GHELLI, ANNA MARIA
GHELLI, ANNA MARIA
DIPARTIMENTO DI FARMACIA E BIOTECNOLOGIE
Docenti di ruolo di IIa fascia
Mitochondrial chaperonin DNAJC15 promotes vulnerability to ferroptosis of chemoresistant ovarian cancer cells
2025 Miglietta, Stefano; Sollazzo, Manuela; Gherardi, Iacopo; Milioni, Sara; Cavina, Beatrice; Marchio, Lorena; De Luise, Monica; Coada, Camelia Alexandra; Fiorillo, Marco; Perrone, Anna Myriam; Kurelac, Ivana; Gasparre, Giuseppe; Iommarini, Luisa; Ghelli, Anna Maria; Porcelli, Anna Maria
A computational study to assess the pathogenicity of single or combinations of missense variants on respiratory complex I
2024 Rigobello L.; Lugli F.; Caporali L.; Bartocci A.; Fadanni J.; Zerbetto F.; Iommarini L.; Carelli V.; Ghelli A.M.; Musiani F.
Biochemical and computational approaches to dissect the effect of MT-CYB pathogenic mutations on respiratory chain activity and assembly
2024 Tioli, G; Musiani, F; Iommarini, L; Porcelli, Am; Carelli, V; Ghelli, Am
Genetic variants affecting NQO1 protein levels impact the efficacy of idebenone treatment in Leber hereditary optic neuropathy
2024 Aleo S.J.; Del Dotto V.; Romagnoli M.; Fiorini C.; Capirossi G.; Peron C.; Maresca A.; Caporali L.; Capristo M.; Tropeano C.V.; Zanna C.; Ross-Cisneros F.N.; Sadun A.A.; Pignataro M.G.; Giordano C.; Fasano C.; Cavaliere A.; Porcelli A.M.; Tioli G.; Musiani F.; Catania A.; Lamperti C.; Marzoli S.B.; De Negri A.; Cascavilla M.L.; Battista M.; Barboni P.; Carbonelli M.; Amore G.; La Morgia C.; Smirnov D.; Vasilescu C.; Farzeen A.; Blickhaeuser B.; Prokisch H.; Priglinger C.; Livonius B.; Catarino C.B.; Klopstock T.; Tiranti V.; Carelli V.; Ghelli A.M.
Mitochondrial Chaperonin MCJ Promotes Vulnerability to Ferroptosis of Chemoresistant Ovarian Cancer Cells – Dataset
2024 Stefano Miglietta; Manuela Sollazzo; Iacopo Gherardi; Sara Milioni; Beatrice Cavina; Lorena Marchio; Monica De Luise; Camelia Alexandra Coada; Marco Fiorillo; Anna Myriam Perrone; Ivana Kurelac; Giuseppe Gasparre; Luisa Iommarini; Anna Maria Ghelli; Anna Maria Porcelli
Respiratory complex I deficiency triggers OMA1-mediated integrated stress response and affects lipid homeostasis during glucose restriction
2024 Milioni, S; Sollazzo, M; Zanna, C; Kurelac, I; Tartagni, O; Gherardi, I; Ghelli, Am; Filho, Adc; Schulze, A; Gasparre, G; Porcelli, Am; Iommarini, L
Use of bacterial photosynthetic vesicles to evaluate the effect of ionic liquids on the permeability of biological membranes
2024 Bin, Tancredi; Venturoli, Giovanni; Ghelli, Anna Maria; Francia, Francesco
Inducing respiratory complex I impairment elicits an increase in PGC1α in ovarian cancer
2022 De Luise, Monica; Sollazzo, Manuela; Lama, Eleonora; Coadă, Camelia Alexandra; Bressi, Licia; Iorio, Maria; Cavina, Beatrice; D’Angelo, Luigi; Milioni, Sara; Marchio, Lorena; Miglietta, Stefano; Coluccelli, Sara; Tedesco, Greta; Ghelli, Anna; Lemma, Silvia; Perrone, Anna Myriam; Kurelac, Ivana; Iommarini, Luisa; Porcelli, Anna Maria; Gasparre, Giuseppe
MCJ/DNAJC15 mitochondrial chaperone as a metabolic “balance needle” in ovarian cancer chemoresistance
