In recent years the necessity for quick, reliable, easy-access and low-cost devices for healthcare assessment has increased steadily, especially during the ongoing SARS-CoV-2 pandemic where the market for such products experienced a fast growth. This contribution deals with a novel class of textile Point-of-Care devices based on poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) for the detection of chloride concentration and pH in excreted fluids (such as sweat or wound exudate), as well as moisture in the wound bed which are relevant biomarkers linked to the determination of hydration status, diagnosis of cystic fibrosis and wound health status. The use of special textile materials grants the wearability of the device and the continuous, passive and noninvasive sampling of biological fluids, which are still scarcely explored in the medical literature, and could represent the next step in the evolution of personal healthcare monitoring. The sensing layer of the devices was realized by screen-printing a pattern of PEDOT:PSS on medical-grade gauzes. The electrical contacts were made by sewing conductive textile threads. To achieve selectivity towards chloride and pH, Ag/AgCl and Iridium Oxide particles were electrodeposited on the PEDOT:PSS channel by means of electrochemical techniques, while the detection of moisture relied on the intrinsic characteristics of PEDOT:PSS. The determination of the analytes was conducted in both standard solutions and artificial fluids (AF), employing potentiostatic and impedance-based methods while operating in flow conditions by using a HPLC pump, to simulate the spontaneous fluid excretion at 0.05 mL/min. The sensitivities reported for chloride and pH detection were respectively -43.1 ± 0.7 μA decade-1 (R2 = 0.9997; LOD: 0.06 mM) and 59 ± 4 μA pH−1 (R2 = 0.993), while the moisture sensors were capable of reversibly differentiating between a “wet” and “dry” state upon animpedance variation of several orders of magnitude.
TEXTILE CHEMICAL SENSORS FOR HEALTHCARE MONITORING / Danilo Arcangeli, Federica Mariani, Isacco Gualandi, Marta Tessarolo, Domenica Tonelli, Beatrice Fraboni, Erika Scavetta. - STAMPA. - (2021), pp. 27-27. (Intervento presentato al convegno XXI Edizione della Giornata della Chimica dell’Emilia-Romagna tenutosi a Ferrara, Italy nel 17/12/2021).
TEXTILE CHEMICAL SENSORS FOR HEALTHCARE MONITORING
Danilo Arcangeli;Federica Mariani;Isacco Gualandi;Marta Tessarolo;Domenica Tonelli;Beatrice Fraboni;Erika Scavetta
2021
Abstract
In recent years the necessity for quick, reliable, easy-access and low-cost devices for healthcare assessment has increased steadily, especially during the ongoing SARS-CoV-2 pandemic where the market for such products experienced a fast growth. This contribution deals with a novel class of textile Point-of-Care devices based on poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) for the detection of chloride concentration and pH in excreted fluids (such as sweat or wound exudate), as well as moisture in the wound bed which are relevant biomarkers linked to the determination of hydration status, diagnosis of cystic fibrosis and wound health status. The use of special textile materials grants the wearability of the device and the continuous, passive and noninvasive sampling of biological fluids, which are still scarcely explored in the medical literature, and could represent the next step in the evolution of personal healthcare monitoring. The sensing layer of the devices was realized by screen-printing a pattern of PEDOT:PSS on medical-grade gauzes. The electrical contacts were made by sewing conductive textile threads. To achieve selectivity towards chloride and pH, Ag/AgCl and Iridium Oxide particles were electrodeposited on the PEDOT:PSS channel by means of electrochemical techniques, while the detection of moisture relied on the intrinsic characteristics of PEDOT:PSS. The determination of the analytes was conducted in both standard solutions and artificial fluids (AF), employing potentiostatic and impedance-based methods while operating in flow conditions by using a HPLC pump, to simulate the spontaneous fluid excretion at 0.05 mL/min. The sensitivities reported for chloride and pH detection were respectively -43.1 ± 0.7 μA decade-1 (R2 = 0.9997; LOD: 0.06 mM) and 59 ± 4 μA pH−1 (R2 = 0.993), while the moisture sensors were capable of reversibly differentiating between a “wet” and “dry” state upon animpedance variation of several orders of magnitude.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
