The efficacy of metformin in treating cancer has been extensively investigated since epidemiologic studies associated this anti-diabetic drug with a lower risk of cancer incidence. Since tumors are complex systems, in which cancer cells coexist and interact with several different types of non-malignant cells, it is not surprising that anti-cancer drugs affect not only cancer cells, but also the abundance and functions of cells of the tumor microenvironment. Recent years have seen a wide collection of reports showing how metformin, as well as other complex I inhibitors, may influence cancer progression by modulating the phenotype of non-transformed cells in a tumor. In this review, we particularly focus on the effect of metformin on angiogenesis, cancer-associated fibroblasts, tumor-associated macrophages and cancer immunosuppression.
The multifaceted effects of metformin on tumor microenvironment / Kurelac, Ivana; Ganesh, Nikkitha Umesh; Iorio, Maria; Porcelli, Anna Maria; Gasparre, Giuseppe. - In: SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY. - ISSN 1096-3634. - ELETTRONICO. - 98:(2020), pp. 90-97. [10.1016/j.semcdb.2019.05.010]
The multifaceted effects of metformin on tumor microenvironment
Kurelac, Ivana
;Ganesh, Nikkitha Umesh;IORIO, MARIA;Porcelli, Anna Maria;Gasparre, Giuseppe
2020
Abstract
The efficacy of metformin in treating cancer has been extensively investigated since epidemiologic studies associated this anti-diabetic drug with a lower risk of cancer incidence. Since tumors are complex systems, in which cancer cells coexist and interact with several different types of non-malignant cells, it is not surprising that anti-cancer drugs affect not only cancer cells, but also the abundance and functions of cells of the tumor microenvironment. Recent years have seen a wide collection of reports showing how metformin, as well as other complex I inhibitors, may influence cancer progression by modulating the phenotype of non-transformed cells in a tumor. In this review, we particularly focus on the effect of metformin on angiogenesis, cancer-associated fibroblasts, tumor-associated macrophages and cancer immunosuppression.File | Dimensione | Formato | |
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