FALCHI, FEDERICO
FALCHI, FEDERICO
DIPARTIMENTO DI FARMACIA E BIOTECNOLOGIE
Docenti di ruolo di IIa fascia
Probing allosteric communication with combined molecular dynamics simulations and network analysis
2024 Bernetti, Mattia; Bosio, Stefano; Bresciani, Veronica; Falchi, Federico; Masetti, Matteo
Innovative Strategy toward Mutant CFTR Rescue in Cystic Fibrosis: Design and Synthesis of Thiadiazole Inhibitors of the E3 Ligase RNF5
2023 Brusa, Irene; Sondo, Elvira; Pesce, Emanuela; Tomati, Valeria; Gioia, Dario; Falchi, Federico; Balboni, Beatrice; Ortega Martínez, Jose Antonio; Veronesi, Marina; Romeo, Elisa; Margaroli, Natasha; Recanatini, Maurizio; Girotto, Stefania; Pedemonte, Nicoletta; Roberti, Marinella; Cavalli, Andrea
Proteostasis Regulators in Cystic Fibrosis: Current Development and Future Perspectives
2022 Brusa I.; Sondo E.; Falchi F.; Pedemonte N.; Roberti M.; Cavalli A.
Divide et impera: An in silico screening targeting hcmv ppul44 processivity factor homodimerization identifies small molecules inhibiting viral replication
2021 Ghassabian H.; Falchi F.; Timmoneri M.; Mercorelli B.; Loregian A.; Palu G.; Alvisi G.
Searching for New Microbiome-Targeted Therapeutics through a Drug Repurposing Approach
2021 Barone M.; Rampelli S.; Biagi E.; Bertozzi S.M.; Falchi F.; Cavalli A.; Armirotti A.; Brigidi P.; Turroni S.; Candela M.
Synthetic Lethality in Pancreatic Cancer: Discovery of a New RAD51-BRCA2 Small Molecule Disruptor That Inhibits Homologous Recombination and Synergizes with Olaparib
2020 Bagnolini G.; Milano D.; Manerba M.; Schipani F.; Ortega J.A.; Gioia D.; Falchi F.; Balboni A.; Farabegoli F.; De Franco F.; Robertson J.; Pellicciari R.; Pallavicini I.; Peri S.; Minucci S.; Girotto S.; Di Stefano G.; Roberti M.; Cavalli A.
Targeting the Protein Tunnels of the Urease Accessory Complex: A Theoretical Investigation
2020 Masetti, Matteo; Falchi, Federico; Gioia, Dario; Recanatini, Maurizio; Ciurli, Stefano; Musiani, Francesco
Rad51/Brca2 Disruptors Inhibit Homologous Recombination and Synergize with Olaparib in Pancreatic Cancer Cells
2019 Marinella Roberti, Fabrizio Schipani, Greta Bagnolini, Domenico Milano, Elisa Giacomini, Federico Falchi, Andrea Balboni, Marcella Manerba, Fulvia Farabegoli, Francesca De Franco, Janet Robertson, Saverio Minucci, Isabella Pallavicini, Giuseppina Di Stefano, Stefania Girotto, Roberto Pellicciari, and Andrea Cavalli
Structure-based virtual screening allows the identification of efficient modulators of E-cadherin-mediated cell-cell adhesion
2019 Vedove A.D.; Falchi F.; Donini S.; Dobric A.; Germain S.; Martino G.P.D.; Prosdocimi T.; Vettraino C.; Torretta A.; Cavalli A.; Rigot V.; Andre F.; Parisini E.
