Density functional theory (DFT) calculations were carried out to study the molecular mechanism of the phosphoryl transfer reaction catalyzed by cyclin-dependent kinases (CDKs). The DFT study presented here shows that CDKs catalyze the phosphoryl transfer reaction from ATP to the serine substrate through a single step mechanism with a SN2-like transition state. © 2003 The Royal Society of Chemistry.
Cavalli A., De Vivo M., Recanatini M. (2003). Density functional study of the enzymatic reaction catalyzed by a cyclin-dependent kinase. CHEMICAL COMMUNICATIONS, 3(11), 1308-1309 [10.1039/b212618d].
Density functional study of the enzymatic reaction catalyzed by a cyclin-dependent kinase
Cavalli A.;De Vivo M.;Recanatini M.
2003
Abstract
Density functional theory (DFT) calculations were carried out to study the molecular mechanism of the phosphoryl transfer reaction catalyzed by cyclin-dependent kinases (CDKs). The DFT study presented here shows that CDKs catalyze the phosphoryl transfer reaction from ATP to the serine substrate through a single step mechanism with a SN2-like transition state. © 2003 The Royal Society of Chemistry.File in questo prodotto:
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