We performed a genetic association study with the LDL receptor gene (LDLR) on chromosome 19p13.2 in 360 migraine patients, 220 with migraine without aura (MO) and 140 with migraine with aura (MA), and 200 controls, by analysing two polymorphic markers, a G142A transition in exon 10 and a triallelic (TA)n repeat in exon 18. The allelic distribution of the (TA)n polymorphism was significantly different between migraine without aura (MO) and both controls and migraine with aura (MA). We suggest a possible predisposition to MO in the studied population through this polymorphism or another polymorphism in linkage disequilibrium with (TA)n. © 2003 Elsevier Science B.V. All rights reserved.
Mochi M., Cevoli S., Cortelli P., Pierangeli G., Scapoli C., Soriani S., et al. (2003). Investigation of an LDLR gene polymorphism (19p13.2) in susceptibility to migraine without aura. JOURNAL OF THE NEUROLOGICAL SCIENCES, 213(1-2), 7-10 [10.1016/S0022-510X(03)00124-2].
Investigation of an LDLR gene polymorphism (19p13.2) in susceptibility to migraine without aura
Mochi M.;Cevoli S.;Cortelli P.;Pierangeli G.;Montagna P.
2003
Abstract
We performed a genetic association study with the LDL receptor gene (LDLR) on chromosome 19p13.2 in 360 migraine patients, 220 with migraine without aura (MO) and 140 with migraine with aura (MA), and 200 controls, by analysing two polymorphic markers, a G142A transition in exon 10 and a triallelic (TA)n repeat in exon 18. The allelic distribution of the (TA)n polymorphism was significantly different between migraine without aura (MO) and both controls and migraine with aura (MA). We suggest a possible predisposition to MO in the studied population through this polymorphism or another polymorphism in linkage disequilibrium with (TA)n. © 2003 Elsevier Science B.V. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
