CRIS Current Research Information System

CAVALLI, ANDREA
 Distribuzione geografica
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Continente #
AS - Asia 21.611
NA - Nord America 20.921
EU - Europa 14.362
SA - Sud America 4.046
AF - Africa 2.121
Continente sconosciuto - Info sul continente non disponibili 973
OC - Oceania 62
Totale 64.096
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Nazione #
US - Stati Uniti d'America 20.147
CN - Cina 5.284
SG - Singapore 4.924
VN - Vietnam 4.378
IT - Italia 3.647
GB - Regno Unito 3.048
BR - Brasile 2.730
DE - Germania 1.706
IN - India 1.315
HK - Hong Kong 1.185
FR - Francia 1.116
SE - Svezia 922
UA - Ucraina 816
RU - Federazione Russa 815
VE - Venezuela 606
IL - Israele 533
IQ - Iraq 519
KR - Corea 517
ZA - Sudafrica 514
SA - Arabia Saudita 507
IE - Irlanda 454
JP - Giappone 401
BD - Bangladesh 397
MA - Marocco 394
CI - Costa d'Avorio 347
KZ - Kazakistan 328
MX - Messico 318
AR - Argentina 292
NL - Olanda 287
CA - Canada 232
FI - Finlandia 230
TG - Togo 225
EE - Estonia 207
JO - Giordania 167
PK - Pakistan 158
PH - Filippine 151
ES - Italia 147
TN - Tunisia 147
AE - Emirati Arabi Uniti 136
AT - Austria 127
CH - Svizzera 125
HR - Croazia 111
SC - Seychelles 101
EG - Egitto 98
TR - Turchia 93
CO - Colombia 90
ID - Indonesia 89
CL - Cile 88
DZ - Algeria 86
EC - Ecuador 86
PL - Polonia 86
TW - Taiwan 86
BG - Bulgaria 85
TH - Thailandia 69
IR - Iran 59
GR - Grecia 58
BE - Belgio 57
AU - Australia 56
CZ - Repubblica Ceca 52
NG - Nigeria 51
OM - Oman 48
UZ - Uzbekistan 47
PY - Paraguay 46
DK - Danimarca 41
RO - Romania 41
UY - Uruguay 41
CR - Costa Rica 40
LB - Libano 37
NP - Nepal 37
PE - Perù 37
KE - Kenya 36
SN - Senegal 34
HN - Honduras 32
MY - Malesia 27
PA - Panama 27
GT - Guatemala 26
MD - Moldavia 26
DO - Repubblica Dominicana 25
AZ - Azerbaigian 24
BO - Bolivia 24
GA - Gabon 23
JM - Giamaica 21
LT - Lituania 21
PT - Portogallo 21
PS - Palestinian Territory 19
AO - Angola 18
ET - Etiopia 17
EU - Europa 17
BY - Bielorussia 16
HU - Ungheria 16
LV - Lettonia 16
NI - Nicaragua 15
SK - Slovacchia (Repubblica Slovacca) 13
SY - Repubblica araba siriana 12
CG - Congo 11
RS - Serbia 11
AM - Armenia 10
NO - Norvegia 10
SV - El Salvador 10
BZ - Belize 9
Totale 63.002
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Città #
Singapore 3.434
Southend 2.493
Fairfield 1.947
Ashburn 1.814
San Jose 1.137
Hong Kong 1.087
Chandler 983
Hefei 947
Woodbridge 946
Ho Chi Minh City 934
Bologna 919
Santa Clara 899
Seattle 882
Wilmington 873
Houston 838
Hanoi 829
Ann Arbor 745
Dong Ket 718
Cambridge 668
Princeton 630
Council Bluffs 571
Beijing 560
Jacksonville 503
Dublin 449
Boardman 431
Seoul 415
Lauterbourg 362
Abidjan 344
Tokyo 320
Los Angeles 310
Nanjing 282
Westminster 261
Milan 251
Padova 245
Lomé 225
New York 221
Tel Aviv 220
Berlin 211
São Paulo 209
Jeddah 190
Buffalo 186
Helsinki 181
Amman 164
Baghdad 163
Frankfurt am Main 162
Dallas 156
Riyadh 152
Jinan 140
Saint Petersburg 133
Bengaluru 130
Johannesburg 129
Caracas 125
Haiphong 125
Da Nang 124
San Diego 122
Shenyang 119
Casablanca 117
Redondo Beach 116
Maracaibo 114
Guangzhou 113
Redmond 111
Almaty 109
Shanghai 106
Erbil 105
Changsha 98
Rome 97
Tianjin 94
Mülheim 93
Nanchang 93
Hebei 92
Chicago 85
Medford 84
Cape Town 77
Florence 74
Munich 72
Falls Church 71
Rio de Janeiro 71
Sofia 71
Dammam 69
Genoa 69
Turin 69
Vienna 69
Phoenix 68
Des Moines 64
Toronto 64
Amsterdam 63
Tunis 63
Verona 63
Zhengzhou 61
Belo Horizonte 60
Montreal 60
Paris 59
Medina 56
Modena 56
Brasília 55
Biên Hòa 53
Dearborn 53
London 53
Orem 53
Barcelona 52
Totale 36.009
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Nome #
Watching the release of a photopharmacological drug from tubulin using time-resolved serial crystallography 8.422
A small molecule targeting the multifactorial nature of Alzheimer's disease 537
