Our data provide further knowledge on the incidence of IDH1/2 gene mutations in leukemias. On the other hand, they question a leading role for these mutations in progression from the chronic to the acute phase of CML, and underline the importance of a precise understanding of the biological consequences these mutations bring in leukemic cells.
IDH2 somatic mutations in chronic myeloid leukemia patients in blast crisis / Soverini S.; Score J.; Iacobucci I.; Poerio A.; Lonetti A.; Gnani A.; Colarossi S.; Ferrari A.; Castagnetti F.; Rosti G.; Cervantes F.; Hochhaus A.; Delledonne M.; Ferrarini A.; Sazzini M.; Luiselli D.; Baccarani M.; Cross NC.; Martinelli G.. - In: LEUKEMIA. - ISSN 0887-6924. - STAMPA. - 25:(2011), pp. 178-181. [10.1038/leu.2010.236]
IDH2 somatic mutations in chronic myeloid leukemia patients in blast crisis.
SOVERINI, SIMONA;IACOBUCCI, ILARIA;LONETTI, ANNALISA;FERRARI, ANNA;CASTAGNETTI, FAUSTO;SAZZINI, MARCO;LUISELLI, DONATA;BACCARANI, MICHELE;MARTINELLI, GIOVANNI
2011
Abstract
Our data provide further knowledge on the incidence of IDH1/2 gene mutations in leukemias. On the other hand, they question a leading role for these mutations in progression from the chronic to the acute phase of CML, and underline the importance of a precise understanding of the biological consequences these mutations bring in leukemic cells.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
