Gene enrichment analysis is a common technique for highlighting molecular pathways and biological processes of a phenotype. Such technique has recently evolved exploiting the information contained in biological networks. We developed NET-GE, a web server for network-based gene enrichment analyses. NET-GE defines functional associations between a list of genes/proteins and biological processes or pathways by identifying function-specific modules in a molecular interaction network. The peculiarity of NET-GE is the possibility to enrich terms not detectable by standard enrichment procedure. Here, we highlight with two specific applications the performances of NET-GE by computing which functional phenotypes can be associated with two different sets of genes related to Attention Deficit Hyperactivity Disorder and to an Obsessive-compulsive disorder, respectively.
From Protein Variations to Biological Processes and Pathways with NET-GE / Casadio, Rita; Fariselli, Piero; Martelli, Pier Luigi; Di Lena, Pietro; Bovo, Samuele. - In: GENOMICS AND COMPUTATIONAL BIOLOGY. - ISSN 2365-7154. - ELETTRONICO. - 3:3(2017), pp. e45.1-e45.6. [10.18547/gcb.2017.vol3.iss3.e45]
From Protein Variations to Biological Processes and Pathways with NET-GE
Casadio, Rita;Fariselli, Piero;Martelli, Pier Luigi;Di Lena, Pietro;Bovo, Samuele
2017
Abstract
Gene enrichment analysis is a common technique for highlighting molecular pathways and biological processes of a phenotype. Such technique has recently evolved exploiting the information contained in biological networks. We developed NET-GE, a web server for network-based gene enrichment analyses. NET-GE defines functional associations between a list of genes/proteins and biological processes or pathways by identifying function-specific modules in a molecular interaction network. The peculiarity of NET-GE is the possibility to enrich terms not detectable by standard enrichment procedure. Here, we highlight with two specific applications the performances of NET-GE by computing which functional phenotypes can be associated with two different sets of genes related to Attention Deficit Hyperactivity Disorder and to an Obsessive-compulsive disorder, respectively.File | Dimensione | Formato | |
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