CRIS Current Research Information System

GOBBI, SILVIA
 Distribuzione geografica
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Continente #
NA - Nord America 7.033
AS - Asia 5.798
EU - Europa 4.107
Continente sconosciuto - Info sul continente non disponibili 375
AF - Africa 312
SA - Sud America 293
OC - Oceania 12
Totale 17.930
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Nazione #
US - Stati Uniti d'America 6.878
SG - Singapore 1.498
CN - Cina 1.477
VN - Vietnam 1.450
IT - Italia 1.051
GB - Regno Unito 810
DE - Germania 534
HK - Hong Kong 353
SE - Svezia 317
IN - India 273
UA - Ucraina 245
FR - Francia 234
RU - Federazione Russa 204
BR - Brasile 196
NL - Olanda 141
BD - Bangladesh 140
IE - Irlanda 125
JP - Giappone 114
KR - Corea 112
CA - Canada 101
CI - Costa d'Avorio 98
JO - Giordania 96
FI - Finlandia 91
ZA - Sudafrica 87
BG - Bulgaria 58
TG - Togo 56
EE - Estonia 52
AR - Argentina 41
PH - Filippine 41
ID - Indonesia 40
ES - Italia 37
CH - Svizzera 36
PL - Polonia 35
SC - Seychelles 30
AT - Austria 29
IR - Iran 29
PK - Pakistan 26
TH - Thailandia 26
TR - Turchia 25
MX - Messico 24
IQ - Iraq 20
BE - Belgio 18
GR - Grecia 17
CZ - Repubblica Ceca 16
EC - Ecuador 14
MY - Malesia 14
CO - Colombia 12
EG - Egitto 12
HR - Croazia 12
SA - Arabia Saudita 11
TW - Taiwan 11
NG - Nigeria 10
AU - Australia 9
LB - Libano 8
LT - Lituania 8
CL - Cile 7
KZ - Kazakistan 7
PT - Portogallo 7
VE - Venezuela 7
HU - Ungheria 6
JM - Giamaica 6
GT - Guatemala 5
KE - Kenya 5
MD - Moldavia 5
PE - Perù 5
PS - Palestinian Territory 5
RO - Romania 5
CR - Costa Rica 4
DZ - Algeria 4
HN - Honduras 4
OM - Oman 4
PY - Paraguay 4
A2 - ???statistics.table.value.countryCode.A2??? 3
AE - Emirati Arabi Uniti 3
AL - Albania 3
BO - Bolivia 3
BY - Bielorussia 3
ET - Etiopia 3
NP - Nepal 3
NZ - Nuova Zelanda 3
PA - Panama 3
RS - Serbia 3
UZ - Uzbekistan 3
AO - Angola 2
BB - Barbados 2
GY - Guiana 2
KW - Kuwait 2
NO - Norvegia 2
TN - Tunisia 2
UY - Uruguay 2
AM - Armenia 1
AZ - Azerbaigian 1
BA - Bosnia-Erzegovina 1
BS - Bahamas 1
CW - ???statistics.table.value.countryCode.CW??? 1
DO - Repubblica Dominicana 1
GH - Ghana 1
GI - Gibilterra 1
HT - Haiti 1
KG - Kirghizistan 1
Totale 17.549
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Città #
Singapore 1.003
Ashburn 696
Southend 694
Fairfield 547
Chandler 521
San Jose 444
Santa Clara 358
Bologna 351
Hong Kong 335
Woodbridge 313
Ho Chi Minh City 290
Houston 267
Hanoi 261
Hefei 259
Seattle 249
Wilmington 241
Dong Ket 239
Cambridge 207
Council Bluffs 193
Beijing 182
Princeton 172
Ann Arbor 158
Jacksonville 158
New York 148
Boardman 139
Dublin 124
Seoul 100
Abidjan 98
Amman 96
Tokyo 93
Los Angeles 92
Dallas 89
Lauterbourg 77
Nanjing 73
Westminster 73
Buffalo 72
Helsinki 69
Padova 64
Sofia 57
Lomé 56
Berlin 54
Munich 54
Milan 52
Bremen 47
San Diego 43
Da Nang 42
Jinan 41
Shenyang 39
Saint Petersburg 38
Redondo Beach 34
Haiphong 33
Redmond 32
Frankfurt am Main 31
Guangzhou 31
Bern 29
Jakarta 29
Tianjin 29
Mülheim 28
Toronto 28
Hebei 27
Bengaluru 26
Nanchang 25
São Paulo 24
Chicago 23
Shanghai 23
Warsaw 23
Orem 22
Changsha 20
Johannesburg 20
Nuremberg 20
Rimini 20
Phoenix 19
Des Moines 18
Montreal 18
Quận Bình Thạnh 18
Rome 18
The Dalles 18
Vienna 18
Boydton 17
Brussels 17
Jiaxing 17
Mahé 17
Zhengzhou 17
Sant Cugat del Vallès 16
Venezia 16
Brooklyn 15
Can Tho 15
London 15
Medford 15
Mexico City 15
Olalla 15
Redwood City 15
Verona 15
Atlanta 14
Augusta 14
Dearborn 14
Hải Dương 14
Kunming 14
Mountain View 14
Biên Hòa 13
Totale 11.106
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Nome #
1,4-dihydropyridine derivatives as calcium channel modulators: the role of 3-methoxy-flavone moiety 355
