Our data provide further knowledge on the incidence of IDH1/2 gene mutations in leukemias. On the other hand, they question a leading role for these mutations in progression from the chronic to the acute phase of CML, and underline the importance of a precise understanding of the biological consequences these mutations bring in leukemic cells.
Soverini S., Score J., Iacobucci I., Poerio A., Lonetti A., Gnani A., et al. (2011). IDH2 somatic mutations in chronic myeloid leukemia patients in blast crisis. LEUKEMIA, 25, 178-181 [10.1038/leu.2010.236].
IDH2 somatic mutations in chronic myeloid leukemia patients in blast crisis.
SOVERINI, SIMONA;IACOBUCCI, ILARIA;LONETTI, ANNALISA;FERRARI, ANNA;CASTAGNETTI, FAUSTO;SAZZINI, MARCO;LUISELLI, DONATA;BACCARANI, MICHELE;MARTINELLI, GIOVANNI
2011
Abstract
Our data provide further knowledge on the incidence of IDH1/2 gene mutations in leukemias. On the other hand, they question a leading role for these mutations in progression from the chronic to the acute phase of CML, and underline the importance of a precise understanding of the biological consequences these mutations bring in leukemic cells.File in questo prodotto:
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