromatase inhibitors identified through a multidisciplinary medicinal chemistry approach 182
Single-digit nanomolar inhibitors lock the aromatase active site via a dualsteric targeting strategy 176
Anthracene Based Compounds as New L-type Ca2+ Channel Blockers: Design, Synthesis, and Full Biological Profile 176
A Computational Assay of Estrogen Receptor α Antagonists Reveals the Key Common Structural Traits of Drugs Effectively Fighting Refractory Breast Cancers 176
Polycyclic maleimide-based derivatives as first dual modulators of neuronal calcium channels and GSK-3β for Alzheimer's disease treatment 174
New Coumarin derivatives as cholinergic and cannabinoid system modulators 174
Lead optimization providing a series of flavone derivatives as potent nonsteroidal inhibitors of the cytochrome P450 aromatase enzyme 173
Emerging targets in neurodegeneration: new opportunities for Alzheimer's disease treatment? 172
Nonsteroidal Aromatase inhibitors: synthesis and evaluation of new flavone derivatives 171
Homopterocarpanes as bridged triarylethylene analogues: synthesis and antagonistic effects in human MCF-7 breast cancer cells 171
Clobenpropit analogs as dual activity ligands for the histamine H3 and H4 receptors: synthesis, pharmacological evaluation, and cross-target QSAR studies. 170
Derivati a struttura benzofenonica come inibitori dell'acetilcolinesterasi 169
Multifaceted activity of polyciclic MDR revertant agents in drug-resistant leukemic cells: Role of the spacer 169
Fluorinated benzophenone derivatives: balanced multipotent agents for Alzheimer's disease 168
Design, synthesis, and evaluation of benzophenone derivatives as novel acetylcholinesterase inhibitors 166
Antitumor profile of new phenothiazine derivatives 165
Targeting Alzheimer’s disease: Novel indanone hybrids bearing a pharmacophoric fragment of AP2238 165
Imidazolylmethylbenzophenones as highly potent aromatase inhibitors. 162
Reconsidering Aromatase for Breast Cancer Treatment: New Roles for an Old Target 162
PREPARATION AND STEREOCHEMICAL CHARACTERIZATION OF ENANTIOMERIC HOMOISOFLAVONES ACTIVE AS AROMATASE INHIBITORS 159
Improved eradication efficacy of a combination of newly identified antimicrobial agents in C. albicans and S. aureus mixed-species biofilm 157
In vitro studies of flavon-8-acetic acid analogues 155
New derivatives of xanthenone-4-acetic acid: synthesis, pharmacological profile and effect on TNF-alpha and NO production by human immune cells 155
Naturally Inspired Coumarin Derivatives in Alzheimer’s Disease Drug Discovery: Latest Advances and Current Challenges 153
Switching from Aromatase Inhibitors to Dual Targeting Flavonoid-Based Compounds for Breast Cancer Treatment 153
Studies on cytostatic and cytotoxic activity of new flavopiridol analogues 153
Hybrid drugs for Alzheimer's disease: new indanone derivatives bearing a pharmacophoric fragment of AP2238 153
Benzophenone derivatives as Inhibitors of Acetylcholinesterase 153
In vitro biological activity of new analogues of flavon-8-acetic acid 151
Functionalization of the chalcone scaffold for the discovery of novel lead compounds targeting fungal infections 151
From AChE to BACE1 inhibitors: The role of the amine on the indanone scaffold 148
Targeting Orthosteric and Allosteric Pockets of Aromatase via Dual-Mode Novel Azole Inhibitors 147
Flavonoid-inspired vascular disrupting agents: Exploring flavone-8-acetic acid and derivatives in the new century 147
Design, Synthesis, and Biological and Crystallographic Evaluation of Novel Inhibitors ofPlasmodium falciparumEnoyl-ACP-reductase (PfFabI) 146
Multi-target strategy to address Alzheimer’s disease: Design, synthesis and biological evaluation of new tacrine-based dimers 146
Hitting drug-resistant malaria infection with triazole-linked flavonoid–chloroquine hybrid compounds 145
New potent P-glycoprotein inhibitors carrying a polycyclic scaffold 145
Polycyclic Maleimide-based Scaffold as New Privileged Structure for Navigating the Cannabinoid System Opportunities 145