2022 Stefano Miglietta, Manuela Sollazzo, Lorena Marchio, Iacopo Gherardi, Sara Milioni, Luisa Iommarini, Ivana Kurelac, Anna Maria Ghelli, Giuseppe Gasparre, Anna Maria Porcelli
MicroRNA and Metabolic Profiling of a Primary Ovarian Neuroendocrine Carcinoma Pulmonary-Type Reveals a High Degree of Similarity with Small Cell Lung Cancer
2022 Miglietta, Stefano; Girolimetti, Giulia; Marchio, Lorena; Sollazzo, Manuela; Laprovitera, Noemi; Coluccelli, Sara; De Biase, Dario; De Leo, Antonio; Santini, Donatella; Kurelac, Ivana; Iommarini, Luisa; Ghelli, Anna; Campana, Davide; Ferracin, Manuela; Perrone, Anna Myriam; Gasparre, Giuseppe; Porcelli, Anna Maria
NDUFS3 knockout cancer cells and molecular docking reveal specificity and mode of action of anti-cancer respiratory complex I inhibitors
2022 Kurelac, Ivana; Cavina, Beatrice; Sollazzo, Manuela; Miglietta, Stefano; Fornasa, Agnese; De Luise, Monica; Iorio, Maria; Lama, Eleonora; Traversa, Daniele; Nasiri, Hamid Razi; Ghelli, Anna; Musiani, Francesco; Porcelli, Anna Maria; Iommarini, Luisa; Gasparre, Giuseppe
New Insights on Rotenone Resistance of Complex I Induced by the m.11778G>A/MT-ND4 Mutation Associated with Leber’s Hereditary Optic Neuropathy
2022 Musiani F.; Rigobello L.; Iommarini L.; Carelli V.; Esposti M.D.; Ghelli A.M.
Respiratory complex I null cancer cells and molecular docking reveal specificity and mode of action inhibitors with anticancer activity
2022 Iommarini, Luisa; Kurelac, Ivana; Cavina, Beatrice; Fornasa, Agnese; Traversa, Daniele; Iorio, Maria; Sollazzo, Manuela; De Luise, Monica; Lama, Eleonora; Nasiri, Hamid Razi; Ghelli, Anna; Musiani, Francesco; Gasparre, Giuseppe; Porcelli, Anna Maria
Duplexing complexome profiling with SILAC to study human respiratory chain assembly defects
2021 Palenikova P.; Harbour M.E.; Prodi F.; Minczuk M.; Zeviani M.; Ghelli A.; Fernandez-Vizarra E.
Organization of the respiratory supercomplexes in cells with defective complex III: Structural features and metabolic consequences
2021 Rugolo M.; Zanna C.; Ghelli A.M.
Drug repositioning as a therapeutic strategy for neurodegenerations associated with OPA1 mutations
2020 Aleo, Serena J; Del Dotto, Valentina; Fogazza, Mario; Maresca, Alessandra; Lodi, Tiziana; Goffrini, Paola; Ghelli, Anna; Rugolo, Michela; Carelli, Valerio; Baruffini, Enrico; Zanna, Claudia
Exogenous peptides are able to penetrate human cell and mitochondrial membranes, stabilize mitochondrial tRNA structures, and rescue severe mitochondrial defects
2020 Perli, Elena; Pisano, Annalinda; Pignataro, Maria Gemma; Campese, Antonio Francesco; Pelullo, Maria; Genovese, Ilaria; de Turris, Valeria; Ghelli, Anna Maria; Cerbelli, Bruna; Giordano, Carla; Colotti, Gianni; Morea, Veronica; d'Amati, Giulia
Fine-tuning of the respiratory complexes stability and supercomplexes assembly in cells defective of complex III
2020 Tropeano C.V.; Aleo S.J.; Zanna C.; Roberti M.; Scandiffio L.; Loguercio Polosa P.; Fiori J.; Porru E.; Roda A.; Carelli V.; Steimle S.; Daldal F.; Rugolo M.; Ghelli A.
