CRIS Current Research Information System

GOBBI, SILVIA
 Distribuzione geografica
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Continente #
NA - Nord America 6.250
AS - Asia 5.617
EU - Europa 3.940
AF - Africa 306
SA - Sud America 273
OC - Oceania 12
Continente sconosciuto - Info sul continente non disponibili 4
Totale 16.402
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Nazione #
US - Stati Uniti d'America 6.147
SG - Singapore 1.481
CN - Cina 1.464
VN - Vietnam 1.432
IT - Italia 901
GB - Regno Unito 806
DE - Germania 534
HK - Hong Kong 337
SE - Svezia 317
IN - India 263
UA - Ucraina 245
FR - Francia 232
RU - Federazione Russa 204
BR - Brasile 182
NL - Olanda 139
IE - Irlanda 125
JP - Giappone 114
KR - Corea 112
CI - Costa d'Avorio 98
JO - Giordania 96
FI - Finlandia 91
ZA - Sudafrica 87
CA - Canada 68
BG - Bulgaria 58
TG - Togo 56
EE - Estonia 52
PH - Filippine 41
ID - Indonesia 40
AR - Argentina 39
BD - Bangladesh 36
CH - Svizzera 36
PL - Polonia 35
ES - Italia 34
AT - Austria 29
IR - Iran 29
SC - Seychelles 28
PK - Pakistan 25
TH - Thailandia 25
TR - Turchia 25
IQ - Iraq 20
MX - Messico 20
BE - Belgio 17
CZ - Repubblica Ceca 16
GR - Grecia 16
EC - Ecuador 14
MY - Malesia 14
HR - Croazia 11
SA - Arabia Saudita 11
CO - Colombia 10
NG - Nigeria 10
TW - Taiwan 10
AU - Australia 9
EG - Egitto 8
LB - Libano 8
LT - Lituania 8
CL - Cile 7
KZ - Kazakistan 7
VE - Venezuela 7
HU - Ungheria 6
PT - Portogallo 6
KE - Kenya 5
PS - Palestinian Territory 5
DZ - Algeria 4
GT - Guatemala 4
MD - Moldavia 4
OM - Oman 4
PE - Perù 4
PY - Paraguay 4
RO - Romania 4
A2 - ???statistics.table.value.countryCode.A2??? 3
AE - Emirati Arabi Uniti 3
AL - Albania 3
BO - Bolivia 3
BY - Bielorussia 3
ET - Etiopia 3
HN - Honduras 3
NP - Nepal 3
NZ - Nuova Zelanda 3
PA - Panama 3
RS - Serbia 3
UZ - Uzbekistan 3
AO - Angola 2
KW - Kuwait 2
NO - Norvegia 2
TN - Tunisia 2
UY - Uruguay 2
AM - Armenia 1
AZ - Azerbaigian 1
BA - Bosnia-Erzegovina 1
BB - Barbados 1
CR - Costa Rica 1
CW - ???statistics.table.value.countryCode.CW??? 1
DO - Repubblica Dominicana 1
GH - Ghana 1
GI - Gibilterra 1
GY - Guiana 1
JM - Giamaica 1
KG - Kirghizistan 1
KH - Cambogia 1
LA - Repubblica Popolare Democratica del Laos 1
Totale 16.396
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Città #
Singapore 988
Southend 694
Ashburn 639
Fairfield 547
Chandler 521
Santa Clara 336
Bologna 327
Hong Kong 324
Woodbridge 313
San Jose 305
Ho Chi Minh City 282
Houston 262
Hefei 259
Hanoi 255
Seattle 249
Wilmington 241
Dong Ket 239
Cambridge 207
Beijing 175
Princeton 172
Ann Arbor 158
Jacksonville 158
Boardman 126
Dublin 124
New York 110
Seoul 100
Abidjan 98
Amman 96
Tokyo 93
Council Bluffs 90
Dallas 78
Los Angeles 78
Lauterbourg 77
Nanjing 73
Westminster 73
Helsinki 69
Padova 64
Buffalo 57
Sofia 57
Lomé 56
Berlin 54
Munich 54
Bremen 47
Da Nang 42
Milan 42
San Diego 42
Jinan 41
Shenyang 39
Saint Petersburg 38
Redondo Beach 34
Haiphong 33
Redmond 32
Frankfurt am Main 31
Guangzhou 31
Bern 29
Jakarta 29
Tianjin 29
Mülheim 28
Hebei 27
Bengaluru 25
Nanchang 25
Shanghai 23
Warsaw 23
Orem 22
Changsha 20
Johannesburg 20
Nuremberg 20
São Paulo 19
Des Moines 18
Quận Bình Thạnh 18
Vienna 18
Brussels 17
Jiaxing 17
Mahé 17
Montreal 17
Zhengzhou 17
Phoenix 16
Sant Cugat del Vallès 16
Toronto 16
Venezia 16
Can Tho 15
Chicago 15
London 15
Medford 15
Olalla 15
Redwood City 15
Boydton 14
Dearborn 14
Hải Dương 14
Kunming 14
Mountain View 14
Atlanta 13
Biên Hòa 13
Brooklyn 13
Falkenstein 13
Verona 13
Amsterdam 12
Bangkok 12
Hangzhou 12
Turku 12
Totale 10.545
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Nome #
