Attenzione: i dati modificati non sono ancora stati salvati. Per confermare inserimenti o cancellazioni di voci è necessario confermare con il tasto SALVA/INSERISCI in fondo alla pagina
CRIS Current Research Information System
The life sciences are currently being transformed by an unprecedented wave of developments in molecular analysis, which include important advances in instrumental analysis as well as biocomputing. In light of the central role played by metabolism in nutrition, metabolomics is rapidly being established as a key analytical tool in human nutritional studies. Consequently, an increasing number of nutritionists integrate metabolomics into their study designs. Within this dynamic landscape, the potential of nutritional metabolomics (nutrimetabolomics) to be translated into a science, which can impact on health policies, still needs to be realized. A key element to reach this goal is the ability of the research community to join, to collectively make the best use of the potential offered by nutritional metabolomics. This article, therefore, provides a methodological description of nutritional metabolomics that reflects on the state-of-the-art techniques used in the laboratories of the Food Biomarker Alliance (funded by the European Joint Programming Initiative "A Healthy Diet for a Healthy Life" (JPI HDHL)) as well as points of reflections to harmonize this field. It is not intended to be exhaustive but rather to present a pragmatic guidance on metabolomic methodologies, providing readers with useful "tips and tricks" along the analytical workflow.
Nutrimetabolomics: An Integrative Action for Metabolomic Analyses in Human Nutritional Studies / Marynka M. Ulaszewska, Christoph H. Weinert, Alessia Trimigno, Reto Portmann, Cristina Andres Lacueva, Rene Badertscher, Lorraine Brennan, Carl Brunius, Achim Bub, Francesco Capozzi, Marta Cialie Rosso, Chiara E. Cordero, Hannelore Daniel,Stephanie Durand, Bjoern Egert, Paola G. Ferrario, Edith J.M. Feskens, Pietro Franceschi, Mar Garcia-Aloy, Franck Giacomoni, Pieter Giesbertz, Raul Gonzalez-Domınguez,Kati Hanhineva, Lieselot Y. Hemeryck, Joachim Kopka, Sabine E. Kulling, Rafael Llorach, Claudine Manach, Fulvio Mattivi, Carole Migne, Linda H. Munger, Beate Ott, Gianfranco Picone, Gregory Pimentel, Estelle Pujos-Guillot, Samantha Riccadonna,
Manuela J. Rist, Caroline Rombouts, Josep Rubert, Thomas Skurk, Pedapati S. C. Sri Harsha, Lieven Van Meulebroek, Lynn Vanhaecke, Rosa Vazquez-Fresno, David Wishart,Guy Vergeres. - In: MOLECULAR NUTRITION & FOOD RESEARCH. - ISSN 1613-4125. - STAMPA. - 63:(2019), pp. 1800384.1-1800384.38. [10.1002/mnfr.201800384]
Nutrimetabolomics: An Integrative Action for Metabolomic Analyses in Human Nutritional Studies
Marynka M. Ulaszewska;Christoph H. Weinert;Alessia Trimigno;Reto Portmann;Cristina Andres Lacueva;Rene Badertscher;Lorraine Brennan;Carl Brunius;Achim Bub;Francesco Capozzi;Marta Cialie Rosso;Chiara E. Cordero;Hannelore Daniel;Stephanie Durand;Bjoern Egert;Paola G. Ferrario;Edith J. M. Feskens;Pietro Franceschi;Mar Garcia-Aloy;Franck Giacomoni;Pieter Giesbertz;Raul Gonzalez-Domınguez;Kati Hanhineva;Lieselot Y. Hemeryck;Joachim Kopka;Sabine E. Kulling;Rafael Llorach;Claudine Manach;Fulvio Mattivi;Carole Migne;Linda H. Munger;Beate Ott;Gianfranco Picone;Gregory Pimentel;Estelle Pujos-Guillot;Samantha Riccadonna;Manuela J. Rist;Caroline Rombouts;Josep Rubert;Thomas Skurk;Pedapati S. C. Sri Harsha;Lieven Van Meulebroek;Lynn Vanhaecke;Rosa Vazquez-Fresno;David Wishart;Guy Vergeres
2019
Abstract
The life sciences are currently being transformed by an unprecedented wave of developments in molecular analysis, which include important advances in instrumental analysis as well as biocomputing. In light of the central role played by metabolism in nutrition, metabolomics is rapidly being established as a key analytical tool in human nutritional studies. Consequently, an increasing number of nutritionists integrate metabolomics into their study designs. Within this dynamic landscape, the potential of nutritional metabolomics (nutrimetabolomics) to be translated into a science, which can impact on health policies, still needs to be realized. A key element to reach this goal is the ability of the research community to join, to collectively make the best use of the potential offered by nutritional metabolomics. This article, therefore, provides a methodological description of nutritional metabolomics that reflects on the state-of-the-art techniques used in the laboratories of the Food Biomarker Alliance (funded by the European Joint Programming Initiative "A Healthy Diet for a Healthy Life" (JPI HDHL)) as well as points of reflections to harmonize this field. It is not intended to be exhaustive but rather to present a pragmatic guidance on metabolomic methodologies, providing readers with useful "tips and tricks" along the analytical workflow.
