CRIS Current Research Information System

SPINELLI, DOMENICO
 Distribuzione geografica
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Continente #
NA - Nord America 3.694
EU - Europa 3.542
AS - Asia 1.026
AF - Africa 188
SA - Sud America 10
OC - Oceania 5
Continente sconosciuto - Info sul continente non disponibili 2
Totale 8.467
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Nazione #
US - Stati Uniti d'America 3.690
GB - Regno Unito 1.053
IT - Italia 575
DE - Germania 435
SE - Svezia 435
CN - Cina 422
UA - Ucraina 381
VN - Vietnam 320
IN - India 166
IE - Irlanda 153
FR - Francia 149
RU - Federazione Russa 127
ZA - Sudafrica 76
BE - Belgio 69
EE - Estonia 67
JO - Giordania 64
TG - Togo 50
SC - Seychelles 35
CH - Svizzera 28
JP - Giappone 22
GR - Grecia 16
HR - Croazia 16
CI - Costa d'Avorio 13
FI - Finlandia 12
NG - Nigeria 12
NL - Olanda 9
LB - Libano 7
TR - Turchia 6
AU - Australia 4
BR - Brasile 4
CL - Cile 4
IR - Iran 4
SG - Singapore 4
CA - Canada 3
CZ - Repubblica Ceca 3
ES - Italia 3
KR - Corea 3
RO - Romania 3
A2 - ???statistics.table.value.countryCode.A2??? 2
AR - Argentina 2
PL - Polonia 2
UZ - Uzbekistan 2
AE - Emirati Arabi Uniti 1
AM - Armenia 1
AT - Austria 1
BG - Bulgaria 1
DK - Danimarca 1
EG - Egitto 1
LK - Sri Lanka 1
MA - Marocco 1
MD - Moldavia 1
MX - Messico 1
MY - Malesia 1
NO - Norvegia 1
NZ - Nuova Zelanda 1
PH - Filippine 1
PT - Portogallo 1
SA - Arabia Saudita 1
Totale 8.467
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Città #
Southend 919
Fairfield 468
Chandler 463
Jacksonville 278
Wilmington 239
Woodbridge 233
Ashburn 224
Ann Arbor 221
Seattle 201
Princeton 194
Houston 186
Dong Ket 183
Cambridge 157
Dublin 153
Nanjing 95
Westminster 92
Padova 89
Turin 87
Berlin 72
Bologna 69
Brussels 69
Amman 64
Jinan 50
Lomé 50
Beijing 43
Milan 43
Saint Petersburg 43
Medford 42
Shenyang 40
San Diego 37
Mülheim 34
Mahé 33
Changsha 29
Boardman 25
Nanchang 24
Redmond 22
Tianjin 22
Tokyo 22
Bern 21
Bremen 21
Hebei 21
Dearborn 18
Verona 18
Redwood City 17
Olalla 16
Abidjan 13
Jiaxing 13
Norwalk 13
Abeokuta 12
Helsinki 12
London 12
Haikou 11
Des Moines 10
Lanzhou 10
Zhengzhou 9
Los Angeles 8
Ningbo 8
Rome 8
Hangzhou 7
Kunming 7
Buffalo 6
Frankfurt Am Main 6
New York 6
Fremont 5
Fuzhou 5
Istanbul 5
Naples 5
Taizhou 5
Chicago 4
Falls Church 4
Guangzhou 4
Meppel 4
Palermo 4
Paris 4
Singapore 4
São Paulo 4
Adria 3
Chioggia 3
Costa Mesa 3
Florence 3
Forlì 3
Minturno 3
Moscow 3
Torino 3
Bitritto 2
Canberra 2
Clearwater 2
Dairago 2
Genova 2
Genzano Di Roma 2
Hanoi 2
Islington 2
Lausanne 2
Mountain View 2
Perugia 2
Pianoro 2
Reggio Emilia 2
San Jose 2
San Venanzo 2
Sant'Elia Fiumerapido 2
Totale 5.731
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Nome #
A new class of selective myocardial calcium channel modulators 2. Role of the acetal chain in oxadiazol-3-one derivatives 182
null 173
Sintesi di tioeteri, solfossidi, solfoni e tioesteri dei 3-aroil-4(Z)-[1-metil-2-sulfanil-vinil]-4H-[1,2,4]ossadiazol-5-oni e loro attività come calcio antagonisti 144