Discovery of novel benzofuran-based compounds with neuroprotective and immunomodulatory properties for Alzheimer's disease treatment 345
Chalcones induce apoptosis, autophagy and reduce spreading in osteosarcoma 3D models 313
Multitarget Strategy to Address Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and Computational Studies of Coumarin-Based Derivatives 299
Benzofuran-Based Hybrid Compounds for the Inhibition of Cholinesterase Activity, Abeta Amyloid Aggregation, and Abeta Neurotoxicity 286
Cholinesterase inhibitors: xanthostigmine derivatives blocking the acetylcholinesterase-induced beta-amyloid aggregation. 256
Progettazione e sintesi di derivati benzofuranici per la malattia di Alzheimer 243
Targeting neuronal calcium channels and GSK3β for Alzheimer's disease with naturally-inspired Diels-Alder adducts 233
Characterization and Heterologous Expression of the Oxalyl Coenzyme A Decarboxylase Gene from Bifidobacterium lactis 229
Design, synthesis and biological profile of new inhibitors of multidrug resistance associated proteins carrying a polycyclic scaffold 229
Identification of chalcone-based antileishmanial agents targeting trypanothione reductase 226
Balanced dual acting compounds targeting aromatase and estrogen receptor α as an emerging therapeutic opportunity to counteract estrogen responsive breast cancer 223
Analogues of the dual acetylcholinesterase inhibitor AP2238: synthesis and SAR 222
Versatility of the Curcumin Scaffold: Discovery of Potent and Balanced Dual BACE-1 and GSK-3β Inhibitors 222
Benzophenones as xanthone-open model CYP11B1 inhibitors potentially useful for promoting wound healing 221
Exploiting the chalcone scaffold to develop multifunctional agents for Alzheimer’s disease 220
Fatty Acid Amide Hydrolase (FAAH), Acetylcholinesterase (AChE), and Butyrylcholinesterase (BuChE): Networked Targets for the Development of Carbamates as Potential Anti-Alzheimer's Disease Agents 217
Natural-like Chalcones with Antitumor Activity on Human MG63 Osteosarcoma Cells 215
Identification of a new tamoxifen-xanthene hybrid as pro-apoptotic anticancer agent 210
Targeting the multifaceted neurotoxicity of Alzheimer's disease by tailored functionalisation of the curcumin scaffold 208
2-Arylbenzofuran-based molecules as multipotent Alzheimer's disease modifying agents 208
Extensive SAR and computational studies of 3-{4-[(benzylmethylamino)methyl]phenyl}-6,7-dimethoxy-2H-2-chromenone (AP2238) derivatives. 200
Interplay Between Endocannabinoid System and Neurodegeneration: Focus on Polypharmacology 199
Naturally inspired molecules as multifunctional agents for Alzheimer's disease treatment 199
Cardiovascular profile of xanthone-based 1,4 dihydropyridines bearing a lidoflazine pharmacophore fragment 194
Curcumin-1,2,3-triazole conjugation for targeting the cancer apoptosis machinery. 193
Novel Curcumin-Diethyl Fumarate Hybrid as a Dualistic GSK-3β Inhibitor/Nrf2 Inducer for the Treatment of Parkinson's Disease 192
CHOLINESTERASE INHIBITORS: SAR AND ENZYME INHIBITORY ACTIVITY OF 3-[omega-(BENZYLMETHYLAMINO)ALKOXY]XANTHEN-9-ONES 187
Enantioselective nonsteroidal aromatase inhibitors identified through a multidisciplinary medicinal chemistry approach 184
A Computational Assay of Estrogen Receptor α Antagonists Reveals the Key Common Structural Traits of Drugs Effectively Fighting Refractory Breast Cancers 183
Single-digit nanomolar inhibitors lock the aromatase active site via a dualsteric targeting strategy 181
Anthracene Based Compounds as New L-type Ca2+ Channel Blockers: Design, Synthesis, and Full Biological Profile 178
New Coumarin derivatives as cholinergic and cannabinoid system modulators 176
Emerging targets in neurodegeneration: new opportunities for Alzheimer's disease treatment? 175