1,4-dihydropyridine derivatives as calcium channel modulators: the role of 3-methoxy-flavone moiety 348
Discovery of novel benzofuran-based compounds with neuroprotective and immunomodulatory properties for Alzheimer's disease treatment 325
Multitarget Strategy to Address Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and Computational Studies of Coumarin-Based Derivatives 287
Benzofuran-Based Hybrid Compounds for the Inhibition of Cholinesterase Activity, Abeta Amyloid Aggregation, and Abeta Neurotoxicity 281
Cholinesterase inhibitors: xanthostigmine derivatives blocking the acetylcholinesterase-induced beta-amyloid aggregation. 250
Progettazione e sintesi di derivati benzofuranici per la malattia di Alzheimer 236
Chalcones induce apoptosis, autophagy and reduce spreading in osteosarcoma 3D models 229
Characterization and Heterologous Expression of the Oxalyl Coenzyme A Decarboxylase Gene from Bifidobacterium lactis 225
Design, synthesis and biological profile of new inhibitors of multidrug resistance associated proteins carrying a polycyclic scaffold 218
Analogues of the dual acetylcholinesterase inhibitor AP2238: synthesis and SAR 216
Benzophenones as xanthone-open model CYP11B1 inhibitors potentially useful for promoting wound healing 215
Targeting neuronal calcium channels and GSK3β for Alzheimer's disease with naturally-inspired Diels-Alder adducts 214
Versatility of the Curcumin Scaffold: Discovery of Potent and Balanced Dual BACE-1 and GSK-3β Inhibitors 214
Identification of chalcone-based antileishmanial agents targeting trypanothione reductase 210
Fatty Acid Amide Hydrolase (FAAH), Acetylcholinesterase (AChE), and Butyrylcholinesterase (BuChE): Networked Targets for the Development of Carbamates as Potential Anti-Alzheimer's Disease Agents 210
Exploiting the chalcone scaffold to develop multifunctional agents for Alzheimer’s disease 209
2-Arylbenzofuran-based molecules as multipotent Alzheimer's disease modifying agents 206
Identification of a new tamoxifen-xanthene hybrid as pro-apoptotic anticancer agent 203
Targeting the multifaceted neurotoxicity of Alzheimer's disease by tailored functionalisation of the curcumin scaffold 200
Balanced dual acting compounds targeting aromatase and estrogen receptor α as an emerging therapeutic opportunity to counteract estrogen responsive breast cancer 199
Extensive SAR and computational studies of 3-{4-[(benzylmethylamino)methyl]phenyl}-6,7-dimethoxy-2H-2-chromenone (AP2238) derivatives. 197
Naturally inspired molecules as multifunctional agents for Alzheimer's disease treatment 195
Natural-like Chalcones with Antitumor Activity on Human MG63 Osteosarcoma Cells 194
Cardiovascular profile of xanthone-based 1,4 dihydropyridines bearing a lidoflazine pharmacophore fragment 192
Interplay Between Endocannabinoid System and Neurodegeneration: Focus on Polypharmacology 189
Curcumin-1,2,3-triazole conjugation for targeting the cancer apoptosis machinery. 189
CHOLINESTERASE INHIBITORS: SAR AND ENZYME INHIBITORY ACTIVITY OF 3-[omega-(BENZYLMETHYLAMINO)ALKOXY]XANTHEN-9-ONES 186
Novel Curcumin-Diethyl Fumarate Hybrid as a Dualistic GSK-3β Inhibitor/Nrf2 Inducer for the Treatment of Parkinson's Disease 186
Enantioselective nonsteroidal aromatase inhibitors identified through a multidisciplinary medicinal chemistry approach 179
Polycyclic maleimide-based derivatives as first dual modulators of neuronal calcium channels and GSK-3β for Alzheimer's disease treatment 173
A Computational Assay of Estrogen Receptor α Antagonists Reveals the Key Common Structural Traits of Drugs Effectively Fighting Refractory Breast Cancers 171