Pharmacological Inhibition of the Ubiquitin Ligase RNF5 Rescues F508del-CFTR in Cystic Fibrosis Airway Epithelia
2018 Sondo, Elvira; Falchi, Federico; Caci, Emanuela; Ferrera, Loretta; Giacomini, Elisa; Pesce, Emanuela; Tomati, Valeria; Mandrup Bertozzi, Sine; Goldoni, Luca; Armirotti, Andrea; Ravazzolo, Roberto; Cavalli, Andrea; Pedemonte, Nicoletta
Chalcone-based carbamates for Alzheimer's disease treatment
2017 Rampa, Angela; Montanari, Serena; Pruccoli, Letizia; Bartolini, Manuela; Falchi, Federico; Feoli, Alessandra; Cavalli, Andrea; Belluti, Federica; Gobbi, Silvia; Tarozzi, Andrea; Bisi, Alessandra
Crassiflorone derivatives that inhibit Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase (TbGAPDH) and Trypanosoma cruzi trypanothione reductase (TcTR) and display trypanocidal activity
2017 Uliassi, Elisa; Fiorani, Giulia; Krauth-Siegel, R. Luise; Bergamini, Christian; Fato, Romana; Bianchini, Giulia; Carlos Menéndez, J.; Molina, Maria Teresa; López-Montero, Eulogio; Falchi, Federico; Cavalli, Andrea; Gul, Sheraz; Kuzikov, Maria; Ellinger, Bernhard; Witt, Gesa; Moraes, Carolina B.; Freitas-Junior, Lucio H.; Borsari, Chiara; Costi, Maria Paola; Bolognesi, Maria Laura*
Development of a multisite model for Ni(II) ion in solution from thermodynamic and kinetic data
2017 Masetti, Matteo; Musiani, Francesco; Bernetti, Mattia; Falchi, Federico; Cavalli, Andrea; Ciurli, Stefano; Recanatini, Maurizio
Discovery of Multitarget Agents Active as Broad-Spectrum Antivirals and Correctors of Cystic Fibrosis Transmembrane Conductance Regulator for Associated Pulmonary Diseases
2017 Tassini, Sabrina; Sun, Liang; Lanko, Kristina; Crespan, Emmanuele; Langron, Emily; Falchi, Federico; Kissova, Miroslava; Armijos-Rivera, Jorge I.; Delang, Leen; Mirabelli, Carmen; Neyts, Johan; Pieroni, Marco; Cavalli, Andrea; Costantino, Gabriele; Maga, Giovanni; Vergani, Paola; Leyssen, Pieter; Radi, Marco
Protein Tunnels: The Case of Urease Accessory Proteins
2017 Musiani, Francesco; Gioia, Dario; Masetti, Matteo; Falchi, Federico; Cavalli, Andrea; Recanatini, Maurizio; Ciurli, Stefano
Synthetic Lethality Triggered by Combining Olaparib with BRCA2-Rad51 Disruptors
2017 Falchi, Federico; Giacomini, Elisa; Masini, Tiziana; Boutard, Nicolas; Di Ianni, Lorenza; Manerba, Marcella; Farabegoli, Fulvia; Rossini, Lara; Robertson, Janet; Minucci, Saverio; Pallavicini, Isabella; Di Stefano, Giuseppina; Roberti, Marinella; Pellicciari, Roberto; Cavalli, Andrea
Kernel-Based, Partial Least Squares Quantitative Structure-Retention Relationship Model for UPLC Retention Time Prediction: A Useful Tool for Metabolite Identification
2016 Falchi, Federico; Bertozzi, Sine Mandrup; Ottonello, Giuliana; Ruda, Gian Filippo; Colombano, Giampiero; Fiorelli, Claudio; Martucci, Cataldo; Bertorelli, Rosalia; Scarpelli, Rita; Cavalli, Andrea; Bandiera, Tiziano; Armirotti, Andrea
Multitarget Strategy to Address Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and Computational Studies of Coumarin-Based Derivatives
