Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes

Ruderfer, Douglas M.; Ripke, Stephan; Mcquillin, Andrew; Boocock, James; Stahl, Eli A.; Pavlides, Jennifer M. Whitehead; Mullins, Niamh; Charney, Alexander W.; Ori, Anil P. S.; Loohuis, Loes M. Olde; Domenici, Enrico; Di Florio, Arianna; Papiol, Sergi; Kalman, Janos L.; Trubetskoy, Vassily; Adolfsson, Rolf; Agartz, Ingrid; Agerbo, Esben; Akil, Huda; Albani, Diego; Albus, Margot; Alda, Martin; Alexander, Madeline; Alliey-Rodriguez, Ney; Als, Thomas D.; Amin, Farooq; Anjorin, Adebayo; Arranz, Maria J.; Awasthi, Swapnil; Bacanu, Silviu A.; Badner, Judith A.; Baekvad-Hansen, Marie; Bakker, Steven; Band, Gavin; Barchas, Jack D.; Barroso, Ines; Bass, Nicholas; Bauer, Michael; Baune, Bernhard T.; Begemann, Martin; Bellenguez, Celine; Belliveau, Richard A.; Bellivier, Frank; Bender, Stephan; Bene, Judit; Bergen, Sarah E.; Berrettini, Wade H.; Bevilacqua, Elizabeth; Biernacka, Joanna M.; Bigdeli, Tim B.; Black, Donald W.; Blackburn, Hannah; Blackwell, Jenefer M.; Blackwood, Douglas H. R.; Pedersen, Carsten Bocker; Boehnke, Michael; Boks, Marco; Borglum, Anders D.; Bramon, Elvira; Breen, Gerome; Brown, Matthew A.; Bruggeman, Richard; Buccola, Nancy G.; Buckner, Randy L.; Budde, Monika; Bulik-Sullivan, Brendan; Bumpstead, Suzannah J.; Bunney, William; Burmeister, Margit; Buxbaum, Joseph D.; Bybjerg-Grauholm, Jonas; Byerley, William; Cahn, Wiepke; Cai, Guiqing; Cairns, Murray J.; Campion, Dominique; Cantor, Rita M.; Carr, Vaughan J.; Carrera, Noa; Casas, Juan P.; Casas, Miquel; Catts, Stanley V.; Cervantes, Pablo; Chambert, Kimberley D.; Chan, Raymond C. K.; Chen, Eric Y. H.; Chen, Ronald Y. L.; Cheng, Wei; Cheung, Eric F. C.; Chong, Siow Ann; Clarke, Toni-Kim; Cloninger, C. Robert; Cohen, David; Cohen, Nadine; Coleman, Jonathan R. I.; Collier, David A.; Cormican, Paul; Coryell, William; Craddock, Nicholas; Craig, David W.; Crespo-Facorro, Benedicto; Crowley, James J.; Cruceanu, Cristiana; Curtis, David; Czerski, Piotr M.; Dale, Anders M.; Daly, Mark J.; Dannlowski, Udo; Darvasi, Ariel; Davidson, Michael; Davis, Kenneth L.; de Leeuw, Christiaan A.; Degenhardt, Franziska; Del Favero, Jurgen; Delisi, Lynn E.; Deloukas, Panos; Demontis, Ditte; Depaulo, J. Raymond; di Forti, Marta; Dikeos, Dimitris; Dinan, Timothy; Djurovic, Srdjan; Dobbyn, Amanda L.; Donnelly, Peter; Donohoe, Gary; Drapeau, Elodie; Dronov, Serge; Duan, Jubao; Dudbridge, Frank; Duncanson, Audrey; Edenberg, Howard; Edkins, Sarah; Ehrenreich, Hannelore; Eichhammer, Peter; Elvsashagen, Torbjorn; Eriksson, Johan; Escott-Price, Valentina; Esko, Tonu; Essioux, Laurent; Etain, Bruno; Fan, Chun Chieh; Farh, Kai-How; Farrell, Martilias S.; Flickinger, Matthew; Foroud, Tatiana M.; Forty, Liz; Frank, Josef; Franke, Lude; Fraser, Christine; Freedman, Robert; Freeman, Colin; Freimer, Nelson