Nonsteroidal Aromatase inhibitors: synthesis and evaluation of new flavone derivatives 174
Lead optimization providing a series of flavone derivatives as potent nonsteroidal inhibitors of the cytochrome P450 aromatase enzyme 174
Polycyclic maleimide-based derivatives as first dual modulators of neuronal calcium channels and GSK-3β for Alzheimer's disease treatment 174
Homopterocarpanes as bridged triarylethylene analogues: synthesis and antagonistic effects in human MCF-7 breast cancer cells 173
Derivati a struttura benzofenonica come inibitori dell'acetilcolinesterasi 172
Clobenpropit analogs as dual activity ligands for the histamine H3 and H4 receptors: synthesis, pharmacological evaluation, and cross-target QSAR studies. 171
Multifaceted activity of polyciclic MDR revertant agents in drug-resistant leukemic cells: Role of the spacer 170
Fluorinated benzophenone derivatives: balanced multipotent agents for Alzheimer's disease 169
Antitumor profile of new phenothiazine derivatives 168
Design, synthesis, and evaluation of benzophenone derivatives as novel acetylcholinesterase inhibitors 167
Targeting Alzheimer’s disease: Novel indanone hybrids bearing a pharmacophoric fragment of AP2238 166
Imidazolylmethylbenzophenones as highly potent aromatase inhibitors. 163
Reconsidering Aromatase for Breast Cancer Treatment: New Roles for an Old Target 163
PREPARATION AND STEREOCHEMICAL CHARACTERIZATION OF ENANTIOMERIC HOMOISOFLAVONES ACTIVE AS AROMATASE INHIBITORS 161
Naturally Inspired Coumarin Derivatives in Alzheimer’s Disease Drug Discovery: Latest Advances and Current Challenges 160
New derivatives of xanthenone-4-acetic acid: synthesis, pharmacological profile and effect on TNF-alpha and NO production by human immune cells 159
Switching from Aromatase Inhibitors to Dual Targeting Flavonoid-Based Compounds for Breast Cancer Treatment 157
Improved eradication efficacy of a combination of newly identified antimicrobial agents in C. albicans and S. aureus mixed-species biofilm 157
In vitro studies of flavon-8-acetic acid analogues 156
Studies on cytostatic and cytotoxic activity of new flavopiridol analogues 155
Hybrid drugs for Alzheimer's disease: new indanone derivatives bearing a pharmacophoric fragment of AP2238 155
Benzophenone derivatives as Inhibitors of Acetylcholinesterase 155
From AChE to BACE1 inhibitors: The role of the amine on the indanone scaffold 154
In vitro biological activity of new analogues of flavon-8-acetic acid 153
Flavonoid-inspired vascular disrupting agents: Exploring flavone-8-acetic acid and derivatives in the new century 153
Functionalization of the chalcone scaffold for the discovery of novel lead compounds targeting fungal infections 151
Polycyclic Maleimide-based Scaffold as New Privileged Structure for Navigating the Cannabinoid System Opportunities 149
Multi-target strategy to address Alzheimer’s disease: Design, synthesis and biological evaluation of new tacrine-based dimers 147
Targeting Orthosteric and Allosteric Pockets of Aromatase via Dual-Mode Novel Azole Inhibitors 147
Hitting drug-resistant malaria infection with triazole-linked flavonoid–chloroquine hybrid compounds 146
Design, Synthesis, and Biological and Crystallographic Evaluation of Novel Inhibitors ofPlasmodium falciparumEnoyl-ACP-reductase (PfFabI) 146
New potent P-glycoprotein inhibitors carrying a polycyclic scaffold 145
Novel Aldosterone Synthase Inhibitors with Extended Carbocyclic Skeleton by a Combined Ligand-Based and Structure-Based Drug Design Approach 144
Targeting the Bacterial Membrane with a New Polycyclic Privileged Structure: A Powerful Tool To Face Staphylococcus aureus Infections 143
