The conformations of all stereoisomers of PMRI cyclotetrapeptide mimetics 1-8 are essentially determined by the predisposition of the diamine to stabilize -turns. The peptide mimetics can be regarded as 3D scaffolds for designing molecules with a predictable display of the pharmacophores. We used the models for testing novel RGD analogues as alfavbeta3-integrin receptor antagonists
Synthesis and Conformational Analysis of Cyclotetrapeptide Mimetic beta-Turn Templates and Validation as 3D Scaffolds
GENTILUCCI, LUCA;CARDILLO, GIULIANA;TOLOMELLI, ALESSANDRA;DE MARCO, ROSSELLA;GARELLI, ANDREA;SPAMPINATO, SANTI MARIO;
2009
Abstract
The conformations of all stereoisomers of PMRI cyclotetrapeptide mimetics 1-8 are essentially determined by the predisposition of the diamine to stabilize -turns. The peptide mimetics can be regarded as 3D scaffolds for designing molecules with a predictable display of the pharmacophores. We used the models for testing novel RGD analogues as alfavbeta3-integrin receptor antagonistsFile in questo prodotto:
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