Sfoglia per Autore
A novel class of multitarget anti-Alzheimer benzohomoadamantane‒chlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors
2019 Perez-Areales F.J.; Turcu A.L.; Barniol-Xicota M.; Pont C.; Pivetta D.; Espargaro A.; Bartolini M.; De Simone A.; Andrisano V.; Perez B.; Sabate R.; Sureda F.X.; Vazquez S.; Munoz-Torrero D.
Investigating in vitro amyloid peptide 1−42 aggregation: Impact of higher molecular weight stable adducts
2019 De Simone A.; Naldi M.; Tedesco D.; Milelli A.; Bartolini M.; Davani L.; Widera D.; Dallas M.L.; Andrisano V.
Amaryllidaceae alkaloids from Narcissus pseudonarcissus L. cv. Dutch Master as potential drugs in treatment of Alzheimer's disease
2019 Hulcova D.; Marikova J.; Korabecny J.; Hostalkova A.; Jun D.; Kunes J.; Chlebek J.; Opletal L.; De Simone A.; Novakova L.; Andrisano V.; Ruzicka A.; Cahlikova L.
Pyridinylimidazoles as GSK3β Inhibitors: The Impact of Tautomerism on Compound Activity via Water Networks
2019 Heider F.; Pantsar T.; Kudolo M.; Ansideri F.; De Simone A.; Pruccoli L.; Schneider T.; Goettert M.I.; Tarozzi A.; Andrisano V.; Laufer S.A.; Koch P.
Discovery of the First-in-Class GSK-3β/HDAC Dual Inhibitor as Disease-Modifying Agent To Combat Alzheimer's Disease.
2019 De Simone A, La Pietra V, Betari N, Petragnani N, Conte M, Daniele S, Pietrobono D, Martini C, Petralla S, Casadei R, Davani L, Frabetti F, Russomanno P, Novellino E, Montanari S, Tumiatti V, Ballerini P, Sarno F, Nebbioso A, Altucci L, Monti B, Andrisano V, Milelli A.
Histone Deacetylase Inhibitors as Multitarget Ligands: New Players in Alzheimer's Disease Drug Discovery?
2019 De Simone Angela; Milelli Andrea
Immobilized Enzyme Reactors: an Overview of Applications in Drug Discovery from 2008 to 2018
2019 De Simone, Angela*; Naldi, Marina; Bartolini, Manuela; Davani, Lara; Andrisano, Vincenza
Correction: Discovery of the First-in-Class GSK-3β/HDAC Dual Inhibitor as Disease-Modifying Agent to Combat Alzheimer's Disease (ACS Medicinal Chemistry Letters (2019) 10: 4 (469−474) DOI: 10.1021/acsmedchemlett.8b00507)
2019 De Simone A.; La Pietra V.; Betari N.; Petragnani N.; Conte M.; Daniele S.; Pietrobono D.; Martini C.; Petralla S.; Casadei R.; Davani L.; Frabetti F.; Russomanno P.; Novellino E.; Montanari S.; Tumiatti V.; Ballerini P.; Sarno F.; Nebbioso A.; Altucci L.; Monti B.; Andrisano V.; Milelli A.
Advanced analytical methodologies in Alzheimer's disease drug discovery
2020 De Simone A.; Naldi M.; Tedesco D.; Bartolini M.; Davani L.; Andrisano V.
Functionalized aromatic esters of the Amaryllidaceae alkaloid haemanthamine and their in vitro and in silico biological activity connected to Alzheimer's disease
2020 Rozálie Peřinová; Negar Maafi; Jan Korábečný; Eliška Kohelová; Angela De Simone; Abdullah Al Mamun; Daniela Hulcová; Jana Marková; Tomáš Kučera; Daniel Jun; Marcela Šafratová; Jana Maříková; Vincenza Andrisano; Jaroslav Jenčo; Jiří Kuneš; Ana Martinez; Lucie Nováková; Lucie Cahlíková;
Development of an UHPLC-diode arrays detector (DAD) method for the analysis of polydatin in human plasma
