CRIS Current Research Information System

RAMPA, ANGELA
 Distribuzione geografica
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Continente #
NA - Nord America 6.291
AS - Asia 5.453
EU - Europa 3.624
AF - Africa 309
SA - Sud America 259
OC - Oceania 12
Continente sconosciuto - Info sul continente non disponibili 3
Totale 15.951
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Nazione #
US - Stati Uniti d'America 6.189
VN - Vietnam 1.487
SG - Singapore 1.434
CN - Cina 1.373
GB - Regno Unito 812
IT - Italia 692
DE - Germania 497
HK - Hong Kong 358
SE - Svezia 324
IN - India 246
UA - Ucraina 240
FR - Francia 213
RU - Federazione Russa 208
BR - Brasile 168
NL - Olanda 131
IE - Irlanda 125
CI - Costa d'Avorio 101
JO - Giordania 99
JP - Giappone 98
ZA - Sudafrica 85
KR - Corea 83
FI - Finlandia 75
CA - Canada 71
TG - Togo 59
EE - Estonia 56
BG - Bulgaria 55
PH - Filippine 43
AR - Argentina 40
ID - Indonesia 35
BD - Bangladesh 33
PL - Polonia 30
CH - Svizzera 28
SC - Seychelles 27
ES - Italia 23
IR - Iran 23
TH - Thailandia 21
MX - Messico 19
AT - Austria 18
GR - Grecia 18
TR - Turchia 18
PK - Pakistan 17
IQ - Iraq 16
EC - Ecuador 15
BE - Belgio 14
CZ - Repubblica Ceca 14
HR - Croazia 13
TW - Taiwan 11
CO - Colombia 10
MY - Malesia 10
NG - Nigeria 10
AU - Australia 9
SA - Arabia Saudita 9
EG - Egitto 8
LB - Libano 7
VE - Venezuela 7
CL - Cile 6
HU - Ungheria 6
LT - Lituania 6
PT - Portogallo 6
KE - Kenya 5
OM - Oman 5
PS - Palestinian Territory 5
KZ - Kazakistan 4
MD - Moldavia 4
PE - Perù 4
PY - Paraguay 4
RO - Romania 4
TN - Tunisia 4
AE - Emirati Arabi Uniti 3
ET - Etiopia 3
GT - Guatemala 3
HN - Honduras 3
NP - Nepal 3
NZ - Nuova Zelanda 3
RS - Serbia 3
UZ - Uzbekistan 3
A2 - ???statistics.table.value.countryCode.A2??? 2
AL - Albania 2
BO - Bolivia 2
BY - Bielorussia 2
DZ - Algeria 2
KW - Kuwait 2
LK - Sri Lanka 2
MA - Marocco 2
NO - Norvegia 2
UY - Uruguay 2
AM - Armenia 1
AO - Angola 1
AZ - Azerbaigian 1
BA - Bosnia-Erzegovina 1
BB - Barbados 1
CR - Costa Rica 1
CW - ???statistics.table.value.countryCode.CW??? 1
DO - Repubblica Dominicana 1
GH - Ghana 1
GI - Gibilterra 1
GY - Guiana 1
JM - Giamaica 1
KG - Kirghizistan 1
KH - Cambogia 1
Totale 15.946
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Città #
Singapore 950
Southend 706
Ashburn 598
Fairfield 532
Chandler 516
San Jose 387
Santa Clara 365
Hong Kong 339
Ho Chi Minh City 312
Woodbridge 297
Hanoi 268
Dong Ket 251
Wilmington 248
Houston 244
Seattle 239
Bologna 237
Cambridge 205
Beijing 187
Hefei 185
Princeton 170
Ann Arbor 162
Jacksonville 151
Boardman 129
Dublin 125
New York 119
Abidjan 100
Amman 99
Tokyo 83
Los Angeles 82
Nanjing 79
Westminster 75
Seoul 73
Lauterbourg 70
Padova 64
Council Bluffs 62
Dallas 61
Helsinki 61
Lomé 59
Buffalo 58
Sofia 55
Berlin 51
Jinan 49
Da Nang 45
Bremen 43
Munich 41
Shenyang 41
San Diego 38
Haiphong 37
Saint Petersburg 37
Redmond 31
Guangzhou 30
Redondo Beach 30
Milan 28
Tianjin 28
Mülheim 27
Nanchang 27
Hebei 26
Frankfurt am Main 25
Jakarta 25
Quận Bình Thạnh 25
Shanghai 24
Bern 23
Changsha 23
São Paulo 23
Orem 22
Jiaxing 21
Warsaw 21
Mahé 19
Medford 19
Zhengzhou 19
Bengaluru 18
Dearborn 18
Phoenix 18
Biên Hòa 17
Can Tho 17
Hải Dương 17
Johannesburg 17
Des Moines 16
Montreal 16
Nuremberg 16
Olalla 16
Toronto 16
Venezia 16
Chicago 15
Mountain View 15
Redwood City 15
Boydton 14
Brussels 14
London 14
Atlanta 13
Brooklyn 12
Hangzhou 12
Kunming 11
Mexico City 11
Turin 11
Verona 11
Wuhan 11
Fremont 10
San Francisco 10
Taiyuan 10
Totale 10.328
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Nome #