B.; Friedman, Joseph I.; Fromer, Menachem; Frye, Mark A.; Fullerton, Janice M.; Gade, Katrin; Garnham, Julie; Gaspar, Helena A.; Gejman, Pablo V.; Genovese, Giulio; Georgieva, Lyudmila; Giambartolomei, Claudia; Giannoulatou, Eleni; Giegling, Ina; Gill, Michael; Gillman, Matthew; Pedersen, Marianne Giortz; Giusti-Rodriguez, Paola; Godard, Stephanie; Goes, Fernando; Goldstein, Jacqueline I.; Gopal, Srihari; Gordon, Scott D.; Gordon-Smith, Katherine; Gratten, Jacob; Gray, Emma; Green, Elaine K.; Green, Melissa J.; Greenwood, Tiffany A.; Grigoroiu-Serbanescu, Maria; Grove, Jakob; Guan, Weihua; Gurling, Hugh; Parra, Jose Guzman; Gwilliam, Rhian; de Haan, Lieuwe; Hall, Jeremy; Hall, Mei-Hua; Hammer, Christian; Hammond, Naomi; Hamshere, Marian L.; Hansen, Mark; Hansen, Thomas; Haroutunian, Vahram; Hartmann, Annette M.; Hauser, Joanna; Hautzinger, Martin; Heilbronner, Urs; Hellenthal, Garrett; Henskens, Frans A.; Herms, Stefan; Hipolito, Maria; Hirschhorn, Joel N.; Hoffmann, Per; Hollegaard, Mads V.; Hougaard, David M.; Huang, Hailiang; Huckins, Laura; Hultman, Christina M.; Hunt, Sarah E.; Ikeda, Masashi; Iwata, Nakao; Iyegbe, Conrad; Jablensky, Assen V.; Jamain, Stephane; Jankowski, Janusz; Jayakumar, Alagurevathi; Joa, Inge; Jones, Ian; Jones, Lisa A.; Jonsson, Erik G.; Julia, Antonio; Jureus, Anders; Kahler, Anna K.; Kahn, Rene S.; Kalaydjieva, Luba; Kandaswamy, Radhika; Karachanak-Yankova, Sena; Karjalainen, Juha; Karlsson, Robert; Kavanagh, David; Keller, Matthew C.; Kelly, Brian J.; Kelsoe, John; Kennedy, James L.; Khrunin, Andrey; Kim, Yunjung; Kirov, George; Kittel-Schneider, Sarah; Klovins, Janis; Knight, Jo; Knott, Sarah V.; Knowles, James A.; Kogevinas, Manolis; Konte, Bettina; Kravariti, Eugenia; Kucinskas, Vaidutis; Kucinskiene, Zita Ausrele; Kupka, Ralph; Kuzelova-Ptackova, Hana; Landen, Mikael; Langford, Cordelia; Laurent, Claudine; Lawrence, Jacob; Lawrie, Stephen; Lawson, William B.; Leber, Markus; Leboyer, Marion; Lee, Phil H.; Keong, Jimmy Lee Chee; Legge, Sophie E.; Lencz, Todd; Lerer, Bernard; Levinson, Douglas F.; Levy, Shawn E.; Lewis, Cathryn M.; Jun Z., Li; Miaoxin, Li; Qingqin S., Li; Tao, Li; Liang, Kung-Yee; Liddle, Jennifer; Lieberman, Jeffrey; Limborska, Svetlana; Lin, Kuang; Linszen, Don H.; Lissowska, Jolanta; Liu, Chunyu; Liu, Jianjun; Lonnqvist, Jouko; Loughland, Carmel M.; Lubinski, Jan; Lucae, Susanne; Macek, Milan; Macintyre, Donald J.; Magnusson, Patrik K. E.; Maher, Brion S.; Mahon, Pamela B.; Maier, Wolfgang; Malhotra, Anil K.; Mallet, Jacques; Malt, Ulrik F.; Markus, Hugh S.; Marsal, Sara; Martin, Nicholas G.; Mata, Ignacio; Mathew, Christopher G.; Mattheisen, Manuel; Mattingsdal, Morten; Mayoral, Fermin; Mccann, Owen T.; Mccarley, Robert W.; Mccarroll, Steven A.; Mccarthy, Mark I.; Mcdonald, Colm; Mcelroy, Susan