CRIS Current Research Information System

RAMPA, ANGELA
 Distribuzione geografica
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Continente #
NA - Nord America 4.295
EU - Europa 2.955
AS - Asia 1.132
AF - Africa 217
SA - Sud America 11
OC - Oceania 10
Continente sconosciuto - Info sul continente non disponibili 2
Totale 8.622
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Nazione #
US - Stati Uniti d'America 4.274
GB - Regno Unito 784
IT - Italia 602
DE - Germania 404
CN - Cina 393
VN - Vietnam 362
SE - Svezia 321
UA - Ucraina 235
IN - India 169
IE - Irlanda 121
FR - Francia 114
RU - Federazione Russa 110
JO - Giordania 93
CI - Costa d'Avorio 65
ZA - Sudafrica 63
TG - Togo 59
EE - Estonia 56
BG - Bulgaria 54
SG - Singapore 41
CH - Svizzera 26
FI - Finlandia 22
IR - Iran 22
CA - Canada 19
SC - Seychelles 19
JP - Giappone 18
GR - Grecia 15
BE - Belgio 13
CZ - Repubblica Ceca 13
HR - Croazia 13
ES - Italia 12
AT - Austria 7
AU - Australia 7
NL - Olanda 7
PL - Polonia 7
ID - Indonesia 6
LB - Libano 6
NG - Nigeria 6
PT - Portogallo 6
BR - Brasile 4
HU - Ungheria 4
PK - Pakistan 4
RO - Romania 4
TR - Turchia 4
CL - Cile 3
EC - Ecuador 3
EG - Egitto 3
NZ - Nuova Zelanda 3
A2 - ???statistics.table.value.countryCode.A2??? 2
BY - Bielorussia 2
KR - Corea 2
KW - Kuwait 2
MX - Messico 2
MY - Malesia 2
PH - Filippine 2
AR - Argentina 1
BD - Bangladesh 1
DZ - Algeria 1
HK - Hong Kong 1
LA - Repubblica Popolare Democratica del Laos 1
LK - Sri Lanka 1
MD - Moldavia 1
NO - Norvegia 1
RS - Serbia 1
SA - Arabia Saudita 1
SD - Sudan 1
UZ - Uzbekistan 1
Totale 8.622
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Città #
Southend 706
Fairfield 532
Chandler 516
Ashburn 409
Woodbridge 297
Dong Ket 251
Wilmington 248
Houston 242
Seattle 237
Bologna 213
Cambridge 205
Princeton 170
Ann Arbor 162
Jacksonville 151
Dublin 121
Amman 93
Westminster 75
Nanjing 73
New York 70
Abidjan 65
Padova 64
Lomé 59
Sofia 54
Berlin 51
Bremen 40
Jinan 40
San Diego 38
Saint Petersburg 37
Shenyang 37
Beijing 32
Redmond 31
Mülheim 27
Nanchang 27
Hebei 26
Singapore 24
Bern 23
Milan 21
Helsinki 20
Jiaxing 20
Tianjin 20
Mahé 19
Medford 19
Dearborn 18
Boardman 17
Tokyo 17
Los Angeles 16
Olalla 16
Venezia 16
Changsha 15
Des Moines 15
Mountain View 15
Redwood City 15
Boydton 14
Brussels 13
Turin 11
Verona 11
Fremont 10
Phoenix 10
Falls Church 9
Haikou 9
Kunming 9
Norwalk 9
Zhengzhou 9
Brno 8
Guangzhou 8
Taiyuan 8
Casoria 7
London 7
Munich 7
Ningbo 7
Pune 7
Abeokuta 6
Asciano 6
Lanzhou 6
Ravenna 6
San Jose 6
Urbino 6
Jakarta 5
Paris 5
Toronto 5
Vienna 5
Ancona 4
Bühl 4
Delhi 4
Forlì 4
Fuzhou 4
Hangzhou 4
Reggio Nell'emilia 4
Rome 4
Rotterdam 4
São Paulo 4
Acerra 3
Barcelona 3
Chicago 3
Elora 3
Ferrara 3
Hyderabad 3
Imola 3
Istanbul 3
Leawood 3
Totale 6.021
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Nome #
1,4-dihydropyridine derivatives as calcium channel modulators: the role of 3-methoxy-flavone moiety 253
Discovery of novel benzofuran-based compounds with neuroprotective and immunomodulatory properties for Alzheimer's disease treatment 213
Multitarget Strategy to Address Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and Computational Studies of Coumarin-Based Derivatives 182
Cholinesterase inhibitors: xanthostigmine derivatives blocking the acetylcholinesterase-induced beta-amyloid aggregation. 169
2-Arylbenzofuran-based molecules as multipotent Alzheimer's disease modifying agents 155
