Small cell neuroendocrine carcinoma is most frequently found in the lung (SCLC), but it has been also reported, albeit with a very low incidence, in the ovary. Here, we analyze a case of primary small cell carcinoma of the ovary of pulmonary type (SCCOPT), a rare and aggressive tumor with poor prognosis, whose biology and molecular features have not yet been thoroughly investigated. The patient affected by SCCOPT had a residual tumor following chemotherapy which displayed pronounced similarity with neuroendocrine tumors and lung cancer in terms of its microRNA expres- sion profile and mTOR-downstream activation. By analyzing the metabolic markers of the neoplastic lesion, we established a likely glycolytic signature. In conclusion, this in-depth characterization of SCCOPT could be useful for future diagnoses, possibly aided by microRNA profiling, allowing clinicians to adopt the most appropriate therapeutic strategy.

MicroRNA and Metabolic Profiling of a Primary Ovarian Neuroendocrine Carcinoma Pulmonary-Type Reveals a High Degree of Similarity with Small Cell Lung Cancer

Miglietta, Stefano;Girolimetti, Giulia;Marchio, Lorena;Sollazzo, Manuela;Laprovitera, Noemi;Coluccelli, Sara;De Biase, Dario;De Leo, Antonio;Kurelac, Ivana;Iommarini, Luisa;Ghelli, Anna;Campana, Davide;Ferracin, Manuela;Perrone, Anna Myriam;Gasparre, Giuseppe;Porcelli, Anna Maria
2022

Abstract

Small cell neuroendocrine carcinoma is most frequently found in the lung (SCLC), but it has been also reported, albeit with a very low incidence, in the ovary. Here, we analyze a case of primary small cell carcinoma of the ovary of pulmonary type (SCCOPT), a rare and aggressive tumor with poor prognosis, whose biology and molecular features have not yet been thoroughly investigated. The patient affected by SCCOPT had a residual tumor following chemotherapy which displayed pronounced similarity with neuroendocrine tumors and lung cancer in terms of its microRNA expres- sion profile and mTOR-downstream activation. By analyzing the metabolic markers of the neoplastic lesion, we established a likely glycolytic signature. In conclusion, this in-depth characterization of SCCOPT could be useful for future diagnoses, possibly aided by microRNA profiling, allowing clinicians to adopt the most appropriate therapeutic strategy.
Miglietta, Stefano; Girolimetti, Giulia; Marchio, Lorena; Sollazzo, Manuela; Laprovitera, Noemi; Coluccelli, Sara; De Biase, Dario; De Leo, Antonio; Santini, Donatella; Kurelac, Ivana; Iommarini, Luisa; Ghelli, Anna; Campana, Davide; Ferracin, Manuela; Perrone, Anna Myriam; Gasparre, Giuseppe; Porcelli, Anna Maria
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/894767
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