1,4-dihydropyridine derivatives as calcium channel modulators: the role of 3-methoxy-flavone moiety 351
Discovery of novel benzofuran-based compounds with neuroprotective and immunomodulatory properties for Alzheimer's disease treatment 330
Multitarget Strategy to Address Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and Computational Studies of Coumarin-Based Derivatives 288
Benzofuran-Based Hybrid Compounds for the Inhibition of Cholinesterase Activity, Abeta Amyloid Aggregation, and Abeta Neurotoxicity 284
Cholinesterase inhibitors: xanthostigmine derivatives blocking the acetylcholinesterase-induced beta-amyloid aggregation. 251
Structure-Activity Relationships and Binding Mode in the Human Acetylcholinesterase Active Site of Pseudo-Irreversible Inhibitors Related to Xanthostigmine 247
Progettazione e sintesi di derivati benzofuranici per la malattia di Alzheimer 238
Design, synthesis and biological profile of new inhibitors of multidrug resistance associated proteins carrying a polycyclic scaffold 220
Analogues of the dual acetylcholinesterase inhibitor AP2238: synthesis and SAR 219
Benzophenones as xanthone-open model CYP11B1 inhibitors potentially useful for promoting wound healing 217
Targeting neuronal calcium channels and GSK3β for Alzheimer's disease with naturally-inspired Diels-Alder adducts 216
Versatility of the Curcumin Scaffold: Discovery of Potent and Balanced Dual BACE-1 and GSK-3β Inhibitors 215
Identification of chalcone-based antileishmanial agents targeting trypanothione reductase 212
Exploiting the chalcone scaffold to develop multifunctional agents for Alzheimer’s disease 212
Fatty Acid Amide Hydrolase (FAAH), Acetylcholinesterase (AChE), and Butyrylcholinesterase (BuChE): Networked Targets for the Development of Carbamates as Potential Anti-Alzheimer's Disease Agents 210
2-Arylbenzofuran-based molecules as multipotent Alzheimer's disease modifying agents 208
Identification of a new tamoxifen-xanthene hybrid as pro-apoptotic anticancer agent 207
Balanced dual acting compounds targeting aromatase and estrogen receptor α as an emerging therapeutic opportunity to counteract estrogen responsive breast cancer 203
SAR and binding mode at the h-AChE active site of pseudo-irreversible inhibitors related to Xanthostigmine 200
Extensive SAR and computational studies of 3-{4-[(benzylmethylamino)methyl]phenyl}-6,7-dimethoxy-2H-2-chromenone (AP2238) derivatives. 197
Benzophenone-based derivatives: A novel series of potent and selective dual inhibitors of acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation 197
Naturally inspired molecules as multifunctional agents for Alzheimer's disease treatment 196
Interplay Between Endocannabinoid System and Neurodegeneration: Focus on Polypharmacology 193
Cardiovascular profile of xanthone-based 1,4 dihydropyridines bearing a lidoflazine pharmacophore fragment 193
Curcumin-1,2,3-triazole conjugation for targeting the cancer apoptosis machinery. 191
Novel Curcumin-Diethyl Fumarate Hybrid as a Dualistic GSK-3β Inhibitor/Nrf2 Inducer for the Treatment of Parkinson's Disease 190
CHOLINESTERASE INHIBITORS: SAR AND ENZYME INHIBITORY ACTIVITY OF 3-[omega-(BENZYLMETHYLAMINO)ALKOXY]XANTHEN-9-ONES 186
Enantioselective nonsteroidal aromatase inhibitors identified through a multidisciplinary medicinal chemistry approach 180
Anthracene Based Compounds as New L-type Ca2+ Channel Blockers: Design, Synthesis, and Full Biological Profile 174
Polycyclic maleimide-based derivatives as first dual modulators of neuronal calcium channels and GSK-3β for Alzheimer's disease treatment 174
