CRIS Current Research Information System

RAMPA, ANGELA
 Distribuzione geografica
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Continente #
NA - Nord America 6.495
AS - Asia 5.510
EU - Europa 3.651
AF - Africa 311
SA - Sud America 275
OC - Oceania 12
Continente sconosciuto - Info sul continente non disponibili 3
Totale 16.257
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Nazione #
US - Stati Uniti d'America 6.380
VN - Vietnam 1.494
SG - Singapore 1.441
CN - Cina 1.377
GB - Regno Unito 812
IT - Italia 711
DE - Germania 497
HK - Hong Kong 363
SE - Svezia 324
IN - India 249
UA - Ucraina 240
FR - Francia 215
RU - Federazione Russa 208
BR - Brasile 179
NL - Olanda 132
IE - Irlanda 125
CI - Costa d'Avorio 101
JO - Giordania 99
JP - Giappone 98
ZA - Sudafrica 85
KR - Corea 83
CA - Canada 78
FI - Finlandia 75
BD - Bangladesh 63
TG - Togo 59
EE - Estonia 56
BG - Bulgaria 55
PH - Filippine 43
AR - Argentina 42
ID - Indonesia 35
PL - Polonia 30
SC - Seychelles 29
CH - Svizzera 28
ES - Italia 23
IR - Iran 23
TH - Thailandia 22
GR - Grecia 19
MX - Messico 19
AT - Austria 18
TR - Turchia 18
PK - Pakistan 17
IQ - Iraq 16
EC - Ecuador 15
BE - Belgio 14
CZ - Repubblica Ceca 14
HR - Croazia 14
CO - Colombia 13
TW - Taiwan 11
MY - Malesia 10
NG - Nigeria 10
AU - Australia 9
SA - Arabia Saudita 9
EG - Egitto 8
LB - Libano 7
PT - Portogallo 7
VE - Venezuela 7
CL - Cile 6
HU - Ungheria 6
LT - Lituania 6
KE - Kenya 5
MD - Moldavia 5
OM - Oman 5
PS - Palestinian Territory 5
RO - Romania 5
GT - Guatemala 4
KZ - Kazakistan 4
PE - Perù 4
PY - Paraguay 4
TN - Tunisia 4
AE - Emirati Arabi Uniti 3
ET - Etiopia 3
HN - Honduras 3
JM - Giamaica 3
NP - Nepal 3
NZ - Nuova Zelanda 3
RS - Serbia 3
UZ - Uzbekistan 3
A2 - ???statistics.table.value.countryCode.A2??? 2
AL - Albania 2
BO - Bolivia 2
BY - Bielorussia 2
CR - Costa Rica 2
DZ - Algeria 2
KW - Kuwait 2
LK - Sri Lanka 2
MA - Marocco 2
NO - Norvegia 2
UY - Uruguay 2
AM - Armenia 1
AO - Angola 1
AZ - Azerbaigian 1
BA - Bosnia-Erzegovina 1
BB - Barbados 1
CW - ???statistics.table.value.countryCode.CW??? 1
DO - Repubblica Dominicana 1
GH - Ghana 1
GI - Gibilterra 1
GY - Guiana 1
KG - Kirghizistan 1
KH - Cambogia 1
Totale 16.250
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Città #
Singapore 957
Southend 706
Ashburn 619
Fairfield 532
Chandler 516
San Jose 393
Santa Clara 373
Hong Kong 342
Ho Chi Minh City 313
Woodbridge 297
Hanoi 270
Dong Ket 251
Wilmington 249
Houston 245
Bologna 239
Seattle 239
Cambridge 206
Beijing 188
Hefei 185
Princeton 170
Ann Arbor 162
Jacksonville 151
Boardman 138
Dublin 125
New York 125
Council Bluffs 106
Abidjan 100
Amman 99
Los Angeles 86
Tokyo 83
Nanjing 79
Westminster 75
Seoul 73
Lauterbourg 70
Padova 64
Dallas 63
Helsinki 61
Buffalo 59
Lomé 59
Sofia 55
Berlin 51
Jinan 49
Da Nang 45
Bremen 43
Munich 41
Shenyang 41
San Diego 39
Haiphong 37
Saint Petersburg 37
Milan 32
Redmond 31
Guangzhou 30
Redondo Beach 30
Tianjin 28
Mülheim 27
Nanchang 27
Hebei 26
Frankfurt am Main 25
Jakarta 25
Quận Bình Thạnh 25
Shanghai 25
São Paulo 25
Bern 23
Changsha 23
Orem 22
Jiaxing 21
Warsaw 21
Phoenix 20
Chicago 19
Mahé 19
Medford 19
Zhengzhou 19
Bengaluru 18
Dearborn 18
Biên Hòa 17
Can Tho 17
Hải Dương 17
Johannesburg 17
Toronto 17
Boydton 16
Des Moines 16
Montreal 16
Nuremberg 16
Olalla 16
Venezia 16
Mountain View 15
Redwood City 15
Brussels 14
London 14
Atlanta 13
Brooklyn 13
The Dalles 13
Hangzhou 12
Turin 12
Verona 12
Kunming 11
Mexico City 11
Wuhan 11
Charlotte 10
Fremont 10
Totale 10.471
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Nome #