C-C coupling between trinitrothiophenes and triaminobenzenes: Zwitterionic intermediates and new all-conjugated structures 140
Absolute configuration and biological profile of two thiazinooxadiazol-3-ones with L-type calcium channel activity: a study of the structural effects 136
New Model for a Theoretical Density Functional Theory Investigation of the Mechanism of the Carbonic Anhydrase: How Does the Internal Bicarbonate Rearrangement Occur? 135
On the reactivity of some 2-methyleneindolines with b-nitroenamines, a-nitroalkenes, and 1,2-diaza-1,3-butadienes 135
Analysis of the recent antipsychotic aripiprazole in human plasma by capillary electrophoresis and high performance liquid chromatography with diode array detection 132
Can the absence of solvation of neutral reagents by ionic liquids be responsible for the high reactivity in base-assisted intramolecular nucleophilic substitutions in these solvents? 124
Catalytic Mechanism of Diaminopimelate Epimerase: A QM/MM Investigation 120
Convergent results from experimental and theoretical DFT studies of the intramolecular rearrangement of Z-hydrazones of 3-acetyl-1,2,4-oxadiazoles 118
Calcium Antagonists Discovered by a Multidisciplinary Approach. 116
Substituent effect on the electrochemical behaviour of some ortho-substituted (aryl)(2-nitrobenzo[b]thiophen-3-yl)amines. A combined experimental and computational study 115
3-Aryl-4-nitrobenzothiochromans S,S-dioxide: From Calcium-Channel Modulators Properties to Multidrug-Resistance Reverting Activity 113
On the Dichotomic Behavior of the Z-2,4-Dinitrophenylhydrazone of 5-Amino-3-benzoyl-1,2,4-oxadiazole with Acids in Toluene and in Dioxane/Water: Rearrangement versus Hydrolisis 112
L-Type Calcium Channel Blockers: From Diltiazem to 1,2,4-Oxadiazol-5-ones via Thiazinooxadiazol-3-one Derivatives 112
Stereoselective Behavior of the Functional Diltiazem Analogue 1-[(4-Chlorophenyl)sulfonyl]-2-(2-thienyl)pyrrolidine, a New L-Type Calcium Channel Blocker 109
The Catalytic Activity of Diaminopimelate Epimerase: a QM/MM Study 107
Computational QM/MM Study of the Reaction Mechanism of Human Glutathione S-Transferase A3-3 103
Modellistica molecolare applicata a modulatori dei canali del calcio 101
null 100
Bis (2,2,2-trifluoroethyl) Chlorophosphate 100
null 100
Un approccio multidisciplinare per lo studio di modulatori di canali del Ca2+ di tipo-L 100
Discovery of novel and cardioselective diltiazem-like calcium channel blockers via virtual screening. 99
The Catalytic Activity of Proline Racemase: a QM/MM Study 99
NMR study of the (Z)-phenylhydrazones of 5-alkyl- and 5-aryl-3-benzoyl-1,2,4-oxadiazoles: Support for the interpretation of kinetic results on the rearrangement of 1,2,4-oxadiazoles to 1,2,3-triazoles. 98
STEREOSELETTIVITÀ DI UNA BENZENSOLFONAMMIDE (M8), COME MODULATORE DEI CANALI DEL CALCIO DI TIPO-L 98
null 98
SINTESI DI COMPOSTI ETEROCICLICI MEDIANTE ESPANSIONE D’ANELLO DI NITROTIOFENI: 3-ARIL-2-FENIL-4-NITROTIOCROMANI S,S-DIOSSIDI DAL 3-NITROBENZO[b]TIOFENE 96