2016 Montanari, Serena; Bartolini, Manuela; Neviani, Paolo; Belluti, Federica; Gobbi, Silvia; Pruccoli, Letizia; Tarozzi, Andrea; Falchi, Federico; Andrisano, Vincenza; Miszta, Przemysław; Cavalli, Andrea; Filipek, Sławomir; Bisi, Alessandra; Rampa, Angela
Synthesis of natural urolithin M6, a galloflavin mimetic, as a potential inhibitor of lactate dehydrogenase A
2016 Rupiani, Sebastiano; Guidotti, Laura; Manerba, Marcella; DI IANNI, Lorenza; Giacomini, Elisa; Falchi, Federico; DI STEFANO, Giuseppina; Roberti, Marinella; Recanatini, Maurizio
2-Phenoxy-1,4-naphthoquinones: From a Multitarget Antitrypanosomal to a Potential Antitumor Profile
2015 Prati, Federica; Bergamini, Christian; Molina, Maria Teresa; Falchi, Federico; Cavalli, Andrea; Kaiser, Marcel; Brun, Reto; Fato, Romana; Bolognesi, Maria Laura
| Titolo | Autore(i) | Anno | Periodico | Editore | Tipo | File |
|---|---|---|---|---|---|---|
| Probing allosteric communication with combined molecular dynamics simulations and network analysis | Bernetti, Mattia; Bosio, Stefano; Bresciani, Veronica; Falchi, Federico; Masetti, Matteo | 2024-01-01 | CURRENT OPINION IN STRUCTURAL BIOLOGY | - | 1.01 Articolo in rivista | - |
| Innovative Strategy toward Mutant CFTR Rescue in Cystic Fibrosis: Design and Synthesis of Thiadiazole Inhibitors of the E3 Ligase RNF5 | Brusa, Irene; Sondo, Elvira; Pesce, Emanuela; Tomati, Valeria; Gioia, Dario; Falchi, Federico; Ba...lboni, Beatrice; Ortega Martínez, Jose Antonio; Veronesi, Marina; Romeo, Elisa; Margaroli, Natasha; Recanatini, Maurizio; Girotto, Stefania; Pedemonte, Nicoletta; Roberti, Marinella; Cavalli, Andrea | 2023-01-01 | JOURNAL OF MEDICINAL CHEMISTRY | - | 1.01 Articolo in rivista | brusa-et-al-2023-innovative-strategy-toward-mutant-cftr-rescue-in-cystic-fibrosis-design-and-synthesis-of-thiadiazole.pdf |
| Proteostasis Regulators in Cystic Fibrosis: Current Development and Future Perspectives | Brusa I.; Sondo E.; Falchi F.; Pedemonte N.; Roberti M.; Cavalli A. | 2022-01-01 | JOURNAL OF MEDICINAL CHEMISTRY | - | 1.01 Articolo in rivista | acs.jmedchem.1c01897.pdf |
| Divide et impera: An in silico screening targeting hcmv ppul44 processivity factor homodimerization identifies small molecules inhibiting viral replication | Ghassabian H.; Falchi F.; Timmoneri M.; Mercorelli B.; Loregian A.; Palu G.; Alvisi G. | 2021-01-01 | VIRUSES | - | 1.01 Articolo in rivista | Divide et impera_ An In Silico Screening Targeting HCMV ppUL44 Processivity Factor Homodimerization Identifies Small Molecules Inhibiting Viral Replication.pdf |
| Searching for New Microbiome-Targeted Therapeutics through a Drug Repurposing Approach | Barone M.; Rampelli S.; Biagi E.; Bertozzi S.M.; Falchi F.; Cavalli A.; Armirotti A.; Brigidi P.;... Turroni S.; Candela M. | 2021-01-01 | JOURNAL OF MEDICINAL CHEMISTRY | - | 1.01 Articolo in rivista | acs.jmedchem.1c01333.pdf |
| Synthetic Lethality in Pancreatic Cancer: Discovery of a New RAD51-BRCA2 Small Molecule Disruptor That Inhibits Homologous Recombination and Synergizes with Olaparib | Bagnolini G.; Milano D.; Manerba M.; Schipani F.; Ortega J.A.; Gioia D.; Falchi F.; Balboni A.; F...arabegoli F.; De Franco F.; Robertson J.; Pellicciari R.; Pallavicini I.; Peri S.; Minucci S.; Girotto S.; Di Stefano G.; Roberti M.; Cavalli A. | 2020-01-01 | JOURNAL OF MEDICINAL CHEMISTRY | - | 1.01 Articolo in rivista | ASAP_acs.jmedchem.9b01526.pdf |
