Borderline ovarian tumors are rare low malignant potential neoplasms characterized by the absence of stromal invasion, whose main prognostic factors are stage and type of peritoneal implants. The latter are defined as invasive when cell proliferation invades the underlying tissue (peritoneal surface, omentum and intestinal wall), or noninvasive. It is still unknown if these implants are metastatic spread from the primary ovarian mass or a neoplastic transformation de novo of the peritoneal surface. Mitochondrial DNA sequencing was performed to assess clonality in eight patients presenting both borderline ovarian tumors and implants. In 37.5% of the cases, the same mitochondrial DNA mutation was present in both borderline ovarian tumors and the peritoneal implant, being this evidence that implants may arise as a consequence of a spread from a single ovarian site.

Mitochondrial DNA sequencing demonstrates clonality of peritoneal implants of borderline ovarian tumors

GIROLIMETTI, GIULIA;DE IACO, PIERANDREA;PROCACCINI, MARTINA;PANZACCHI, RICCARDO;KURELAC, IVANA;DONDI, GIULIA;CAPRARA, GIACOMO;CECCARELLI, CLAUDIO;PORCELLI, ANNA MARIA;PERRONE, ANNA MYRIAM;GASPARRE, GIUSEPPE
2017

Abstract

Borderline ovarian tumors are rare low malignant potential neoplasms characterized by the absence of stromal invasion, whose main prognostic factors are stage and type of peritoneal implants. The latter are defined as invasive when cell proliferation invades the underlying tissue (peritoneal surface, omentum and intestinal wall), or noninvasive. It is still unknown if these implants are metastatic spread from the primary ovarian mass or a neoplastic transformation de novo of the peritoneal surface. Mitochondrial DNA sequencing was performed to assess clonality in eight patients presenting both borderline ovarian tumors and implants. In 37.5% of the cases, the same mitochondrial DNA mutation was present in both borderline ovarian tumors and the peritoneal implant, being this evidence that implants may arise as a consequence of a spread from a single ovarian site.
2017
Girolimetti, Giulia; De Iaco, Pierandrea; Procaccini, Martina; Panzacchi, Riccardo; Kurelac, Ivana; Amato, Laura Benedetta; Dondi, Giulia; Caprara, Giacomo; Ceccarelli, Claudio; Santini, Donatella; Porcelli, Anna Maria; Perrone, Anna Myriam; Gasparre, Giuseppe
File in questo prodotto:
File Dimensione Formato  
Mol Cancer - GG.pdf

accesso aperto

Tipo: Versione (PDF) editoriale
Licenza: Licenza per Accesso Aperto. Creative Commons Attribuzione (CCBY)
Dimensione 810.04 kB
Formato Adobe PDF
810.04 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/579335
Citazioni
  • ???jsp.display-item.citation.pmc??? 9
  • Scopus 11
  • ???jsp.display-item.citation.isi??? 9
social impact