Novel 4-alkylidene-beta-lactams with a polyphenolic side chain were synthesized and evaluated as radical scavengers. We have undertaken a detailed study of the antioxidant activity in vitro with chemical and biological testing of the new beta-lactams and of the corresponding methyl polyhydroxy benzoates. Antioxidant activity of beta-lactams and methyl benzoates was measured with the Briggs-Rauscher oscillating reaction, the TEAC (Trolox((R)) Equivalent Antioxidant Capacity) assay, and as ability to inhibit ROS (=Reactive Oxygen Species) production on myoblast H9c2 cells. The results were discussed with regard to mechanism and correlated with structural parameters.
Cainelli G., Angeloni C., Cervellati R., Galletti P., Giacomini D., Hrelia S., et al. (2008). New Polyphenolic-Beta-Lactams with Antioxidant Activity. CHEMISTRY & BIODIVERSITY, 5, 811-829 [10.1002/cbdv.200890077].
New Polyphenolic-Beta-Lactams with Antioxidant Activity.
CAINELLI, GIANFRANCO;ANGELONI, CRISTINA;CERVELLATI, RINALDO;GALLETTI, PAOLA;GIACOMINI, DARIA;HRELIA, SILVANA;SINISI, RICCARDO
2008
Abstract
Novel 4-alkylidene-beta-lactams with a polyphenolic side chain were synthesized and evaluated as radical scavengers. We have undertaken a detailed study of the antioxidant activity in vitro with chemical and biological testing of the new beta-lactams and of the corresponding methyl polyhydroxy benzoates. Antioxidant activity of beta-lactams and methyl benzoates was measured with the Briggs-Rauscher oscillating reaction, the TEAC (Trolox((R)) Equivalent Antioxidant Capacity) assay, and as ability to inhibit ROS (=Reactive Oxygen Species) production on myoblast H9c2 cells. The results were discussed with regard to mechanism and correlated with structural parameters.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
