Cellular senescence is a fundamental process that may play positive or detrimental roles for the organism. It is involved in tissue development and in tumor prevention although during aging is becoming a detrimental process contributing to the decline of tissue functions. In previous investigations, we have uncovered a better capacity to detect DNA damage in cells from long-lived mammals. Here, we report that cultured cells derived from long-lived species have a higher propensity to undergo senescence when challenged with DNA damage than cells derived from short-lived species. Using a panel of cells derived from six mammals, which range in lifespan from 3-4 years up to 120 years, we examined cell cycle response, induction of apoptosis and of cellular senescence. All species exhibited a cell cycle arrest while induction of apoptosis was variable. However, a significant positive correlation was found between the relative percent of cells, within a population which entered senescence following damage, and the lifespan of the species. We suggest that cellular senescence may have a positive role during development allowing it to contribute to the evolution of longevity.

Amany Attaallah, M.L. (2020). A pro longevity role for cellular senescence. GEROSCIENCE, 42(3), 867-879 [10.1007/s11357-019-00066-2].

A pro longevity role for cellular senescence

Monia Lenzi
Investigation
;
Silvia Marchionni
Data Curation
;
Veronica Cocchi
Investigation
;
Patrizia Hrelia
Writing – Review & Editing
;
Silvana Hrelia
Writing – Review & Editing
;
Antonello Lorenzini
Writing – Original Draft Preparation
2020

Abstract

Cellular senescence is a fundamental process that may play positive or detrimental roles for the organism. It is involved in tissue development and in tumor prevention although during aging is becoming a detrimental process contributing to the decline of tissue functions. In previous investigations, we have uncovered a better capacity to detect DNA damage in cells from long-lived mammals. Here, we report that cultured cells derived from long-lived species have a higher propensity to undergo senescence when challenged with DNA damage than cells derived from short-lived species. Using a panel of cells derived from six mammals, which range in lifespan from 3-4 years up to 120 years, we examined cell cycle response, induction of apoptosis and of cellular senescence. All species exhibited a cell cycle arrest while induction of apoptosis was variable. However, a significant positive correlation was found between the relative percent of cells, within a population which entered senescence following damage, and the lifespan of the species. We suggest that cellular senescence may have a positive role during development allowing it to contribute to the evolution of longevity.
2020
Amany Attaallah, M.L. (2020). A pro longevity role for cellular senescence. GEROSCIENCE, 42(3), 867-879 [10.1007/s11357-019-00066-2].
Amany Attaallah, Monia Lenzi, Silvia Marchionni, Giacomo Bincoletto, Veronica Cocchi, Eleonora Croco, Patrizia Hrelia, Silvana Hrelia, Christian Sell,...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/763575
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