L.; Mcguffin, Peter; Mcinnis, Melvin G.; Mcintosh, Andrew M.; Mckay, James D.; Mcmahon, Francis J.; Medeiros, Helena; Medland, Sarah E.; Meier, Sandra; Meijer, Carin J.; Melegh, Bela; Melle, Ingrid; Meng, Fan; Mesholam-Gately, Raquelle I.; Metspalu, Andres; Michie, Patricia T.; Milani, Lili; Milanova, Vihra; Mitchell, Philip B.; Mokrab, Younes; Montgomery, Grant W.; Moran, Jennifer L.; Morken, Gunnar; Morris, Derek W.; Mors, Ole; Mortensen, Preben B.; Mowry, Bryan J.; Mühleisen, Thomas W.; Müller-Myhsok, Bertram; Murphy, Kieran C.; Murray, Robin M.; Myers, Richard M.; Myin-Germeys, Inez; Neale, Benjamin M.; Nelis, Mari; Nenadic, Igor; Nertney, Deborah A.; Nestadt, Gerald; Nicodemus, Kristin K.; Nievergelt, Caroline M.; Nikitina-Zake, Liene; Nimgaonkar, Vishwajit; Nisenbaum, Laura; Nordentoft, Merete; Nordin, Annelie; Nöthen, Markus M.; Nwulia, Evaristus A.; O'Callaghan, Eadbhard; O'Donovan, Claire; O'Dushlaine, Colm; O'Neill, F. Anthony; Oedegaard, Ketil J.; Sang-Yun, Oh; Olincy, Ann; Olsen, Line; Oruc, Lilijana; Van Os, Jim; Owen, Michael J.; Paciga, Sara A.; Palmer, Colin N. A.; Palotie, Aarno; Pantelis, Christos; Papadimitriou, George N.; Parkhomenko, Elena; Pato, Carlos; Pato, Michele T.; Paunio, Tiina; Pearson, Richard; Perkins, Diana O.; Perlis, Roy H.; Perry, Amy; Pers, Tune H.; Petryshen, Tracey L.; Pfennig, Andrea; Picchioni, Marco; Pietilainen, Olli; Pimm, Jonathan; Pirinen, Matti; Plomin, Robert; Pocklington, Andrew J.; Posthuma, Danielle; Potash, James B.; Potter, Simon C.; Powell, John; Price, Alkes; Pulver, Ann E.; Purcell, Shaun M.; Quested, Digby; Ramos-Quiroga, Josep Antoni; Rasmussen, Henrik B.; Rautanen, Anna; Ravindrarajah, Radhi; Regeer, Eline J.; Reichenberg, Abraham; Reif, Andreas; Reimers, Mark A.; Ribases, Marta; Rice, John P.; Richards, Alexander L.; Ricketts, Michelle; Riley, Brien P.; Rivas, Fabio; Rivera, Margarita; Roffman, Joshua L.; Rouleau, Guy A.; Roussos, Panos; Rujescu, Dan; Salomaa, Veikko; Sanchez-Mora, Cristina; Sanders, Alan R.; Sawcer, Stephen J.; Schall, Ulrich; Schatzberg, Alan F.; Scheftner, William A.; Schofield, Peter R.; Schork, Nicholas J.; Schwab, Sibylle G.; Scolnick, Edward M.; Scott, Laura J.; Scott, Rodney J.; Seidman, Larry J.; Serretti, Alessandro; Sham, Pak C.; Weickert, Cynthia Shannon; Shehktman, Tatyana; Shi, Jianxin; Shilling, Paul D.; Sigurdsson, Engilbert; Silverman, Jeremy M.; Sim, Kang; Slaney, Claire; Slominsky, Petr; Smeland, Olav B.; Smoller, Jordan W.; Hon-Cheong, So; Sobell, Janet L.; Soderman, Erik; Hansen, Christine Soholm; Spencer, Chris C. A.; Spijker, Anne T.; St Clair, David; Stefansson, Hreinn; Stefansson, Kari; Steinberg, Stacy; Stogmann, Elisabeth; Stordal, Eystein; Strange, Amy; Straub, Richard E.; Strauss, John