The Catalytic Activity of Proline Racemase: a QM/MM Study 96
The First Example of an Irreversible Ring-Degenerate Rearrangement on Five-Membered Heterocycles by Attack of an External Bidentate Nucleophile 95
An Unexpected Pathway to Enantiomerization of Hemithioketals in Toluene Involving a Dimeric Transition State: A Combined Experimental and Computational Study 95
Inhibition of cell proliferation, cytotoxicity and induction of apoptosis of 1,4-bis(1-naphthyl)-2,3-dinitro-1,3-butadiene in gastrointestinal tumour cell lines and preliminary evaluation of its toxicity in vivo. 94
New calcium channel modilators discovered by virtual screening 93
Nitroalkylation and nitroalkenylation reactions of g-lactone enolates. A facile ring switch from polysubstituted g-lactones to polysubstituted g-lactams 93
Fluorinated heterocyclic compounds. An effective strategy for the synthesis of fluorinated Z-oximes of 3-perfluoroalkyl-6-phenyl-2H-1,2,4-triazin- 5-ones via a ring-enlargement reaction of 3-benzoyl-5-perfluoroalkyl-1,2,4-oxadiazoles and hydrazine. 92
Five-to-Six Membered Ring-rearrangements in the Reaction of 5-Perfluoroalkyl-1,2,4-oxadiazoles with Hydrazine and Methylhydrazine 92
A New Class of Selective Myocardial Calcium Channel Modulators: Oxadiazol-1-one Derivatives 92
Mononuclear Rearrangement of the Z-Phenylhydrazones of Some 3-Acyl-1,2,4-oxadiazoles: Effect of Substituents on the Nucleophilic Character of the >c=N-NH-C 6 H 5 Chain and on the Charge Density of N-2 of the 1,2,4-Oxadiazole Ring (Electrophilic Counterpart) 91
Spectroscopic and electrochemical properties of 1- or 2-alkyl substituted 5- and 6-nitroindazoles 90
Interazioni e prodotti nelle reazioni fra elettrofili tiofenici e supernucleofili 90
Reactivity in 7-benzyl-2,7-naphthyridine derivatives: Nucleophilic substitutions, rearrangements, heterocyclizations and related reactions 88
Electron Ionization Induced Fragmentation of some 3-Aroylamino-5-Methyl-1,2,4- Oxadiazoles and 3-Acetylamino-5-Aryl-1,2,4-Oxadiazoles 88
Easy access to 4-nitrothiochroman S.S-dioxides via ring-enlargement from 3-nitrobenzo[b]thiophene 86
Inhibition of MDR1 activity and induction of apoptosis by analogues of nifedipine and diltiazem: an in vitro analysis 85
On the Rearrangement in Dioxane/Water of (Z)-Arylhydrazones of 5-Amino-3-benzoyl-1,2,4-oxadiazole into (2-Aryl-5-phenyl-2H-1,2,3-triazol-4-yl)ureas: Substituent Effects on the Different Reaction Pathways 85
A multidisciplinary study of chemico-physical properties of different classes of 2-aryl-5(or 6)-nitrobenzimidazoles: NMR, electrochemical behavior, ESR, and DFT calculations 85
On the reactivity of nitrosoimidazoles with acids (the Cusmano–Ruccia reaction): a continuous source of new ring-into-ring interconversion 84
TRASPOSIZIONI ETEROCICLICHE MONONUCLEARI. APPLICAZIONE DELL’EQUAZIONE DI FUJITA-NISHIOKA ALLA REATTIVITA’ DI Z FENILIDRAZONI DI- E POLI-SOSTITUITI DEL 3-BENZOIL-5-FENIL-1,2,4-OSSADIAZOLO 82
ANTICANCER ACTIVITY OF 1,4-BIS(1-NAPHTHYL)-2,3-DINITRO-1,3-BUTADIENE:CURRENT STATE OF THE RESEARCH 82
null 82