3,4-Dihydro-1,3,5-triazin-2(1H)-ones as the First Dual BACE-1/GSK-3β Fragment Hits against Alzheimer's Disease 442
A RAD51/BRCA2 small molecule inhibitor enhances the antineoplastic effect of the PARPi talazoparib in pancreatic cancer 364
Role of Molecular Dynamics and Related Methods in Drug Discovery 364
2-Phenoxy-1,4-naphthoquinones: From a Multitarget Antitrypanosomal to a Potential Antitumor Profile 331
The 1,2,4-Triazolo[4,3-a]pyrazin-3-one as a Versatile Scaffold for the Design of Potent Adenosine Human Receptor Antagonists. Structural Investigations to Target the A2AReceptor Subtype 326
The mechanistic understanding of the BRCA2-RAD51 interaction: an integrated structural biophysics study 303
Multitarget Strategy to Address Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and Computational Studies of Coumarin-Based Derivatives 299
Synthetic Lethality in Pancreatic Cancer: Discovery of a New RAD51-BRCA2 Small Molecule Disruptor That Inhibits Homologous Recombination and Synergizes with Olaparib 284
La metadinamica nello studio dell'energia libera di complessi recettoriali binari 281
Rad51/Brca2 Disruptors Inhibit Homologous Recombination and Synergize with Olaparib in Pancreatic Cancer Cells 277
A journey through targeting BRCA2-RAD51 protein-protein interaction to establish synthetic lethality as paradigm for anticancer drug discovery 276
Galantamine-memantine hybrids for Alzheimer's disease: The influence of linker rigidity in biological activity and pharmacokinetic properties 271
Insights into the activity of ARN24089, a new RAD51-BRCA2 disruptor that inhibits homologous recombination and achieves synthetic lethality in pancreatic cancer 264
A small chemical library of 2-aminoimidazole derivatives as BACE-1 inhibitors: structure-based design, synthesis, and biological evaluation 261
An automated docking protocol for HERG channel blockers. 260
Cholinesterase inhibitors: xanthostigmine derivatives blocking the acetylcholinesterase-induced beta-amyloid aggregation. 256
Structure-Activity Relationships and Binding Mode in the Human Acetylcholinesterase Active Site of Pseudo-Irreversible Inhibitors Related to Xanthostigmine 255
New Horizons of Synthetic Lethality in Cancer: Current Development and Future Perspectives 254
Investigating synthetic lethality and PARP inhibitor resistance in pancreatic cancer through enantiomer differential activity 252
Dynamic Docking: A Paradigm Shift in Computational Drug Discovery 245
Whole blood and oral fluid microsampling for the monitoring of patients under treatment with antidepressant drugs 245
Lactate dehydrogenase inhibition affects homologous recombination repair independently of cell metabolic asset; implications for anticancer treatment 241
Computational design and discovery of "minimally structured" hERG blockers. 239
Assessment of capillary volumetric blood microsampling for the analysis of central nervous system drugs and metabolites 236
A Catalytic Mechanism for Cysteine N-Terminal Nucleophile Hydrolases, as Revealed by Free Energy Simulations 233
New-generation, non-SSRI antidepressants: Drug-drug interactions and therapeutic drug monitoring. Part 2: NaSSAs, NRIs, SNDRIs, MASSAs, NDRIs, and others 232
Preomic profile of BxPC-3 cells after treatment with BRC4 228
Identification and subsequent development of RAD51-BRCA2 disruptors through a fragment-based approach 226
Protein Tunnels: The Case of Urease Accessory Proteins 223
A molecular dynamics study of reovirus attachment protein sigma1 reveals conformational changes in sigma1 structure 222
Analogues of the dual acetylcholinesterase inhibitor AP2238: synthesis and SAR 222
Versatility of the Curcumin Scaffold: Discovery of Potent and Balanced Dual BACE-1 and GSK-3β Inhibitors 222
An integrative structural study of RAD52, an emerging target in anticancer drug discovery 221