From the dual function lead AP2238 to AP2469, a multi-target-directed ligand for the treatment of Alzheimer’s disease 173
Lead optimization providing a series of flavone derivatives as potent nonsteroidal inhibitors of the cytochrome P450 aromatase enzyme 171
Homopterocarpanes as bridged triarylethylene analogues: synthesis and antagonistic effects in human MCF-7 breast cancer cells 171
Emerging targets in neurodegeneration: new opportunities for Alzheimer's disease treatment? 171
New Coumarin derivatives as cholinergic and cannabinoid system modulators 171
Nonsteroidal Aromatase inhibitors: synthesis and evaluation of new flavone derivatives 169
Multifaceted activity of polyciclic MDR revertant agents in drug-resistant leukemic cells: Role of the spacer 169
Derivati a struttura benzofenonica come inibitori dell'acetilcolinesterasi 167
Fluorinated benzophenone derivatives: balanced multipotent agents for Alzheimer's disease 166
Targeting Alzheimer’s disease: Novel indanone hybrids bearing a pharmacophoric fragment of AP2238 164
Design, synthesis, and evaluation of benzophenone derivatives as novel acetylcholinesterase inhibitors 162
Reconsidering Aromatase for Breast Cancer Treatment: New Roles for an Old Target 162
Antitumor profile of new phenothiazine derivatives 160
Multi-target-directed coumarin derivatives: hAChE and BAC1 inhibitors as potential anti-Alzheimer compounds 158
Characterization of Cholinesterase inhibitors by means of immobilized enzyme reactor 154
Naturally Inspired Coumarin Derivatives in Alzheimer’s Disease Drug Discovery: Latest Advances and Current Challenges 153
In vitro studies of flavon-8-acetic acid analogues 153
Benzophenone derivatives as Inhibitors of Acetylcholinesterase 153
Switching from Aromatase Inhibitors to Dual Targeting Flavonoid-Based Compounds for Breast Cancer Treatment 152
New derivatives of xanthenone-4-acetic acid: synthesis, pharmacological profile and effect on TNF-alpha and NO production by human immune cells 152
Studies on cytostatic and cytotoxic activity of new flavopiridol analogues 151
Phytoestrogens in postmenopause: the state of the art from a chemical, pharmacological and regulatory perspective 150
Functionalization of the chalcone scaffold for the discovery of novel lead compounds targeting fungal infections 150
In vitro biological activity of new analogues of flavon-8-acetic acid 149
Hybrid drugs for Alzheimer's disease: new indanone derivatives bearing a pharmacophoric fragment of AP2238 149
From AChE to BACE1 inhibitors: The role of the amine on the indanone scaffold 148
Curcumin derivatives as beta-secretase (BACE1) inhibitors. 146
Flavonoid-inspired vascular disrupting agents: Exploring flavone-8-acetic acid and derivatives in the new century 146
Design, Synthesis, and Biological and Crystallographic Evaluation of Novel Inhibitors ofPlasmodium falciparumEnoyl-ACP-reductase (PfFabI) 145
New potent P-glycoprotein inhibitors carrying a polycyclic scaffold 145
Multi-target strategy to address Alzheimer’s disease: Design, synthesis and biological evaluation of new tacrine-based dimers 145
Polycyclic Maleimide-based Scaffold as New Privileged Structure for Navigating the Cannabinoid System Opportunities 145
High-throughput screening of beta-secretase inhibitors by multiwell FRET assay 143
Targeting the Bacterial Membrane with a New Polycyclic Privileged Structure: A Powerful Tool To Face Staphylococcus aureus Infections 142
Hitting drug-resistant malaria infection with triazole-linked flavonoid–chloroquine hybrid compounds 139
