Gene enrichment analysis is a common technique for highlighting molecular pathways and biological processes of a phenotype. Such technique has recently evolved exploiting the information contained in biological networks. We developed NET-GE, a web server for network-based gene enrichment analyses. NET-GE defines functional associations between a list of genes/proteins and biological processes or pathways by identifying function-specific modules in a molecular interaction network. The peculiarity of NET-GE is the possibility to enrich terms not detectable by standard enrichment procedure. Here, we highlight with two specific applications the performances of NET-GE by computing which functional phenotypes can be associated with two different sets of genes related to Attention Deficit Hyperactivity Disorder and to an Obsessive-compulsive disorder, respectively.

Casadio, R., Fariselli, P., Martelli, P.L., Di Lena, P., Bovo, S. (2017). From Protein Variations to Biological Processes and Pathways with NET-GE. GENOMICS AND COMPUTATIONAL BIOLOGY, 3(3), 1-6 [10.18547/gcb.2017.vol3.iss3.e45].

From Protein Variations to Biological Processes and Pathways with NET-GE

Casadio, Rita;Fariselli, Piero;Martelli, Pier Luigi;Di Lena, Pietro;Bovo, Samuele
2017

Abstract

Gene enrichment analysis is a common technique for highlighting molecular pathways and biological processes of a phenotype. Such technique has recently evolved exploiting the information contained in biological networks. We developed NET-GE, a web server for network-based gene enrichment analyses. NET-GE defines functional associations between a list of genes/proteins and biological processes or pathways by identifying function-specific modules in a molecular interaction network. The peculiarity of NET-GE is the possibility to enrich terms not detectable by standard enrichment procedure. Here, we highlight with two specific applications the performances of NET-GE by computing which functional phenotypes can be associated with two different sets of genes related to Attention Deficit Hyperactivity Disorder and to an Obsessive-compulsive disorder, respectively.
2017
Casadio, R., Fariselli, P., Martelli, P.L., Di Lena, P., Bovo, S. (2017). From Protein Variations to Biological Processes and Pathways with NET-GE. GENOMICS AND COMPUTATIONAL BIOLOGY, 3(3), 1-6 [10.18547/gcb.2017.vol3.iss3.e45].
Casadio, Rita; Fariselli, Piero; Martelli, Pier Luigi; Di Lena, Pietro; Bovo, Samuele
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/673372
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