Novel 4-alkylidene-beta-lactams with a polyphenolic side chain were synthesized and evaluated as radical scavengers. We have undertaken a detailed study of the antioxidant activity in vitro with chemical and biological testing of the new beta-lactams and of the corresponding methyl polyhydroxy benzoates. Antioxidant activity of beta-lactams and methyl benzoates was measured with the Briggs-Rauscher oscillating reaction, the TEAC (Trolox((R)) Equivalent Antioxidant Capacity) assay, and as ability to inhibit ROS (=Reactive Oxygen Species) production on myoblast H9c2 cells. The results were discussed with regard to mechanism and correlated with structural parameters.
New Polyphenolic-Beta-Lactams with Antioxidant Activity / Cainelli G.; Angeloni C.; Cervellati R.; Galletti P.; Giacomini D.; Hrelia S.; Sinisi R.. - In: CHEMISTRY & BIODIVERSITY. - ISSN 1612-1872. - STAMPA. - 5:(2008), pp. 811-829. [10.1002/cbdv.200890077]
New Polyphenolic-Beta-Lactams with Antioxidant Activity.
CAINELLI, GIANFRANCO;ANGELONI, CRISTINA;CERVELLATI, RINALDO;GALLETTI, PAOLA;GIACOMINI, DARIA;HRELIA, SILVANA;SINISI, RICCARDO
2008
Abstract
Novel 4-alkylidene-beta-lactams with a polyphenolic side chain were synthesized and evaluated as radical scavengers. We have undertaken a detailed study of the antioxidant activity in vitro with chemical and biological testing of the new beta-lactams and of the corresponding methyl polyhydroxy benzoates. Antioxidant activity of beta-lactams and methyl benzoates was measured with the Briggs-Rauscher oscillating reaction, the TEAC (Trolox((R)) Equivalent Antioxidant Capacity) assay, and as ability to inhibit ROS (=Reactive Oxygen Species) production on myoblast H9c2 cells. The results were discussed with regard to mechanism and correlated with structural parameters.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