2021 Montanari S.; Davani L.; Tumiatti V.; Dimilta M.; Gaddi A.V.; De Simone A.; Andrisano V.
Combined Methodologies for Determining In Vitro Bioavailability of Drugs and Prediction of In Vivo Bioequivalence From Pharmaceutical Oral Formulations
2021 De Simone A.; Davani L.; Montanari S.; Tumiatti V.; Avanessian S.; Testi F.; Andrisano V.
(±)- BIGI-3h: Pentatarget-Directed Ligand combining Cholinesterase, Monoamine Oxidase, and Glycogen Synthase Kinase 3β Inhibition with Calcium Channel Antagonism and Antiaggregating Properties for Alzheimer's Disease
2021 Ismaili L.; Monnin J.; Etievant A.; Arribas R.L.; Viejo L.; Refouvelet B.; Soukup O.; Janockova J.; Hepnarova V.; Korabecny J.; Kucera T.; Jun D.; Andrys R.; Musilek K.; Baguet A.; Garcia-Frutos E.M.; De Simone A.; Andrisano V.; Bartolini M.; De Los Rios C.; Marco-Contelles J.; Haffen E.
Aß42 peptide toxicity on neuronal cells: a lipidomic study in view of Alzheimer’s Disease drug discovery
2021 Lara Davani, Xiaoqing Fu, Angela De Simone, Peng Li, Serena Montanari, Michael Lämmerhofer, Vincenza Andrisano
From virtual screening hits targeting a cryptic pocket in BACE-1 to a nontoxic brain permeable multitarget anti-Alzheimer lead with disease-modifying and cognition-enhancing effects
2021 Pont C.; Ginex T.; Grinan-Ferre C.; Scheiner M.; Mattellone A.; Martinez N.; Arce E.M.; Soriano-Fernandez Y.; Naldi M.; De Simone A.; Barenys M.; Gomez-Catalan J.; Perez B.; Sabate R.; Andrisano V.; Loza M.I.; Brea J.; Bartolini M.; Bolognesi M.L.; Decker M.; Pallas M.; Luque F.J.; Munoz-Torrero D.
PROTAC-INDUCED GLYCOGEN SYNTHASE KINASE 3B DEGRADATION
2022 Santini, A.; Pruccoli, L.; Guardigni, M.; De Simone, A.; Spyrakis, F.; Frabetti, F.; Andrisano, V.; Bolognesi, M. L.; Tarozzi, A.; Milelli, A.
Valorization of by-products from agro-foods for pharmaceutical, cosmetic, nutraceutical applications
2022 Cristina Terenzi, Lara Davani, Serena Montanari, Angela De Simone, Vincenza Andrisano
Fentanyl pharmacokinetics in blood of cancer patients by Gas Chromatography - Mass Spectrometry
2022 Montanari, Serena; Davani, Lara; Terenzi, Cristina; Maltoni, Marco; Andrisano, Vincenza; De Simone, Angela; Ricci, Marianna
Characterization of polyphenolic composition in Leccinum Scabrum and Leccinum Versipelle mushrooms
2023 Medri Francesca, Terenzi Cristina, Davani Lara, Montanari Serena, De Simone Angela, Andrisano Vincenza
Analytical characterization of fruits waste for their valorization as sources of bioactive compounds.