1,4-dihydropyridine derivatives as calcium channel modulators: the role of 3-methoxy-flavone moiety 354
Discovery of novel benzofuran-based compounds with neuroprotective and immunomodulatory properties for Alzheimer's disease treatment 342
Multitarget Strategy to Address Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and Computational Studies of Coumarin-Based Derivatives 297
Benzofuran-Based Hybrid Compounds for the Inhibition of Cholinesterase Activity, Abeta Amyloid Aggregation, and Abeta Neurotoxicity 286
Cholinesterase inhibitors: xanthostigmine derivatives blocking the acetylcholinesterase-induced beta-amyloid aggregation. 255
Structure-Activity Relationships and Binding Mode in the Human Acetylcholinesterase Active Site of Pseudo-Irreversible Inhibitors Related to Xanthostigmine 254
Progettazione e sintesi di derivati benzofuranici per la malattia di Alzheimer 242
Design, synthesis and biological profile of new inhibitors of multidrug resistance associated proteins carrying a polycyclic scaffold 227
Targeting neuronal calcium channels and GSK3β for Alzheimer's disease with naturally-inspired Diels-Alder adducts 225
Versatility of the Curcumin Scaffold: Discovery of Potent and Balanced Dual BACE-1 and GSK-3β Inhibitors 222
Analogues of the dual acetylcholinesterase inhibitor AP2238: synthesis and SAR 221
Identification of chalcone-based antileishmanial agents targeting trypanothione reductase 221
Benzophenones as xanthone-open model CYP11B1 inhibitors potentially useful for promoting wound healing 220
Balanced dual acting compounds targeting aromatase and estrogen receptor α as an emerging therapeutic opportunity to counteract estrogen responsive breast cancer 220
Fatty Acid Amide Hydrolase (FAAH), Acetylcholinesterase (AChE), and Butyrylcholinesterase (BuChE): Networked Targets for the Development of Carbamates as Potential Anti-Alzheimer's Disease Agents 217
Exploiting the chalcone scaffold to develop multifunctional agents for Alzheimer’s disease 215
Identification of a new tamoxifen-xanthene hybrid as pro-apoptotic anticancer agent 209
2-Arylbenzofuran-based molecules as multipotent Alzheimer's disease modifying agents 208
Extensive SAR and computational studies of 3-{4-[(benzylmethylamino)methyl]phenyl}-6,7-dimethoxy-2H-2-chromenone (AP2238) derivatives. 200
SAR and binding mode at the h-AChE active site of pseudo-irreversible inhibitors related to Xanthostigmine 200
Naturally inspired molecules as multifunctional agents for Alzheimer's disease treatment 199
Benzophenone-based derivatives: A novel series of potent and selective dual inhibitors of acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation 198
Interplay Between Endocannabinoid System and Neurodegeneration: Focus on Polypharmacology 195
Cardiovascular profile of xanthone-based 1,4 dihydropyridines bearing a lidoflazine pharmacophore fragment 193
Curcumin-1,2,3-triazole conjugation for targeting the cancer apoptosis machinery. 192
Novel Curcumin-Diethyl Fumarate Hybrid as a Dualistic GSK-3β Inhibitor/Nrf2 Inducer for the Treatment of Parkinson's Disease 192
CHOLINESTERASE INHIBITORS: SAR AND ENZYME INHIBITORY ACTIVITY OF 3-[omega-(BENZYLMETHYLAMINO)ALKOXY]XANTHEN-9-ONES 186
Enantioselective nonsteroidal aromatase inhibitors identified through a multidisciplinary medicinal chemistry approach 182
Anthracene Based Compounds as New L-type Ca2+ Channel Blockers: Design, Synthesis, and Full Biological Profile 177
From the dual function lead AP2238 to AP2469, a multi-target-directed ligand for the treatment of Alzheimer’s disease 177
