We present a first catalogue of genetic variants influencing the porcine metabolome and an in silico reconstruction of metabolic pathways in two pig breeds: Large White and Duroc. For about 1300 pigs, targeted metabolomic profiles (186 metabolites each), were used for modelling metabolite relationships via Gaussian Graphical Models. Metabolic networks presented breed similarities as well as specific features. Coupling via genome scans the metabolomic and the genomic profiles (>60,000 variants each), we identified >50 DNA markers and >20 candidate genes controlling the plasma concentrations of about 40 metabolites. Overall, these results pointed out several similarities between the porcine and the human metabolism, that strength the usefulness of the pig as animal model. The obtained catalogue of genomic variants, in addition to the medium-high genomic heritability obtained for several metabolites (h2 >0.50-0.60), represents a relevant source of information for the use of metabolomic markers as intermediate phenotypes to explain more complex traits.
Bovo S., S.G. (2022). Unravelling the genetic basis governing the porcine metabolism [10.3920/978-90-8686-940-4].
Unravelling the genetic basis governing the porcine metabolism
Bovo S.;Schiavo G.;Fanelli F.;Ribani A.;Bertolini F.;Utzeri V. J.;Galimberti G.;Dall'Olio S.;Martelli P. L.;Casadio R.;Pagotto U.;Fontanesi L.
2022
Abstract
We present a first catalogue of genetic variants influencing the porcine metabolome and an in silico reconstruction of metabolic pathways in two pig breeds: Large White and Duroc. For about 1300 pigs, targeted metabolomic profiles (186 metabolites each), were used for modelling metabolite relationships via Gaussian Graphical Models. Metabolic networks presented breed similarities as well as specific features. Coupling via genome scans the metabolomic and the genomic profiles (>60,000 variants each), we identified >50 DNA markers and >20 candidate genes controlling the plasma concentrations of about 40 metabolites. Overall, these results pointed out several similarities between the porcine and the human metabolism, that strength the usefulness of the pig as animal model. The obtained catalogue of genomic variants, in addition to the medium-high genomic heritability obtained for several metabolites (h2 >0.50-0.60), represents a relevant source of information for the use of metabolomic markers as intermediate phenotypes to explain more complex traits.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