2023 Cristina Terenzi, Gabriela Alejandra Bermudez Leon, Lara Davani, Serena Montanari, Francesca Medri, Angela De Simone, Vincenza Andrisano
| Titolo | Autore(i) | Anno | Periodico | Editore | Tipo | File |
|---|---|---|---|---|---|---|
| A novel class of multitarget anti-Alzheimer benzohomoadamantane‒chlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors | Perez-Areales F.J.; Turcu A.L.; Barniol-Xicota M.; Pont C.; Pivetta D.; Espargaro A.; Bartolini M....; De Simone A.; Andrisano V.; Perez B.; Sabate R.; Sureda F.X.; Vazquez S.; Munoz-Torrero D. | 2019-01-01 | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - | 1.01 Articolo in rivista | - |
| Investigating in vitro amyloid peptide 1−42 aggregation: Impact of higher molecular weight stable adducts | De Simone A.; Naldi M.; Tedesco D.; Milelli A.; Bartolini M.; Davani L.; Widera D.; Dallas M.L.; ...Andrisano V. | 2019-01-01 | ACS OMEGA | - | 1.01 Articolo in rivista | 024_2019-acsomega-4_12308.pdf |
| Amaryllidaceae alkaloids from Narcissus pseudonarcissus L. cv. Dutch Master as potential drugs in treatment of Alzheimer's disease | Hulcova D.; Marikova J.; Korabecny J.; Hostalkova A.; Jun D.; Kunes J.; Chlebek J.; Opletal L.; D...e Simone A.; Novakova L.; Andrisano V.; Ruzicka A.; Cahlikova L. | 2019-01-01 | PHYTOCHEMISTRY | - | 1.01 Articolo in rivista | - |
| Pyridinylimidazoles as GSK3β Inhibitors: The Impact of Tautomerism on Compound Activity via Water Networks | Heider F.; Pantsar T.; Kudolo M.; Ansideri F.; De Simone A.; Pruccoli L.; Schneider T.; Goettert ...M.I.; Tarozzi A.; Andrisano V.; Laufer S.A.; Koch P. | 2019-01-01 | ACS MEDICINAL CHEMISTRY LETTERS | - | 1.01 Articolo in rivista | - |
| Discovery of the First-in-Class GSK-3β/HDAC Dual Inhibitor as Disease-Modifying Agent To Combat Alzheimer's Disease. | De Simone A, La Pietra V, Betari N, Petragnani N, Conte M, Daniele S, Pietrobono D, Martini C, Pe...tralla S, Casadei R, Davani L, Frabetti F, Russomanno P, Novellino E, Montanari S, Tumiatti V, Ballerini P, Sarno F, Nebbioso A, Altucci L, Monti B, Andrisano V, Milelli A. | 2019-01-01 | ACS MEDICINAL CHEMISTRY LETTERS | - | 1.01 Articolo in rivista | AM11585-685764.pdf |
| Histone Deacetylase Inhibitors as Multitarget Ligands: New Players in Alzheimer's Disease Drug Discovery? | De Simone Angela; Milelli Andrea | 2019-01-01 | CHEMMEDCHEM | - | 1.01 Articolo in rivista | - |
| Immobilized Enzyme Reactors: an Overview of Applications in Drug Discovery from 2008 to 2018 | De Simone, Angela*; Naldi, Marina; Bartolini, Manuela; Davani, Lara; Andrisano, Vincenza | 2019-01-01 | CHROMATOGRAPHIA | - | 1.01 Articolo in rivista | - |
| Correction: Discovery of the First-in-Class GSK-3β/HDAC Dual Inhibitor as Disease-Modifying Agent to Combat Alzheimer's Disease (ACS Medicinal Chemistry Letters (2019) 10: 4 (469−474) DOI: 10.1021/acsmedchemlett.8b00507) | De Simone A.; La Pietra V.; Betari N.; Petragnani N.; Conte M.; Daniele S.; Pietrobono D.; Martin...i C.; Petralla S.; Casadei R.; Davani L.; Frabetti F.; Russomanno P.; Novellino E.; Montanari S.; Tumiatti V.; Ballerini P.; Sarno F.; Nebbioso A.; Altucci L.; Monti B.; Andrisano V.; Milelli A. | 2019-01-01 | ACS MEDICINAL CHEMISTRY LETTERS | - | 1.01 Articolo in rivista | - |
| Advanced analytical methodologies in Alzheimer's disease drug discovery | De Simone A.; Naldi M.; Tedesco D.; Bartolini M.; Davani L.; Andrisano V. | 2020-01-01 | JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | - | 1.01 Articolo in rivista | - |
| Functionalized aromatic esters of the Amaryllidaceae alkaloid haemanthamine and their in vitro and in silico biological activity connected to Alzheimer's disease | Rozálie Peřinová; Negar Maafi; Jan Korábečný; Eliška Kohelová; Angela De Simone; Abdullah Al Mamu...n; Daniela Hulcová; Jana Marková; Tomáš Kučera; Daniel Jun; Marcela Šafratová; Jana Maříková; Vincenza Andrisano; Jaroslav Jenčo; Jiří Kuneš; Ana Martinez; Lucie Nováková; Lucie Cahlíková; | 2020-01-01 | BIOORGANIC CHEMISTRY | - | 1.01 Articolo in rivista | - |
