Some coumarin-, flavonol- and flavanon-acetic acids are described. The cytotoxicity of the synthesized compounds was determined on a human colon carcinoma cell line (LoVo) through evaluation of neutral red uptake, performed by the Riddel method. All tested derivatives were able to induce a statistically significant reduction of lysosomal neutral red uptake at 5 x 10(-5) M concentration. Some compounds were more active than the reference compound flavon-8-acetic acid.
Valenti P., Fabbri G., Rampa A., Bisi A., Gobbi S., Da Re P., et al. (1996). Synthesis and antitumor activity of some analogues of flavone acetic acid. ANTI-CANCER DRUG DESIGN, 11(3), 243-252.
Synthesis and antitumor activity of some analogues of flavone acetic acid
Valenti P.;Fabbri G.;Rampa A.;Bisi A.;Gobbi S.;Da Re P.;
1996
Abstract
Some coumarin-, flavonol- and flavanon-acetic acids are described. The cytotoxicity of the synthesized compounds was determined on a human colon carcinoma cell line (LoVo) through evaluation of neutral red uptake, performed by the Riddel method. All tested derivatives were able to induce a statistically significant reduction of lysosomal neutral red uptake at 5 x 10(-5) M concentration. Some compounds were more active than the reference compound flavon-8-acetic acid.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