Design of Multifunctional Compounds for Cardiovascular Disease: From Natural Scaffolds to “Classical” Multitarget Approach 137
Novel highly potent and selective nonsteroidal aromatase inhibitors: synthesis, biological evaluation and structure-activity relationships investigation 133
New potent inhibitors of cytochrome P450 aromatase 131
Chalcone-based carbamates for Alzheimer's disease treatment 129
The ability of coumarin-, flavanon- and flavonol-analogues of flavone acetic acid to stimulate human monocytes. 128
Imidazolylmethylxanthones as potent inhibitors of cytochrome P450 aromatase 128
Hybrid-Based Multi-Target Ligands for the Treatment of Alzheimer's Disease 126
Multidrug resistance reverting activity and antitumor profile of new phenothiazine derivatives 125
Coumarin derivatives as potential antitumor agents: Growth inhibition, apoptosis induction and multidrug resistance reverting activity 125
The first dual ChE/FAAH inhibitors: new perspectives for Alzheimer's disease? 124
null 123
Nonsteroidal aromatase inhibitors for the treatment of breast cancer: an update. 122
Modulation of Cytochromes P450 with Xanthone-Based Molecules: From Aromatase to Aldosterone Synthase and Steroid 11β-Hydroxylase Inhibition 121
Mono- or di-fluorinated analogues of Flavone-8-acetic acid: synthesis and in vitro biological activity 121
Tackling Alzheimer's Disease with Existing Drugs:A Promising Strategy for Bypassing Obstacles 120
null 118
Small-molecule inhibitors/modulators of amyloid-β peptide aggregation and toxicity for the treatment of Alzheimer's disease: a patent review (2010 – 2012) 112
null 105
Recent progress on curcumin-based therapeutics: a patent review (2012-2016). Part I: Curcumin 91
Recent progress on curcumin-based therapeutics: a patent review (2012-2016). Part II: curcumin derivatives in cancer and neurodegeneration 87
New approaches to the treatment of Alzheimer's disease. 85
null 82
null 79
3-(4-{[benzyl(methyl)amino]methyl}-phenyl)-6,7-dimethoxy-2H-2-chromenone (AP2238) inhibits both acetylcholinesterase and acetylcholinesterase-induced β-amyloid aggregation: A dual function lead for Alzheimer's disease therapy 78
null 76
Cardiovascular hybrid drugs: New benzazepinone derivatives as bradycardic agents endowed with selective β1-Non-competitive antagonism 75
Drifting of heme-coordinating group in imidazolylmethylxanthones leading to improved selective inhibition of CYP11B1 71
null 70
null 67
Acetylcholinesterase inhibitors: SAR and kinetic studies on ω-[N-methyl-N-(3-alkylcarbamoyloxyphenyl]methyl] aminoalkoxyaryl derivatives 66
Targeting Steroidogenic Cytochromes P450 (CYPs) with 6-Substituted 1-Imidazolylmethylxanthones 66
Synthesis and antitumor activity of new derivatives of xanthen-9-one-4-acetic acid 65
SAR of 9-amino-1,2,3-4-tetrahydroacridine-based acetylcholinesterase inhibitors: Synthesis, enzyme inhibitory activity, QSAR, and structure-based CoMFA of tacrine analogues 61
Synthesis and biological evaluation of 3-alkoxy analogues of flavone-8-acetic acid 60
null 58
Totale 15.508
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Categoria #
all - tutte 44.809
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 44.809
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021504 0 0 0 0 0 0 0 0 0 0 88 416
2021/20221.615 150 44 97 86 136 84 42 152 89 132 313 290
2022/20232.125 188 235 91 266 164 159 67 121 451 60 162 161
2023/2024592 37 84 35 67 52 172 32 32 10 22 23 26
2024/20252.267 68 339 244 104 520 116 176 52 53 160 94 341
2025/20265.168 647 451 521 385 595 282 506 186 1.015 396 184 0
Totale 16.267