S.; Streit, Fabian; Strengman, Eric; Strohmaier, Jana; Stroup, T. Scott; Zhan, Su; Subramaniam, Mythily; Suvisaari, Jaana; Svrakic, Dragan M.; Szatkiewicz, Jin P.; Szelinger, Szabolcs; Tashakkori-Ghanbaria, Avazeh; Thirumalai, Srinivas; Thompson, Robert C.; Thorgeirsson, Thorgeir E.; Toncheva, Draga; Tooney, Paul A.; Tosato, Sarah; Toulopoulou, Timothea; Trembath, Richard C.; Treutlein, Jens; Turecki, Gustavo; Vaaler, Arne E.; Vedder, Helmut; Vieta, Eduard; Vincent, John; Visscher, Peter M.; Viswanathan, Ananth C.; Vukcevic, Damjan; Waddington, John; Waller, Matthew; Walsh, Dermot; Walshe, Muriel; Walters, James T. R.; Wang, Dai; Wang, Qiang; Wang, Weiqing; Wang, Yunpeng; Watson, Stanley J.; Webb, Bradley T.; Weickert, Thomas W.; Weinberger, Daniel R.; Weisbrod, Matthias; Weiser, Mark; Werge, Thomas; Weston, Paul; Whittaker, Pamela; Widaa, Sara; Wiersma, Durk; Wildenauer, Dieter B.; Williams, Nigel M.; Williams, Stephanie; Witt, Stephanie H.; Wolen, Aaron R.; Wong, Emily H. M.; Wood, Nicholas W.; Wormley, Brandon K.; Jing Qin, Wu; Simon, Xi; Wei, Xu; Young, Allan H.; Zai, Clement C.; Zandi, Peter; Zhang, Peng; Zheng, Xuebin; Zimprich, Fritz; Zollner, Sebastian; Corvin, Aiden; Fanous, Ayman H.; Cichon, Sven; Rietschel, Marcella; Gershon, Elliot S.; Schulze, Thomas G.; Cuellar-Barboza, Alfredo B.; Forstner, Andreas J.; Holmans, Peter A.; Nurnberger, John I.; Andreassen, Ole A.; Lee, S. Hong; O'Donovan, Michael C.; Sullivan, Patrick F.; Ophoff, Roel A.; Wray, Naomi R.; Sklar, Pamela; Kendler, Kenneth S.

doi:10.1016/j.cell.2018.05.046

Schizophrenia and bipolar disorder are two distinct diagnoses that share symptomology. Understanding the genetic factors contributing to the shared and disorder-specific symptoms will be crucial for improving diagnosis and treatment. In genetic data consisting of 53,555 cases (20,129 bipolar disorder [BD], 33,426 schizophrenia [SCZ]) and 54,065 controls, we identified 114 genome-wide significant loci implicating synaptic and neuronal pathways shared between disorders. Comparing SCZ to BD (23,585 SCZ, 15,270 BD) identified four genomic regions including one with disorder-independent causal variants and potassium ion response genes as contributing to differences in biology between the disorders. Polygenic risk score (PRS) analyses identified several significant correlations within case-only phenotypes including SCZ PRS with psychotic features and age of onset in BD. For the first time, we discover specific loci that distinguish between BD and SCZ and identify polygenic components underlying multiple symptom dimensions. These results point to the utility of genetics to inform symptomology and potential treatment. Genetic analysis of multiple bipolar disorder and schizophrenia cohorts reveals loci and polygenic risk scores that differentiate the clinical symptoms of these two highly correlated disorders.

Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes / Ruderfer, Douglas M.; Ripke, Stephan; McQuillin, Andrew; Boocock, James; Stahl, Eli A.; Pavlides, Jennifer M. Whitehead; Mullins, Niamh; Charney, Alexander W.; Ori, Anil P.S.; Loohuis, Loes M. Olde; Domenici, Enrico; Di Florio, Arianna; Papiol, Sergi; Kalman, Janos L.; Trubetskoy, Vassily; Adolfsson, Rolf; Agartz, Ingrid; Agerbo, Esben; Akil, Huda; Albani, Diego; Albus, Margot; Alda, Martin; Alexander, Madeline; Alliey-Rodriguez, Ney; Als, Thomas D.; Amin, Farooq; Anjorin, Adebayo; Arranz, Maria J.; Awasthi, Swapnil; Bacanu, Silviu A.; Badner, Judith A.; Baekvad-Hansen, Marie; Bakker, Steven; Band, Gavin; Barchas, Jack D.; Barroso, Ines; Bass, Nicholas; Bauer, Michael; Baune, Bernhard T.; Begemann, Martin; Bellenguez, Celine; Belliveau, Richard A.; Bellivier, Frank; Bender, Stephan; Bene, Judit; Bergen, Sarah E.; Berrettini, Wade H.; Bevilacqua, Elizabeth; Biernacka, Joanna M.; Bigdeli, Tim B.; Black, Donald W.; Blackburn, Hannah; Blackwell, Jenefer M.; Blackwood, Douglas H.R.; Pedersen, Carsten Bocker; Boehnke, Michael; Boks, Marco; Borglum, Anders D.; Bramon, Elvira; Breen, Gerome; Brown, Matthew A.; Bruggeman, Richard; Buccola, Nancy G.; Buckner, Randy L.; Budde, Monika; Bulik-Sullivan, Brendan; Bumpstead, Suzannah J.; Bunney, William; Burmeister, Margit; Buxbaum, Joseph D.; Bybjerg-Grauholm, Jonas; Byerley, William; Cahn, Wiepke; Cai, Guiqing; Cairns, Murray J.; Campion, Dominique; Cantor, Rita M.; Carr, Vaughan J.; Carrera, Noa; Casas, Juan P.; Casas, Miquel; Catts, Stanley V.; Cervantes, Pablo; Chambert, Kimberley D.; Chan, Raymond C.K.; Chen, Eric Y.H.; Chen, Ronald Y.L.; Cheng, Wei; Cheung, Eric F.C.; Chong, Siow Ann; Clarke, Toni-Kim; Cloninger, C. Robert; Cohen, David; Cohen, Nadine; Coleman, Jonathan R.I.; Collier, David A.; Cormican, Paul; Coryell, William; Craddock, Nicholas; Craig, David W.; Crespo-Facorro, Benedicto; Crowley, James J.; Cruceanu, Cristiana; Curtis, David; Czerski, Piotr M.; Dale, Anders M.; Daly, Mark J.; Dannlowski, Udo; Darvasi, Ariel; Davidson, Michael; Davis, Kenneth L.; de Leeuw, Christiaan A.; Degenhardt, Franziska; Del Favero, Jurgen; DeLisi, Lynn E.; Deloukas, Panos; Demontis, Ditte; DePaulo, J. Raymond; di Forti, Marta; Dikeos, Dimitris; Dinan, Timothy; Djurovic, Srdjan; Dobbyn, Amanda L.; Donnelly, Peter; Donohoe, Gary; Drapeau, Elodie; Dronov, Serge; Duan, Jubao; Dudbridge, Frank; Duncanson, Audrey; Edenberg, Howard; Edkins, Sarah; Ehrenreich, Hannelore; Eichhammer, Peter; Elvsashagen, Torbjorn; Eriksson, Johan; Escott-Price, Valentina; Esko, Tonu; Essioux, Laurent; Etain, Bruno; Fan, Chun