Differential diagnosis between primary progressive aphasia (PPA) and Alzheimer's disease (AD) could be difficult if based on clinical grounds alone. We evaluated the combination of proton MR spectroscopy of posterior cingulate cortex (PCC) and quantitative structural imaging asymmetries to differentiate PPA from AD patients. A greater left-lateralized temporo-parietal atrophy (higher accuracy for the PCC, 81.4%) and metabolic neurodegenerative changes in PCC (accuracy 76.8%) was demonstrated in PPA versus AD. The combined multiparametric approach increased the accuracy to 94%in the differential diagnosis between these two neurodegenerative diseases.
Mitolo M., Stanzani-Maserati M., Manners D.N., Capellari S., Testa C., Talozzi L., et al. (2021). The combination of metabolic posterior cingulate cortical abnormalities and structural asymmetries improves the differential diagnosis between primary progressive aphasia and alzheimer's disease. JOURNAL OF ALZHEIMER'S DISEASE, 82(4), 1467-1473 [10.3233/JAD-210211].
The combination of metabolic posterior cingulate cortical abnormalities and structural asymmetries improves the differential diagnosis between primary progressive aphasia and alzheimer's disease
Mitolo M.;Manners D. N.;Capellari S.;Testa C.;Talozzi L.;Evangelisti S.;Gramegna L. L.;Liguori R.;Lodi R.;Tonon C.
2021
Abstract
Differential diagnosis between primary progressive aphasia (PPA) and Alzheimer's disease (AD) could be difficult if based on clinical grounds alone. We evaluated the combination of proton MR spectroscopy of posterior cingulate cortex (PCC) and quantitative structural imaging asymmetries to differentiate PPA from AD patients. A greater left-lateralized temporo-parietal atrophy (higher accuracy for the PCC, 81.4%) and metabolic neurodegenerative changes in PCC (accuracy 76.8%) was demonstrated in PPA versus AD. The combined multiparametric approach increased the accuracy to 94%in the differential diagnosis between these two neurodegenerative diseases.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