Analogues of the dual acetylcholinesterase inhibitor AP2238: synthesis and SAR 142
Benzophenones as xanthone-open model CYP11B1 inhibitors potentially useful for promoting wound healing 141
Benzofuran-Based Hybrid Compounds for the Inhibition of Cholinesterase Activity, Abeta Amyloid Aggregation, and Abeta Neurotoxicity 140
Benzophenone-based derivatives: A novel series of potent and selective dual inhibitors of acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation 139
Exploiting the chalcone scaffold to develop multifunctional agents for Alzheimer’s disease 138
Design, synthesis and biological profile of new inhibitors of multidrug resistance associated proteins carrying a polycyclic scaffold 136
Versatility of the Curcumin Scaffold: Discovery of Potent and Balanced Dual BACE-1 and GSK-3β Inhibitors 136
Fatty Acid Amide Hydrolase (FAAH), Acetylcholinesterase (AChE), and Butyrylcholinesterase (BuChE): Networked Targets for the Development of Carbamates as Potential Anti-Alzheimer's Disease Agents 136
Cardiovascular profile of xanthone-based 1,4 dihydropyridines bearing a lidoflazine pharmacophore fragment 134
Anthracene Based Compounds as New L-type Ca2+ Channel Blockers: Design, Synthesis, and Full Biological Profile 133
Extensive SAR and computational studies of 3-{4-[(benzylmethylamino)methyl]phenyl}-6,7-dimethoxy-2H-2-chromenone (AP2238) derivatives. 128
Emerging targets in neurodegeneration: new opportunities for Alzheimer's disease treatment? 126
CHOLINESTERASE INHIBITORS: SAR AND ENZYME INHIBITORY ACTIVITY OF 3-[omega-(BENZYLMETHYLAMINO)ALKOXY]XANTHEN-9-ONES 124
null 123
Identification of chalcone-based antileishmanial agents targeting trypanothione reductase 123
Identification of a new tamoxifen-xanthene hybrid as pro-apoptotic anticancer agent 122
null 118
Enantioselective nonsteroidal aromatase inhibitors identified through a multidisciplinary medicinal chemistry approach 114
Fluorinated benzophenone derivatives: balanced multipotent agents for Alzheimer's disease 112
From the dual function lead AP2238 to AP2469, a multi-target-directed ligand for the treatment of Alzheimer’s disease 110
Characterization of Cholinesterase inhibitors by means of immobilized enzyme reactor 109
Antitumor profile of new phenothiazine derivatives 106
Targeting Alzheimer’s disease: Novel indanone hybrids bearing a pharmacophoric fragment of AP2238 106
Lead optimization providing a series of flavone derivatives as potent nonsteroidal inhibitors of the cytochrome P450 aromatase enzyme 105
null 105
Design, synthesis, and evaluation of benzophenone derivatives as novel acetylcholinesterase inhibitors 103
Polycyclic maleimide-based derivatives as first dual modulators of neuronal calcium channels and GSK-3β for Alzheimer's disease treatment 103
Naturally inspired molecules as multifunctional agents for Alzheimer's disease treatment 102
New potent P-glycoprotein inhibitors carrying a polycyclic scaffold 100
Benzophenone derivatives as Inhibitors of Acetylcholinesterase 99
Phytoestrogens in postmenopause: the state of the art from a chemical, pharmacological and regulatory perspective 99
Structure-Activity Relationships and Binding Mode in the Human Acetylcholinesterase Active Site of Pseudo-Irreversible Inhibitors Related to Xanthostigmine 98
Homopterocarpanes as bridged triarylethylene analogues: synthesis and antagonistic effects in human MCF-7 breast cancer cells 98
