Hypoxia-inducible factor 1 alpha (HIF-1α) orchestrates cellular adaptation to low oxygen and nutrient-deprived environment and drives progression to malignancy in human solid cancers. Its canonical regulation involves prolyl hydroxylases (PHDs), which in normoxia induce degradation, whereas in hypoxia allow stabilization of HIF-1α. However, in certain circumstances, HIF-1α regulation goes beyond the actual external oxygen levels and involves PHD-independent mechanisms. Here, we gather and discuss the evidence on the non-canonical HIF-1α regulation, focusing in particular on the consequences of mitochondrial respiratory complexes damage on stabilization of this pleiotropic transcription factor.

Iommarini, L., Porcelli, A.M., Gasparre, G., Kurelac, I. (2017). Non-Canonical Mechanisms Regulating Hypoxia-Inducible Factor 1 Alpha in Cancer. FRONTIERS IN ONCOLOGY, 7, 1-9 [10.3389/fonc.2017.00286].

Non-Canonical Mechanisms Regulating Hypoxia-Inducible Factor 1 Alpha in Cancer

Iommarini, Luisa;Porcelli, Anna Maria;Gasparre, Giuseppe;Kurelac, Ivana
2017

Abstract

Hypoxia-inducible factor 1 alpha (HIF-1α) orchestrates cellular adaptation to low oxygen and nutrient-deprived environment and drives progression to malignancy in human solid cancers. Its canonical regulation involves prolyl hydroxylases (PHDs), which in normoxia induce degradation, whereas in hypoxia allow stabilization of HIF-1α. However, in certain circumstances, HIF-1α regulation goes beyond the actual external oxygen levels and involves PHD-independent mechanisms. Here, we gather and discuss the evidence on the non-canonical HIF-1α regulation, focusing in particular on the consequences of mitochondrial respiratory complexes damage on stabilization of this pleiotropic transcription factor.
2017
Iommarini, L., Porcelli, A.M., Gasparre, G., Kurelac, I. (2017). Non-Canonical Mechanisms Regulating Hypoxia-Inducible Factor 1 Alpha in Cancer. FRONTIERS IN ONCOLOGY, 7, 1-9 [10.3389/fonc.2017.00286].
Iommarini, Luisa; Porcelli, Anna Maria; Gasparre, Giuseppe; Kurelac, Ivana
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/613931
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