Recent studies have shown that copy number variants (CNVs) are important sources of variability of mammalian genomes. We applied a cross species array comparative genome hybridization (aCGH) experiment using as reference the cattle genome to investigate, for the first time, variability in the sheep and goat genomes derived from copy number variation and identified 431 and 358 CNVs, respectively. A comparison of these results to those obtained in other mammals for similar experiments is reported. The identified CNVs could be important in determining phenotypic and production differences between and within breeds. Further studies will be carried out to evaluate the identified CNVs from both functional and evolutionary points of view.

A Comparative Analysis of Copy Number Variation of the Sheep and Goat Genomes

FONTANESI, LUCA;BERETTI, FRANCESCA;DALL'OLIO, STEFANIA;MARTELLI, PIER LUIGI;CASADIO, RITA;RUSSO, VINCENZO
2010

Abstract

Recent studies have shown that copy number variants (CNVs) are important sources of variability of mammalian genomes. We applied a cross species array comparative genome hybridization (aCGH) experiment using as reference the cattle genome to investigate, for the first time, variability in the sheep and goat genomes derived from copy number variation and identified 431 and 358 CNVs, respectively. A comparison of these results to those obtained in other mammals for similar experiments is reported. The identified CNVs could be important in determining phenotypic and production differences between and within breeds. Further studies will be carried out to evaluate the identified CNVs from both functional and evolutionary points of view.
Proceedings of the 9th World Congress on Genetics Applied to Livestock Production
696
696
Fontanesi L. ; Beretti F.; Riggio V.; Dall'Olio S.; Occidente M.; Incoronato C.; Martelli P.L.; Casadio R.; Portolano B.; Matassino D.; Russo V.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/97918
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