New Coumarin derivatives as cholinergic and cannabinoid system modulators 175
Lead optimization providing a series of flavone derivatives as potent nonsteroidal inhibitors of the cytochrome P450 aromatase enzyme 174
Polycyclic maleimide-based derivatives as first dual modulators of neuronal calcium channels and GSK-3β for Alzheimer's disease treatment 174
Emerging targets in neurodegeneration: new opportunities for Alzheimer's disease treatment? 173
Nonsteroidal Aromatase inhibitors: synthesis and evaluation of new flavone derivatives 172
Homopterocarpanes as bridged triarylethylene analogues: synthesis and antagonistic effects in human MCF-7 breast cancer cells 172
Derivati a struttura benzofenonica come inibitori dell'acetilcolinesterasi 171
Fluorinated benzophenone derivatives: balanced multipotent agents for Alzheimer's disease 169
Multifaceted activity of polyciclic MDR revertant agents in drug-resistant leukemic cells: Role of the spacer 169
Antitumor profile of new phenothiazine derivatives 166
Design, synthesis, and evaluation of benzophenone derivatives as novel acetylcholinesterase inhibitors 166
Targeting Alzheimer’s disease: Novel indanone hybrids bearing a pharmacophoric fragment of AP2238 166
Multi-target-directed coumarin derivatives: hAChE and BAC1 inhibitors as potential anti-Alzheimer compounds 162
Reconsidering Aromatase for Breast Cancer Treatment: New Roles for an Old Target 162
Characterization of Cholinesterase inhibitors by means of immobilized enzyme reactor 158
New derivatives of xanthenone-4-acetic acid: synthesis, pharmacological profile and effect on TNF-alpha and NO production by human immune cells 156
In vitro studies of flavon-8-acetic acid analogues 155
Naturally Inspired Coumarin Derivatives in Alzheimer’s Disease Drug Discovery: Latest Advances and Current Challenges 154
Switching from Aromatase Inhibitors to Dual Targeting Flavonoid-Based Compounds for Breast Cancer Treatment 154
Studies on cytostatic and cytotoxic activity of new flavopiridol analogues 154
From AChE to BACE1 inhibitors: The role of the amine on the indanone scaffold 154
Hybrid drugs for Alzheimer's disease: new indanone derivatives bearing a pharmacophoric fragment of AP2238 154
Phytoestrogens in postmenopause: the state of the art from a chemical, pharmacological and regulatory perspective 154
Benzophenone derivatives as Inhibitors of Acetylcholinesterase 153
In vitro biological activity of new analogues of flavon-8-acetic acid 152
Functionalization of the chalcone scaffold for the discovery of novel lead compounds targeting fungal infections 151
Flavonoid-inspired vascular disrupting agents: Exploring flavone-8-acetic acid and derivatives in the new century 148
Multi-target strategy to address Alzheimer’s disease: Design, synthesis and biological evaluation of new tacrine-based dimers 147
Curcumin derivatives as beta-secretase (BACE1) inhibitors. 147
Polycyclic Maleimide-based Scaffold as New Privileged Structure for Navigating the Cannabinoid System Opportunities 147
Design, Synthesis, and Biological and Crystallographic Evaluation of Novel Inhibitors ofPlasmodium falciparumEnoyl-ACP-reductase (PfFabI) 146
Hitting drug-resistant malaria infection with triazole-linked flavonoid–chloroquine hybrid compounds 145
High-throughput screening of beta-secretase inhibitors by multiwell FRET assay 145
New potent P-glycoprotein inhibitors carrying a polycyclic scaffold 145
Targeting the Bacterial Membrane with a New Polycyclic Privileged Structure: A Powerful Tool To Face Staphylococcus aureus Infections 142