Chieh; Farh, Kai-How; Farrell, Martilias S.; Flickinger, Matthew; Foroud, Tatiana M.; Forty, Liz; Frank, Josef; Franke, Lude; Fraser, Christine; Freedman, Robert; Freeman, Colin; Freimer, Nelson B.; Friedman, Joseph I.; Fromer, Menachem; Frye, Mark A.; Fullerton, Janice M.; Gade, Katrin; Garnham, Julie; Gaspar, Helena A.; Gejman, Pablo V.; Genovese, Giulio; Georgieva, Lyudmila; Giambartolomei, Claudia; Giannoulatou, Eleni; Giegling, Ina; Gill, Michael; Gillman, Matthew; Pedersen, Marianne Giortz; Giusti-Rodriguez, Paola; Godard, Stephanie; Goes, Fernando; Goldstein, Jacqueline I.; Gopal, Srihari; Gordon, Scott D.; Gordon-Smith, Katherine; Gratten, Jacob; Gray, Emma; Green, Elaine K.; Green, Melissa J.; Greenwood, Tiffany A.; Grigoroiu-Serbanescu, Maria; Grove, Jakob; Guan, Weihua; Gurling, Hugh; Parra, Jose Guzman; Gwilliam, Rhian; de Haan, Lieuwe; Hall, Jeremy; Hall, Mei-Hua; Hammer, Christian; Hammond, Naomi; Hamshere, Marian L.; Hansen, Mark; Hansen, Thomas; Haroutunian, Vahram; Hartmann, Annette M.; Hauser, Joanna; Hautzinger, Martin; Heilbronner, Urs; Hellenthal, Garrett; Henskens, Frans A.; Herms, Stefan; Hipolito, Maria; Hirschhorn, Joel N.; Hoffmann, Per; Hollegaard, Mads V.; Hougaard, David M.; Huang, Hailiang; Huckins, Laura; Hultman, Christina M.; Hunt, Sarah E.; Ikeda, Masashi; Iwata, Nakao; Iyegbe, Conrad; Jablensky, Assen V.; Jamain, Stephane; Jankowski, Janusz; Jayakumar, Alagurevathi; Joa, Inge; Jones, Ian; Jones, Lisa A.; Jonsson, Erik G.; Julia, Antonio; Jureus, Anders; Kahler, Anna K.; Kahn, Rene S.; Kalaydjieva, Luba; Kandaswamy, Radhika; Karachanak-Yankova, Sena; Karjalainen, Juha; Karlsson, Robert; Kavanagh, David; Keller, Matthew C.; Kelly, Brian J.; Kelsoe, John; Kennedy, James L.; Khrunin, Andrey; Kim, Yunjung; Kirov, George; Kittel-Schneider, Sarah; Klovins, Janis; Knight, Jo; Knott, Sarah V.; Knowles, James A.; Kogevinas, Manolis; Konte, Bettina; Kravariti, Eugenia; Kucinskas, Vaidutis; Kucinskiene, Zita Ausrele; Kupka, Ralph; Kuzelova-Ptackova, Hana; Landen, Mikael; Langford, Cordelia; Laurent, Claudine; Lawrence, Jacob; Lawrie, Stephen; Lawson, William B.; Leber, Markus; Leboyer, Marion; Lee, Phil H.; Keong, Jimmy Lee Chee; Legge, Sophie E.; Lencz, Todd; Lerer, Bernard; Levinson, Douglas F.; Levy, Shawn E.; Lewis, Cathryn M.; Li, Jun Z.; Li, Miaoxin; Li, Qingqin