Two turmeric food powders (C1 and C2) were studied for curcuminoid content and their effects on the guinea pig intestinal tract in vitro. C1 contained a higher curcuminoid content than C2 (5.22% vs 2.31%). C1 and C2 increased gallbladder (~10%) and biliary smooth muscle tone (~15%), without affecting the sphincter of Oddi smooth muscle contractility. C2 was more effective than C1 in lowering ileum tone (–22% vs 􀀀 37%), whereas the reverse occurred in the colon (-50% vs 􀀀 20%). Standard Fast Fourier transforms and absolute powers analysis of the frequency bands highlighted that, in the bile duct, C2 induced contractions of higher variability and ampler oscillations of low-frequency waves. At the Oddi sphincter, C1 had a biphasic effect, increasing and then drastically decreasing the oscillations. The same occurred with C2 in the ileum, while both samples reduced the fluctuations in the colon.

Effects of turmeric powder on intestinal and biliary functions: The influence of curcuminoids concentration on spontaneous contractility

Budriesi, Roberta;Mandrioli, Mara;Tura, Matilde;Corazza, Ivan;Aldini, Rita;Mattioli, Laura Beatrice;Gallina Toschi, Tullia
2022

Abstract

Two turmeric food powders (C1 and C2) were studied for curcuminoid content and their effects on the guinea pig intestinal tract in vitro. C1 contained a higher curcuminoid content than C2 (5.22% vs 2.31%). C1 and C2 increased gallbladder (~10%) and biliary smooth muscle tone (~15%), without affecting the sphincter of Oddi smooth muscle contractility. C2 was more effective than C1 in lowering ileum tone (–22% vs 􀀀 37%), whereas the reverse occurred in the colon (-50% vs 􀀀 20%). Standard Fast Fourier transforms and absolute powers analysis of the frequency bands highlighted that, in the bile duct, C2 induced contractions of higher variability and ampler oscillations of low-frequency waves. At the Oddi sphincter, C1 had a biphasic effect, increasing and then drastically decreasing the oscillations. The same occurred with C2 in the ileum, while both samples reduced the fluctuations in the colon.
Micucci, Matteo; Budriesi, Roberta; Mandrioli, Mara; Tura, Matilde; Corazza, Ivan; Frosini, Maria; Aldini, Rita; Mattioli, Laura Beatrice; Gallina Toschi, Tullia
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/902851
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