To determine whether: 1) the immunofluorescence (IF) is a reproducible technique in detecting misfolded α-synuclein (α-syn) in skin nerves; and subsequently 2) IF and RT-QuIC (both in skin and CSF) show a comparable in vivo diagnostic accuracy in distinguish synucleinopathies (SOPs) from non-synucleinopathies (non-SOPs) in a large cohort of patients.
In Vivo Diagnosis of Synucleinopathies: A Comparative Study of Skin Biopsy and RT-QuIC / Donadio, Vincenzo; Wang, Zerui; Incensi, Alex; Rizzo, Giovanni; Fileccia, Enrico; Vacchiano, Veria; Capellari, Sabina; Magnani, Martina; Scaglione, Cesa; Stanzani Maserati, Michelangelo; Avoni, Patrizia; Liguori, Rocco; Zou, Wenquan. - In: NEUROLOGY. - ISSN 0028-3878. - ELETTRONICO. - 96:20(2021), pp. e2513-e2524. [10.1212/WNL.0000000000011935]
In Vivo Diagnosis of Synucleinopathies: A Comparative Study of Skin Biopsy and RT-QuIC
Vacchiano, Veria;Capellari, Sabina;Avoni, Patrizia;Liguori, Rocco;
2021
Abstract
To determine whether: 1) the immunofluorescence (IF) is a reproducible technique in detecting misfolded α-synuclein (α-syn) in skin nerves; and subsequently 2) IF and RT-QuIC (both in skin and CSF) show a comparable in vivo diagnostic accuracy in distinguish synucleinopathies (SOPs) from non-synucleinopathies (non-SOPs) in a large cohort of patients.| File | Dimensione | Formato | |
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