Metabolomics hallmarks OPA1 variants correlating with their in-vitro phenotype and predicting clinical severity
2020 Barca, Juan Manuel Chao; Fogazza, Mario; Rugolo, Michela; Chupin, Stéphanie; Del Dotto, Valentina; Ghelli, Anna Maria; Carelli, Valerio; Simard, Gilles; Procaccio, Vincent; Bonneau, Dominique; Lenaers, Guy; Reynier, Pascal; Zanna, Claudia
Methods and models for functional studies on mtDNA mutations
2020 Iommarini, L.; Ghelli, A.; Diaz, F.
| Titolo | Autore(i) | Anno | Periodico | Editore | Tipo | File |
|---|---|---|---|---|---|---|
| Mitochondrial chaperonin DNAJC15 promotes vulnerability to ferroptosis of chemoresistant ovarian cancer cells | Miglietta, Stefano; Sollazzo, Manuela; Gherardi, Iacopo; Milioni, Sara; Cavina, Beatrice; Marchio..., Lorena; De Luise, Monica; Coada, Camelia Alexandra; Fiorillo, Marco; Perrone, Anna Myriam; Kurelac, Ivana; Gasparre, Giuseppe; Iommarini, Luisa; Ghelli, Anna Maria; Porcelli, Anna Maria | 2025-01-01 | OPEN BIOLOGY | - | 1.01 Articolo in rivista | - |
| A computational study to assess the pathogenicity of single or combinations of missense variants on respiratory complex I | Rigobello L.; Lugli F.; Caporali L.; Bartocci A.; Fadanni J.; Zerbetto F.; Iommarini L.; Carelli ...V.; Ghelli A.M.; Musiani F. | 2024-01-01 | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | - | 1.01 Articolo in rivista | 92_2024_Rigobello_IntJBiolMacromol_compressed (1).pdf; 1-s2.0-S0141813024038911-mmc1.pdf |
| Biochemical and computational approaches to dissect the effect of MT-CYB pathogenic mutations on respiratory chain activity and assembly | Tioli, G; Musiani, F; Iommarini, L; Porcelli, Am; Carelli, V; Ghelli, Am | 2024-01-01 | BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS | - | 1.06 Abstract in rivista | - |
| Genetic variants affecting NQO1 protein levels impact the efficacy of idebenone treatment in Leber hereditary optic neuropathy | Aleo S.J.; Del Dotto V.; Romagnoli M.; Fiorini C.; Capirossi G.; Peron C.; Maresca A.; Caporali L....; Capristo M.; Tropeano C.V.; Zanna C.; Ross-Cisneros F.N.; Sadun A.A.; Pignataro M.G.; Giordano C.; Fasano C.; Cavaliere A.; Porcelli A.M.; Tioli G.; Musiani F.; Catania A.; Lamperti C.; Marzoli S.B.; De Negri A.; Cascavilla M.L.; Battista M.; Barboni P.; Carbonelli M.; Amore G.; La Morgia C.; Smirnov D.; Vasilescu C.; Farzeen A.; Blickhaeuser B.; Prokisch H.; Priglinger C.; Livonius B.; Catarino C.B.; Klopstock T.; Tiranti V.; Carelli V.; Ghelli A.M. | 2024-01-01 | CELL REPORTS MEDICINE | - | 1.01 Articolo in rivista | 2024 - Aleo - Idebenone and NQO1 - Cell reports Medicine.pdf |
| Mitochondrial Chaperonin MCJ Promotes Vulnerability to Ferroptosis of Chemoresistant Ovarian Cancer Cells – Dataset | Stefano Miglietta; Manuela Sollazzo; Iacopo Gherardi; Sara Milioni; Beatrice Cavina; Lorena March...io; Monica De Luise; Camelia Alexandra Coada; Marco Fiorillo; Anna Myriam Perrone; Ivana Kurelac; Giuseppe Gasparre; Luisa Iommarini; Anna Maria Ghelli; Anna Maria Porcelli | 2024-01-01 | - | - | 7.05 Banche dati | - |
