There is growing interest in dietary strategies aimed at counteracting oxidative stress induced neuronal death associated with Parkinson's disease (PD). Isothiocyanates (ITCs), present in Cruciferous vegetables, are known as cancer chemopreventive agents and strong inducers of phase II detoxification enzymes. Among the various ITCs, sulforaphane (SUL) has recently gained attention as a potential neuroprotective agent. In this study, we investigated the mechanism basis of the neuroprotective potential of SUL in a neuronal cell model of PD. In particular, we demonstrated that treatment of human neuronal like SH-SY5Y cells with SUL prevents the oxidative damage and neuronal death induced by 6-hydroxidopamine (6-OHDA), a specific neurotoxin. In parallel, we found a potent indirect antioxidant activity of SUL on neuronal cells that could be ascribed to increased GSH levels and phase II enzyme activities, such as glutathione-S-transferase, gutathione reductase and NADPH-quinone oxidoreductase. Interestingly, SUL also showed an ability to rescue the neuronal death induced by 6-OHDA through the activation of neuronal survival pathways such as PI3K/AKT and MEK/ERK. Taken together, these findings suggest thath SUL may have a positive impact on PD to retard or reverse the accellerated rate of neuronal degeneration.

Neuroprotective effects of sulforaphane in an in vitro model of Parkinson’s disease / A.Tarozzi; F. Morroni; A. Merlicco; C. Angeloni; S. Hrelia; G. Cantelli Forti; P. Hrelia. - STAMPA. - (2008), pp. 124-124. (Intervento presentato al convegno A Meeting of the Oxygen Club of California tenutosi a Santa Barbara (CA-USA) nel 12-15 marzo 2008).

Neuroprotective effects of sulforaphane in an in vitro model of Parkinson’s disease

TAROZZI, ANDREA;MORRONI, FABIANA;MERLICCO, ADRIANA;ANGELONI, CRISTINA;HRELIA, SILVANA;CANTELLI FORTI, GIORGIO;HRELIA, PATRIZIA
2008

Abstract

There is growing interest in dietary strategies aimed at counteracting oxidative stress induced neuronal death associated with Parkinson's disease (PD). Isothiocyanates (ITCs), present in Cruciferous vegetables, are known as cancer chemopreventive agents and strong inducers of phase II detoxification enzymes. Among the various ITCs, sulforaphane (SUL) has recently gained attention as a potential neuroprotective agent. In this study, we investigated the mechanism basis of the neuroprotective potential of SUL in a neuronal cell model of PD. In particular, we demonstrated that treatment of human neuronal like SH-SY5Y cells with SUL prevents the oxidative damage and neuronal death induced by 6-hydroxidopamine (6-OHDA), a specific neurotoxin. In parallel, we found a potent indirect antioxidant activity of SUL on neuronal cells that could be ascribed to increased GSH levels and phase II enzyme activities, such as glutathione-S-transferase, gutathione reductase and NADPH-quinone oxidoreductase. Interestingly, SUL also showed an ability to rescue the neuronal death induced by 6-OHDA through the activation of neuronal survival pathways such as PI3K/AKT and MEK/ERK. Taken together, these findings suggest thath SUL may have a positive impact on PD to retard or reverse the accellerated rate of neuronal degeneration.
2008
Oxidants and Antioxidants in Biology
124
124
Neuroprotective effects of sulforaphane in an in vitro model of Parkinson’s disease / A.Tarozzi; F. Morroni; A. Merlicco; C. Angeloni; S. Hrelia; G. Cantelli Forti; P. Hrelia. - STAMPA. - (2008), pp. 124-124. (Intervento presentato al convegno A Meeting of the Oxygen Club of California tenutosi a Santa Barbara (CA-USA) nel 12-15 marzo 2008).
A.Tarozzi; F. Morroni; A. Merlicco; C. Angeloni; S. Hrelia; G. Cantelli Forti; P. Hrelia
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/61240
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