Anthracene Based Compounds as New L-type Ca2+ Channel Blockers: Design, Synthesis, and Full Biological Profile 170
New Coumarin derivatives as cholinergic and cannabinoid system modulators 170
Lead optimization providing a series of flavone derivatives as potent nonsteroidal inhibitors of the cytochrome P450 aromatase enzyme 168
Clobenpropit analogs as dual activity ligands for the histamine H3 and H4 receptors: synthesis, pharmacological evaluation, and cross-target QSAR studies. 168
Multifaceted activity of polyciclic MDR revertant agents in drug-resistant leukemic cells: Role of the spacer 168
Emerging targets in neurodegeneration: new opportunities for Alzheimer's disease treatment? 167
Single-digit nanomolar inhibitors lock the aromatase active site via a dualsteric targeting strategy 166
Nonsteroidal Aromatase inhibitors: synthesis and evaluation of new flavone derivatives 166
Derivati a struttura benzofenonica come inibitori dell'acetilcolinesterasi 164
Homopterocarpanes as bridged triarylethylene analogues: synthesis and antagonistic effects in human MCF-7 breast cancer cells 163
Fluorinated benzophenone derivatives: balanced multipotent agents for Alzheimer's disease 162
Design, synthesis, and evaluation of benzophenone derivatives as novel acetylcholinesterase inhibitors 161
Targeting Alzheimer’s disease: Novel indanone hybrids bearing a pharmacophoric fragment of AP2238 161
Reconsidering Aromatase for Breast Cancer Treatment: New Roles for an Old Target 160
Antitumor profile of new phenothiazine derivatives 158
Imidazolylmethylbenzophenones as highly potent aromatase inhibitors. 158
PREPARATION AND STEREOCHEMICAL CHARACTERIZATION OF ENANTIOMERIC HOMOISOFLAVONES ACTIVE AS AROMATASE INHIBITORS 156
New derivatives of xanthenone-4-acetic acid: synthesis, pharmacological profile and effect on TNF-alpha and NO production by human immune cells 151
Improved eradication efficacy of a combination of newly identified antimicrobial agents in C. albicans and S. aureus mixed-species biofilm 151
Naturally Inspired Coumarin Derivatives in Alzheimer’s Disease Drug Discovery: Latest Advances and Current Challenges 150
In vitro studies of flavon-8-acetic acid analogues 150
Studies on cytostatic and cytotoxic activity of new flavopiridol analogues 150
Functionalization of the chalcone scaffold for the discovery of novel lead compounds targeting fungal infections 149
In vitro biological activity of new analogues of flavon-8-acetic acid 148
Benzophenone derivatives as Inhibitors of Acetylcholinesterase 148
Switching from Aromatase Inhibitors to Dual Targeting Flavonoid-Based Compounds for Breast Cancer Treatment 147
Hybrid drugs for Alzheimer's disease: new indanone derivatives bearing a pharmacophoric fragment of AP2238 147
From AChE to BACE1 inhibitors: The role of the amine on the indanone scaffold 145
Multi-target strategy to address Alzheimer’s disease: Design, synthesis and biological evaluation of new tacrine-based dimers 145
Design, Synthesis, and Biological and Crystallographic Evaluation of Novel Inhibitors ofPlasmodium falciparumEnoyl-ACP-reductase (PfFabI) 144
Flavonoid-inspired vascular disrupting agents: Exploring flavone-8-acetic acid and derivatives in the new century 144
New potent P-glycoprotein inhibitors carrying a polycyclic scaffold 143
Targeting Orthosteric and Allosteric Pockets of Aromatase via Dual-Mode Novel Azole Inhibitors 143
Polycyclic Maleimide-based Scaffold as New Privileged Structure for Navigating the Cannabinoid System Opportunities 142
Targeting the Bacterial Membrane with a New Polycyclic Privileged Structure: A Powerful Tool To Face Staphylococcus aureus Infections 137