Computational drug discovery under RNA times 218
Dissecting the BRCA2 - RAD51 interaction by integrating computational and experimental biophysics 214
An 19F NMR fragment-based approach for the discovery and development of BRCA2-RAD51 inhibitors to pursuit synthetic lethality in combination with PARP inhibition in pancreatic cancer 213
Probabilistic Pocket Druggability Prediction via One-Class Learning 212
Polyamine conjugation of curcumin analogues toward the discovery of mitochondria-directed neuroprotective agents. 210
Curcumin analogs as multi-target antioxidants: focus on mitochondria. 210
Design, synthesis, and biological evaluation of conformationally restricted rivastigmine analogues 209
Elucidating the BRCA2-RAD51 interaction through an integrated biophysical and structural biology approach 205
Computational approaches to the study of dual-site and peripheral site binding ache inhibitors 205
Progettazione e sintesi di derivati poliamminici per il trattamento della malattia di Alzheimer 205
Antiproliferative agents that interfere with the cell cycle at the G(1)-->S transition: further development and characterization of a small library of stilbene-derived compounds 205
Binding Residence Time through Scaled Molecular Dynamics: A Prospective Application to hDAAO Inhibitors 203
Elucidating the BRCA2-RAD51 interaction through an integrated structural biophysics approach 201
Differential enantiomers activity of ARN24089 to achieve synthetic lethality in pancreatic cancer 201
SAR and binding mode at the h-AChE active site of pseudo-irreversible inhibitors related to Xanthostigmine 201
Extensive SAR and computational studies of 3-{4-[(benzylmethylamino)methyl]phenyl}-6,7-dimethoxy-2H-2-chromenone (AP2238) derivatives. 200
Benzophenone-based derivatives: A novel series of potent and selective dual inhibitors of acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation 200
Synthetic Lethality Triggered by Combining Olaparib with BRCA2-Rad51 Disruptors 199
Design and synthesis of RAD51-BRCA2 protein-protein interaction disruptors to trigger synthetic lethality with Olaparib in pancreatic cancer cells 195
AClAP, Autonomous hierarchical agglomerative Cluster Analysis based protocol to partition conformational datasets 195
A comparative study on the application of hierarchical-agglomerative clustering approaches to organize outputs of reiterated docking runs. 194
BACE-1 Inhibitors: From Recent Single-Target Molecules to Multitarget Compounds for Alzheimer's Disease 194
Blood microsampling for untargeted lipidomics 194
Collecting and assessing human lactate dehydrogenase-A conformations for structure-based virtual screening 190
Complementary medicinal chemistry-driven strategies toward new antitrypanosomal and antileishmanial lead drug candidates 190
A Triazolotriazine-Based Dual GSK-3β/CK-1δ Ligand as a Potential Neuroprotective Agent Presenting Two Different Mechanisms of Enzymatic Inhibition 190
Synthetic Lethality through the Lens of Medicinal Chemistry 190
Density Functional Studies on the Nazarov Reaction Involving Cyclic Systems. 189
Design and synthesis of RAD51-BRCA2 disruptors to inhibit homologous recombination and achieve synthetic lethality in pancreatic cancer cells 189
Elucidating the BRCA2 - RAD51 interaction by integrating computational and experimental biophysics 188
Searching for New Microbiome-Targeted Therapeutics through a Drug Repurposing Approach 188
Alpha7 nicotinic acetylcholine receptor agonists: prediction of their binding affinity through a molecular mechanics Poisson-Boltzmann surface area approach 187
Novel Insights into RAD52’s Structure, Function, and Druggability for Synthetic Lethality and Innovative Anticancer Therapies 186
Role of phosphorylated Thr160 for the activation of the CDK2/Cyclin A complex 186