S.; Li, Tao; Liang, Kung-Yee; Liddle, Jennifer; Lieberman, Jeffrey; Limborska, Svetlana; Lin, Kuang; Linszen, Don H.; Lissowska, Jolanta; Liu, Chunyu; Liu, Jianjun; Lonnqvist, Jouko; Loughland, Carmel M.; Lubinski, Jan; Lucae, Susanne; Macek, Milan; MacIntyre, Donald J.; Magnusson, Patrik K.E.; Maher, Brion S.; Mahon, Pamela B.; Maier, Wolfgang; Malhotra, Anil K.; Mallet, Jacques; Malt, Ulrik F.; Markus, Hugh S.; Marsal, Sara; Martin, Nicholas G.; Mata, Ignacio; Mathew, Christopher G.; Mattheisen, Manuel; Mattingsdal, Morten; Mayoral, Fermin; McCann, Owen T.; McCarley, Robert W.; McCarroll, Steven A.; McCarthy, Mark I.; McDonald, Colm; McElroy, Susan L.; McGuffin, Peter; McInnis, Melvin G.; McIntosh, Andrew M.; McKay, James D.; McMahon, Francis J.; Medeiros, Helena; Medland, Sarah E.; Meier, Sandra; Meijer, Carin J.; Melegh, Bela; Melle, Ingrid; Meng, Fan; Mesholam-Gately, Raquelle I.; Metspalu, Andres; Michie, Patricia T.; Milani, Lili; Milanova, Vihra; Mitchell, Philip B.; Mokrab, Younes; Montgomery, Grant W.; Moran, Jennifer L.; Morken, Gunnar; Morris, Derek W.; Mors, Ole; Mortensen, Preben B.; Mowry, Bryan J.; Mühleisen, Thomas W.; Müller-Myhsok, Bertram; Murphy, Kieran C.; Murray, Robin M.; Myers, Richard M.; Myin-Germeys, Inez; Neale, Benjamin M.; Nelis, Mari; Nenadic, Igor; Nertney, Deborah A.; Nestadt, Gerald; Nicodemus, Kristin K.; Nievergelt, Caroline M.; Nikitina-Zake, Liene; Nimgaonkar, Vishwajit; Nisenbaum, Laura; Nordentoft, Merete; Nordin, Annelie; Nöthen, Markus M.; Nwulia, Evaristus A.; O'Callaghan, Eadbhard; O'Donovan, Claire; O'Dushlaine, Colm; O'Neill, F. Anthony; Oedegaard, Ketil J.; Oh, Sang-Yun; Olincy, Ann; Olsen, Line; Oruc, Lilijana; Van Os, Jim; Owen, Michael J.; Paciga, Sara A.; Palmer, Colin N.A.; Palotie, Aarno; Pantelis, Christos; Papadimitriou, George N.; Parkhomenko, Elena; Pato, Carlos; Pato, Michele T.; Paunio, Tiina; Pearson, Richard; Perkins, Diana O.; Perlis, Roy H.; Perry, Amy; Pers, Tune H.; Petryshen, Tracey L.; Pfennig, Andrea; Picchioni, Marco; Pietilainen, Olli; Pimm, Jonathan; Pirinen, Matti; Plomin, Robert; Pocklington, Andrew J.; Posthuma, Danielle; Potash, James B.; Potter, Simon C.; Powell, John; Price, Alkes; Pulver, Ann E.; Purcell, Shaun M.; Quested, Digby; Ramos-Quiroga, Josep Antoni; Rasmussen, Henrik B.; Rautanen, Anna; Ravindrarajah, Radhi; Regeer, Eline J.; Reichenberg, Abraham; Reif, Andreas; Reimers, Mark A.; Ribases, Marta; Rice, John P.; Richards, Alexander L.; Ricketts, Michelle; Riley, Brien P.; Rivas, Fabio; Rivera, Margarita; Roffman, Joshua