Design of Multifunctional Compounds for Cardiovascular Disease: From Natural Scaffolds to “Classical” Multitarget Approach 135
Novel Aldosterone Synthase Inhibitors with Extended Carbocyclic Skeleton by a Combined Ligand-Based and Structure-Based Drug Design Approach 134
Novel highly potent and selective nonsteroidal aromatase inhibitors: synthesis, biological evaluation and structure-activity relationships investigation 133
New potent inhibitors of cytochrome P450 aromatase 131
Imidazolylmethylxanthones as potent inhibitors of cytochrome P450 aromatase 127
The ability of coumarin-, flavanon- and flavonol-analogues of flavone acetic acid to stimulate human monocytes. 126
Hybrid-Based Multi-Target Ligands for the Treatment of Alzheimer's Disease 125
Multidrug resistance reverting activity and antitumor profile of new phenothiazine derivatives 125
Chalcone-based carbamates for Alzheimer's disease treatment 125
null 123
The first dual ChE/FAAH inhibitors: new perspectives for Alzheimer's disease? 122
Nonsteroidal aromatase inhibitors for the treatment of breast cancer: an update. 121
Mono- or di-fluorinated analogues of Flavone-8-acetic acid: synthesis and in vitro biological activity 121
Modulation of Cytochromes P450 with Xanthone-Based Molecules: From Aromatase to Aldosterone Synthase and Steroid 11β-Hydroxylase Inhibition 119
Coumarin derivatives as potential antitumor agents: Growth inhibition, apoptosis induction and multidrug resistance reverting activity 118
null 118
Tackling Alzheimer's Disease with Existing Drugs:A Promising Strategy for Bypassing Obstacles 116
Immune-modulating and anti-vascular activities of two xanthenone acetic acid analogues: a comparative study to DMXAA. 115
From nonsteroidal aromatase inhibitors to multifunctional drug candidates: classic and innovative strategies for the treatment of breast cancer. 112
Hitting drug-resistant malaria infection with triazole-linked flavonoid–chloroquine hybrid compounds 111
Small-molecule inhibitors/modulators of amyloid-β peptide aggregation and toxicity for the treatment of Alzheimer's disease: a patent review (2010 – 2012) 110
null 105
Chromone-based small molecules for multistep shutdown of arachidonate pathway: Simultaneous inhibition of COX-2, 15-LOX and mPGES-1 enzymes 101
Extended Antimicrobial Profile of Chromone–Butenafine Hybrids 96
Recent progress on curcumin-based therapeutics: a patent review (2012-2016). Part I: Curcumin 88
Recent progress on curcumin-based therapeutics: a patent review (2012-2016). Part II: curcumin derivatives in cancer and neurodegeneration 86
null 82
Exploiting acylaminopyrazole scaffold for polypharmacology approach in Alzheimer's disease 81
null 79
3-(4-{[benzyl(methyl)amino]methyl}-phenyl)-6,7-dimethoxy-2H-2-chromenone (AP2238) inhibits both acetylcholinesterase and acetylcholinesterase-induced β-amyloid aggregation: A dual function lead for Alzheimer's disease therapy 76
null 76
Cardiovascular hybrid drugs: New benzazepinone derivatives as bradycardic agents endowed with selective β1-Non-competitive antagonism 72
null 70
null 67
Totale 15.812
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Categoria #
all - tutte 45.005
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 45.005
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021601 0 0 0 0 0 0 0 0 0 76 94 431
2021/20221.612 144 39 108 86 134 82 48 159 90 125 303 294
2022/20232.157 197 247 92 262 168 169 53 129 448 59 156 177
2023/2024663 34 78 33 86 48 191 40 32 14 34 34 39
2024/20252.446 83 341 263 133 500 122 199 68 55 172 148 362
2025/20265.369 542 548 577 445 635 291 551 254 1.129 397 0 0
Totale 16.768