Mapping cholesterol interaction sites on serotonin transporter through coarse-grained molecular dynamics 186
In vivo characterization of ARN14140, a memantine/galantamine-based multi-target compound for Alzheimer's disease 185
Targeting the JAK/STAT Pathway: A Combined Ligand- And Target-Based Approach 185
Enantioselective nonsteroidal aromatase inhibitors identified through a multidisciplinary medicinal chemistry approach 184
Combining Dyad Protonation and Active Site Plasticity in BACE-1 Structure-Based Drug Design 184
Innovative Strategy toward Mutant CFTR Rescue in Cystic Fibrosis: Design and Synthesis of Thiadiazole Inhibitors of the E3 Ligase RNF5 182
Bivalent tacrine-based acetylcholinesterase inhibitors: role of the spacer in the recognition process of the enzyme gorge 180
Target-related applications of first principles quantum chemical methods in drug design 179
Parallel Synthesis, Evaluation, and Preliminary Structure-Activity Relationship of 2,5-Diamino-1,4-benzoquinones as a Novel Class of Bivalent Anti-Prion Compound. 179
An Integrated Markov State Model and Path Metadynamics Approach to Characterize Drug Binding Processes 179
AN INNOVATIVE PROTOCOL FOR COMPARING PROTEIN BINDING SITES VIA ATOMIC GRID MAPS 178
Predicting Residence Time and Drug Unbinding Pathway through Scaled Molecular Dynamics 178
Enhanced Molecular Dynamics Simulations of Intrinsically Disordered Proteins 178
Density functional study of the enzymatic reaction catalyzed by a cyclin-dependent kinase 177
Toward a rational design of multitarget-directed antioxidants: merging memoquin and lipoic acid molecular frameworks 177
Investigating Drug-Target Residence Time in Kinases through Enhanced Sampling Simulations 177
Exploring Conformational Dynamics of the Extracellular Venus flytrap Domain of the GABAB Receptor: A Path-Metadynamics Study 177
Multi-Target-Directed Drug Design Strategy: From a Dual Binding Site Acetylcholinesterase Inhibitor to a Trifunctional Compound against Alzheimer's Disease 176
A Computational Study of the Binding of Propidium to the Peripheral Anionic Site of Human Acetylcholinesterase 176
Exploring complex protein-ligand recognition mechanisms with coarse metadynamics 175
Machine learning for precision diagnostics of autoimmunity 174
Nonsteroidal Aromatase inhibitors: synthesis and evaluation of new flavone derivatives 174
Lead optimization providing a series of flavone derivatives as potent nonsteroidal inhibitors of the cytochrome P450 aromatase enzyme 174
Derivati a struttura benzofenonica come inibitori dell'acetilcolinesterasi 172
Influence of the Ion Coordination Number on Cation Exchange Reactions with Copper Telluride Nanocrystals 172
AMCG: a graph dual atomic-molecular conditional molecular generator 171
The Mechanistic Understanding of RAD51 Defibrillation: A Critical Step in BRCA2-Mediated DNA Repair by Homologous Recombination 171
Hybrid Lipoic Acid Derivatives to Attack Prion Disease on Multiple Fronts 171
Proteostasis Regulators in Cystic Fibrosis: Current Development and Future Perspectives 171
Exploration of Tools for the Interpretation of Human Non-Coding Variants 170
Dihydroquinoline pyrazoline-based compound as a new RAD51-BRCA2 protein-protein disruptor to trigger synthetic lethality in pancreatic cancer 170
Totale 30.052
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Categoria #
all - tutte 160.797
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 160.797
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20224.473 0 151 355 274 488 354 147 421 286 264 802 931
2022/20235.273 562 775 280 619 420 335 183 318 914 205 377 285
2023/20242.229 164 298 138 179 217 317 163 164 75 159 182 173
2024/20257.653 313 1.135 733 438 1.306 404 559 297 249 363 409 1.447
2025/202627.412 2.113 3.019 2.370 3.826 4.175 2.513 2.184 979 3.174 1.208 857 994
2026/20271.318 626 692 0 0 0 0 0 0 0 0 0 0
Totale 64.096