Trinitrothiophenes/Tris(alkylamino)benzenes reactions: new insights on nucleophilic/electrophilic interaction 82
EFFETTI DELLA LUNGHEZZA DELLA CATENA ALCHILICA SULLA VELOCITA’ DI TRASPOSIZIONE DI ALCUNI Z-FENILIDRAZONI DI 5-ALCHILI-3-BENZOIL-1,2,4-OSSADIAZOLI 81
New classes of calcium channel modulators: thiazinooxadiazol-3-one and oxadiazol-5-one derivatives 80
SINTESI DI COMPOSTI ETEROCICLICI MEDIANTE ESPANSIONE D’ANELLO DI NITROTIOFENI: 3-ARIL-4-NITROTIOCROMANI E 3-ARIL-4-TIOCROMANONI S,S-DIOSSIDI DAL 3-NITROBENZO[b]TIOFENE 80
STUDIO CINETICO DELLA TRASPOSIZIONE DI Z-FENILIDRAZONI POLISOSTITUITI DEL 3-BENZOIL-5-FENIL-1,2,4-OSSADIAZOLI NEI CORRISPONDENTI 2-ARIL-5-FENIL-1,2,3-TRIAZOLI IN H2O/DIOSSANO 80
REATTIVITA’ DEGLI Z-IDRAZONI, -SEMICARBAZONI E -FENILSEMICARBAZONI DEL 3 BENZOIL-5-FENIL-1,2,4-OSSADIAZOLO: EFFETTO DELLA STRUTTURA DELLA CATENA LATERALE 79
null 79
Study of Aromatic Nucleophilic Substitution with Amines on Nitrothiophenes in Room-Temperature Ionic Liquids: Are the Diffrent Effects on the Behavior of para-Like and ortho-Like Isomers on Going from Conventional Solvents to Room-Temperature Ionic Liquids Related to Solvatation Effects? 79
null 79
TRASPOSIZIONI MONONUCLEARI DI ETEROCICLI. REATTIVITA’ DI Z-ARILIDRAZONI DEL 5-AMMINO-3-BENZOIL-1,2,4-OSSADIAZOLO IN D/W: EFFETTO DEI SOSTITUENTI 78
Condensed 2-pyrrolidinone-1,2-oxazines from lithium enolate of 1-benzyl-5-oxo-pyrrolinecarboxylic acid and b-aryl, b-nitroenamines 78
Preliminary Evaluation of Antitumor Activity of 1,4-bis(1-naphtyl)-2,3-dinitro-1,3-butadiene(naph-DNB) in Gastrointesinal Tumor Cell Lines 77
null 74
Understanding Oxadiazolothiazinone Biological Properties: Negative Inotropic Activity versus Cytochrome P450-Mediated Metabolism 74
L’ASSENZA DI SOLVATAZIONE PUÒ’ GIUSTIFICARE L’AUMENTO DELLA VELOCITA’ DEI PROCESSI DI INTERCONVERSIONE DI ANELLO IN LIQUIDI IONICI? 72
Il ruolo della catena acetalica in derivati dell’ossadiazol-3-one: una nuova classe di modulatori dei canali del calcio 72
NUOVE TRASFORMAZIONI DI BUILDING-BLOCKS DINITROBUTADIENICI DERIVANTI DALL’APERTURA D’ANELLO DEL 3,4-DINITROTIOFENE 71
REATTIVITA’ DI Z-ARILIDRAZONI DEL 5-AMMINO-3-BENZOIL-1,2,4-OSSADIAZOLO IN PRESENZA DI ACIDO TRICLOROACETICO E DI PIPERIDINA IN TOLUENE: CONFRONTO CON I DATI IN DIOSSANO-ACQUA 71
SINTESI DI OMO- ED ETERO-CICLI MEDIANTE PROCESSI DI APERTURA / CHIUSURA D’ANELLO A PARTIRE DA NITROTIOFENI 71
null 70
Utilizzo dei Campi di Interazione Molecolare nella Ricerca di Molecole Biologicamente Attive 69
SEAr/SNAr Reactions between Trinitrothiophene Derivatives and Supernucleophiles at the Neutral Carbon Atom 69
Valutazione del contenuto di ammine adrenergiche nell’epicarpo di Citrus aurantium nelle varie fasi di maturazione 69
The Effect of Ionic Liquids on the Rate of an Intramolecular Nucleophilic Substitution:The Study of Monocyclic Rearrangement of Heterocycles 67
Reazione di 2-nitrotiofeni-4-sostituiti con ammine secondarie 67
On the Nucleophilic Reactivity of 4,6-Dichloro-5-nitrobenzofuroxan with Some Aliphatic and Aromatic Amines: Selective nucleophilic substitution 67