Nutrimetabolomics: An Integrative Action for Metabolomic Analyses in Human Nutritional Studies / Marynka M. Ulaszewska, Christoph H. Weinert, Alessia Trimigno, Reto Portmann, Cristina Andres Lacueva, Rene Badertscher, Lorraine Brennan, Carl Brunius, Achim Bub, Francesco Capozzi, Marta Cialie Rosso, Chiara E. Cordero, Hannelore Daniel,Stephanie Durand, Bjoern Egert, Paola G. Ferrario, Edith J.M. Feskens, Pietro Franceschi, Mar Garcia-Aloy, Franck Giacomoni, Pieter Giesbertz, Raul Gonzalez-Domınguez,Kati Hanhineva, Lieselot Y. Hemeryck, Joachim Kopka, Sabine E. Kulling, Rafael Llorach, Claudine Manach, Fulvio Mattivi, Carole Migne, Linda H. Munger, Beate Ott, Gianfranco Picone, Gregory Pimentel, Estelle Pujos-Guillot, Samantha Riccadonna,
Manuela J. Rist, Caroline Rombouts, Josep Rubert, Thomas Skurk, Pedapati S. C. Sri Harsha, Lieven Van Meulebroek, Lynn Vanhaecke, Rosa Vazquez-Fresno, David Wishart,Guy Vergeres. - In: MOLECULAR NUTRITION & FOOD RESEARCH. - ISSN 1613-4125. - STAMPA. - 63:(2019), pp. 1800384.1-1800384.38. [10.1002/mnfr.201800384]
Marynka M. Ulaszewska, Christoph H. Weinert, Alessia Trimigno, Reto Portmann, Cristina Andres Lacueva, Rene Badertscher, Lorraine Brennan, Carl Brunius, Achim Bub, Francesco Capozzi, Marta Cialie Rosso, Chiara E. Cordero, Hannelore Daniel,Stephanie Durand, Bjoern Egert, Paola G. Ferrario, Edith J.M. Feskens, Pietro Franceschi, Mar Garcia-Aloy, Franck Giacomoni, Pieter Giesbertz, Raul Gonzalez-Domınguez,Kati Hanhineva, Lieselot Y. Hemeryck, Joachim Kopka, Sabine E. Kulling, Rafael Llorach, Claudine Manach, Fulvio Mattivi, Carole Migne, Linda H. Munger, Beate Ott, Gianfranco Picone, Gregory Pimentel, Estelle Pujos-Guillot, Samantha Riccadonna,
Manuela J. Rist, Caroline Rombouts, Josep Rubert, Thomas Skurk, Pedapati S. C. Sri Harsha, Lieven Van Meulebroek, Lynn Vanhaecke, Rosa Vazquez-Fresno, David Wishart,Guy Vergeres
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/647235
Citazioni
80
162
156
social impact
Conferma cancellazione
Sei sicuro che questo prodotto debba essere cancellato?
simulazione ASN
Il report seguente simula gli indicatori relativi alla propria produzione scientifica in relazione alle soglie ASN 2023-2025 del proprio SC/SSD. Si ricorda che il superamento dei valori soglia (almeno 2 su 3) è requisito necessario ma non sufficiente al conseguimento dell'abilitazione. La simulazione si basa sui dati IRIS e sugli indicatori bibliometrici alla data indicata e non tiene conto di eventuali periodi di congedo obbligatorio, che in sede di domanda ASN danno diritto a incrementi percentuali dei valori. La simulazione può differire dall'esito di un’eventuale domanda ASN sia per errori di catalogazione e/o dati mancanti in IRIS, sia per la variabilità dei dati bibliometrici nel tempo. Si consideri che Anvur calcola i valori degli indicatori all'ultima data utile per la presentazione delle domande.
La presente simulazione è stata realizzata sulla base delle specifiche raccolte sul tavolo ER del Focus Group IRIS coordinato dall’Università di Modena e Reggio Emilia e delle regole riportate nel DM 589/2018 e allegata Tabella A. Cineca, l’Università di Modena e Reggio Emilia e il Focus Group IRIS non si assumono alcuna responsabilità in merito all’uso che il diretto interessato o terzi faranno della simulazione. Si specifica inoltre che la simulazione contiene calcoli effettuati con dati e algoritmi di pubblico dominio e deve quindi essere considerata come un mero ausilio al calcolo svolgibile manualmente o con strumenti equivalenti.