| Respiratory complex I deficiency triggers OMA1-mediated integrated stress response and affects lipid homeostasis during glucose restriction | Milioni, S; Sollazzo, M; Zanna, C; Kurelac, I; Tartagni, O; Gherardi, I; Ghelli, Am; Filho, Adc; ...Schulze, A; Gasparre, G; Porcelli, Am; Iommarini, L | 2024-01-01 | BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS | - | 1.06 Abstract in rivista | - |
| Use of bacterial photosynthetic vesicles to evaluate the effect of ionic liquids on the permeability of biological membranes | Bin, Tancredi; Venturoli, Giovanni; Ghelli, Anna Maria; Francia, Francesco | 2024-01-01 | BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | - | 1.01 Articolo in rivista | BBAbiomembranesIonicLiquids2024.pdf |
| Inducing respiratory complex I impairment elicits an increase in PGC1α in ovarian cancer | De Luise, Monica; Sollazzo, Manuela; Lama, Eleonora; Coadă, Camelia Alexandra; Bressi, Licia; Ior...io, Maria; Cavina, Beatrice; D’Angelo, Luigi; Milioni, Sara; Marchio, Lorena; Miglietta, Stefano; Coluccelli, Sara; Tedesco, Greta; Ghelli, Anna; Lemma, Silvia; Perrone, Anna Myriam; Kurelac, Ivana; Iommarini, Luisa; Porcelli, Anna Maria; Gasparre, Giuseppe | 2022-01-01 | SCIENTIFIC REPORTS | - | 1.01 Articolo in rivista | Sci Rep.pdf; 41598_2022_11620_MOESM1_ESM.pdf |
| MCJ/DNAJC15 mitochondrial chaperone as a metabolic “balance needle” in ovarian cancer chemoresistance | Stefano Miglietta, Manuela Sollazzo, Lorena Marchio, Iacopo Gherardi, Sara Milioni, Luisa Iommari...ni, Ivana Kurelac, Anna Maria Ghelli, Giuseppe Gasparre, Anna Maria Porcelli | 2022-01-01 | - | - | 4.01 Contributo in Atti di convegno | - |
| MicroRNA and Metabolic Profiling of a Primary Ovarian Neuroendocrine Carcinoma Pulmonary-Type Reveals a High Degree of Similarity with Small Cell Lung Cancer | Miglietta, Stefano; Girolimetti, Giulia; Marchio, Lorena; Sollazzo, Manuela; Laprovitera, Noemi; ...Coluccelli, Sara; De Biase, Dario; De Leo, Antonio; Santini, Donatella; Kurelac, Ivana; Iommarini, Luisa; Ghelli, Anna; Campana, Davide; Ferracin, Manuela; Perrone, Anna Myriam; Gasparre, Giuseppe; Porcelli, Anna Maria | 2022-01-01 | NON-CODING RNA | - | 1.01 Articolo in rivista | NcRNA.pdf |
| NDUFS3 knockout cancer cells and molecular docking reveal specificity and mode of action of anti-cancer respiratory complex I inhibitors | Kurelac, Ivana; Cavina, Beatrice; Sollazzo, Manuela; Miglietta, Stefano; Fornasa, Agnese; De Luis...e, Monica; Iorio, Maria; Lama, Eleonora; Traversa, Daniele; Nasiri, Hamid Razi; Ghelli, Anna; Musiani, Francesco; Porcelli, Anna Maria; Iommarini, Luisa; Gasparre, Giuseppe | 2022-01-01 | OPEN BIOLOGY | - | 1.01 Articolo in rivista | rsob.220198.pdf |
| New Insights on Rotenone Resistance of Complex I Induced by the m.11778G>A/MT-ND4 Mutation Associated with Leber’s Hereditary Optic Neuropathy | Musiani F.; Rigobello L.; Iommarini L.; Carelli V.; Esposti M.D.; Ghelli A.M. | 2022-01-01 | MOLECULES | - | 1.01 Articolo in rivista | molecules-27-01341.pdf; molecules-27-01341-s001.zip |
| Respiratory complex I null cancer cells and molecular docking reveal specificity and mode of action inhibitors with anticancer activity | Iommarini, Luisa; Kurelac, Ivana; Cavina, Beatrice; Fornasa, Agnese; Traversa, Daniele; Iorio, Ma...ria; Sollazzo, Manuela; De Luise, Monica; Lama, Eleonora; Nasiri, Hamid Razi; Ghelli, Anna; Musiani, Francesco; Gasparre, Giuseppe; Porcelli, Anna Maria | 2022-01-01 | BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS | - | 4.02 Riassunto (Abstract) | - |
