The conformations of all stereoisomers of PMRI cyclotetrapeptide mimetics 1-8 are essentially determined by the predisposition of the diamine to stabilize -turns. The peptide mimetics can be regarded as 3D scaffolds for designing molecules with a predictable display of the pharmacophores. We used the models for testing novel RGD analogues as alfavbeta3-integrin receptor antagonists
L. Gentilucci, G. Cardillo, A. Tolomelli, R. De Marco, A. Garelli, S. Spampinato, et al. (2009). Synthesis and Conformational Analysis of Cyclotetrapeptide Mimetic beta-Turn Templates and Validation as 3D Scaffolds. CHEMMEDCHEM, 4, 517-523 [10.1002/cmdc.200800407].
Synthesis and Conformational Analysis of Cyclotetrapeptide Mimetic beta-Turn Templates and Validation as 3D Scaffolds
GENTILUCCI, LUCA;CARDILLO, GIULIANA;TOLOMELLI, ALESSANDRA;DE MARCO, ROSSELLA;GARELLI, ANDREA;SPAMPINATO, SANTI MARIO;
2009
Abstract
The conformations of all stereoisomers of PMRI cyclotetrapeptide mimetics 1-8 are essentially determined by the predisposition of the diamine to stabilize -turns. The peptide mimetics can be regarded as 3D scaffolds for designing molecules with a predictable display of the pharmacophores. We used the models for testing novel RGD analogues as alfavbeta3-integrin receptor antagonistsI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