Exploiting acylaminopyrazole scaffold for polypharmacology approach in Alzheimer's disease 140
Design of Multifunctional Compounds for Cardiovascular Disease: From Natural Scaffolds to “Classical” Multitarget Approach 140
New potent inhibitors of cytochrome P450 aromatase 138
Targeting Alzheimer’s disease neurotoxicity by functionalization of the chalcone scaffold 136
Novel highly potent and selective nonsteroidal aromatase inhibitors: synthesis, biological evaluation and structure-activity relationships investigation 134
The ability of coumarin-, flavanon- and flavonol-analogues of flavone acetic acid to stimulate human monocytes. 133
Chalcone-based carbamates for Alzheimer's disease treatment 131
Extended Antimicrobial Profile of Chromone–Butenafine Hybrids 130
Imidazolylmethylxanthones as potent inhibitors of cytochrome P450 aromatase 130
Multidrug resistance reverting activity and antitumor profile of new phenothiazine derivatives 128
The first dual ChE/FAAH inhibitors: new perspectives for Alzheimer's disease? 128
Coumarin derivatives as potential antitumor agents: Growth inhibition, apoptosis induction and multidrug resistance reverting activity 128
Hybrid-Based Multi-Target Ligands for the Treatment of Alzheimer's Disease 127
Nonsteroidal aromatase inhibitors for the treatment of breast cancer: an update. 126
Tackling Alzheimer's Disease with Existing Drugs:A Promising Strategy for Bypassing Obstacles 125
Mono- or di-fluorinated analogues of Flavone-8-acetic acid: synthesis and in vitro biological activity 124
null 123
Modulation of Cytochromes P450 with Xanthone-Based Molecules: From Aromatase to Aldosterone Synthase and Steroid 11β-Hydroxylase Inhibition 121
Immune-modulating and anti-vascular activities of two xanthenone acetic acid analogues: a comparative study to DMXAA. 119
null 118
From nonsteroidal aromatase inhibitors to multifunctional drug candidates: classic and innovative strategies for the treatment of breast cancer. 116
Chromone-based small molecules for multistep shutdown of arachidonate pathway: Simultaneous inhibition of COX-2, 15-LOX and mPGES-1 enzymes 114
Small-molecule inhibitors/modulators of amyloid-β peptide aggregation and toxicity for the treatment of Alzheimer's disease: a patent review (2010 – 2012) 113
null 105
Recent progress on curcumin-based therapeutics: a patent review (2012-2016). Part II: curcumin derivatives in cancer and neurodegeneration 95
Recent progress on curcumin-based therapeutics: a patent review (2012-2016). Part I: Curcumin 94
SAR of 9-amino-1,2,3-4-tetrahydroacridine-based acetylcholinesterase inhibitors: Synthesis, enzyme inhibitory activity, QSAR, and structure-based CoMFA of tacrine analogues 91
null 82
3-(4-{[benzyl(methyl)amino]methyl}-phenyl)-6,7-dimethoxy-2H-2-chromenone (AP2238) inhibits both acetylcholinesterase and acetylcholinesterase-induced β-amyloid aggregation: A dual function lead for Alzheimer's disease therapy 79
null 79
Cardiovascular hybrid drugs: New benzazepinone derivatives as bradycardic agents endowed with selective β1-Non-competitive antagonism 76
Drifting of heme-coordinating group in imidazolylmethylxanthones leading to improved selective inhibition of CYP11B1 76
Totale 16.717
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Categoria #
all - tutte 50.220
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 50.220
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20221.468 0 39 108 86 134 82 48 159 90 125 303 294
2022/20232.157 197 247 92 262 168 169 53 129 448 59 156 177
2023/2024663 34 78 33 86 48 191 40 32 14 34 34 39
2024/20252.446 83 341 263 133 500 122 199 68 55 172 148 362
2025/20266.161 542 548 577 445 635 291 551 254 1.129 493 411 285
2026/2027370 226 144 0 0 0 0 0 0 0 0 0 0
Totale 17.930