| Targeting the Protein Tunnels of the Urease Accessory Complex: A Theoretical Investigation | Masetti, Matteo; Falchi, Federico; Gioia, Dario; Recanatini, Maurizio; Ciurli, Stefano; Musiani, ...Francesco | 2020-01-01 | MOLECULES | - | 1.01 Articolo in rivista | 63_2020_Masetti_Molecules.pdf |
| Rad51/Brca2 Disruptors Inhibit Homologous Recombination and Synergize with Olaparib in Pancreatic Cancer Cells | Marinella Roberti, Fabrizio Schipani, Greta Bagnolini, Domenico Milano, Elisa Giacomini, Federico... Falchi, Andrea Balboni, Marcella Manerba, Fulvia Farabegoli, Francesca De Franco, Janet Robertson, Saverio Minucci, Isabella Pallavicini, Giuseppina Di Stefano, Stefania Girotto, Roberto Pellicciari, and Andrea Cavalli | 2019-01-01 | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - | 1.01 Articolo in rivista | - |
| Structure-based virtual screening allows the identification of efficient modulators of E-cadherin-mediated cell-cell adhesion | Vedove A.D.; Falchi F.; Donini S.; Dobric A.; Germain S.; Martino G.P.D.; Prosdocimi T.; Vettrain...o C.; Torretta A.; Cavalli A.; Rigot V.; Andre F.; Parisini E. | 2019-01-01 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - | 1.01 Articolo in rivista | - |
| Pharmacological Inhibition of the Ubiquitin Ligase RNF5 Rescues F508del-CFTR in Cystic Fibrosis Airway Epithelia | Sondo, Elvira; Falchi, Federico; Caci, Emanuela; Ferrera, Loretta; Giacomini, Elisa; Pesce, Emanu...ela; Tomati, Valeria; Mandrup Bertozzi, Sine; Goldoni, Luca; Armirotti, Andrea; Ravazzolo, Roberto; Cavalli, Andrea; Pedemonte, Nicoletta | 2018-01-01 | CELL CHEMICAL BIOLOGY | - | 1.01 Articolo in rivista | - |
| Chalcone-based carbamates for Alzheimer's disease treatment | Rampa, Angela; Montanari, Serena; Pruccoli, Letizia; Bartolini, Manuela; Falchi, Federico; Feoli,... Alessandra; Cavalli, Andrea; Belluti, Federica; Gobbi, Silvia; Tarozzi, Andrea; Bisi, Alessandra | 2017-01-01 | FUTURE MEDICINAL CHEMISTRY | - | 1.01 Articolo in rivista | - |
| Crassiflorone derivatives that inhibit Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase (TbGAPDH) and Trypanosoma cruzi trypanothione reductase (TcTR) and display trypanocidal activity | Uliassi, Elisa; Fiorani, Giulia; Krauth-Siegel, R. Luise; Bergamini, Christian; Fato, Romana; Bia...nchini, Giulia; Carlos Menéndez, J.; Molina, Maria Teresa; López-Montero, Eulogio; Falchi, Federico; Cavalli, Andrea; Gul, Sheraz; Kuzikov, Maria; Ellinger, Bernhard; Witt, Gesa; Moraes, Carolina B.; Freitas-Junior, Lucio H.; Borsari, Chiara; Costi, Maria Paola; Bolognesi, Maria Laura* | 2017-01-01 | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - | 1.01 Articolo in rivista | - |
| Development of a multisite model for Ni(II) ion in solution from thermodynamic and kinetic data | Masetti, Matteo; Musiani, Francesco; Bernetti, Mattia; Falchi, Federico; Cavalli, Andrea; Ciurli,... Stefano; Recanatini, Maurizio | 2017-01-01 | JOURNAL OF COMPUTATIONAL CHEMISTRY | - | 1.01 Articolo in rivista | - |