| Duplexing complexome profiling with SILAC to study human respiratory chain assembly defects | Palenikova P.; Harbour M.E.; Prodi F.; Minczuk M.; Zeviani M.; Ghelli A.; Fernandez-Vizarra E. | 2021-01-01 | BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS | - | 1.01 Articolo in rivista | 2021 - Palenikova - BBA-Bioenerg.pdf; Microsoft Word - SILAC-CP_Supplementary_Figs_Final.docx.pdf |
| Organization of the respiratory supercomplexes in cells with defective complex III: Structural features and metabolic consequences | Rugolo M.; Zanna C.; Ghelli A.M. | 2021-01-01 | LIFE | - | 1.01 Articolo in rivista | 2021 - Rugolo et al - Review CIII and SCs.pdf |
| Drug repositioning as a therapeutic strategy for neurodegenerations associated with OPA1 mutations | Aleo, Serena J; Del Dotto, Valentina; Fogazza, Mario; Maresca, Alessandra; Lodi, Tiziana; Goffrin...i, Paola; Ghelli, Anna; Rugolo, Michela; Carelli, Valerio; Baruffini, Enrico; Zanna, Claudia | 2020-01-01 | HUMAN MOLECULAR GENETICS | - | 1.01 Articolo in rivista | 2021 - Aleo et al HMG.pdf; supplementary_material_19-10-20_ddaa244.docx |
| Exogenous peptides are able to penetrate human cell and mitochondrial membranes, stabilize mitochondrial tRNA structures, and rescue severe mitochondrial defects | Perli, Elena; Pisano, Annalinda; Pignataro, Maria Gemma; Campese, Antonio Francesco; Pelullo, Mar...ia; Genovese, Ilaria; de Turris, Valeria; Ghelli, Anna Maria; Cerbelli, Bruna; Giordano, Carla; Colotti, Gianni; Morea, Veronica; d'Amati, Giulia | 2020-01-01 | THE FASEB JOURNAL | - | 1.01 Articolo in rivista | 2020 - Perli - Exogenous peptides and tRNA mitochondrial defects - FASEB J.pdf; fsb220504-sup-0006-figs6.tif; fsb220504-sup-0003-figs3.tif; fsb220504-sup-0004-figs4.tif; fsb220504-sup-0005-figs5.tif; fsb220504-sup-0002-figs2.tif |
| Fine-tuning of the respiratory complexes stability and supercomplexes assembly in cells defective of complex III | Tropeano C.V.; Aleo S.J.; Zanna C.; Roberti M.; Scandiffio L.; Loguercio Polosa P.; Fiori J.; Por...ru E.; Roda A.; Carelli V.; Steimle S.; Daldal F.; Rugolo M.; Ghelli A. | 2020-01-01 | BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS | - | 1.01 Articolo in rivista | Fine-tuning of the respiratory complexes stability and supercomplexes assembly in cells defective of complex III.pdf |
| Metabolomics hallmarks OPA1 variants correlating with their in-vitro phenotype and predicting clinical severity | Barca, Juan Manuel Chao; Fogazza, Mario; Rugolo, Michela; Chupin, Stéphanie; Del Dotto, Valentina...; Ghelli, Anna Maria; Carelli, Valerio; Simard, Gilles; Procaccio, Vincent; Bonneau, Dominique; Lenaers, Guy; Reynier, Pascal; Zanna, Claudia | 2020-01-01 | HUMAN MOLECULAR GENETICS ONLINE | - | 1.01 Articolo in rivista | Metabolomics hallmarks OPA1 variants correlating with their in-vitro phenotype and predicting clinical severity.pdf |
| Methods and models for functional studies on mtDNA mutations | Iommarini, L.; Ghelli, A.; Diaz, F. | 2020-01-01 | - | Elsevier | 2.01 Capitolo / saggio in libro | - |