Design of Multifunctional Compounds for Cardiovascular Disease: From Natural Scaffolds to “Classical” Multitarget Approach 139
New potent inhibitors of cytochrome P450 aromatase 136
Novel highly potent and selective nonsteroidal aromatase inhibitors: synthesis, biological evaluation and structure-activity relationships investigation 133
The ability of coumarin-, flavanon- and flavonol-analogues of flavone acetic acid to stimulate human monocytes. 131
Imidazolylmethylxanthones as potent inhibitors of cytochrome P450 aromatase 129
Chalcone-based carbamates for Alzheimer's disease treatment 129
Coumarin derivatives as potential antitumor agents: Growth inhibition, apoptosis induction and multidrug resistance reverting activity 128
Multidrug resistance reverting activity and antitumor profile of new phenothiazine derivatives 127
Hybrid-Based Multi-Target Ligands for the Treatment of Alzheimer's Disease 126
The first dual ChE/FAAH inhibitors: new perspectives for Alzheimer's disease? 124
null 123
Tackling Alzheimer's Disease with Existing Drugs:A Promising Strategy for Bypassing Obstacles 123
Nonsteroidal aromatase inhibitors for the treatment of breast cancer: an update. 122
Mono- or di-fluorinated analogues of Flavone-8-acetic acid: synthesis and in vitro biological activity 122
Modulation of Cytochromes P450 with Xanthone-Based Molecules: From Aromatase to Aldosterone Synthase and Steroid 11β-Hydroxylase Inhibition 121
null 118
Small-molecule inhibitors/modulators of amyloid-β peptide aggregation and toxicity for the treatment of Alzheimer's disease: a patent review (2010 – 2012) 112
null 105
Recent progress on curcumin-based therapeutics: a patent review (2012-2016). Part I: Curcumin 93
Recent progress on curcumin-based therapeutics: a patent review (2012-2016). Part II: curcumin derivatives in cancer and neurodegeneration 93
SAR of 9-amino-1,2,3-4-tetrahydroacridine-based acetylcholinesterase inhibitors: Synthesis, enzyme inhibitory activity, QSAR, and structure-based CoMFA of tacrine analogues 89
New approaches to the treatment of Alzheimer's disease. 85
null 82
3-(4-{[benzyl(methyl)amino]methyl}-phenyl)-6,7-dimethoxy-2H-2-chromenone (AP2238) inhibits both acetylcholinesterase and acetylcholinesterase-induced β-amyloid aggregation: A dual function lead for Alzheimer's disease therapy 79
null 79
null 76
Cardiovascular hybrid drugs: New benzazepinone derivatives as bradycardic agents endowed with selective β1-Non-competitive antagonism 75
Drifting of heme-coordinating group in imidazolylmethylxanthones leading to improved selective inhibition of CYP11B1 74
null 70
Targeting Steroidogenic Cytochromes P450 (CYPs) with 6-Substituted 1-Imidazolylmethylxanthones 70
null 67
Acetylcholinesterase inhibitors: SAR and kinetic studies on ω-[N-methyl-N-(3-alkylcarbamoyloxyphenyl]methyl] aminoalkoxyaryl derivatives 66
Synthesis and antitumor activity of new derivatives of xanthen-9-one-4-acetic acid 66
Synthesis and biological evaluation of 3-alkoxy analogues of flavone-8-acetic acid 61
null 58
Totale 15.789
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Categoria #
all - tutte 46.863
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 46.863
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20221.615 150 44 97 86 136 84 42 152 89 132 313 290
2022/20232.125 188 235 91 266 164 159 67 121 451 60 162 161
2023/2024592 37 84 35 67 52 172 32 32 10 22 23 26
2024/20252.267 68 339 244 104 520 116 176 52 53 160 94 341
2025/20265.408 647 451 521 385 595 282 506 186 1.015 396 229 195
2026/202766 66 0 0 0 0 0 0 0 0 0 0 0
Totale 16.573