| Discovery of Multitarget Agents Active as Broad-Spectrum Antivirals and Correctors of Cystic Fibrosis Transmembrane Conductance Regulator for Associated Pulmonary Diseases | Tassini, Sabrina; Sun, Liang; Lanko, Kristina; Crespan, Emmanuele; Langron, Emily; Falchi, Federi...co; Kissova, Miroslava; Armijos-Rivera, Jorge I.; Delang, Leen; Mirabelli, Carmen; Neyts, Johan; Pieroni, Marco; Cavalli, Andrea; Costantino, Gabriele; Maga, Giovanni; Vergani, Paola; Leyssen, Pieter; Radi, Marco | 2017-01-01 | JOURNAL OF MEDICINAL CHEMISTRY | - | 1.01 Articolo in rivista | - |
| Protein Tunnels: The Case of Urease Accessory Proteins | Musiani, Francesco; Gioia, Dario; Masetti, Matteo; Falchi, Federico; Cavalli, Andrea; Recanatini,... Maurizio; Ciurli, Stefano | 2017-01-01 | JOURNAL OF CHEMICAL THEORY AND COMPUTATION | - | 1.01 Articolo in rivista | Musiani_2017_JCTC(1).pdf |
| Synthetic Lethality Triggered by Combining Olaparib with BRCA2-Rad51 Disruptors | Falchi, Federico; Giacomini, Elisa; Masini, Tiziana; Boutard, Nicolas; Di Ianni, Lorenza; Manerba..., Marcella; Farabegoli, Fulvia; Rossini, Lara; Robertson, Janet; Minucci, Saverio; Pallavicini, Isabella; Di Stefano, Giuseppina; Roberti, Marinella; Pellicciari, Roberto; Cavalli, Andrea | 2017-01-01 | ACS CHEMICAL BIOLOGY | - | 1.01 Articolo in rivista | - |
| Kernel-Based, Partial Least Squares Quantitative Structure-Retention Relationship Model for UPLC Retention Time Prediction: A Useful Tool for Metabolite Identification | Falchi, Federico; Bertozzi, Sine Mandrup; Ottonello, Giuliana; Ruda, Gian Filippo; Colombano, Gia...mpiero; Fiorelli, Claudio; Martucci, Cataldo; Bertorelli, Rosalia; Scarpelli, Rita; Cavalli, Andrea; Bandiera, Tiziano; Armirotti, Andrea | 2016-01-01 | ANALYTICAL CHEMISTRY | - | 1.01 Articolo in rivista | - |
| Multitarget Strategy to Address Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and Computational Studies of Coumarin-Based Derivatives | Montanari, Serena; Bartolini, Manuela; Neviani, Paolo; Belluti, Federica; Gobbi, Silvia; Pruccoli..., Letizia; Tarozzi, Andrea; Falchi, Federico; Andrisano, Vincenza; Miszta, Przemysław; Cavalli, Andrea; Filipek, Sławomir; Bisi, Alessandra; Rampa, Angela | 2016-01-01 | CHEMMEDCHEM | - | 1.01 Articolo in rivista | ChemMedChem VQR.pdf |
| Synthesis of natural urolithin M6, a galloflavin mimetic, as a potential inhibitor of lactate dehydrogenase A | Rupiani, Sebastiano; Guidotti, Laura; Manerba, Marcella; DI IANNI, Lorenza; Giacomini, Elisa; Fal...chi, Federico; DI STEFANO, Giuseppina; Roberti, Marinella; Recanatini, Maurizio | 2016-01-01 | ORGANIC & BIOMOLECULAR CHEMISTRY | - | 1.01 Articolo in rivista | - |
| 2-Phenoxy-1,4-naphthoquinones: From a Multitarget Antitrypanosomal to a Potential Antitumor Profile | Prati, Federica; Bergamini, Christian; Molina, Maria Teresa; Falchi, Federico; Cavalli, Andrea; K...aiser, Marcel; Brun, Reto; Fato, Romana; Bolognesi, Maria Laura | 2015-01-01 | JOURNAL OF MEDICINAL CHEMISTRY | - | 1.01 Articolo in rivista | - |