Multi-target-directed coumarin derivatives: hAChE and BAC1 inhibitors as potential anti-Alzheimer compounds 97
Multi-target strategy to address Alzheimer’s disease: Design, synthesis and biological evaluation of new tacrine-based dimers 95
Novel Curcumin-Diethyl Fumarate Hybrid as a Dualistic GSK-3β Inhibitor/Nrf2 Inducer for the Treatment of Parkinson's Disease 95
Curcumin-1,2,3-triazole conjugation for targeting the cancer apoptosis machinery. 94
Derivati a struttura benzofenonica come inibitori dell'acetilcolinesterasi 92
In vitro biological activity of new analogues of flavon-8-acetic acid 91
New derivatives of xanthenone-4-acetic acid: synthesis, pharmacological profile and effect on TNF-alpha and NO production by human immune cells 90
Functionalization of the chalcone scaffold for the discovery of novel lead compounds targeting fungal infections 90
In vitro studies of flavon-8-acetic acid analogues 88
Hybrid drugs for Alzheimer's disease: new indanone derivatives bearing a pharmacophoric fragment of AP2238 88
High-throughput screening of beta-secretase inhibitors by multiwell FRET assay 88
Design, Synthesis, and Biological and Crystallographic Evaluation of Novel Inhibitors ofPlasmodium falciparumEnoyl-ACP-reductase (PfFabI) 88
Multidrug resistance reverting activity and antitumor profile of new phenothiazine derivatives 88
Targeting the Bacterial Membrane with a New Polycyclic Privileged Structure: A Powerful Tool To Face Staphylococcus aureus Infections 87
Design of Multifunctional Compounds for Cardiovascular Disease: From Natural Scaffolds to “Classical” Multitarget Approach 86
Nonsteroidal Aromatase inhibitors: synthesis and evaluation of new flavone derivatives 85
Hybrid-Based Multi-Target Ligands for the Treatment of Alzheimer's Disease 85
Novel highly potent and selective nonsteroidal aromatase inhibitors: synthesis, biological evaluation and structure-activity relationships investigation 85
Modulation of Cytochromes P450 with Xanthone-Based Molecules: From Aromatase to Aldosterone Synthase and Steroid 11β-Hydroxylase Inhibition 83
null 82
New Coumarin derivatives as cholinergic and cannabinoid system modulators 82
Studies on cytostatic and cytotoxic activity of new flavopiridol analogues 81
Balanced dual acting compounds targeting aromatase and estrogen receptor α as an emerging therapeutic opportunity to counteract estrogen responsive breast cancer 81
The first dual ChE/FAAH inhibitors: new perspectives for Alzheimer's disease? 80
Curcumin derivatives as beta-secretase (BACE1) inhibitors. 80
Progettazione e sintesi di derivati benzofuranici per la malattia di Alzheimer 79
null 79
Polycyclic Maleimide-based Scaffold as New Privileged Structure for Navigating the Cannabinoid System Opportunities 79
Nonsteroidal aromatase inhibitors for the treatment of breast cancer: an update. 78
Reconsidering Aromatase for Breast Cancer Treatment: New Roles for an Old Target 78
Mono- or di-fluorinated analogues of Flavone-8-acetic acid: synthesis and in vitro biological activity 76
null 76
Multifaceted activity of polyciclic MDR revertant agents in drug-resistant leukemic cells: Role of the spacer 73
The ability of coumarin-, flavanon- and flavonol-analogues of flavone acetic acid to stimulate human monocytes. 71
Small-molecule inhibitors/modulators of amyloid-β peptide aggregation and toxicity for the treatment of Alzheimer's disease: a patent review (2010 – 2012) 70