| Development of an UHPLC-diode arrays detector (DAD) method for the analysis of polydatin in human plasma | Montanari S.; Davani L.; Tumiatti V.; Dimilta M.; Gaddi A.V.; De Simone A.; Andrisano V. | 2021-01-01 | JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | - | 1.01 Articolo in rivista | aam h_11585_854120.pdf |
| Combined Methodologies for Determining In Vitro Bioavailability of Drugs and Prediction of In Vivo Bioequivalence From Pharmaceutical Oral Formulations | De Simone A.; Davani L.; Montanari S.; Tumiatti V.; Avanessian S.; Testi F.; Andrisano V. | 2021-01-01 | FRONTIERS IN CHEMISTRY | - | 1.01 Articolo in rivista | fchem-09-741876 (1).pdf |
| (±)- BIGI-3h: Pentatarget-Directed Ligand combining Cholinesterase, Monoamine Oxidase, and Glycogen Synthase Kinase 3β Inhibition with Calcium Channel Antagonism and Antiaggregating Properties for Alzheimer's Disease | Ismaili L.; Monnin J.; Etievant A.; Arribas R.L.; Viejo L.; Refouvelet B.; Soukup O.; Janockova J....; Hepnarova V.; Korabecny J.; Kucera T.; Jun D.; Andrys R.; Musilek K.; Baguet A.; Garcia-Frutos E.M.; De Simone A.; Andrisano V.; Bartolini M.; De Los Rios C.; Marco-Contelles J.; Haffen E. | 2021-01-01 | ACS CHEMICAL NEUROSCIENCE | - | 1.01 Articolo in rivista | - |
| Aß42 peptide toxicity on neuronal cells: a lipidomic study in view of Alzheimer’s Disease drug discovery | Lara Davani, Xiaoqing Fu, Angela De Simone, Peng Li, Serena Montanari, Michael Lämmerhofer, Vince...nza Andrisano | 2021-01-01 | - | - | 4.03 Poster | - |
| From virtual screening hits targeting a cryptic pocket in BACE-1 to a nontoxic brain permeable multitarget anti-Alzheimer lead with disease-modifying and cognition-enhancing effects | Pont C.; Ginex T.; Grinan-Ferre C.; Scheiner M.; Mattellone A.; Martinez N.; Arce E.M.; Soriano-F...ernandez Y.; Naldi M.; De Simone A.; Barenys M.; Gomez-Catalan J.; Perez B.; Sabate R.; Andrisano V.; Loza M.I.; Brea J.; Bartolini M.; Bolognesi M.L.; Decker M.; Pallas M.; Luque F.J.; Munoz-Torrero D. | 2021-01-01 | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - | 1.01 Articolo in rivista | 1-s2.0-S0223523421006280-main.pdf |
| PROTAC-INDUCED GLYCOGEN SYNTHASE KINASE 3B DEGRADATION | Santini, A.; Pruccoli, L.; Guardigni, M.; De Simone, A.; Spyrakis, F.; Frabetti, F.; Andrisano, V....; Bolognesi, M. L.; Tarozzi, A.; Milelli, A. | 2022-01-01 | - | - | 4.03 Poster | - |
| Valorization of by-products from agro-foods for pharmaceutical, cosmetic, nutraceutical applications | Cristina Terenzi, Lara Davani, Serena Montanari, Angela De Simone, Vincenza Andrisano | 2022-01-01 | - | - | 4.03 Poster | - |
| Fentanyl pharmacokinetics in blood of cancer patients by Gas Chromatography - Mass Spectrometry | Montanari, Serena; Davani, Lara; Terenzi, Cristina; Maltoni, Marco; Andrisano, Vincenza; De Simon...e, Angela; Ricci, Marianna | 2022-01-01 | JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | - | 1.01 Articolo in rivista | - |
| Characterization of polyphenolic composition in Leccinum Scabrum and Leccinum Versipelle mushrooms | Medri Francesca, Terenzi Cristina, Davani Lara, Montanari Serena, De Simone Angela, Andrisano Vin...cenza | 2023-01-01 | - | - | 4.03 Poster | - |
| Analytical characterization of fruits waste for their valorization as sources of bioactive compounds. | Cristina Terenzi, Gabriela Alejandra Bermudez Leon, Lara Davani, Serena Montanari, Francesca Medr...i, Angela De Simone, Vincenza Andrisano | 2023-01-01 | - | - | 4.03 Poster | - |
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