L.; Rouleau, Guy A.; Roussos, Panos; Rujescu, Dan; Salomaa, Veikko; Sanchez-Mora, Cristina; Sanders, Alan R.; Sawcer, Stephen J.; Schall, Ulrich; Schatzberg, Alan F.; Scheftner, William A.; Schofield, Peter R.; Schork, Nicholas J.; Schwab, Sibylle G.; Scolnick, Edward M.; Scott, Laura J.; Scott, Rodney J.; Seidman, Larry J.; Serretti, Alessandro; Sham, Pak C.; Weickert, Cynthia Shannon; Shehktman, Tatyana; Shi, Jianxin; Shilling, Paul D.; Sigurdsson, Engilbert; Silverman, Jeremy M.; Sim, Kang; Slaney, Claire; Slominsky, Petr; Smeland, Olav B.; Smoller, Jordan W.; So, Hon-Cheong; Sobell, Janet L.; Soderman, Erik; Hansen, Christine Soholm; Spencer, Chris C.A.; Spijker, Anne T.; St Clair, David; Stefansson, Hreinn; Stefansson, Kari; Steinberg, Stacy; Stogmann, Elisabeth; Stordal, Eystein; Strange, Amy; Straub, Richard E.; Strauss, John S.; Streit, Fabian; Strengman, Eric; Strohmaier, Jana; Stroup, T. Scott; Su, Zhan; Subramaniam, Mythily; Suvisaari, Jaana; Svrakic, Dragan M.; Szatkiewicz, Jin P.; Szelinger, Szabolcs; Tashakkori-Ghanbaria, Avazeh; Thirumalai, Srinivas; Thompson, Robert C.; Thorgeirsson, Thorgeir E.; Toncheva, Draga; Tooney, Paul A.; Tosato, Sarah; Toulopoulou, Timothea; Trembath, Richard C.; Treutlein, Jens; Turecki, Gustavo; Vaaler, Arne E.; Vedder, Helmut; Vieta, Eduard; Vincent, John; Visscher, Peter M.; Viswanathan, Ananth C.; Vukcevic, Damjan; Waddington, John; Waller, Matthew; Walsh, Dermot; Walshe, Muriel; Walters, James T.R.; Wang, Dai; Wang, Qiang; Wang, Weiqing; Wang, Yunpeng; Watson, Stanley J.; Webb, Bradley T.; Weickert, Thomas W.; Weinberger, Daniel R.; Weisbrod, Matthias; Weiser, Mark; Werge, Thomas; Weston, Paul; Whittaker, Pamela; Widaa, Sara; Wiersma, Durk; Wildenauer, Dieter B.; Williams, Nigel M.; Williams, Stephanie; Witt, Stephanie H.; Wolen, Aaron R.; Wong, Emily H.M.; Wood, Nicholas W.; Wormley, Brandon K.; Wu, Jing Qin; Xi, Simon; Xu, Wei; Young, Allan H.; Zai, Clement C.; Zandi, Peter; Zhang, Peng; Zheng, Xuebin; Zimprich, Fritz; Zollner, Sebastian; Corvin, Aiden; Fanous, Ayman H.; Cichon, Sven; Rietschel, Marcella; Gershon, Elliot S.; Schulze, Thomas G.; Cuellar-Barboza, Alfredo B.; Forstner, Andreas J.; Holmans, Peter A.; Nurnberger, John I.; Andreassen, Ole A.; Lee, S. Hong; O'Donovan, Michael C.; Sullivan, Patrick F.; Ophoff, Roel A.; Wray, Naomi R.; Sklar, Pamela; Kendler, Kenneth S.. - In: CELL. - ISSN 0092-8674. - STAMPA. - 173:7(2018), pp. 1705-1715.e16. [10.1016/j.cell.2018.05.046]