null 70
Imidazolylmethylxanthones as potent inhibitors of cytochrome P450 aromatase 70
null 67
SAR and binding mode at the h-AChE active site of pseudo-irreversible inhibitors related to Xanthostigmine 64
New potent inhibitors of cytochrome P450 aromatase 60
null 58
Targeting neuronal calcium channels and GSK3β for Alzheimer's disease with naturally-inspired Diels-Alder adducts 56
Chalcone-based carbamates for Alzheimer's disease treatment 51
Tackling Alzheimer's Disease with Existing Drugs:A Promising Strategy for Bypassing Obstacles 49
Coumarin derivatives as potential antitumor agents: Growth inhibition, apoptosis induction and multidrug resistance reverting activity 45
Flavonoid-inspired vascular disrupting agents: Exploring flavone-8-acetic acid and derivatives in the new century 43
From AChE to BACE1 inhibitors: The role of the amine on the indanone scaffold 41
New approaches to the treatment of Alzheimer's disease. 40
Hitting drug-resistant malaria infection with triazole-linked flavonoid–chloroquine hybrid compounds 34
Interplay Between Endocannabinoid System and Neurodegeneration: Focus on Polypharmacology 33
3-(4-{[benzyl(methyl)amino]methyl}-phenyl)-6,7-dimethoxy-2H-2-chromenone (AP2238) inhibits both acetylcholinesterase and acetylcholinesterase-induced β-amyloid aggregation: A dual function lead for Alzheimer's disease therapy 26
Acetylcholinesterase inhibitors: SAR and kinetic studies on ω-[N-methyl-N-(3-alkylcarbamoyloxyphenyl]methyl] aminoalkoxyaryl derivatives 24
Recent progress on curcumin-based therapeutics: a patent review (2012-2016). Part I: Curcumin 23
Cardiovascular hybrid drugs: New benzazepinone derivatives as bradycardic agents endowed with selective β1-Non-competitive antagonism 22
Recent progress on curcumin-based therapeutics: a patent review (2012-2016). Part II: curcumin derivatives in cancer and neurodegeneration 20
Acetylcholinesterase inhibitors for potential use in Alzheimer's disease: Molecular modeling, synthesis and kinetic evaluation of 11H-indeno-[1,2-b]-quinolin-10-ylamine derivatives 17
A new class of nonsteroidal aromatase inhibitors: Design and synthesis of chromone and xanthone derivatives and inhibition of the P450 enzymes aromatase and 17α-hydroxylase/C17,20-lyase 17
Drifting of heme-coordinating group in imidazolylmethylxanthones leading to improved selective inhibition of CYP11B1 17
SAR of 9-amino-1,2,3-4-tetrahydroacridine-based acetylcholinesterase inhibitors: Synthesis, enzyme inhibitory activity, QSAR, and structure-based CoMFA of tacrine analogues 16
1,4-Dihydropyridine bearing a pharmacophoric fragment of lidoflazine 16
Targeting Steroidogenic Cytochromes P450 (CYPs) with 6-Substituted 1-Imidazolylmethylxanthones 16
4-Heterotricyclic substituted 1,4-dihydropyridines with a potent selective bradycardic effect 14
Totale 8.829
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Categoria #
all - tutte 23.706
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 23.706
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20202.041 0 44 50 135 233 234 284 332 308 168 105 148
2020/20211.400 274 86 19 61 27 80 35 138 99 77 88 416
2021/20221.615 150 44 97 86 136 84 42 152 89 132 313 290
2022/20232.125 188 235 91 266 164 159 67 121 451 60 162 161
2023/2024592 37 84 35 67 52 172 32 32 10 22 23 26
2024/202579 68 11 0 0 0 0 0 0 0 0 0 0
Totale 8.911