Targeting the Bacterial Membrane with a New Polycyclic Privileged Structure: A Powerful Tool To Face Staphylococcus aureus Infections 142
Novel Aldosterone Synthase Inhibitors with Extended Carbocyclic Skeleton by a Combined Ligand-Based and Structure-Based Drug Design Approach 141
Design of Multifunctional Compounds for Cardiovascular Disease: From Natural Scaffolds to “Classical” Multitarget Approach 137
New potent inhibitors of cytochrome P450 aromatase 134
Novel highly potent and selective nonsteroidal aromatase inhibitors: synthesis, biological evaluation and structure-activity relationships investigation 133
The ability of coumarin-, flavanon- and flavonol-analogues of flavone acetic acid to stimulate human monocytes. 130
Imidazolylmethylxanthones as potent inhibitors of cytochrome P450 aromatase 129
Chalcone-based carbamates for Alzheimer's disease treatment 129
Hybrid-Based Multi-Target Ligands for the Treatment of Alzheimer's Disease 126
Multidrug resistance reverting activity and antitumor profile of new phenothiazine derivatives 126
Coumarin derivatives as potential antitumor agents: Growth inhibition, apoptosis induction and multidrug resistance reverting activity 125
Exploiting acylaminopyrazole scaffold for polypharmacology approach in Alzheimer's disease 124
The first dual ChE/FAAH inhibitors: new perspectives for Alzheimer's disease? 124
null 123
Extended Antimicrobial Profile of Chromone–Butenafine Hybrids 122
Nonsteroidal aromatase inhibitors for the treatment of breast cancer: an update. 122
Tackling Alzheimer's Disease with Existing Drugs:A Promising Strategy for Bypassing Obstacles 122
Modulation of Cytochromes P450 with Xanthone-Based Molecules: From Aromatase to Aldosterone Synthase and Steroid 11β-Hydroxylase Inhibition 121
Mono- or di-fluorinated analogues of Flavone-8-acetic acid: synthesis and in vitro biological activity 121
null 118
Immune-modulating and anti-vascular activities of two xanthenone acetic acid analogues: a comparative study to DMXAA. 116
From nonsteroidal aromatase inhibitors to multifunctional drug candidates: classic and innovative strategies for the treatment of breast cancer. 114
Small-molecule inhibitors/modulators of amyloid-β peptide aggregation and toxicity for the treatment of Alzheimer's disease: a patent review (2010 – 2012) 112
Chromone-based small molecules for multistep shutdown of arachidonate pathway: Simultaneous inhibition of COX-2, 15-LOX and mPGES-1 enzymes 107
null 105
Recent progress on curcumin-based therapeutics: a patent review (2012-2016). Part I: Curcumin 92
Recent progress on curcumin-based therapeutics: a patent review (2012-2016). Part II: curcumin derivatives in cancer and neurodegeneration 92
SAR of 9-amino-1,2,3-4-tetrahydroacridine-based acetylcholinesterase inhibitors: Synthesis, enzyme inhibitory activity, QSAR, and structure-based CoMFA of tacrine analogues 89
null 82
3-(4-{[benzyl(methyl)amino]methyl}-phenyl)-6,7-dimethoxy-2H-2-chromenone (AP2238) inhibits both acetylcholinesterase and acetylcholinesterase-induced β-amyloid aggregation: A dual function lead for Alzheimer's disease therapy 79
null 79
null 76
Cardiovascular hybrid drugs: New benzazepinone derivatives as bradycardic agents endowed with selective β1-Non-competitive antagonism 75
Drifting of heme-coordinating group in imidazolylmethylxanthones leading to improved selective inhibition of CYP11B1 74
Totale 16.391
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Categoria #
all - tutte 48.044
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 48.044
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021431 0 0 0 0 0 0 0 0 0 0 0 431
2021/20221.612 144 39 108 86 134 82 48 159 90 125 303 294
2022/20232.157 197 247 92 262 168 169 53 129 448 59 156 177
2023/2024663 34 78 33 86 48 191 40 32 14 34 34 39
2024/20252.446 83 341 263 133 500 122 199 68 55 172 148 362
2025/20266.124 542 548 577 445 635 291 551 254 1.129 493 411 248
Totale 17.523