null 64
ELETTROCICLIZZAZIONE ED ADDIZIONE DI MICHAEL: DICOTOMIA DI COMPORTAMENTO NEL PROCESSO DI CHIUSURA D’ANELLO DI BUILDING-BLOCKS NITROBUTADIENICI 63
Pursuing the challenge to detect labile intermediates in the SEAr/SNAr reaction: first evidence of Wheland-Meisenheimer complexes in thiophenic series 63
null 63
OMO- ED ETERO-CICLI DA BUILDING-BLOCKS NITROVINILICI: NITROTIOCROMANI E TIOCROMANONI DAL 3-NITROBENZO[b]TIOFENE 62
Rischi e benefici degli integratori anti-obesità a base di arance amare: il ruolo dell'analisi chimico-tossicologica 61
Room Temperature Ionic Liquids Structure and its Effects on the Mononuclear Rearrangement of Heterocycles 59
Methyl bis(2,2,2-trifluoroethyl) bromophosphonoacetate 57
Sintesi e Reattività di 5-alchil-3-benzoil-1,2,4-ossadiazoli 57
4,6-dichloro-5-nitrobenzofuroxan: Different polymorphisms and dft investigation of its reactivity with nucleophiles 57
Nitrobutadienes from β-nitrothiophenes: Valuable building-blocks in the overall ring-opening / ring-closure protocol to homo- or hetero-cycles. 56
PURSUING THE CHALLENGE TO DETECT LABILE INTERMEDIATES IN THE SEAR/SNAR REACTION: FIRST EVIDENCE OF WHELAND-MEISENHEIMER INTERMEDIATES IN THIOPHENIC SERIES 54
null 50
Comparative spectroscopic and electrochemical study of N-1 or N-2-alkylated 4-nitro and 7-nitroindazoles 46
Il ruolo della catena acetalica in derivati dell'ossadiazol-3-one: una nuova classe di modulatori dei canali del calcio 45
null 45
null 39
Effect of Linear 5-alkyl Substituents on the Rearrangement Rate of the Z-Phenylhydrazone of Some 5-Alkyl-3-benzoil-1,2,4-oxadiazole 36
A Novel Approach to the Evaluation of the Importance of Steric and Electronic Effects in SNAr Reactions: A Computational, Thermodynamic and 1H and 13C NMR Study of "Meisenheimer-Type" Adducts in the Benzo[b]thiophene Series. 35
On the application of the extended Fujita-Nishioka equation to polysubstitued system. A kinetic study of the rearrangement of several poly-substitued Z-arylhydrazones of 3-benzoyl-5-phenyl-1,2,4-oxadiazole into 2-aryl-4-benzoylamino-5-phenyl-1,2,3-triazoles in dioxane/water 35
Substituent effects on the mechanism changeover in a multi-pathway reaction: a model for the behavior of biological system? 31
Mononuclear rearrangements of heterocycles in water/-CD: information on the real site of reaction from structural modifications of substrates and from proton concentration dependence of the reactivity 29
Totale 8.517
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Categoria #
all - tutte 15.178
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 15.178
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/2019631 0 0 1 147 17 70 52 27 74 124 58 61
2019/20202.366 447 56 54 148 194 234 262 311 252 194 74 140
2020/20211.468 302 88 47 100 83 99 22 94 100 86 77 370
2021/20221.605 180 60 126 114 150 90 32 103 71 98 278 303
2022/20232.051 217 305 111 222 151 160 58 115 351 43 220 98
2023/2024169 41 92 36 0 0 0 0 0 0 0 0 0
Totale 8.677